Rattus norvegicus

123 known processes

Tsc1

tuberous sclerosis 1

Tsc1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
intracellular signal transduction GO:0035556 314 0.491
positive regulation of multicellular organismal process GO:0051240 387 0.167
regulation of phosphate metabolic process GO:0019220 349 0.150
positive regulation of phosphate metabolic process GO:0045937 262 0.101
regulation of programmed cell death GO:0043067 341 0.098
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.097
regulation of molecular function GO:0065009 398 0.090
regulation of nucleic acid templated transcription GO:1903506 380 0.090
response to inorganic substance GO:0010035 377 0.086
regulation of rna metabolic process GO:0051252 391 0.079
regulation of rna biosynthetic process GO:2001141 381 0.078
regulation of catalytic activity GO:0050790 304 0.077
regulation of multicellular organismal development GO:2000026 376 0.074
positive regulation of molecular function GO:0044093 230 0.068
regulation of intracellular signal transduction GO:1902531 218 0.068
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.067
cellular response to endogenous stimulus GO:0071495 377 0.066
positive regulation of response to stimulus GO:0048584 285 0.064
brain development GO:0007420 247 0.062
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.061
regulation of cell differentiation GO:0045595 320 0.061
rna biosynthetic process GO:0032774 380 0.060
negative regulation of cellular metabolic process GO:0031324 281 0.060
nucleic acid templated transcription GO:0097659 379 0.060
regulation of transcription dna templated GO:0006355 374 0.059
rna metabolic process GO:0016070 406 0.058
enzyme linked receptor protein signaling pathway GO:0007167 116 0.057
positive regulation of cellular biosynthetic process GO:0031328 295 0.054
transcription from rna polymerase ii promoter GO:0006366 252 0.053
regulation of protein metabolic process GO:0051246 289 0.053
protein phosphorylation GO:0006468 345 0.051
neuron apoptotic process GO:0051402 88 0.051
regulation of phosphorylation GO:0042325 248 0.050
positive regulation of phosphorylation GO:0042327 177 0.050
macromolecular complex assembly GO:0065003 273 0.050
positive regulation of biosynthetic process GO:0009891 319 0.049
regulation of signal transduction GO:0009966 318 0.047
regulation of phosphorus metabolic process GO:0051174 349 0.045
central nervous system development GO:0007417 311 0.045
regulation of cellular protein metabolic process GO:0032268 267 0.044
protein complex assembly GO:0006461 263 0.044
multicellular organismal reproductive process GO:0048609 233 0.043
positive regulation of cell proliferation GO:0008284 249 0.043
negative regulation of cell death GO:0060548 229 0.043
transcription dna templated GO:0006351 377 0.041
positive regulation of cellular protein metabolic process GO:0032270 167 0.041
head development GO:0060322 247 0.041
nucleobase containing compound catabolic process GO:0034655 152 0.040
locomotion GO:0040011 237 0.040
negative regulation of macromolecule metabolic process GO:0010605 260 0.040
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.039
small gtpase mediated signal transduction GO:0007264 36 0.039
regulation of neuron death GO:1901214 115 0.039
regulation of kinase activity GO:0043549 117 0.038
cell cycle GO:0007049 101 0.038
regulation of immune system process GO:0002682 123 0.038
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.038
organic substance catabolic process GO:1901575 316 0.037
cellular component assembly GO:0022607 360 0.036
protein oligomerization GO:0051259 191 0.036
reproduction GO:0000003 245 0.036
nucleoside phosphate metabolic process GO:0006753 283 0.035
regulation of protein phosphorylation GO:0001932 183 0.035
positive regulation of intracellular signal transduction GO:1902533 138 0.035
cellular catabolic process GO:0044248 295 0.034
response to camp GO:0051591 91 0.034
protein complex biogenesis GO:0070271 263 0.033
positive regulation of cell death GO:0010942 184 0.033
response to acid chemical GO:0001101 222 0.033
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.033
positive regulation of nucleic acid templated transcription GO:1903508 197 0.033
positive regulation of protein metabolic process GO:0051247 178 0.033
protein complex subunit organization GO:0071822 302 0.033
response to nutrient levels GO:0031667 370 0.032
positive regulation of signal transduction GO:0009967 175 0.032
immune system process GO:0002376 204 0.032
regulation of nervous system development GO:0051960 264 0.032
mapk cascade GO:0000165 140 0.031
catabolic process GO:0009056 351 0.031
single organism catabolic process GO:0044712 283 0.031
response to decreased oxygen levels GO:0036293 237 0.031
cellular response to oxygen containing compound GO:1901701 386 0.030
negative regulation of metabolic process GO:0009892 331 0.030
cell migration GO:0016477 197 0.030
carbohydrate derivative metabolic process GO:1901135 346 0.029
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.029
regulation of protein modification process GO:0031399 194 0.029
protein transport GO:0015031 132 0.029
regulation of cell development GO:0060284 263 0.029
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.029
positive regulation of programmed cell death GO:0043068 157 0.028
programmed cell death GO:0012501 392 0.028
regulation of neurogenesis GO:0050767 247 0.028
positive regulation of signaling GO:0023056 270 0.028
response to oxygen levels GO:0070482 265 0.028
response to peptide GO:1901652 292 0.028
positive regulation of developmental process GO:0051094 283 0.027
response to peptide hormone GO:0043434 278 0.027
negative regulation of molecular function GO:0044092 133 0.027
cellular protein localization GO:0034613 122 0.026
response to extracellular stimulus GO:0009991 380 0.026
leukocyte activation GO:0045321 76 0.026
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.026
positive regulation of phosphorus metabolic process GO:0010562 262 0.026
macromolecule localization GO:0033036 252 0.026
macromolecular complex subunit organization GO:0043933 339 0.026
antral ovarian follicle growth GO:0001547 3 0.026
carbohydrate derivative catabolic process GO:1901136 147 0.026
cell type specific apoptotic process GO:0097285 134 0.026
regulation of cell proliferation GO:0042127 359 0.026
pro t cell differentiation GO:0002572 1 0.025
positive regulation of gene expression GO:0010628 244 0.025
negative regulation of cellular biosynthetic process GO:0031327 161 0.025
negative regulation of biosynthetic process GO:0009890 168 0.025
adult locomotory behavior GO:0008344 4 0.025
regulation of transferase activity GO:0051338 123 0.025
negative regulation of protein metabolic process GO:0051248 114 0.025
ras protein signal transduction GO:0007265 29 0.024
response to insulin GO:0032868 133 0.024
cellular lipid metabolic process GO:0044255 208 0.024
apoptotic process GO:0006915 381 0.024
cellular response to nitrogen compound GO:1901699 210 0.024
positive regulation of catalytic activity GO:0043085 184 0.024
cellular component movement GO:0006928 248 0.024
positive regulation of apoptotic process GO:0043065 154 0.023
cellular response to insulin stimulus GO:0032869 81 0.023
positive regulation of protein phosphorylation GO:0001934 135 0.023
amine metabolic process GO:0009308 38 0.023
positive regulation of rna biosynthetic process GO:1902680 197 0.023
regulation of apoptotic process GO:0042981 335 0.023
negative regulation of rna metabolic process GO:0051253 123 0.023
membrane organization GO:0061024 94 0.022
regulation of hydrolase activity GO:0051336 143 0.022
response to wounding GO:0009611 254 0.022
cell motility GO:0048870 202 0.022
regulation of cellular component organization GO:0051128 368 0.021
regulation of neuron apoptotic process GO:0043523 83 0.021
regeneration GO:0031099 163 0.021
positive regulation of neurogenesis GO:0050769 165 0.021
nucleoside metabolic process GO:0009116 179 0.021
heterocycle catabolic process GO:0046700 167 0.021
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.020
cellular response to hormone stimulus GO:0032870 247 0.020
anatomical structure morphogenesis GO:0009653 298 0.020
negative regulation of cell proliferation GO:0008285 119 0.020
positive regulation of cell communication GO:0010647 271 0.020
regulation of small gtpase mediated signal transduction GO:0051056 48 0.020
negative regulation of cellular protein metabolic process GO:0032269 106 0.020
purine containing compound catabolic process GO:0072523 138 0.020
organophosphate metabolic process GO:0019637 370 0.020
nucleoside phosphate catabolic process GO:1901292 140 0.020
cellular component biogenesis GO:0044085 368 0.020
negative regulation of programmed cell death GO:0043069 183 0.019
multi organism reproductive process GO:0044703 262 0.019
purine ribonucleotide catabolic process GO:0009154 136 0.019
negative regulation of response to stimulus GO:0048585 155 0.019
positive regulation of cell development GO:0010720 176 0.019
positive regulation of cell projection organization GO:0031346 111 0.019
tissue development GO:0009888 252 0.019
positive regulation of rna metabolic process GO:0051254 203 0.019
signal transduction by phosphorylation GO:0023014 144 0.019
regulation of hormone levels GO:0010817 187 0.018
regulation of mapk cascade GO:0043408 116 0.018
negative regulation of signal transduction GO:0009968 83 0.018
regulation of response to stress GO:0080134 126 0.018
aging GO:0007568 241 0.018
response to radiation GO:0009314 137 0.018
positive regulation of cell differentiation GO:0045597 217 0.018
developmental process involved in reproduction GO:0003006 159 0.018
smooth muscle cell proliferation GO:0048659 77 0.018
cell projection organization GO:0030030 302 0.017
purine nucleoside metabolic process GO:0042278 169 0.017
rhythmic process GO:0048511 156 0.017
response to growth factor GO:0070848 189 0.017
glycosyl compound metabolic process GO:1901657 182 0.017
tube development GO:0035295 89 0.017
positive regulation of cellular component organization GO:0051130 200 0.017
cellular response to peptide GO:1901653 133 0.017
epithelial cell differentiation GO:0030855 71 0.017
single organism reproductive process GO:0044702 297 0.017
positive regulation of nervous system development GO:0051962 178 0.017
intracellular transport GO:0046907 185 0.016
intracellular protein transport GO:0006886 79 0.016
neurological system process GO:0050877 219 0.016
regulation of neuron projection development GO:0010975 161 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
regulation of cell projection organization GO:0031344 175 0.016
regulation of cell motility GO:2000145 131 0.015
protein heterooligomerization GO:0051291 89 0.015
cellular response to stress GO:0033554 269 0.015
negative regulation of nucleic acid templated transcription GO:1903507 117 0.015
multicellular organism growth GO:0035264 1 0.015
negative regulation of rna biosynthetic process GO:1902679 118 0.015
response to metal ion GO:0010038 253 0.015
protein localization GO:0008104 191 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.015
organ regeneration GO:0031100 101 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.014
organelle organization GO:0006996 266 0.014
response to estrogen GO:0043627 232 0.014
ribonucleotide catabolic process GO:0009261 136 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
regulation of defense response GO:0031347 68 0.014
immune response GO:0006955 104 0.014
response to molecule of bacterial origin GO:0002237 194 0.014
regulation of catabolic process GO:0009894 113 0.014
purine ribonucleoside metabolic process GO:0046128 168 0.014
response to retinoic acid GO:0032526 63 0.014
organophosphate catabolic process GO:0046434 148 0.014
spindle organization GO:0007051 2 0.014
purine nucleotide catabolic process GO:0006195 136 0.014
positive regulation of protein modification process GO:0031401 142 0.014
negative regulation of cell differentiation GO:0045596 99 0.014
neuronal action potential GO:0019228 35 0.014
regulation of cellular ketone metabolic process GO:0010565 27 0.013
transmission of nerve impulse GO:0019226 42 0.013
nucleobase containing small molecule metabolic process GO:0055086 316 0.013
establishment of protein localization GO:0045184 141 0.013
cellular response to organonitrogen compound GO:0071417 197 0.013
protein homooligomerization GO:0051260 91 0.013
response to toxic substance GO:0009636 133 0.013
hematopoietic progenitor cell differentiation GO:0002244 2 0.013
neuron differentiation GO:0030182 368 0.013
positive regulation of isotype switching GO:0045830 1 0.013
multicellular organism reproduction GO:0032504 233 0.013
single organism intracellular transport GO:1902582 166 0.013
regulation of cellular amine metabolic process GO:0033238 8 0.013
neuron development GO:0048666 286 0.013
negative regulation of catalytic activity GO:0043086 103 0.013
defense response GO:0006952 194 0.013
maintenance of location GO:0051235 17 0.012
dephosphorylation GO:0016311 98 0.012
nucleoside triphosphate catabolic process GO:0009143 123 0.012
proteolysis GO:0006508 175 0.012
epithelium development GO:0060429 96 0.012
response to glucocorticoid GO:0051384 223 0.012
aromatic compound catabolic process GO:0019439 168 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
cellular response to peptide hormone stimulus GO:0071375 120 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.012
localization of cell GO:0051674 202 0.012
positive regulation of immunoglobulin production GO:0002639 4 0.012
response to organophosphorus GO:0046683 102 0.012
cellular ketone metabolic process GO:0042180 51 0.012
peptidyl tyrosine modification GO:0018212 72 0.012
growth GO:0040007 165 0.012
cellular amine metabolic process GO:0044106 38 0.012
anion transport GO:0006820 178 0.012
macromolecule catabolic process GO:0009057 58 0.012
negative regulation of gene expression GO:0010629 199 0.012
gamete generation GO:0007276 124 0.012
response to external biotic stimulus GO:0043207 221 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
positive regulation of transferase activity GO:0051347 81 0.012
cellular amino acid metabolic process GO:0006520 107 0.012
protein processing GO:0016485 68 0.012
insulin like growth factor receptor signaling pathway GO:0048009 3 0.012
regulation of epithelial cell proliferation GO:0050678 49 0.011
response to lipopolysaccharide GO:0032496 191 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
cellular homeostasis GO:0019725 252 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
b cell activation involved in immune response GO:0002312 1 0.011
regulation of immunoglobulin production GO:0002637 4 0.011
nitrogen compound transport GO:0071705 229 0.011
nucleoside catabolic process GO:0009164 126 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
regulation of lipid metabolic process GO:0019216 68 0.011
muscle cell proliferation GO:0033002 84 0.011
synaptic growth at neuromuscular junction GO:0051124 1 0.011
negative regulation of intracellular signal transduction GO:1902532 38 0.011
response to nutrient GO:0007584 248 0.011
response to bacterium GO:0009617 200 0.011
cytoplasmic transport GO:0016482 115 0.011
regulation of protein serine threonine kinase activity GO:0071900 64 0.011
axis specification GO:0009798 4 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
intracellular receptor signaling pathway GO:0030522 35 0.010
response to oxidative stress GO:0006979 186 0.010
response to hypoxia GO:0001666 231 0.010
regulation of mrna splicing via spliceosome GO:0048024 3 0.010
gastrulation GO:0007369 2 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
sequestering of metal ion GO:0051238 9 0.010
regulation of cell cycle GO:0051726 73 0.010
cellular component morphogenesis GO:0032989 155 0.010
reproductive process GO:0022414 372 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.010
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.010

Tsc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.025
disease of metabolism DOID:0014667 0 0.016
central nervous system disease DOID:331 0 0.011