Rattus norvegicus

17 known processes

Pkn1

protein kinase N1

(Aliases: PAK-1,Prkcl1)

Pkn1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
metal ion transport GO:0030001 289 0.088
protein phosphorylation GO:0006468 345 0.083
cation transport GO:0006812 382 0.080
organophosphate catabolic process GO:0046434 148 0.077
homeostatic process GO:0042592 331 0.070
Mouse
purine containing compound metabolic process GO:0072521 253 0.066
cation transmembrane transport GO:0098655 263 0.066
regulation of molecular function GO:0065009 398 0.066
Mouse
positive regulation of response to stimulus GO:0048584 285 0.064
Fly
transmembrane transport GO:0055085 412 0.055
regulation of ion transport GO:0043269 245 0.054
catabolic process GO:0009056 351 0.050
nucleoside phosphate metabolic process GO:0006753 283 0.048
intracellular signal transduction GO:0035556 314 0.048
nucleic acid templated transcription GO:0097659 379 0.047
Human
divalent metal ion transport GO:0070838 132 0.045
nucleotide metabolic process GO:0009117 279 0.044
organophosphate metabolic process GO:0019637 370 0.044
purine ribonucleotide metabolic process GO:0009150 227 0.044
organonitrogen compound biosynthetic process GO:1901566 167 0.043
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.043
organelle organization GO:0006996 266 0.041
Human Fly
ribonucleotide metabolic process GO:0009259 231 0.039
regulation of catalytic activity GO:0050790 304 0.039
Mouse
single organism biosynthetic process GO:0044711 342 0.039
nucleobase containing small molecule metabolic process GO:0055086 316 0.039
macromolecular complex subunit organization GO:0043933 339 0.038
Human
positive regulation of transport GO:0051050 245 0.038
response to inorganic substance GO:0010035 377 0.037
purine nucleotide metabolic process GO:0006163 229 0.037
cation homeostasis GO:0055080 195 0.037
carbohydrate derivative metabolic process GO:1901135 346 0.037
positive regulation of cell communication GO:0010647 271 0.036
regulation of purine nucleotide metabolic process GO:1900542 115 0.035
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.035
metal ion homeostasis GO:0055065 186 0.035
cellular divalent inorganic cation homeostasis GO:0072503 162 0.035
positive regulation of molecular function GO:0044093 230 0.034
rna biosynthetic process GO:0032774 380 0.034
Human
reproductive process GO:0022414 372 0.034
programmed cell death GO:0012501 392 0.033
Mouse
neuron differentiation GO:0030182 368 0.033
monovalent inorganic cation transport GO:0015672 172 0.032
positive regulation of signaling GO:0023056 270 0.032
regulation of hydrolase activity GO:0051336 143 0.032
response to other organism GO:0051707 220 0.031
immune system process GO:0002376 204 0.031
Mouse
regulation of rna metabolic process GO:0051252 391 0.031
Human
nucleoside triphosphate metabolic process GO:0009141 144 0.031
cell projection organization GO:0030030 302 0.031
ion homeostasis GO:0050801 212 0.031
calcium ion transport GO:0006816 131 0.030
small molecule biosynthetic process GO:0044283 124 0.030
response to metal ion GO:0010038 253 0.030
lipid metabolic process GO:0006629 283 0.030
heterocycle catabolic process GO:0046700 167 0.030
negative regulation of metabolic process GO:0009892 331 0.030
Mouse
cellular calcium ion homeostasis GO:0006874 160 0.030
divalent inorganic cation transport GO:0072511 134 0.029
regulation of metal ion transport GO:0010959 118 0.029
response to extracellular stimulus GO:0009991 380 0.029
oxoacid metabolic process GO:0043436 290 0.029
cellular ion homeostasis GO:0006873 184 0.029
store operated calcium entry GO:0002115 2 0.029
calcium ion homeostasis GO:0055074 162 0.029
cellular chemical homeostasis GO:0055082 247 0.029
cellular ketone metabolic process GO:0042180 51 0.029
cellular amine metabolic process GO:0044106 38 0.029
regulation of cellular amine metabolic process GO:0033238 8 0.029
chemical homeostasis GO:0048878 292 0.028
regulation of intracellular signal transduction GO:1902531 218 0.028
cellular response to endogenous stimulus GO:0071495 377 0.028
positive regulation of developmental process GO:0051094 283 0.027
regulation of signal transduction GO:0009966 318 0.027
organophosphate biosynthetic process GO:0090407 143 0.027
amine metabolic process GO:0009308 38 0.027
transcription dna templated GO:0006351 377 0.027
Human
cellular homeostasis GO:0019725 252 0.026
transcription from rna polymerase ii promoter GO:0006366 252 0.026
Human
regulation of phosphorus metabolic process GO:0051174 349 0.026
Mouse
regulation of multicellular organismal development GO:2000026 376 0.026
cellular cation homeostasis GO:0030003 180 0.026
regulation of cell differentiation GO:0045595 320 0.026
ribonucleoside triphosphate metabolic process GO:0009199 141 0.026
response to fatty acid GO:0070542 65 0.026
single organism catabolic process GO:0044712 283 0.026
ribonucleoside triphosphate catabolic process GO:0009203 122 0.026
purine nucleoside triphosphate metabolic process GO:0009144 141 0.025
regulation of mapk cascade GO:0043408 116 0.025
divalent inorganic cation homeostasis GO:0072507 165 0.025
cellular response to stress GO:0033554 269 0.025
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.025
chromosome organization GO:0051276 36 0.025
Human
purine ribonucleoside metabolic process GO:0046128 168 0.025
neuron development GO:0048666 286 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
nucleoside metabolic process GO:0009116 179 0.025
neurological system process GO:0050877 219 0.024
response to acid chemical GO:0001101 222 0.024
inorganic cation transmembrane transport GO:0098662 202 0.024
regulation of rna biosynthetic process GO:2001141 381 0.024
Human
nucleoside phosphate catabolic process GO:1901292 140 0.024
cellular amino acid metabolic process GO:0006520 107 0.024
response to purine containing compound GO:0014074 126 0.024
small gtpase mediated signal transduction GO:0007264 36 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.024
purine nucleoside metabolic process GO:0042278 169 0.024
inorganic ion transmembrane transport GO:0098660 229 0.024
defense response GO:0006952 194 0.024
response to nutrient levels GO:0031667 370 0.024
response to peptide GO:1901652 292 0.024
regulation of phosphate metabolic process GO:0019220 349 0.023
Mouse
ribose phosphate metabolic process GO:0019693 235 0.023
response to bacterium GO:0009617 200 0.023
peptidyl amino acid modification GO:0018193 126 0.023
Human
ion transmembrane transport GO:0034220 365 0.023
single organism organelle organization GO:1902589 180 0.022
Human Fly
negative regulation of signaling GO:0023057 157 0.022
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.022
response to peptide hormone GO:0043434 278 0.022
negative regulation of neuron differentiation GO:0045665 62 0.022
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.022
carboxylic acid metabolic process GO:0019752 289 0.021
positive regulation of transcription dna templated GO:0045893 197 0.021
multi multicellular organism process GO:0044706 138 0.021
cellular response to oxygen containing compound GO:1901701 386 0.021
neuron projection development GO:0031175 273 0.021
regulation of phosphorylation GO:0042325 248 0.021
Mouse
ribonucleoside catabolic process GO:0042454 126 0.021
response to oxidative stress GO:0006979 186 0.021
lipid biosynthetic process GO:0008610 128 0.021
sensory perception GO:0007600 101 0.021
nucleobase containing compound catabolic process GO:0034655 152 0.021
learning or memory GO:0007611 90 0.021
organic cyclic compound catabolic process GO:1901361 175 0.021
regulation of protein kinase activity GO:0045859 105 0.021
Mouse
ribonucleoside metabolic process GO:0009119 174 0.021
cellular response to external stimulus GO:0071496 118 0.021
cytosolic calcium ion homeostasis GO:0051480 140 0.021
cell type specific apoptotic process GO:0097285 134 0.021
Mouse
cellular metal ion homeostasis GO:0006875 172 0.020
protein complex subunit organization GO:0071822 302 0.020
central nervous system development GO:0007417 311 0.020
response to biotic stimulus GO:0009607 226 0.020
purine ribonucleotide biosynthetic process GO:0009152 81 0.020
organic substance catabolic process GO:1901575 316 0.020
glycosyl compound metabolic process GO:1901657 182 0.020
response to nutrient GO:0007584 248 0.020
alcohol biosynthetic process GO:0046165 38 0.020
regulation of protein phosphorylation GO:0001932 183 0.020
Mouse
rna metabolic process GO:0016070 406 0.020
Human
regulation of cell proliferation GO:0042127 359 0.020
Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.020
negative regulation of innate immune response GO:0045824 4 0.020
response to cytokine GO:0034097 215 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
organic acid metabolic process GO:0006082 292 0.020
regulation of nucleotide metabolic process GO:0006140 117 0.020
head development GO:0060322 247 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
Mouse
nitrogen compound transport GO:0071705 229 0.019
aging GO:0007568 241 0.019
positive regulation of phosphate metabolic process GO:0045937 262 0.019
multicellular organism reproduction GO:0032504 233 0.019
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.019
single organism carbohydrate metabolic process GO:0044723 118 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.019
Mouse
negative regulation of biosynthetic process GO:0009890 168 0.019
regulation of immune system process GO:0002682 123 0.019
Mouse
multi organism reproductive process GO:0044703 262 0.019
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.019
positive regulation of cell differentiation GO:0045597 217 0.019
carbohydrate derivative biosynthetic process GO:1901137 124 0.019
apoptotic process GO:0006915 381 0.019
Mouse
positive regulation of immune system process GO:0002684 90 0.019
chromatin assembly or disassembly GO:0006333 1 0.019
purine ribonucleoside catabolic process GO:0046130 124 0.018
organonitrogen compound catabolic process GO:1901565 179 0.018
organic acid biosynthetic process GO:0016053 83 0.018
purine nucleoside catabolic process GO:0006152 124 0.018
carbohydrate derivative catabolic process GO:1901136 147 0.018
regulation of nucleic acid templated transcription GO:1903506 380 0.018
Human
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.018
response to growth factor GO:0070848 189 0.018
response to external biotic stimulus GO:0043207 221 0.018
positive regulation of cell death GO:0010942 184 0.018
alcohol metabolic process GO:0006066 77 0.018
cellular response to lipid GO:0071396 201 0.018
locomotion GO:0040011 237 0.018
Human
aromatic compound catabolic process GO:0019439 168 0.017
positive regulation of multicellular organismal process GO:0051240 387 0.017
positive regulation of phosphorus metabolic process GO:0010562 262 0.017
regulation of cellular component organization GO:0051128 368 0.017
negative regulation of cell death GO:0060548 229 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
ribonucleotide catabolic process GO:0009261 136 0.017
regulation of cell development GO:0060284 263 0.017
protein localization GO:0008104 191 0.017
positive regulation of programmed cell death GO:0043068 157 0.017
embryonic pattern specification GO:0009880 1 0.017
nucleoside catabolic process GO:0009164 126 0.017
regulation of transmembrane transporter activity GO:0022898 49 0.017
nucleotide catabolic process GO:0009166 139 0.017
mitotic spindle organization GO:0007052 2 0.017
positive regulation of rna biosynthetic process GO:1902680 197 0.017
cellular nitrogen compound catabolic process GO:0044270 163 0.017
cellular response to nitrogen compound GO:1901699 210 0.017
regulation of calcium ion transport GO:0051924 77 0.017
regulation of cell projection organization GO:0031344 175 0.017
cellular component biogenesis GO:0044085 368 0.017
single organism intracellular transport GO:1902582 166 0.017
purine ribonucleotide catabolic process GO:0009154 136 0.016
positive regulation of nucleic acid templated transcription GO:1903508 197 0.016
regulation of homeostatic process GO:0032844 101 0.016
positive regulation of ion transport GO:0043270 94 0.016
response to reactive oxygen species GO:0000302 120 0.016
cellular catabolic process GO:0044248 295 0.016
cellular response to organic cyclic compound GO:0071407 202 0.016
regulation of ion transmembrane transport GO:0034765 121 0.016
negative regulation of cell communication GO:0010648 158 0.016
regulation of neurogenesis GO:0050767 247 0.016
organic hydroxy compound biosynthetic process GO:1901617 51 0.016
regulation of programmed cell death GO:0043067 341 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
spindle organization GO:0007051 2 0.016
response to camp GO:0051591 91 0.016
purine containing compound catabolic process GO:0072523 138 0.016
regulation of cation channel activity GO:2001257 23 0.016
signal transduction by phosphorylation GO:0023014 144 0.016
axis specification GO:0009798 4 0.016
positive regulation of signal transduction GO:0009967 175 0.015
response to wounding GO:0009611 254 0.015
Fly
regulation of neuron differentiation GO:0045664 208 0.015
response to organophosphorus GO:0046683 102 0.015
intracellular transport GO:0046907 185 0.015
cellular component assembly GO:0022607 360 0.015
cellular lipid metabolic process GO:0044255 208 0.015
regulation of membrane potential GO:0042391 110 0.015
macromolecule localization GO:0033036 252 0.015
cellular component movement GO:0006928 248 0.015
Human
regulation of transmembrane transport GO:0034762 122 0.015
purine nucleotide biosynthetic process GO:0006164 83 0.015
guanosine containing compound metabolic process GO:1901068 74 0.015
anterior posterior pattern specification GO:0009952 1 0.015
cell motility GO:0048870 202 0.015
Human
female pregnancy GO:0007565 122 0.015
reproduction GO:0000003 245 0.015
glycosyl compound catabolic process GO:1901658 126 0.014
cell cycle GO:0007049 101 0.014
response to lipopolysaccharide GO:0032496 191 0.014
regulation of transcription dna templated GO:0006355 374 0.014
Human
regulation of cellular localization GO:0060341 263 0.014
sensory organ development GO:0007423 74 0.014
g protein coupled receptor signaling pathway GO:0007186 242 0.014
positive regulation of cell proliferation GO:0008284 249 0.014
regulation of defense response GO:0031347 68 0.014
regulation of hormone levels GO:0010817 187 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
cellular macromolecule localization GO:0070727 122 0.014
single organism reproductive process GO:0044702 297 0.014
positive regulation of intracellular signal transduction GO:1902533 138 0.014
salivary gland development GO:0007431 3 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.014
positive regulation of catalytic activity GO:0043085 184 0.013
behavior GO:0007610 205 0.013
macromolecular complex assembly GO:0065003 273 0.013
carboxylic acid biosynthetic process GO:0046394 83 0.013
ras protein signal transduction GO:0007265 29 0.013
positive regulation of cellular component organization GO:0051130 200 0.013
regulation of gtpase activity GO:0043087 57 0.013
brain development GO:0007420 247 0.013
regulation of neuron projection development GO:0010975 161 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
multicellular organismal reproductive process GO:0048609 233 0.013
protein complex biogenesis GO:0070271 263 0.013
regulation of ion transmembrane transporter activity GO:0032412 48 0.013
cyclic nucleotide biosynthetic process GO:0009190 63 0.013
response to decreased oxygen levels GO:0036293 237 0.013
asymmetric protein localization GO:0008105 2 0.013
enzyme linked receptor protein signaling pathway GO:0007167 116 0.013
response to monosaccharide GO:0034284 159 0.013
regulation of purine nucleotide catabolic process GO:0033121 65 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.012
positive regulation of t cell mediated cytotoxicity GO:0001916 4 0.012
response to glucocorticoid GO:0051384 223 0.012
regulation of kinase activity GO:0043549 117 0.012
Mouse
regulation of protein metabolic process GO:0051246 289 0.012
Mouse
nucleoside phosphate biosynthetic process GO:1901293 102 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
cellular response to peptide hormone stimulus GO:0071375 120 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
regulation of immune response GO:0050776 55 0.012
Mouse
response to ethanol GO:0045471 162 0.012
regulation of lipid metabolic process GO:0019216 68 0.012
membrane organization GO:0061024 94 0.012
potassium ion transport GO:0006813 97 0.012
vesicle mediated transport GO:0016192 181 0.012
regulation of locomotion GO:0040012 148 0.012
Human
regulation of nucleotide catabolic process GO:0030811 65 0.012
wound healing GO:0042060 122 0.012
Fly
defense response to gram negative bacterium GO:0050829 3 0.012
proteolysis GO:0006508 175 0.012
carboxylic acid transport GO:0046942 115 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
nucleoside triphosphate catabolic process GO:0009143 123 0.012
positive regulation of calcium ion transport GO:0051928 36 0.012
positive regulation of cell development GO:0010720 176 0.012
anion transport GO:0006820 178 0.012
cyclic nucleotide metabolic process GO:0009187 80 0.012
fatty acid metabolic process GO:0006631 99 0.012
establishment of protein localization GO:0045184 141 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
heart morphogenesis GO:0003007 3 0.012
sequestering of calcium ion GO:0051208 8 0.012
organic hydroxy compound metabolic process GO:1901615 115 0.012
single organism cellular localization GO:1902580 102 0.012
regulation of cell motility GO:2000145 131 0.012
Human
protein oligomerization GO:0051259 191 0.012
monocarboxylic acid metabolic process GO:0032787 152 0.012
response to calcium ion GO:0051592 59 0.012
response to insulin GO:0032868 133 0.012
response to mechanical stimulus GO:0009612 134 0.011
purine nucleoside monophosphate metabolic process GO:0009126 84 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
negative regulation of macromolecule metabolic process GO:0010605 260 0.011
Mouse
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.011
circulatory system process GO:0003013 183 0.011
muscle structure development GO:0061061 87 0.011
regeneration GO:0031099 163 0.011
cellular response to peptide GO:1901653 133 0.011
gtp catabolic process GO:0006184 71 0.011
cellular response to extracellular stimulus GO:0031668 73 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
regulation of blood circulation GO:1903522 110 0.011
negative regulation of rna metabolic process GO:0051253 123 0.011
sexual reproduction GO:0019953 148 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
Mouse
neuron death GO:0070997 127 0.011
anatomical structure morphogenesis GO:0009653 298 0.011
Mouse Fly
cell cell signaling GO:0007267 335 0.011
positive regulation of nervous system development GO:0051962 178 0.011
gtp metabolic process GO:0046039 72 0.011
organic anion transport GO:0015711 132 0.011
response to oxygen levels GO:0070482 265 0.011
negative regulation of gene expression GO:0010629 199 0.011
response to osmotic stress GO:0006970 42 0.011
Mouse
peptidyl tyrosine modification GO:0018212 72 0.011
regulation of sodium ion transport GO:0002028 21 0.011
regulation of anatomical structure size GO:0090066 135 0.011
positive regulation of homeostatic process GO:0032846 49 0.011
negative regulation of transcription dna templated GO:0045892 116 0.011
growth GO:0040007 165 0.011
positive regulation of immune response GO:0050778 42 0.011
positive regulation of cellular component movement GO:0051272 102 0.010
organic acid transport GO:0015849 116 0.010
response to alkaloid GO:0043279 132 0.010
negative regulation of programmed cell death GO:0043069 183 0.010
maintenance of location GO:0051235 17 0.010
positive regulation of biosynthetic process GO:0009891 319 0.010
positive regulation of response to external stimulus GO:0032103 51 0.010
regulation of catabolic process GO:0009894 113 0.010
chromatin modification GO:0016568 33 0.010
Human
regulation of nervous system development GO:0051960 264 0.010
response to radiation GO:0009314 137 0.010
sequestering of metal ion GO:0051238 9 0.010
regulation of apoptotic process GO:0042981 335 0.010
response to carbohydrate GO:0009743 183 0.010
inflammatory response GO:0006954 150 0.010
response to corticosteroid GO:0031960 235 0.010
regulation of cell migration GO:0030334 128 0.010
ribonucleotide biosynthetic process GO:0009260 85 0.010

Pkn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.012
inherited metabolic disorder DOID:655 0 0.012
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011