Rattus norvegicus

23 known processes

Alox12e

arachidonate 12-lipoxygenase, epidermal

Alox12e biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of signaling GO:0023056 270 0.252
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.171
positive regulation of multicellular organismal process GO:0051240 387 0.169
Rat
transcription from rna polymerase ii promoter GO:0006366 252 0.116
regulation of cell proliferation GO:0042127 359 0.115
Rat
multi organism reproductive process GO:0044703 262 0.114
regulation of catalytic activity GO:0050790 304 0.092
Rat
programmed cell death GO:0012501 392 0.091
Rat
response to nutrient levels GO:0031667 370 0.091
Rat
positive regulation of signal transduction GO:0009967 175 0.090
cellular response to endogenous stimulus GO:0071495 377 0.084
regulation of molecular function GO:0065009 398 0.078
Rat
regulation of phosphorus metabolic process GO:0051174 349 0.075
intracellular signal transduction GO:0035556 314 0.075
regulation of nucleic acid templated transcription GO:1903506 380 0.073
regulation of signal transduction GO:0009966 318 0.073
response to molecule of bacterial origin GO:0002237 194 0.070
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.069
positive regulation of response to stimulus GO:0048584 285 0.069
localization of cell GO:0051674 202 0.067
Rat
positive regulation of nervous system development GO:0051962 178 0.067
response to biotic stimulus GO:0009607 226 0.066
regulation of neurogenesis GO:0050767 247 0.065
regulation of phosphate metabolic process GO:0019220 349 0.064
apoptotic process GO:0006915 381 0.064
Rat
regulation of cell differentiation GO:0045595 320 0.063
Rat
response to extracellular stimulus GO:0009991 380 0.063
Rat
regulation of rna biosynthetic process GO:2001141 381 0.063
positive regulation of developmental process GO:0051094 283 0.062
Rat
regulation of protein metabolic process GO:0051246 289 0.062
Rat
neuron differentiation GO:0030182 368 0.061
cell migration GO:0016477 197 0.061
Rat
negative regulation of gene expression GO:0010629 199 0.060
nucleic acid templated transcription GO:0097659 379 0.058
response to estrogen GO:0043627 232 0.057
positive regulation of cell proliferation GO:0008284 249 0.056
Rat
positive regulation of cell communication GO:0010647 271 0.056
regulation of programmed cell death GO:0043067 341 0.055
Rat
reproductive process GO:0022414 372 0.055
inflammatory response GO:0006954 150 0.054
Rat
single organism reproductive process GO:0044702 297 0.053
positive regulation of phosphate metabolic process GO:0045937 262 0.052
cellular response to oxygen containing compound GO:1901701 386 0.052
positive regulation of cell motility GO:2000147 97 0.051
Rat
positive regulation of neurogenesis GO:0050769 165 0.050
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.050
rna metabolic process GO:0016070 406 0.049
negative regulation of metabolic process GO:0009892 331 0.049
regulation of cell development GO:0060284 263 0.049
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.048
response to monosaccharide GO:0034284 159 0.048
multicellular organism reproduction GO:0032504 233 0.047
protein phosphorylation GO:0006468 345 0.047
negative regulation of macromolecule metabolic process GO:0010605 260 0.046
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.046
cation transport GO:0006812 382 0.046
cell motility GO:0048870 202 0.046
Rat
neuron projection development GO:0031175 273 0.045
positive regulation of cell differentiation GO:0045597 217 0.044
Rat
negative regulation of cell death GO:0060548 229 0.044
Rat
ion transmembrane transport GO:0034220 365 0.044
carboxylic acid metabolic process GO:0019752 289 0.043
regulation of kinase activity GO:0043549 117 0.042
reproduction GO:0000003 245 0.042
negative regulation of cellular metabolic process GO:0031324 281 0.040
locomotion GO:0040011 237 0.040
Rat
central nervous system development GO:0007417 311 0.039
positive regulation of molecular function GO:0044093 230 0.038
Rat
regulation of nervous system development GO:0051960 264 0.038
tissue development GO:0009888 252 0.038
Rat
positive regulation of cellular biosynthetic process GO:0031328 295 0.038
regulation of system process GO:0044057 208 0.038
Rat
negative regulation of nucleic acid templated transcription GO:1903507 117 0.038
positive regulation of biosynthetic process GO:0009891 319 0.038
positive regulation of phosphorus metabolic process GO:0010562 262 0.037
positive regulation of cell migration GO:0030335 96 0.037
Rat
positive regulation of gene expression GO:0010628 244 0.036
Rat
regulation of cell projection organization GO:0031344 175 0.036
chemical homeostasis GO:0048878 292 0.036
Rat
response to corticosteroid GO:0031960 235 0.036
cellular amino acid metabolic process GO:0006520 107 0.036
regulation of cell motility GO:2000145 131 0.035
Rat
epithelium development GO:0060429 96 0.035
Rat
response to carbohydrate GO:0009743 183 0.035
regulation of phosphorylation GO:0042325 248 0.034
cell projection organization GO:0030030 302 0.034
positive regulation of intracellular signal transduction GO:1902533 138 0.034
regulation of intracellular signal transduction GO:1902531 218 0.034
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.034
gland development GO:0048732 155 0.033
response to wounding GO:0009611 254 0.033
regulation of rna metabolic process GO:0051252 391 0.033
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.033
smooth muscle cell proliferation GO:0048659 77 0.033
Rat
epithelial cell differentiation GO:0030855 71 0.033
Rat
positive regulation of catalytic activity GO:0043085 184 0.032
Rat
proteolysis GO:0006508 175 0.032
Rat
cellular component movement GO:0006928 248 0.032
Rat
organic acid metabolic process GO:0006082 292 0.031
signal transduction by phosphorylation GO:0023014 144 0.031
multicellular organismal reproductive process GO:0048609 233 0.031
jak stat cascade GO:0007259 26 0.031
regulation of apoptotic process GO:0042981 335 0.030
Rat
positive regulation of cell development GO:0010720 176 0.030
cellular amine metabolic process GO:0044106 38 0.030
response to external biotic stimulus GO:0043207 221 0.029
response to inorganic substance GO:0010035 377 0.029
regulation of transcription dna templated GO:0006355 374 0.029
cellular response to nitrogen compound GO:1901699 210 0.029
response to hypoxia GO:0001666 231 0.029
head development GO:0060322 247 0.029
positive regulation of rna biosynthetic process GO:1902680 197 0.029
response to hexose GO:0009746 144 0.028
transcription dna templated GO:0006351 377 0.028
nitrogen compound transport GO:0071705 229 0.028
regulation of cellular ketone metabolic process GO:0010565 27 0.028
response to bacterium GO:0009617 200 0.028
neuron projection morphogenesis GO:0048812 122 0.027
transmembrane transport GO:0055085 412 0.027
positive regulation of phosphorylation GO:0042327 177 0.027
negative regulation of biosynthetic process GO:0009890 168 0.027
response to glucose GO:0009749 136 0.026
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.026
immune system process GO:0002376 204 0.026
organ formation GO:0048645 3 0.026
response to ketone GO:1901654 182 0.026
negative regulation of rna biosynthetic process GO:1902679 118 0.026
response to peptide GO:1901652 292 0.025
neuron death GO:0070997 127 0.025
positive regulation of rna metabolic process GO:0051254 203 0.025
oxoacid metabolic process GO:0043436 290 0.025
regulation of cellular component organization GO:0051128 368 0.025
carbohydrate derivative metabolic process GO:1901135 346 0.024
amine metabolic process GO:0009308 38 0.024
regulation of multicellular organismal development GO:2000026 376 0.024
Rat
defense response GO:0006952 194 0.024
Rat
regulation of neuron differentiation GO:0045664 208 0.024
regulation of cellular protein metabolic process GO:0032268 267 0.023
Rat
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.023
response to decreased oxygen levels GO:0036293 237 0.023
rna biosynthetic process GO:0032774 380 0.023
response to acid chemical GO:0001101 222 0.023
regulation of cellular amino acid metabolic process GO:0006521 2 0.023
cellular response to hormone stimulus GO:0032870 247 0.023
negative regulation of transcription dna templated GO:0045892 116 0.023
regulation of locomotion GO:0040012 148 0.022
Rat
mapk cascade GO:0000165 140 0.022
response to cytokine GO:0034097 215 0.021
rhythmic process GO:0048511 156 0.021
blood circulation GO:0008015 183 0.021
Rat
regulation of transferase activity GO:0051338 123 0.020
response to lipopolysaccharide GO:0032496 191 0.020
response to nutrient GO:0007584 248 0.020
Rat
gonad development GO:0008406 104 0.020
secretion GO:0046903 307 0.020
positive regulation of nucleic acid templated transcription GO:1903508 197 0.020
cation transmembrane transport GO:0098655 263 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
sulfur compound metabolic process GO:0006790 70 0.020
female pregnancy GO:0007565 122 0.019
lipid metabolic process GO:0006629 283 0.019
positive regulation of transcription dna templated GO:0045893 197 0.019
cellular lipid metabolic process GO:0044255 208 0.019
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.019
regulation of protein modification process GO:0031399 194 0.019
reproductive system development GO:0061458 128 0.019
response to other organism GO:0051707 220 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
salivary gland development GO:0007431 3 0.019
anatomical structure morphogenesis GO:0009653 298 0.019
organic substance catabolic process GO:1901575 316 0.019
negative regulation of response to stimulus GO:0048585 155 0.019
negative regulation of innate immune response GO:0045824 4 0.018
negative regulation of rna metabolic process GO:0051253 123 0.018
regulation of neuron apoptotic process GO:0043523 83 0.018
regulation of mapk cascade GO:0043408 116 0.018
nucleoside phosphate metabolic process GO:0006753 283 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
regulation of neuron projection development GO:0010975 161 0.018
positive regulation of protein phosphorylation GO:0001934 135 0.018
positive regulation of cellular protein metabolic process GO:0032270 167 0.018
Rat
cellular component assembly GO:0022607 360 0.018
positive regulation of programmed cell death GO:0043068 157 0.018
Rat
secretion by cell GO:0032940 248 0.017
aging GO:0007568 241 0.017
Rat
cellular response to stress GO:0033554 269 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
regulation of cellular localization GO:0060341 263 0.017
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.017
metal ion transport GO:0030001 289 0.017
regulation of neuron death GO:1901214 115 0.017
brain development GO:0007420 247 0.017
catabolic process GO:0009056 351 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
Rat
cellular ketone metabolic process GO:0042180 51 0.017
circadian rhythm GO:0007623 88 0.017
dendrite development GO:0016358 72 0.016
cell morphogenesis involved in differentiation GO:0000904 119 0.016
regulation of secretion GO:0051046 224 0.016
protein processing GO:0016485 68 0.016
negative regulation of signal transduction GO:0009968 83 0.016
response to oxygen levels GO:0070482 265 0.016
Rat
cell part morphogenesis GO:0032990 123 0.016
cellular chemical homeostasis GO:0055082 247 0.016
transmission of nerve impulse GO:0019226 42 0.016
negative regulation of signaling GO:0023057 157 0.016
establishment of protein localization GO:0045184 141 0.016
cell type specific apoptotic process GO:0097285 134 0.016
neuron development GO:0048666 286 0.015
anion transport GO:0006820 178 0.015
positive regulation of apoptotic process GO:0043065 154 0.015
Rat
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
regulation of protein phosphorylation GO:0001932 183 0.015
cellular response to reactive oxygen species GO:0034614 55 0.015
regulation of response to stress GO:0080134 126 0.015
negative regulation of cell communication GO:0010648 158 0.015
sexual reproduction GO:0019953 148 0.015
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.015
positive regulation of cellular component movement GO:0051272 102 0.015
Rat
multicellular organismal signaling GO:0035637 44 0.015
hormone secretion GO:0046879 115 0.014
protein transport GO:0015031 132 0.014
regulation of cellular component movement GO:0051270 150 0.014
Rat
multi multicellular organism process GO:0044706 138 0.014
development of primary sexual characteristics GO:0045137 107 0.014
regulation of epithelial cell proliferation GO:0050678 49 0.014
response to insulin GO:0032868 133 0.014
positive regulation of protein modification process GO:0031401 142 0.014
cellular component biogenesis GO:0044085 368 0.014
response to vitamin GO:0033273 131 0.014
insulin like growth factor receptor signaling pathway GO:0048009 3 0.014
acute inflammatory response GO:0002526 58 0.014
Rat
negative regulation of apoptotic process GO:0043066 181 0.014
Rat
axon development GO:0061564 96 0.014
negative regulation of molecular function GO:0044092 133 0.014
protein homooligomerization GO:0051260 91 0.013
alditol metabolic process GO:0019400 4 0.013
cellular response to abiotic stimulus GO:0071214 85 0.013
regulation of secretion by cell GO:1903530 208 0.013
circulatory system process GO:0003013 183 0.013
Rat
response to glucocorticoid GO:0051384 223 0.013
cellular response to oxidative stress GO:0034599 76 0.013
regulation of peptide transport GO:0090087 87 0.013
negative regulation of neuron death GO:1901215 69 0.013
protein maturation GO:0051604 68 0.013
positive regulation of kinase activity GO:0033674 77 0.013
developmental process involved in reproduction GO:0003006 159 0.013
inorganic cation transmembrane transport GO:0098662 202 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
single organism biosynthetic process GO:0044711 342 0.013
Rat
regulation of smooth muscle cell proliferation GO:0048660 75 0.013
Rat
calcium ion transport GO:0006816 131 0.013
positive regulation of secretion by cell GO:1903532 128 0.013
forebrain development GO:0030900 98 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
epithelial cell proliferation GO:0050673 54 0.013
leukocyte activation GO:0045321 76 0.013
carbohydrate metabolic process GO:0005975 130 0.013
negative regulation of cell differentiation GO:0045596 99 0.013
cellular response to insulin stimulus GO:0032869 81 0.012
peptidyl amino acid modification GO:0018193 126 0.012
regulation of hydrolase activity GO:0051336 143 0.012
Rat
reproductive structure development GO:0048608 128 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
circulatory system development GO:0072359 134 0.012
action potential GO:0001508 54 0.012
behavior GO:0007610 205 0.012
regulation of transmembrane transport GO:0034762 122 0.012
positive regulation of mapk cascade GO:0043410 92 0.012
positive regulation of protein metabolic process GO:0051247 178 0.012
Rat
regulation of proteolysis GO:0030162 66 0.012
Rat
enzyme linked receptor protein signaling pathway GO:0007167 116 0.012
cellular homeostasis GO:0019725 252 0.012
positive regulation of epithelial cell proliferation GO:0050679 32 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
establishment of tissue polarity GO:0007164 2 0.012
response to radiation GO:0009314 137 0.012
small molecule catabolic process GO:0044282 59 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
single organism catabolic process GO:0044712 283 0.012
hexose metabolic process GO:0019318 58 0.012
positive regulation of response to external stimulus GO:0032103 51 0.012
cellular catabolic process GO:0044248 295 0.012
morphogenesis of a polarized epithelium GO:0001738 1 0.012
sex differentiation GO:0007548 113 0.012
monosaccharide metabolic process GO:0005996 61 0.012
response to estradiol GO:0032355 164 0.011
homeostatic process GO:0042592 331 0.011
Rat
regulation of lipid metabolic process GO:0019216 68 0.011
negative regulation of cellular biosynthetic process GO:0031327 161 0.011
cofactor metabolic process GO:0051186 95 0.011
neurological system process GO:0050877 219 0.011
Rat
gliogenesis GO:0042063 93 0.011
heart morphogenesis GO:0003007 3 0.011
response to oxidative stress GO:0006979 186 0.011
glycosyl compound metabolic process GO:1901657 182 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
purine containing compound metabolic process GO:0072521 253 0.011
regulation of establishment of planar polarity GO:0090175 2 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
protein complex assembly GO:0006461 263 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.011
organophosphate metabolic process GO:0019637 370 0.010
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.010
divalent metal ion transport GO:0070838 132 0.010
respiratory system development GO:0060541 45 0.010
macromolecule localization GO:0033036 252 0.010
purine ribonucleotide metabolic process GO:0009150 227 0.010
lung development GO:0030324 43 0.010
cellular response to hexose stimulus GO:0071331 65 0.010
carbohydrate homeostasis GO:0033500 75 0.010
positive regulation of jnk cascade GO:0046330 13 0.010
regulation of cell projection size GO:0032536 1 0.010
growth GO:0040007 165 0.010
cellular ion homeostasis GO:0006873 184 0.010

Alox12e disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
nervous system disease DOID:863 0 0.038