Rattus norvegicus

106 known processes

Prkaa2

protein kinase, AMP-activated, alpha 2 catalytic subunit

(Aliases: AMPK)

Prkaa2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of rna biosynthetic process GO:2001141 381 0.197
neuron differentiation GO:0030182 368 0.191
Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.172
regulation of nucleic acid templated transcription GO:1903506 380 0.154
regulation of transcription dna templated GO:0006355 374 0.147
positive regulation of gene expression GO:0010628 244 0.114
carboxylic acid metabolic process GO:0019752 289 0.100
amine metabolic process GO:0009308 38 0.098
response to monosaccharide GO:0034284 159 0.097
regulation of rna metabolic process GO:0051252 391 0.093
nucleic acid templated transcription GO:0097659 379 0.084
organic acid metabolic process GO:0006082 292 0.077
positive regulation of biosynthetic process GO:0009891 319 0.074
Yeast
rna metabolic process GO:0016070 406 0.074
cellular ketone metabolic process GO:0042180 51 0.073
Yeast
positive regulation of cellular biosynthetic process GO:0031328 295 0.071
Yeast
response to carbohydrate GO:0009743 183 0.066
regulation of cell development GO:0060284 263 0.064
protein phosphorylation GO:0006468 345 0.064
response to hexose GO:0009746 144 0.063
oxoacid metabolic process GO:0043436 290 0.062
single organism catabolic process GO:0044712 283 0.062
protein complex assembly GO:0006461 263 0.062
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.061
response to glucose GO:0009749 136 0.061
cellular amino acid metabolic process GO:0006520 107 0.060
response to nutrient levels GO:0031667 370 0.059
Yeast Mouse Fly
rna biosynthetic process GO:0032774 380 0.058
ribose phosphate metabolic process GO:0019693 235 0.055
response to oxygen levels GO:0070482 265 0.054
Rat
organelle organization GO:0006996 266 0.053
Mouse
transcription dna templated GO:0006351 377 0.053
response to decreased oxygen levels GO:0036293 237 0.053
Rat
regulation of molecular function GO:0065009 398 0.053
response to corticosteroid GO:0031960 235 0.053
monosaccharide metabolic process GO:0005996 61 0.052
Yeast
programmed cell death GO:0012501 392 0.052
Mouse
regulation of catalytic activity GO:0050790 304 0.052
organic substance catabolic process GO:1901575 316 0.050
transmembrane transport GO:0055085 412 0.050
neuron development GO:0048666 286 0.050
Fly
regulation of protein metabolic process GO:0051246 289 0.049
Yeast
response to other organism GO:0051707 220 0.049
negative regulation of cellular metabolic process GO:0031324 281 0.048
Yeast
indole containing compound metabolic process GO:0042430 11 0.047
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.047
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.047
regulation of cellular amine metabolic process GO:0033238 8 0.046
positive regulation of multicellular organismal process GO:0051240 387 0.045
Worm
cellular homeostasis GO:0019725 252 0.045
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.044
neuron projection development GO:0031175 273 0.043
Fly
cellular amine metabolic process GO:0044106 38 0.043
regulation of signal transduction GO:0009966 318 0.042
Mouse
nitrogen compound transport GO:0071705 229 0.042
regulation of multicellular organismal development GO:2000026 376 0.042
Worm
protein complex subunit organization GO:0071822 302 0.040
negative regulation of cellular biosynthetic process GO:0031327 161 0.040
Yeast
synaptic transmission GO:0007268 235 0.039
response to acid chemical GO:0001101 222 0.039
nucleobase containing small molecule metabolic process GO:0055086 316 0.038
cell cell signaling GO:0007267 335 0.038
regulation of protein modification process GO:0031399 194 0.038
positive regulation of transcription dna templated GO:0045893 197 0.037
organophosphate metabolic process GO:0019637 370 0.037
cellular catabolic process GO:0044248 295 0.036
negative regulation of macromolecule metabolic process GO:0010605 260 0.036
Yeast
response to peptide hormone GO:0043434 278 0.036
Rat
response to extracellular stimulus GO:0009991 380 0.036
Yeast Mouse Fly
carbohydrate derivative metabolic process GO:1901135 346 0.035
secretion GO:0046903 307 0.035
chemical homeostasis GO:0048878 292 0.035
cellular response to oxygen containing compound GO:1901701 386 0.035
Rat
negative regulation of calcium ion transport into cytosol GO:0010523 4 0.034
regulation of phosphorylation GO:0042325 248 0.034
regulation of cellular amino acid metabolic process GO:0006521 2 0.034
intracellular signal transduction GO:0035556 314 0.034
Mouse
positive regulation of molecular function GO:0044093 230 0.034
regulation of phosphorus metabolic process GO:0051174 349 0.033
dendrite morphogenesis GO:0048813 43 0.033
Fly
regulation of ion transport GO:0043269 245 0.033
glycosyl compound metabolic process GO:1901657 182 0.033
ion transmembrane transport GO:0034220 365 0.033
response to inorganic substance GO:0010035 377 0.032
Rat
positive regulation of rna metabolic process GO:0051254 203 0.032
homeostatic process GO:0042592 331 0.032
regulation of cellular ketone metabolic process GO:0010565 27 0.032
Yeast
negative regulation of rna biosynthetic process GO:1902679 118 0.032
catabolic process GO:0009056 351 0.032
positive regulation of phosphorus metabolic process GO:0010562 262 0.031
carbohydrate metabolic process GO:0005975 130 0.031
cellular response to organonitrogen compound GO:0071417 197 0.031
cellular response to endogenous stimulus GO:0071495 377 0.031
cation transport GO:0006812 382 0.031
brain development GO:0007420 247 0.030
neuron neuron synaptic transmission GO:0007270 60 0.030
cellular chemical homeostasis GO:0055082 247 0.030
anatomical structure morphogenesis GO:0009653 298 0.030
Fly
cellular component biogenesis GO:0044085 368 0.030
regulation of cell differentiation GO:0045595 320 0.030
protein complex biogenesis GO:0070271 263 0.029
central nervous system development GO:0007417 311 0.029
negative regulation of gene expression GO:0010629 199 0.029
Yeast
regulation of cellular localization GO:0060341 263 0.029
lipid metabolic process GO:0006629 283 0.029
regulation of phosphate metabolic process GO:0019220 349 0.028
response to peptide GO:1901652 292 0.028
Rat
response to hypoxia GO:0001666 231 0.027
Rat
single organism carbohydrate metabolic process GO:0044723 118 0.027
cellular carbohydrate metabolic process GO:0044262 72 0.027
anion transport GO:0006820 178 0.027
response to ketone GO:1901654 182 0.027
positive regulation of developmental process GO:0051094 283 0.026
Worm
macromolecular complex subunit organization GO:0043933 339 0.026
neurological system process GO:0050877 219 0.026
negative regulation of metabolic process GO:0009892 331 0.026
Yeast
cell migration GO:0016477 197 0.026
cellular component morphogenesis GO:0032989 155 0.026
Fly
l glutamate import GO:0051938 2 0.025
locomotion GO:0040011 237 0.025
Fly
negative regulation of rna metabolic process GO:0051253 123 0.025
cell morphogenesis GO:0000902 142 0.025
Fly
positive regulation of cellular amine metabolic process GO:0033240 3 0.025
nucleoside phosphate metabolic process GO:0006753 283 0.025
behavior GO:0007610 205 0.025
positive regulation of protein modification process GO:0031401 142 0.025
purine containing compound metabolic process GO:0072521 253 0.024
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.024
Fly
regulation of catabolic process GO:0009894 113 0.024
positive regulation of cellular protein metabolic process GO:0032270 167 0.024
organonitrogen compound catabolic process GO:1901565 179 0.024
positive regulation of rna biosynthetic process GO:1902680 197 0.024
vesicle mediated transport GO:0016192 181 0.024
Rat Fly
locomotory exploration behavior GO:0035641 1 0.024
regulation of cellular component organization GO:0051128 368 0.024
Fly
negative regulation of nucleic acid templated transcription GO:1903507 117 0.024
positive regulation of phosphate metabolic process GO:0045937 262 0.024
cellular response to nitrogen compound GO:1901699 210 0.024
cellular response to lipid GO:0071396 201 0.024
regulation of anatomical structure size GO:0090066 135 0.024
Fly
response to nutrient GO:0007584 248 0.024
nucleotide metabolic process GO:0009117 279 0.024
monocarboxylic acid metabolic process GO:0032787 152 0.023
regulation of programmed cell death GO:0043067 341 0.023
Mouse
purine ribonucleoside metabolic process GO:0046128 168 0.023
cellular ion homeostasis GO:0006873 184 0.023
metal ion transport GO:0030001 289 0.023
cell projection organization GO:0030030 302 0.023
Fly
regulation of cellular carbohydrate metabolic process GO:0010675 39 0.022
cell morphogenesis involved in differentiation GO:0000904 119 0.022
Fly
positive regulation of protein phosphorylation GO:0001934 135 0.022
positive regulation of cellular component organization GO:0051130 200 0.022
cellular response to stress GO:0033554 269 0.022
Yeast Mouse Rat Fly
head development GO:0060322 247 0.021
positive regulation of lipid catabolic process GO:0050996 4 0.021
organic cyclic compound catabolic process GO:1901361 175 0.021
response to growth factor GO:0070848 189 0.021
neuron projection morphogenesis GO:0048812 122 0.021
Fly
response to glucocorticoid GO:0051384 223 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.021
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.021
negative regulation of transcription dna templated GO:0045892 116 0.021
regulation of apoptotic process GO:0042981 335 0.021
Mouse
apoptotic process GO:0006915 381 0.021
Mouse
ion homeostasis GO:0050801 212 0.021
cell projection morphogenesis GO:0048858 123 0.020
Fly
circadian rhythm GO:0007623 88 0.020
Mouse
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 3 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
positive regulation of phosphorylation GO:0042327 177 0.020
regulation of response to stress GO:0080134 126 0.020
Yeast
cellular response to growth factor stimulus GO:0071363 162 0.020
positive regulation of receptor activity GO:2000273 4 0.020
aging GO:0007568 241 0.020
Yeast Worm
anion transmembrane transport GO:0098656 77 0.020
axis specification GO:0009798 4 0.020
regeneration GO:0031099 163 0.020
cell part morphogenesis GO:0032990 123 0.020
Fly
negative regulation of cell death GO:0060548 229 0.020
Mouse
positive regulation of response to stimulus GO:0048584 285 0.019
Yeast
cellular component movement GO:0006928 248 0.019
Fly
transcription from rna polymerase ii promoter GO:0006366 252 0.019
cellular response to insulin stimulus GO:0032869 81 0.019
Rat
ribonucleotide metabolic process GO:0009259 231 0.019
cellular response to hormone stimulus GO:0032870 247 0.019
Rat
response to metal ion GO:0010038 253 0.019
response to estradiol GO:0032355 164 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.018
Yeast
regulation of homeostatic process GO:0032844 101 0.018
positive regulation of peptide hormone secretion GO:0090277 50 0.018
negative regulation of transport GO:0051051 136 0.018
Rat
purine containing compound catabolic process GO:0072523 138 0.018
ribonucleoside triphosphate metabolic process GO:0009199 141 0.018
regulation of secretion by cell GO:1903530 208 0.018
peptide hormone secretion GO:0030072 84 0.018
localization of cell GO:0051674 202 0.018
neural crest cell differentiation GO:0014033 2 0.018
response to ethanol GO:0045471 162 0.018
Rat
response to estrogen GO:0043627 232 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.018
Yeast
nucleobase containing compound catabolic process GO:0034655 152 0.018
single organism intracellular transport GO:1902582 166 0.017
carboxylic acid transport GO:0046942 115 0.017
positive regulation of cell development GO:0010720 176 0.017
purine nucleoside metabolic process GO:0042278 169 0.017
glucose homeostasis GO:0042593 75 0.017
Mouse
negative regulation of molecular function GO:0044092 133 0.017
regulation of body fluid levels GO:0050878 90 0.017
serotonin metabolic process GO:0042428 3 0.017
multicellular organism growth GO:0035264 1 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
Mouse
oxidation reduction process GO:0055114 304 0.017
hormone secretion GO:0046879 115 0.017
positive regulation of peptide secretion GO:0002793 52 0.017
regulation of intracellular signal transduction GO:1902531 218 0.017
Mouse
positive regulation of nucleic acid templated transcription GO:1903508 197 0.017
eye morphogenesis GO:0048592 4 0.017
intracellular transport GO:0046907 185 0.016
positive regulation of nervous system development GO:0051962 178 0.016
glycosyl compound catabolic process GO:1901658 126 0.016
single organism reproductive process GO:0044702 297 0.016
mapk cascade GO:0000165 140 0.016
macromolecule localization GO:0033036 252 0.016
Fly
purine ribonucleoside catabolic process GO:0046130 124 0.016
g protein coupled receptor signaling pathway GO:0007186 242 0.016
synaptic growth at neuromuscular junction GO:0051124 1 0.016
cellular cation homeostasis GO:0030003 180 0.016
response to bacterium GO:0009617 200 0.016
signal transduction by phosphorylation GO:0023014 144 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
regulation of hormone levels GO:0010817 187 0.015
cellular response to hexose stimulus GO:0071331 65 0.015
cellular component assembly GO:0022607 360 0.015
negative regulation of biosynthetic process GO:0009890 168 0.015
Yeast
cellular nitrogen compound catabolic process GO:0044270 163 0.015
lipid biosynthetic process GO:0008610 128 0.015
Mouse
response to molecule of bacterial origin GO:0002237 194 0.015
rhythmic process GO:0048511 156 0.015
Mouse
positive regulation of locomotion GO:0040017 102 0.015
regulation of anion transport GO:0044070 43 0.015
peptide secretion GO:0002790 86 0.015
regulation of insulin secretion GO:0050796 65 0.015
positive regulation of secretion by cell GO:1903532 128 0.015
negative regulation of apoptotic process GO:0043066 181 0.015
Mouse
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.015
Yeast
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.015
protein localization GO:0008104 191 0.015
regulation of protein phosphorylation GO:0001932 183 0.015
positive regulation of secretion GO:0051047 140 0.014
macromolecular complex assembly GO:0065003 273 0.014
regulation of membrane potential GO:0042391 110 0.014
signal release GO:0023061 145 0.014
response to camp GO:0051591 91 0.014
regulation of nervous system development GO:0051960 264 0.014
enzyme linked receptor protein signaling pathway GO:0007167 116 0.014
regulation of lipid metabolic process GO:0019216 68 0.014
regulation of synapse maturation GO:0090128 2 0.014
nucleoside metabolic process GO:0009116 179 0.014
secretion by cell GO:0032940 248 0.014
negative regulation of developmental process GO:0051093 125 0.014
positive regulation of cell communication GO:0010647 271 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
ribonucleoside monophosphate metabolic process GO:0009161 88 0.014
multi organism reproductive process GO:0044703 262 0.014
negative regulation of cellular component organization GO:0051129 83 0.014
organic acid transport GO:0015849 116 0.014
insulin secretion GO:0030073 69 0.014
regulation of cell growth GO:0001558 85 0.014
Fly
regulation of alternative mrna splicing via spliceosome GO:0000381 2 0.014
erythrocyte differentiation GO:0030218 1 0.013
ribonucleoside metabolic process GO:0009119 174 0.013
heterocycle catabolic process GO:0046700 167 0.013
aromatic compound catabolic process GO:0019439 168 0.013
positive regulation of transport GO:0051050 245 0.013
response to cytokine GO:0034097 215 0.013
regulation of anatomical structure morphogenesis GO:0022603 141 0.013
positive regulation of transferase activity GO:0051347 81 0.013
kidney development GO:0001822 67 0.013
single organism biosynthetic process GO:0044711 342 0.013
Yeast Mouse
positive regulation of cell proliferation GO:0008284 249 0.013
Rat
membrane depolarization during cardiac muscle cell action potential GO:0086012 1 0.013
cell motility GO:0048870 202 0.013
regulation of peptide transport GO:0090087 87 0.013
neural crest cell development GO:0014032 2 0.013
regulation of cell motility GO:2000145 131 0.013
regulation of transmembrane transport GO:0034762 122 0.013
positive regulation of triglyceride biosynthetic process GO:0010867 4 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
cell cycle checkpoint GO:0000075 2 0.013
cytoplasmic transport GO:0016482 115 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.013
regulation of peptide hormone secretion GO:0090276 80 0.013
negative regulation of ion transport GO:0043271 51 0.013
nucleoside catabolic process GO:0009164 126 0.013
regulation of carbohydrate metabolic process GO:0006109 41 0.012
regulation of neurogenesis GO:0050767 247 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
cellular lipid metabolic process GO:0044255 208 0.012
b cell differentiation GO:0030183 2 0.012
circulatory system process GO:0003013 183 0.012
female pregnancy GO:0007565 122 0.012
regulation of neuron death GO:1901214 115 0.012
purine nucleotide biosynthetic process GO:0006164 83 0.012
sodium ion transport GO:0006814 82 0.012
organonitrogen compound biosynthetic process GO:1901566 167 0.012
tissue development GO:0009888 252 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.012
defense response GO:0006952 194 0.012
heart morphogenesis GO:0003007 3 0.012
purine ribonucleotide catabolic process GO:0009154 136 0.012
heart development GO:0007507 72 0.012
response to biotic stimulus GO:0009607 226 0.012
cell growth GO:0016049 104 0.012
Yeast Fly
reproduction GO:0000003 245 0.012
Worm
regulation of cell projection organization GO:0031344 175 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
s shaped body morphogenesis GO:0072050 2 0.012
positive regulation of catabolic process GO:0009896 78 0.012
regulation of protein kinase activity GO:0045859 105 0.012
response to toxic substance GO:0009636 133 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
cellular response to carbohydrate stimulus GO:0071322 72 0.012
growth GO:0040007 165 0.012
Yeast Fly
carbohydrate derivative catabolic process GO:1901136 147 0.012
somatic stem cell maintenance GO:0035019 2 0.012
ribonucleotide catabolic process GO:0009261 136 0.012
inorganic ion transmembrane transport GO:0098660 229 0.012
regulation of peptide secretion GO:0002791 82 0.012
maintenance of location GO:0051235 17 0.012
Fly
cell type specific apoptotic process GO:0097285 134 0.012
positive regulation of hormone secretion GO:0046887 65 0.011
calcium ion homeostasis GO:0055074 162 0.011
peptide transport GO:0015833 97 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
dephosphorylation GO:0016311 98 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
exploration behavior GO:0035640 1 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
cation homeostasis GO:0055080 195 0.011
amide transport GO:0042886 105 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
protein oligomerization GO:0051259 191 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
positive regulation of signaling GO:0023056 270 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.011
cellular response to peptide GO:1901653 133 0.011
Rat
peptidyl tyrosine modification GO:0018212 72 0.011
carboxylic acid biosynthetic process GO:0046394 83 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
regulation of immune system process GO:0002682 123 0.011
cellular response to cytokine stimulus GO:0071345 127 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
regulation of organelle organization GO:0033043 80 0.011
regulation of ion transmembrane transport GO:0034765 121 0.011
metal ion homeostasis GO:0055065 186 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
Yeast
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
reproductive process GO:0022414 372 0.011
calcium mediated signaling using intracellular calcium source GO:0035584 1 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.010
carbohydrate derivative biosynthetic process GO:1901137 124 0.010
positive regulation of cell differentiation GO:0045597 217 0.010
anterior posterior pattern specification GO:0009952 1 0.010
positive regulation of apoptotic process GO:0043065 154 0.010
alpha amino acid metabolic process GO:1901605 71 0.010
proteolysis GO:0006508 175 0.010
embryonic pattern specification GO:0009880 1 0.010
organophosphate biosynthetic process GO:0090407 143 0.010
erythrocyte homeostasis GO:0034101 2 0.010
nucleoside phosphate catabolic process GO:1901292 140 0.010
cofactor metabolic process GO:0051186 95 0.010
development of primary sexual characteristics GO:0045137 107 0.010

Prkaa2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.017
disease of cellular proliferation DOID:14566 0 0.012
cancer DOID:162 0 0.011
organ system cancer DOID:0050686 0 0.011
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011