Rattus norvegicus

15 known processes

Arfgef2

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

(Aliases: Big2)

Arfgef2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular protein metabolic process GO:0032268 267 0.107
rna metabolic process GO:0016070 406 0.105
intracellular signal transduction GO:0035556 314 0.081
Human
rna biosynthetic process GO:0032774 380 0.074
regulation of signal transduction GO:0009966 318 0.073
catabolic process GO:0009056 351 0.073
Human
cellular response to endogenous stimulus GO:0071495 377 0.068
response to extracellular stimulus GO:0009991 380 0.068
protein complex assembly GO:0006461 263 0.068
regulation of rna metabolic process GO:0051252 391 0.068
regulation of rna biosynthetic process GO:2001141 381 0.065
macromolecular complex assembly GO:0065003 273 0.063
macromolecular complex subunit organization GO:0043933 339 0.062
organophosphate metabolic process GO:0019637 370 0.060
Human
nucleoside phosphate metabolic process GO:0006753 283 0.059
Human
regulation of transcription dna templated GO:0006355 374 0.056
response to nutrient levels GO:0031667 370 0.055
regulation of cell proliferation GO:0042127 359 0.055
protein complex subunit organization GO:0071822 302 0.054
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.053
Human
programmed cell death GO:0012501 392 0.052
secretion by cell GO:0032940 248 0.052
regulation of programmed cell death GO:0043067 341 0.052
transcription dna templated GO:0006351 377 0.052
head development GO:0060322 247 0.051
nucleic acid templated transcription GO:0097659 379 0.051
anatomical structure morphogenesis GO:0009653 298 0.049
regulation of protein metabolic process GO:0051246 289 0.049
regulation of phosphate metabolic process GO:0019220 349 0.049
Human
vesicle mediated transport GO:0016192 181 0.048
response to nutrient GO:0007584 248 0.047
single organism catabolic process GO:0044712 283 0.047
Human
regulation of apoptotic process GO:0042981 335 0.047
regulation of protein modification process GO:0031399 194 0.047
negative regulation of metabolic process GO:0009892 331 0.046
regulation of phosphorylation GO:0042325 248 0.046
cellular response to nitrogen compound GO:1901699 210 0.045
positive regulation of phosphate metabolic process GO:0045937 262 0.044
Human
central nervous system development GO:0007417 311 0.044
homeostatic process GO:0042592 331 0.043
apoptotic process GO:0006915 381 0.043
regulation of secretion GO:0051046 224 0.042
organelle organization GO:0006996 266 0.042
Human
cellular response to organonitrogen compound GO:0071417 197 0.042
cell cell signaling GO:0007267 335 0.042
regulation of nucleic acid templated transcription GO:1903506 380 0.042
positive regulation of multicellular organismal process GO:0051240 387 0.040
Human
organic acid metabolic process GO:0006082 292 0.040
regulation of intracellular signal transduction GO:1902531 218 0.040
positive regulation of rna metabolic process GO:0051254 203 0.040
cellular catabolic process GO:0044248 295 0.040
Human
ribonucleotide metabolic process GO:0009259 231 0.040
Human
positive regulation of developmental process GO:0051094 283 0.039
regulation of catalytic activity GO:0050790 304 0.039
Human
positive regulation of cellular biosynthetic process GO:0031328 295 0.039
cellular response to oxygen containing compound GO:1901701 386 0.039
single organism intracellular transport GO:1902582 166 0.038
Human
chemical homeostasis GO:0048878 292 0.037
multi organism reproductive process GO:0044703 262 0.037
purine ribonucleotide metabolic process GO:0009150 227 0.036
Human
brain development GO:0007420 247 0.036
negative regulation of macromolecule metabolic process GO:0010605 260 0.035
multicellular organismal reproductive process GO:0048609 233 0.035
oxoacid metabolic process GO:0043436 290 0.035
cellular response to stress GO:0033554 269 0.034
reproductive process GO:0022414 372 0.034
regulation of cellular component organization GO:0051128 368 0.034
lipid metabolic process GO:0006629 283 0.033
nucleotide metabolic process GO:0009117 279 0.033
Human
single organism reproductive process GO:0044702 297 0.033
positive regulation of biosynthetic process GO:0009891 319 0.033
macromolecule localization GO:0033036 252 0.032
carbohydrate derivative metabolic process GO:1901135 346 0.032
Human
organic substance catabolic process GO:1901575 316 0.032
Human
positive regulation of gene expression GO:0010628 244 0.032
regulation of multicellular organismal development GO:2000026 376 0.032
single organism biosynthetic process GO:0044711 342 0.032
secretion GO:0046903 307 0.031
cellular component biogenesis GO:0044085 368 0.031
response to inorganic substance GO:0010035 377 0.031
tissue development GO:0009888 252 0.030
reproduction GO:0000003 245 0.030
positive regulation of nervous system development GO:0051962 178 0.030
regulation of cell differentiation GO:0045595 320 0.030
regulation of molecular function GO:0065009 398 0.030
Human
carboxylic acid metabolic process GO:0019752 289 0.030
protein complex biogenesis GO:0070271 263 0.030
regulation of phosphorus metabolic process GO:0051174 349 0.030
Human
positive regulation of transcription dna templated GO:0045893 197 0.030
positive regulation of nucleic acid templated transcription GO:1903508 197 0.030
regulation of secretion by cell GO:1903530 208 0.029
protein localization GO:0008104 191 0.029
multicellular organism reproduction GO:0032504 233 0.029
response to growth factor GO:0070848 189 0.029
cellular component assembly GO:0022607 360 0.029
response to peptide GO:1901652 292 0.029
transmembrane transport GO:0055085 412 0.029
positive regulation of cellular component organization GO:0051130 200 0.028
purine nucleotide metabolic process GO:0006163 229 0.028
Human
regulation of canonical wnt signaling pathway GO:0060828 4 0.028
negative regulation of cell communication GO:0010648 158 0.028
cellular response to hormone stimulus GO:0032870 247 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.028
Human
purine containing compound metabolic process GO:0072521 253 0.028
Human
positive regulation of cell differentiation GO:0045597 217 0.028
cellular ketone metabolic process GO:0042180 51 0.028
regulation of neuron differentiation GO:0045664 208 0.027
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
Human
rhythmic process GO:0048511 156 0.027
regulation of nervous system development GO:0051960 264 0.027
neuron development GO:0048666 286 0.027
lipid biosynthetic process GO:0008610 128 0.027
positive regulation of phosphorus metabolic process GO:0010562 262 0.027
Human
cellular amino acid metabolic process GO:0006520 107 0.027
organonitrogen compound catabolic process GO:1901565 179 0.027
Human
cation transmembrane transport GO:0098655 263 0.026
positive regulation of neurogenesis GO:0050769 165 0.026
positive regulation of cell proliferation GO:0008284 249 0.026
negative regulation of protein metabolic process GO:0051248 114 0.026
negative regulation of signaling GO:0023057 157 0.025
ribose phosphate metabolic process GO:0019693 235 0.025
Human
neuron differentiation GO:0030182 368 0.025
negative regulation of programmed cell death GO:0043069 183 0.025
response to peptide hormone GO:0043434 278 0.025
purine nucleoside triphosphate metabolic process GO:0009144 141 0.025
Human
chromosome segregation GO:0007059 2 0.025
negative regulation of gene expression GO:0010629 199 0.025
cellular response to growth factor stimulus GO:0071363 162 0.025
purine nucleoside metabolic process GO:0042278 169 0.024
Human
regulation of neurogenesis GO:0050767 247 0.024
positive regulation of cell development GO:0010720 176 0.024
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.024
regulation of cellular localization GO:0060341 263 0.024
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.024
cellular homeostasis GO:0019725 252 0.024
regulation of system process GO:0044057 208 0.024
negative regulation of response to stimulus GO:0048585 155 0.023
aging GO:0007568 241 0.023
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.023
regulation of response to stress GO:0080134 126 0.023
negative regulation of cellular metabolic process GO:0031324 281 0.023
negative regulation of apoptotic process GO:0043066 181 0.023
positive regulation of cellular protein metabolic process GO:0032270 167 0.023
cellular macromolecule localization GO:0070727 122 0.022
negative regulation of molecular function GO:0044092 133 0.022
lipid localization GO:0010876 62 0.022
cofactor metabolic process GO:0051186 95 0.022
ion transmembrane transport GO:0034220 365 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.022
cellular response to peptide hormone stimulus GO:0071375 120 0.022
regulation of membrane potential GO:0042391 110 0.022
intracellular transport GO:0046907 185 0.022
Human
protein oligomerization GO:0051259 191 0.022
regulation of proteasomal protein catabolic process GO:0061136 4 0.022
behavior GO:0007610 205 0.022
regulation of cell development GO:0060284 263 0.022
purine ribonucleoside metabolic process GO:0046128 168 0.021
Human
ion homeostasis GO:0050801 212 0.021
positive regulation of rna biosynthetic process GO:1902680 197 0.021
neurological system process GO:0050877 219 0.021
regulation of anatomical structure morphogenesis GO:0022603 141 0.021
cellular amine metabolic process GO:0044106 38 0.021
amine metabolic process GO:0009308 38 0.021
positive regulation of catabolic process GO:0009896 78 0.021
Human
enzyme linked receptor protein signaling pathway GO:0007167 116 0.021
nucleoside metabolic process GO:0009116 179 0.021
Human
negative regulation of cellular protein metabolic process GO:0032269 106 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.020
cation transport GO:0006812 382 0.020
protein phosphorylation GO:0006468 345 0.020
negative regulation of cell death GO:0060548 229 0.020
response to wounding GO:0009611 254 0.020
regulation of cellular ketone metabolic process GO:0010565 27 0.020
cellular lipid metabolic process GO:0044255 208 0.020
regulation of immune system process GO:0002682 123 0.020
regulation of protein phosphorylation GO:0001932 183 0.020
proteolysis GO:0006508 175 0.020
positive regulation of protein metabolic process GO:0051247 178 0.019
cellular chemical homeostasis GO:0055082 247 0.019
positive regulation of signaling GO:0023056 270 0.019
anion transport GO:0006820 178 0.019
regulation of cellular catabolic process GO:0031329 101 0.019
Human
cellular protein localization GO:0034613 122 0.019
hormone secretion GO:0046879 115 0.019
response to oxidative stress GO:0006979 186 0.019
hormone transport GO:0009914 121 0.019
purine nucleotide catabolic process GO:0006195 136 0.018
Human
neuron projection development GO:0031175 273 0.018
developmental process involved in reproduction GO:0003006 159 0.018
positive regulation of neuron differentiation GO:0045666 126 0.018
purine nucleoside triphosphate catabolic process GO:0009146 122 0.018
Human
transmission of nerve impulse GO:0019226 42 0.018
response to metal ion GO:0010038 253 0.018
carbohydrate derivative catabolic process GO:1901136 147 0.018
Human
organophosphate catabolic process GO:0046434 148 0.018
Human
locomotion GO:0040011 237 0.018
regulation of catabolic process GO:0009894 113 0.018
Human
coenzyme metabolic process GO:0006732 86 0.018
cell projection organization GO:0030030 302 0.017
regulation of body fluid levels GO:0050878 90 0.017
growth GO:0040007 165 0.017
positive regulation of transport GO:0051050 245 0.017
gamete generation GO:0007276 124 0.017
multicellular organism growth GO:0035264 1 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.017
inorganic cation transmembrane transport GO:0098662 202 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.017
ribonucleoside triphosphate catabolic process GO:0009203 122 0.017
Human
positive regulation of neuron projection development GO:0010976 99 0.017
single organism organelle organization GO:1902589 180 0.017
cytoplasmic transport GO:0016482 115 0.017
Human
response to decreased oxygen levels GO:0036293 237 0.017
metal ion transport GO:0030001 289 0.016
negative regulation of rna metabolic process GO:0051253 123 0.016
circulatory system process GO:0003013 183 0.016
axis specification GO:0009798 4 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
Human
nucleotide catabolic process GO:0009166 139 0.016
Human
positive regulation of phosphorylation GO:0042327 177 0.016
response to ketone GO:1901654 182 0.016
cellular response to organic cyclic compound GO:0071407 202 0.016
protein autophosphorylation GO:0046777 66 0.016
regulation of cellular amino acid metabolic process GO:0006521 2 0.016
purine containing compound catabolic process GO:0072523 138 0.016
Human
purine nucleoside catabolic process GO:0006152 124 0.015
Human
negative regulation of signal transduction GO:0009968 83 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
Human
inorganic ion transmembrane transport GO:0098660 229 0.015
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.015
nucleoside catabolic process GO:0009164 126 0.015
Human
multicellular organismal signaling GO:0035637 44 0.015
regulation of cell morphogenesis GO:0022604 77 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
Human
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.015
Human
heterocycle catabolic process GO:0046700 167 0.015
Human
nucleoside phosphate catabolic process GO:1901292 140 0.015
Human
protein heterooligomerization GO:0051291 89 0.015
synaptic transmission GO:0007268 235 0.015
small gtpase mediated signal transduction GO:0007264 36 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
Human
sexual reproduction GO:0019953 148 0.015
ribonucleotide catabolic process GO:0009261 136 0.015
Human
negative regulation of multicellular organismal process GO:0051241 203 0.015
neuronal action potential GO:0019228 35 0.015
regulation of purine nucleotide metabolic process GO:1900542 115 0.015
Human
nitrogen compound transport GO:0071705 229 0.015
protein transport GO:0015031 132 0.015
regulation of neuron projection development GO:0010975 161 0.015
positive regulation of protein modification process GO:0031401 142 0.015
lipid transport GO:0006869 61 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
Human
negative regulation of biosynthetic process GO:0009890 168 0.014
regulation of cell growth GO:0001558 85 0.014
oxidation reduction process GO:0055114 304 0.014
establishment of protein localization GO:0045184 141 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
response to vitamin GO:0033273 131 0.014
cellular component movement GO:0006928 248 0.014
nucleoside monophosphate metabolic process GO:0009123 93 0.014
cellular cation homeostasis GO:0030003 180 0.014
response to biotic stimulus GO:0009607 226 0.014
nucleoside phosphate biosynthetic process GO:1901293 102 0.014
ribonucleoside catabolic process GO:0042454 126 0.014
Human
immune system process GO:0002376 204 0.014
positive regulation of response to stimulus GO:0048584 285 0.014
regulation of defense response GO:0031347 68 0.014
regulation of growth GO:0040008 105 0.014
acylglycerol metabolic process GO:0006639 21 0.014
response to oxygen levels GO:0070482 265 0.014
cellular response to external stimulus GO:0071496 118 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
positive regulation of molecular function GO:0044093 230 0.014
Human
negative regulation of transport GO:0051051 136 0.014
action potential GO:0001508 54 0.014
blood circulation GO:0008015 183 0.014
spermatogenesis GO:0007283 99 0.014
cellular response to peptide GO:1901653 133 0.014
regulation of response to external stimulus GO:0032101 106 0.014
positive regulation of nucleotide metabolic process GO:0045981 91 0.013
Human
spindle organization GO:0007051 2 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
Human
ras protein signal transduction GO:0007265 29 0.013
cell motility GO:0048870 202 0.013
purine ribonucleoside catabolic process GO:0046130 124 0.013
Human
ribonucleoside monophosphate metabolic process GO:0009161 88 0.013
monocarboxylic acid metabolic process GO:0032787 152 0.013
male gamete generation GO:0048232 99 0.013
negative regulation of transcription dna templated GO:0045892 116 0.013
defense response GO:0006952 194 0.013
regulation of hydrolase activity GO:0051336 143 0.013
Human
regulation of cell projection organization GO:0031344 175 0.013
response to radiation GO:0009314 137 0.013
nucleobase containing compound catabolic process GO:0034655 152 0.013
Human
dna metabolic process GO:0006259 96 0.013
response to hypoxia GO:0001666 231 0.013
signal release GO:0023061 145 0.013
negative regulation of intracellular signal transduction GO:1902532 38 0.013
lipid storage GO:0019915 1 0.013
dephosphorylation GO:0016311 98 0.013
response to insulin GO:0032868 133 0.013
organic anion transport GO:0015711 132 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
cell growth GO:0016049 104 0.013
response to estrogen GO:0043627 232 0.013
development of primary sexual characteristics GO:0045137 107 0.012
regulation of protein kinase activity GO:0045859 105 0.012
regulation of anatomical structure size GO:0090066 135 0.012
response to reactive oxygen species GO:0000302 120 0.012
gastrulation GO:0007369 2 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
developmental growth GO:0048589 100 0.012
nucleotide biosynthetic process GO:0009165 98 0.012
cellular ion homeostasis GO:0006873 184 0.012
glycerolipid metabolic process GO:0046486 67 0.012
response to carbohydrate GO:0009743 183 0.012
regulation of transferase activity GO:0051338 123 0.012
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
atp metabolic process GO:0046034 72 0.012
alpha amino acid metabolic process GO:1901605 71 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.012
Human
negative regulation of nucleic acid templated transcription GO:1903507 117 0.012
glycosyl compound catabolic process GO:1901658 126 0.012
Human
aromatic compound catabolic process GO:0019439 168 0.012
Human
positive regulation of signal transduction GO:0009967 175 0.012
gonad development GO:0008406 104 0.012
endocytosis GO:0006897 84 0.012
sex differentiation GO:0007548 113 0.012
embryonic pattern specification GO:0009880 1 0.012
regulation of hormone secretion GO:0046883 106 0.012
regulation of developmental growth GO:0048638 45 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
response to glucose GO:0009749 136 0.012
metal ion homeostasis GO:0055065 186 0.012
cell morphogenesis GO:0000902 142 0.012
carboxylic acid transport GO:0046942 115 0.012
cellular component morphogenesis GO:0032989 155 0.012
ribonucleotide biosynthetic process GO:0009260 85 0.012
actin filament based process GO:0030029 86 0.011
posttranscriptional regulation of gene expression GO:0010608 37 0.011
cytoskeleton organization GO:0007010 111 0.011
single organism cellular localization GO:1902580 102 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
regulation of hormone levels GO:0010817 187 0.011
maintenance of location GO:0051235 17 0.011
negative regulation of rna biosynthetic process GO:1902679 118 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
Human
hormone metabolic process GO:0042445 69 0.011
forebrain development GO:0030900 98 0.011
eye morphogenesis GO:0048592 4 0.011
positive regulation of lipid catabolic process GO:0050996 4 0.011
purine ribonucleotide catabolic process GO:0009154 136 0.011
Human
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.011
positive regulation of secretion GO:0051047 140 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
peptide biosynthetic process GO:0043043 3 0.011
positive regulation of proteasomal protein catabolic process GO:1901800 3 0.011
single organism behavior GO:0044708 130 0.011
macroautophagy GO:0016236 4 0.011
gland development GO:0048732 155 0.010
mesoderm development GO:0007498 2 0.010
nucleoside triphosphate catabolic process GO:0009143 123 0.010
Human
carbohydrate metabolic process GO:0005975 130 0.010
regulation of nucleotide metabolic process GO:0006140 117 0.010
Human
protein modification by small protein conjugation or removal GO:0070647 35 0.010
cellular response to cytokine stimulus GO:0071345 127 0.010
cell migration GO:0016477 197 0.010
response to hexose GO:0009746 144 0.010
response to monosaccharide GO:0034284 159 0.010
protein homooligomerization GO:0051260 91 0.010
neutral lipid metabolic process GO:0006638 21 0.010
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.010
peptidyl tyrosine modification GO:0018212 72 0.010
purine nucleoside monophosphate catabolic process GO:0009128 55 0.010
actin cytoskeleton organization GO:0030036 73 0.010
ribose phosphate biosynthetic process GO:0046390 87 0.010

Arfgef2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
nervous system disease DOID:863 0 0.033
musculoskeletal system disease DOID:17 0 0.021
sensory system disease DOID:0050155 0 0.015
muscular disease DOID:0080000 0 0.015
muscle tissue disease DOID:66 0 0.015
disease of metabolism DOID:0014667 0 0.014
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011
central nervous system disease DOID:331 0 0.011