Rattus norvegicus

29 known processes

Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

Akr1b10 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.146
nucleic acid templated transcription GO:0097659 379 0.131
rna biosynthetic process GO:0032774 380 0.115
transcription from rna polymerase ii promoter GO:0006366 252 0.112
positive regulation of cellular biosynthetic process GO:0031328 295 0.100
regulation of rna biosynthetic process GO:2001141 381 0.095
regulation of cellular component organization GO:0051128 368 0.082
regulation of transcription dna templated GO:0006355 374 0.082
rna metabolic process GO:0016070 406 0.080
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.080
cellular response to endogenous stimulus GO:0071495 377 0.078
Rat
transcription dna templated GO:0006351 377 0.075
regulation of rna metabolic process GO:0051252 391 0.073
regulation of phosphorus metabolic process GO:0051174 349 0.070
regulation of nucleic acid templated transcription GO:1903506 380 0.069
regulation of signal transduction GO:0009966 318 0.068
Rat
negative regulation of metabolic process GO:0009892 331 0.066
regulation of molecular function GO:0065009 398 0.062
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.061
positive regulation of gene expression GO:0010628 244 0.061
positive regulation of transcription dna templated GO:0045893 197 0.059
protein phosphorylation GO:0006468 345 0.058
nucleobase containing small molecule metabolic process GO:0055086 316 0.056
cellular response to hormone stimulus GO:0032870 247 0.056
regulation of phosphorylation GO:0042325 248 0.056
nucleoside phosphate metabolic process GO:0006753 283 0.055
positive regulation of phosphate metabolic process GO:0045937 262 0.055
cellular component assembly GO:0022607 360 0.053
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.053
regulation of phosphate metabolic process GO:0019220 349 0.051
positive regulation of transport GO:0051050 245 0.051
intracellular signal transduction GO:0035556 314 0.051
Rat
response to nutrient GO:0007584 248 0.051
negative regulation of macromolecule metabolic process GO:0010605 260 0.050
regulation of intracellular signal transduction GO:1902531 218 0.050
Rat
positive regulation of rna biosynthetic process GO:1902680 197 0.049
positive regulation of phosphorus metabolic process GO:0010562 262 0.049
positive regulation of rna metabolic process GO:0051254 203 0.049
regulation of protein metabolic process GO:0051246 289 0.048
positive regulation of cellular component organization GO:0051130 200 0.048
positive regulation of nucleic acid templated transcription GO:1903508 197 0.047
cellular response to nitrogen compound GO:1901699 210 0.046
Rat
positive regulation of cell communication GO:0010647 271 0.045
Rat
negative regulation of cellular metabolic process GO:0031324 281 0.045
ribose phosphate metabolic process GO:0019693 235 0.045
response to nutrient levels GO:0031667 370 0.044
negative regulation of signaling GO:0023057 157 0.043
regulation of cellular localization GO:0060341 263 0.041
regulation of programmed cell death GO:0043067 341 0.041
negative regulation of gene expression GO:0010629 199 0.040
positive regulation of molecular function GO:0044093 230 0.040
regulation of cell differentiation GO:0045595 320 0.039
purine containing compound metabolic process GO:0072521 253 0.038
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.037
regulation of catalytic activity GO:0050790 304 0.037
response to extracellular stimulus GO:0009991 380 0.036
carbohydrate derivative metabolic process GO:1901135 346 0.036
Human
programmed cell death GO:0012501 392 0.036
regulation of cellular ketone metabolic process GO:0010565 27 0.036
reproduction GO:0000003 245 0.036
Rat
regulation of cell projection organization GO:0031344 175 0.035
positive regulation of catalytic activity GO:0043085 184 0.035
regulation of neurogenesis GO:0050767 247 0.035
amine metabolic process GO:0009308 38 0.035
nucleotide metabolic process GO:0009117 279 0.034
multicellular organismal reproductive process GO:0048609 233 0.034
Rat
positive regulation of response to stimulus GO:0048584 285 0.034
Rat
regulation of secretion by cell GO:1903530 208 0.033
positive regulation of protein metabolic process GO:0051247 178 0.033
positive regulation of signaling GO:0023056 270 0.032
Rat
positive regulation of phosphorylation GO:0042327 177 0.031
negative regulation of biosynthetic process GO:0009890 168 0.031
central nervous system development GO:0007417 311 0.031
Rat Fly
regulation of cellular amine metabolic process GO:0033238 8 0.031
protein complex subunit organization GO:0071822 302 0.030
purine ribonucleotide metabolic process GO:0009150 227 0.030
neuron differentiation GO:0030182 368 0.030
cellular amino acid metabolic process GO:0006520 107 0.030
negative regulation of cell death GO:0060548 229 0.029
heterocycle catabolic process GO:0046700 167 0.029
regulation of cellular protein metabolic process GO:0032268 267 0.029
regulation of multicellular organismal development GO:2000026 376 0.028
ion transmembrane transport GO:0034220 365 0.028
small gtpase mediated signal transduction GO:0007264 36 0.028
cellular catabolic process GO:0044248 295 0.028
Human
positive regulation of multicellular organismal process GO:0051240 387 0.028
cellular component biogenesis GO:0044085 368 0.028
positive regulation of developmental process GO:0051094 283 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.027
positive regulation of biosynthetic process GO:0009891 319 0.027
positive regulation of signal transduction GO:0009967 175 0.027
Rat
secretion GO:0046903 307 0.027
signal release GO:0023061 145 0.027
cell cell signaling GO:0007267 335 0.027
cellular ketone metabolic process GO:0042180 51 0.027
Human
regulation of cell proliferation GO:0042127 359 0.027
Rat
cell projection organization GO:0030030 302 0.026
organophosphate metabolic process GO:0019637 370 0.026
cellular chemical homeostasis GO:0055082 247 0.026
biological adhesion GO:0022610 110 0.025
cellular amine metabolic process GO:0044106 38 0.025
organophosphate biosynthetic process GO:0090407 143 0.025
regulation of hormone levels GO:0010817 187 0.025
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
negative regulation of cellular biosynthetic process GO:0031327 161 0.025
protein complex assembly GO:0006461 263 0.025
negative regulation of programmed cell death GO:0043069 183 0.025
secretion by cell GO:0032940 248 0.025
purine nucleotide metabolic process GO:0006163 229 0.025
sensory perception of pain GO:0019233 73 0.024
catabolic process GO:0009056 351 0.024
Human
g protein coupled receptor signaling pathway GO:0007186 242 0.024
signal transduction by phosphorylation GO:0023014 144 0.024
defense response GO:0006952 194 0.024
locomotion GO:0040011 237 0.024
oxidation reduction process GO:0055114 304 0.024
organic acid metabolic process GO:0006082 292 0.024
cellular response to oxygen containing compound GO:1901701 386 0.024
Rat
establishment of tissue polarity GO:0007164 2 0.024
response to glucocorticoid GO:0051384 223 0.024
macromolecular complex subunit organization GO:0043933 339 0.024
regulation of cell development GO:0060284 263 0.023
positive regulation of neurogenesis GO:0050769 165 0.023
negative regulation of cell communication GO:0010648 158 0.023
cell motility GO:0048870 202 0.023
negative regulation of apoptotic process GO:0043066 181 0.023
apoptotic process GO:0006915 381 0.023
response to alkaloid GO:0043279 132 0.023
single organism catabolic process GO:0044712 283 0.023
Human
positive regulation of cell development GO:0010720 176 0.023
neuron projection development GO:0031175 273 0.022
multicellular organism reproduction GO:0032504 233 0.022
Rat
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.022
response to ketone GO:1901654 182 0.022
Rat
regulation of protein phosphorylation GO:0001932 183 0.022
regulation of membrane potential GO:0042391 110 0.022
regulation of catabolic process GO:0009894 113 0.022
response to carbohydrate GO:0009743 183 0.022
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.022
dendrite development GO:0016358 72 0.022
positive regulation of cell differentiation GO:0045597 217 0.022
neuron apoptotic process GO:0051402 88 0.022
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.021
ribonucleotide metabolic process GO:0009259 231 0.021
purine containing compound catabolic process GO:0072523 138 0.021
negative regulation of response to stimulus GO:0048585 155 0.021
positive regulation of cellular protein metabolic process GO:0032270 167 0.021
chromosome segregation GO:0007059 2 0.021
aromatic compound catabolic process GO:0019439 168 0.021
proteolysis GO:0006508 175 0.021
regulation of system process GO:0044057 208 0.021
cellular response to peptide GO:1901653 133 0.021
Rat
synaptic transmission GO:0007268 235 0.021
carboxylic acid metabolic process GO:0019752 289 0.021
regulation of apoptotic process GO:0042981 335 0.021
circulatory system process GO:0003013 183 0.020
response to corticosteroid GO:0031960 235 0.020
glycosyl compound metabolic process GO:1901657 182 0.020
Human
purine nucleoside triphosphate metabolic process GO:0009144 141 0.020
purine ribonucleoside metabolic process GO:0046128 168 0.020
negative regulation of cell development GO:0010721 82 0.020
ribonucleoside metabolic process GO:0009119 174 0.020
cellular component movement GO:0006928 248 0.020
cellular response to stress GO:0033554 269 0.020
Rat
oxoacid metabolic process GO:0043436 290 0.019
negative regulation of transport GO:0051051 136 0.019
cation transmembrane transport GO:0098655 263 0.019
mapk cascade GO:0000165 140 0.019
negative regulation of rna biosynthetic process GO:1902679 118 0.019
metal ion homeostasis GO:0055065 186 0.019
positive regulation of hydrolase activity GO:0051345 86 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
regulation of neuron death GO:1901214 115 0.019
positive regulation of nervous system development GO:0051962 178 0.018
regulation of transferase activity GO:0051338 123 0.018
response to growth factor GO:0070848 189 0.018
regulation of response to stress GO:0080134 126 0.018
reproductive process GO:0022414 372 0.018
Rat
negative regulation of multicellular organismal process GO:0051241 203 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
divalent inorganic cation transport GO:0072511 134 0.018
negative regulation of phosphorus metabolic process GO:0010563 80 0.018
macromolecule localization GO:0033036 252 0.018
regulation of hydrolase activity GO:0051336 143 0.018
regulation of neuron differentiation GO:0045664 208 0.018
negative regulation of signal transduction GO:0009968 83 0.018
regulation of neuron apoptotic process GO:0043523 83 0.018
protein complex biogenesis GO:0070271 263 0.017
regulation of mapk cascade GO:0043408 116 0.017
metal ion transport GO:0030001 289 0.017
stress activated protein kinase signaling cascade GO:0031098 37 0.017
Rat
positive regulation of protein phosphorylation GO:0001934 135 0.017
organic substance catabolic process GO:1901575 316 0.017
Human
response to oxygen levels GO:0070482 265 0.017
divalent inorganic cation homeostasis GO:0072507 165 0.017
cellular response to organic cyclic compound GO:0071407 202 0.017
single organism biosynthetic process GO:0044711 342 0.017
Rat
ras protein signal transduction GO:0007265 29 0.017
action potential GO:0001508 54 0.017
brain development GO:0007420 247 0.017
Rat Fly
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
regulation of nervous system development GO:0051960 264 0.017
response to lipopolysaccharide GO:0032496 191 0.017
head development GO:0060322 247 0.017
Rat Fly
positive regulation of intracellular signal transduction GO:1902533 138 0.017
Rat
negative regulation of rna metabolic process GO:0051253 123 0.017
regulation of secretion GO:0051046 224 0.017
peptidyl amino acid modification GO:0018193 126 0.017
sensory perception GO:0007600 101 0.017
neuromuscular process GO:0050905 2 0.017
regulation of neuron projection development GO:0010975 161 0.017
cation transport GO:0006812 382 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
transmembrane transport GO:0055085 412 0.016
bmp signaling pathway GO:0030509 4 0.016
response to acid chemical GO:0001101 222 0.016
Rat
negative regulation of neuron death GO:1901215 69 0.016
regulation of anatomical structure size GO:0090066 135 0.016
regulation of nucleotide metabolic process GO:0006140 117 0.016
negative regulation of secretion GO:0051048 82 0.016
nucleoside catabolic process GO:0009164 126 0.016
neuron neuron synaptic transmission GO:0007270 60 0.016
response to ethanol GO:0045471 162 0.016
axis specification GO:0009798 4 0.016
response to molecule of bacterial origin GO:0002237 194 0.015
positive regulation of protein modification process GO:0031401 142 0.015
regulation of protein modification process GO:0031399 194 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
protein localization GO:0008104 191 0.015
blood circulation GO:0008015 183 0.015
cytosolic calcium ion homeostasis GO:0051480 140 0.015
response to decreased oxygen levels GO:0036293 237 0.015
response to hexose GO:0009746 144 0.015
hormone transport GO:0009914 121 0.015
ion homeostasis GO:0050801 212 0.015
regulation of proteasomal protein catabolic process GO:0061136 4 0.015
muscle system process GO:0003012 115 0.015
negative regulation of molecular function GO:0044092 133 0.015
cellular cation homeostasis GO:0030003 180 0.015
amine transport GO:0015837 57 0.015
cellular calcium ion homeostasis GO:0006874 160 0.015
non canonical wnt signaling pathway GO:0035567 3 0.015
ribose phosphate biosynthetic process GO:0046390 87 0.015
regulation of smooth muscle cell proliferation GO:0048660 75 0.015
Rat
regulation of kinase activity GO:0043549 117 0.015
tube development GO:0035295 89 0.015
Rat
macromolecular complex assembly GO:0065003 273 0.015
cell type specific apoptotic process GO:0097285 134 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
cell adhesion GO:0007155 110 0.015
behavior GO:0007610 205 0.015
organ regeneration GO:0031100 101 0.015
regulation of establishment of planar polarity GO:0090175 2 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.014
positive regulation of cell death GO:0010942 184 0.014
calcium ion homeostasis GO:0055074 162 0.014
cellular homeostasis GO:0019725 252 0.014
spermatogenesis GO:0007283 99 0.014
neuron development GO:0048666 286 0.014
nucleoside metabolic process GO:0009116 179 0.014
adult locomotory behavior GO:0008344 4 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
organophosphate catabolic process GO:0046434 148 0.014
membrane organization GO:0061024 94 0.014
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.014
cellular nitrogen compound catabolic process GO:0044270 163 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
nitrogen compound transport GO:0071705 229 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
response to estradiol GO:0032355 164 0.014
response to monosaccharide GO:0034284 159 0.014
purine nucleotide catabolic process GO:0006195 136 0.014
response to glucose GO:0009749 136 0.014
growth GO:0040007 165 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
regulation of vesicle mediated transport GO:0060627 81 0.014
circulatory system development GO:0072359 134 0.014
positive regulation of cell proliferation GO:0008284 249 0.013
Rat
amide transport GO:0042886 105 0.013
response to wounding GO:0009611 254 0.013
sequestering of metal ion GO:0051238 9 0.013
dephosphorylation GO:0016311 98 0.013
chemical homeostasis GO:0048878 292 0.013
negative regulation of developmental process GO:0051093 125 0.013
cytoplasmic transport GO:0016482 115 0.013
intracellular transport GO:0046907 185 0.013
glial cell differentiation GO:0010001 65 0.013
cellular response to steroid hormone stimulus GO:0071383 93 0.013
rhythmic process GO:0048511 156 0.013
response to biotic stimulus GO:0009607 226 0.013
sequestering of calcium ion GO:0051208 8 0.013
nucleoside phosphate catabolic process GO:1901292 140 0.013
regulation of protein kinase activity GO:0045859 105 0.013
single organism reproductive process GO:0044702 297 0.013
Rat
single organism carbohydrate metabolic process GO:0044723 118 0.013
Rat
hormone secretion GO:0046879 115 0.013
negative regulation of secretion by cell GO:1903531 72 0.013
regulation of ion transport GO:0043269 245 0.013
cation homeostasis GO:0055080 195 0.012
response to purine containing compound GO:0014074 126 0.012
calcium ion transport GO:0006816 131 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
regulation of response to external stimulus GO:0032101 106 0.012
male gamete generation GO:0048232 99 0.012
morphogenesis of a polarized epithelium GO:0001738 1 0.012
embryonic pattern specification GO:0009880 1 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
cellular divalent inorganic cation homeostasis GO:0072503 162 0.012
cell cycle checkpoint GO:0000075 2 0.012
ribonucleoside catabolic process GO:0042454 126 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
regulation of cytoskeleton organization GO:0051493 49 0.012
establishment of planar polarity GO:0001736 1 0.012
response to other organism GO:0051707 220 0.012
carbohydrate derivative catabolic process GO:1901136 147 0.012
peptide transport GO:0015833 97 0.012
neuron death GO:0070997 127 0.012
regulation of stem cell differentiation GO:2000736 2 0.012
nucleotide catabolic process GO:0009166 139 0.012
negative regulation of amine transport GO:0051953 24 0.012
response to bacterium GO:0009617 200 0.012
regulation of blood pressure GO:0008217 83 0.012
regulation of dendrite development GO:0050773 59 0.012
positive regulation of gtpase activity GO:0043547 47 0.012
cell part morphogenesis GO:0032990 123 0.012
negative regulation of catalytic activity GO:0043086 103 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
camp metabolic process GO:0046058 63 0.011
cardiovascular system development GO:0072358 134 0.011
sulfur compound metabolic process GO:0006790 70 0.011
multi organism reproductive process GO:0044703 262 0.011
Rat
organic cyclic compound catabolic process GO:1901361 175 0.011
response to external biotic stimulus GO:0043207 221 0.011
negative regulation of neuron apoptotic process GO:0043524 45 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
gliogenesis GO:0042063 93 0.011
embryonic axis specification GO:0000578 1 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
cytoskeleton organization GO:0007010 111 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
purine nucleoside triphosphate catabolic process GO:0009146 122 0.011
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.011
Rat
protein oligomerization GO:0051259 191 0.011
response to metal ion GO:0010038 253 0.011
lipid storage GO:0019915 1 0.011
regulation of tube size GO:0035150 89 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
homeostatic process GO:0042592 331 0.011
Rat
nucleoside triphosphate metabolic process GO:0009141 144 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.011
regulation of hormone secretion GO:0046883 106 0.011
purine nucleotide biosynthetic process GO:0006164 83 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
immune system process GO:0002376 204 0.011
cellular response to lipid GO:0071396 201 0.011
gamete generation GO:0007276 124 0.011
neuropeptide signaling pathway GO:0007218 29 0.011
maintenance of location GO:0051235 17 0.011
positive regulation of transferase activity GO:0051347 81 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.010
cellular component morphogenesis GO:0032989 155 0.010
lipid metabolic process GO:0006629 283 0.010
nucleotide biosynthetic process GO:0009165 98 0.010
positive regulation of secretion by cell GO:1903532 128 0.010
regulation of anatomical structure morphogenesis GO:0022603 141 0.010
response to radiation GO:0009314 137 0.010
protein dephosphorylation GO:0006470 38 0.010
neurological system process GO:0050877 219 0.010
cellular response to external stimulus GO:0071496 118 0.010
regulation of cellular response to stress GO:0080135 49 0.010
negative regulation of cell cycle phase transition GO:1901988 4 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
regulation of canonical wnt signaling pathway GO:0060828 4 0.010
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.010

Akr1b10 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.012
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012
disease of metabolism DOID:0014667 0 0.011