Rattus norvegicus

0 known processes

Spam1

sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)

(Aliases: MGC93268,Spam)

Spam1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
blood circulation GO:0008015 183 0.158
regulation of phosphorus metabolic process GO:0051174 349 0.139
cellular response to endogenous stimulus GO:0071495 377 0.135
response to biotic stimulus GO:0009607 226 0.130
calcium ion transport GO:0006816 131 0.128
cellular component biogenesis GO:0044085 368 0.126
sensory perception of pain GO:0019233 73 0.126
regulation of molecular function GO:0065009 398 0.119
negative regulation of macromolecule metabolic process GO:0010605 260 0.113
intracellular signal transduction GO:0035556 314 0.110
positive regulation of signaling GO:0023056 270 0.109
cellular response to hormone stimulus GO:0032870 247 0.103
oxoacid metabolic process GO:0043436 290 0.103
negative regulation of gene expression GO:0010629 199 0.102
positive regulation of multicellular organismal process GO:0051240 387 0.099
regulation of synaptic transmission GO:0050804 141 0.097
regulation of phosphorylation GO:0042325 248 0.092
response to molecule of bacterial origin GO:0002237 194 0.091
angiogenesis GO:0001525 53 0.085
defense response GO:0006952 194 0.084
regulation of system process GO:0044057 208 0.083
negative regulation of nucleic acid templated transcription GO:1903507 117 0.079
cellular homeostasis GO:0019725 252 0.078
cellular response to oxygen containing compound GO:1901701 386 0.078
synaptic transmission GO:0007268 235 0.078
vascular process in circulatory system GO:0003018 96 0.075
protein phosphorylation GO:0006468 345 0.073
regulation of catalytic activity GO:0050790 304 0.070
regulation of protein kinase activity GO:0045859 105 0.070
nucleic acid templated transcription GO:0097659 379 0.070
vasculature development GO:0001944 70 0.070
divalent metal ion transport GO:0070838 132 0.070
circulatory system process GO:0003013 183 0.069
regulation of blood pressure GO:0008217 83 0.066
negative regulation of cell death GO:0060548 229 0.064
response to wounding GO:0009611 254 0.064
response to extracellular stimulus GO:0009991 380 0.063
regulation of cellular protein metabolic process GO:0032268 267 0.061
single organism reproductive process GO:0044702 297 0.060
Mouse
mapk cascade GO:0000165 140 0.060
blood vessel development GO:0001568 69 0.059
regulation of cellular amine metabolic process GO:0033238 8 0.059
cellular amino acid metabolic process GO:0006520 107 0.058
positive regulation of immune system process GO:0002684 90 0.058
chemical homeostasis GO:0048878 292 0.054
response to ketone GO:1901654 182 0.054
regulation of phosphate metabolic process GO:0019220 349 0.053
metal ion homeostasis GO:0055065 186 0.053
ion homeostasis GO:0050801 212 0.052
regulation of cell development GO:0060284 263 0.052
regulation of membrane potential GO:0042391 110 0.052
eating behavior GO:0042755 21 0.051
cellular response to stress GO:0033554 269 0.051
negative regulation of metabolic process GO:0009892 331 0.051
cation homeostasis GO:0055080 195 0.051
transcription dna templated GO:0006351 377 0.050
developmental growth GO:0048589 100 0.050
cellular response to external stimulus GO:0071496 118 0.050
positive regulation of response to stimulus GO:0048584 285 0.050
positive regulation of protein metabolic process GO:0051247 178 0.048
transmembrane transport GO:0055085 412 0.048
rna metabolic process GO:0016070 406 0.048
cellular chemical homeostasis GO:0055082 247 0.047
heart contraction GO:0060047 57 0.047
gamete generation GO:0007276 124 0.047
cellular ketone metabolic process GO:0042180 51 0.047
regulation of cellular component organization GO:0051128 368 0.046
lipid metabolic process GO:0006629 283 0.045
cation transport GO:0006812 382 0.045
circulatory system development GO:0072359 134 0.044
regulation of signal transduction GO:0009966 318 0.043
regulation of blood circulation GO:1903522 110 0.043
anatomical structure morphogenesis GO:0009653 298 0.043
cellular response to organic cyclic compound GO:0071407 202 0.043
cellular response to steroid hormone stimulus GO:0071383 93 0.043
regulation of metal ion transport GO:0010959 118 0.043
positive regulation of protein kinase activity GO:0045860 73 0.043
response to nutrient levels GO:0031667 370 0.042
programmed cell death GO:0012501 392 0.042
positive regulation of signal transduction GO:0009967 175 0.041
cellular response to corticosteroid stimulus GO:0071384 69 0.041
divalent inorganic cation homeostasis GO:0072507 165 0.041
multi multicellular organism process GO:0044706 138 0.041
regulation of cellular amino acid metabolic process GO:0006521 2 0.040
necroptotic process GO:0070266 2 0.040
cellular ion homeostasis GO:0006873 184 0.040
regulation of kinase activity GO:0043549 117 0.040
response to purine containing compound GO:0014074 126 0.039
response to other organism GO:0051707 220 0.039
response to bacterium GO:0009617 200 0.038
proteolysis GO:0006508 175 0.037
cellular component assembly GO:0022607 360 0.036
neurotransmitter gated ion channel clustering GO:0072578 3 0.036
positive regulation of transferase activity GO:0051347 81 0.036
multi organism reproductive process GO:0044703 262 0.036
Mouse
cellular metal ion homeostasis GO:0006875 172 0.036
muscle system process GO:0003012 115 0.035
calcium ion homeostasis GO:0055074 162 0.035
regulation of ion transmembrane transport GO:0034765 121 0.035
negative regulation of chronic inflammatory response GO:0002677 2 0.035
tissue development GO:0009888 252 0.035
regulation of transcription dna templated GO:0006355 374 0.035
amine metabolic process GO:0009308 38 0.034
response to ethanol GO:0045471 162 0.034
cell cell signaling GO:0007267 335 0.034
regulation of transferase activity GO:0051338 123 0.034
cytosolic calcium ion homeostasis GO:0051480 140 0.034
regulation of angiogenesis GO:0045765 39 0.033
response to lipopolysaccharide GO:0032496 191 0.033
regulation of neuron death GO:1901214 115 0.033
regulation of ion transport GO:0043269 245 0.033
regulation of secretion by cell GO:1903530 208 0.033
organic substance catabolic process GO:1901575 316 0.033
protein maturation GO:0051604 68 0.033
immune system process GO:0002376 204 0.033
regulation of programmed cell death GO:0043067 341 0.033
muscle contraction GO:0006936 88 0.032
sensory perception GO:0007600 101 0.032
regulation of vesicle mediated transport GO:0060627 81 0.032
potassium ion transport GO:0006813 97 0.031
cellular amine metabolic process GO:0044106 38 0.031
glomerular mesangium development GO:0072109 4 0.031
regulation of intracellular signal transduction GO:1902531 218 0.031
divalent inorganic cation transport GO:0072511 134 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
single organism biosynthetic process GO:0044711 342 0.030
ion transmembrane transport GO:0034220 365 0.030
carbohydrate derivative metabolic process GO:1901135 346 0.030
regulation of vasculature development GO:1901342 44 0.029
regulation of mapk cascade GO:0043408 116 0.029
single organism catabolic process GO:0044712 283 0.029
positive regulation of developmental process GO:0051094 283 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.029
regulation of the force of heart contraction by chemical signal GO:0003057 2 0.029
response to inorganic substance GO:0010035 377 0.029
response to chromate GO:0046687 3 0.029
regulation of synaptic plasticity GO:0048167 70 0.028
positive regulation of synaptic transmission GO:0050806 62 0.028
reproductive process GO:0022414 372 0.028
Mouse
carbohydrate catabolic process GO:0016052 40 0.028
regulation of cellular localization GO:0060341 263 0.028
cytokine production GO:0001816 61 0.028
cellular cation homeostasis GO:0030003 180 0.028
motor neuron axon guidance GO:0008045 1 0.028
behavior GO:0007610 205 0.028
g protein coupled receptor signaling pathway GO:0007186 242 0.027
response to muscle activity involved in regulation of muscle adaptation GO:0014873 2 0.027
protein oligomerization GO:0051259 191 0.027
regulation of neurological system process GO:0031644 43 0.027
inorganic ion transmembrane transport GO:0098660 229 0.027
positive regulation of phosphorus metabolic process GO:0010562 262 0.027
negative regulation of transport GO:0051051 136 0.027
response to hypoxia GO:0001666 231 0.026
regulation of multicellular organismal development GO:2000026 376 0.026
regulation of blood vessel size GO:0050880 89 0.026
rhythmic process GO:0048511 156 0.026
regulation of response to wounding GO:1903034 69 0.026
positive regulation of neurogenesis GO:0050769 165 0.026
negative regulation of apoptotic process GO:0043066 181 0.026
cellular response to ketone GO:1901655 51 0.025
multicellular organism reproduction GO:0032504 233 0.025
metal ion transport GO:0030001 289 0.025
regulation of growth GO:0040008 105 0.025
regulation of immune system process GO:0002682 123 0.025
positive regulation of catalytic activity GO:0043085 184 0.025
positive regulation of cell death GO:0010942 184 0.025
cellular response to lipid GO:0071396 201 0.025
response to cytokine GO:0034097 215 0.025
monovalent inorganic cation transport GO:0015672 172 0.025
regulation of apoptotic process GO:0042981 335 0.024
dephosphorylation GO:0016311 98 0.024
regulation of cellular component movement GO:0051270 150 0.023
regulation of protein metabolic process GO:0051246 289 0.023
organic acid metabolic process GO:0006082 292 0.023
response to glucocorticoid GO:0051384 223 0.023
glutamate secretion GO:0014047 19 0.023
apoptotic process GO:0006915 381 0.023
regulation of cell differentiation GO:0045595 320 0.023
regulation of homeostatic process GO:0032844 101 0.023
negative regulation of cellular protein metabolic process GO:0032269 106 0.023
positive regulation of cell development GO:0010720 176 0.023
secretion GO:0046903 307 0.022
response to increased oxygen levels GO:0036296 45 0.022
response to hyperoxia GO:0055093 45 0.022
response to peptide hormone GO:0043434 278 0.022
response to nutrient GO:0007584 248 0.022
transmission of nerve impulse GO:0019226 42 0.022
positive regulation of immune response GO:0050778 42 0.022
response to estradiol GO:0032355 164 0.022
regulation of tube size GO:0035150 89 0.022
negative regulation of protein maturation GO:1903318 47 0.022
prepulse inhibition GO:0060134 1 0.022
positive regulation of biosynthetic process GO:0009891 319 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
synaptic transmission glutamatergic GO:0035249 33 0.022
uterine smooth muscle contraction GO:0070471 10 0.022
negative regulation of programmed cell death GO:0043069 183 0.022
positive regulation of phosphate metabolic process GO:0045937 262 0.022
cellular response to nutrient levels GO:0031669 60 0.022
regulation of calcium ion transport GO:0051924 77 0.022
blood vessel morphogenesis GO:0048514 58 0.022
neuronal action potential GO:0019228 35 0.022
inflammatory response GO:0006954 150 0.022
regulation of cell growth GO:0001558 85 0.021
positive regulation of kinase activity GO:0033674 77 0.021
acid secretion GO:0046717 48 0.021
protein complex assembly GO:0006461 263 0.021
gliogenesis GO:0042063 93 0.021
cellular response to histamine GO:0071420 3 0.021
protein transport GO:0015031 132 0.021
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.021
positive regulation of cellular protein metabolic process GO:0032270 167 0.021
negative regulation of protein metabolic process GO:0051248 114 0.021
positive regulation of phosphorylation GO:0042327 177 0.020
circadian rhythm GO:0007623 88 0.020
carboxylic acid metabolic process GO:0019752 289 0.020
regulation of protein phosphorylation GO:0001932 183 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
positive regulation of cell communication GO:0010647 271 0.020
protein complex biogenesis GO:0070271 263 0.020
regulation of hormone levels GO:0010817 187 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
somatostatin receptor signaling pathway GO:0038169 4 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
regulation of systemic arterial blood pressure GO:0003073 30 0.019
tonic smooth muscle contraction GO:0014820 4 0.019
response to corticosteroid GO:0031960 235 0.019
regulation of nervous system development GO:0051960 264 0.019
negative regulation of cellular biosynthetic process GO:0031327 161 0.019
regulation of ion homeostasis GO:2000021 63 0.019
secretion by cell GO:0032940 248 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
cellular divalent inorganic cation homeostasis GO:0072503 162 0.019
regulation of transmembrane transport GO:0034762 122 0.019
establishment of protein localization GO:0045184 141 0.019
cellular response to organonitrogen compound GO:0071417 197 0.019
reproduction GO:0000003 245 0.019
Mouse
growth GO:0040007 165 0.018
positive regulation of cytokine production GO:0001819 42 0.018
response to alkaloid GO:0043279 132 0.018
positive regulation of the force of heart contraction by norepinephrine GO:0003061 1 0.018
positive regulation of protein modification process GO:0031401 142 0.018
cardiovascular system development GO:0072358 134 0.018
cellular response to glucocorticoid stimulus GO:0071385 68 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
response to acid chemical GO:0001101 222 0.018
positive regulation of homeostatic process GO:0032846 49 0.018
renal system process GO:0003014 40 0.018
sexual reproduction GO:0019953 148 0.018
Mouse
positive regulation of secretion GO:0051047 140 0.017
negative regulation of rna metabolic process GO:0051253 123 0.017
regulation of anatomical structure size GO:0090066 135 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
response to oxygen levels GO:0070482 265 0.017
response to decreased oxygen levels GO:0036293 237 0.017
negative regulation of catalytic activity GO:0043086 103 0.017
female pregnancy GO:0007565 122 0.017
neuropeptide signaling pathway GO:0007218 29 0.017
positive regulation of molecular function GO:0044093 230 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
response to temperature stimulus GO:0009266 94 0.017
glomerular mesangial cell proliferation GO:0072110 4 0.017
tube development GO:0035295 89 0.017
positive regulation of protein transport GO:0051222 41 0.017
response to activity GO:0014823 73 0.017
response to growth factor GO:0070848 189 0.017
negative regulation of innate immune response GO:0045824 4 0.017
cellular response to extracellular stimulus GO:0031668 73 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
response to estrogen GO:0043627 232 0.016
negative regulation of uterine smooth muscle contraction GO:0070473 2 0.016
neurological system process GO:0050877 219 0.016
response to oxidative stress GO:0006979 186 0.016
response to corticosterone GO:0051412 40 0.016
regulation of inflammatory response GO:0050727 48 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
acute inflammatory response GO:0002526 58 0.016
response to starvation GO:0042594 59 0.016
protein processing GO:0016485 68 0.016
regulation of rna biosynthetic process GO:2001141 381 0.016
aging GO:0007568 241 0.016
renal system development GO:0072001 67 0.016
steroid biosynthetic process GO:0006694 48 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.016
excretion GO:0007588 24 0.016
macromolecule localization GO:0033036 252 0.016
negative regulation of protein processing GO:0010955 47 0.015
response to mechanical stimulus GO:0009612 134 0.015
regulation of defense response GO:0031347 68 0.015
regulation of nucleic acid templated transcription GO:1903506 380 0.015
positive regulation of blood circulation GO:1903524 65 0.015
cytoplasmic transport GO:0016482 115 0.015
cellular component movement GO:0006928 248 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.015
brain renin angiotensin system GO:0002035 3 0.015
negative regulation of phosphorus metabolic process GO:0010563 80 0.015
positive regulation of glomerulus development GO:0090193 4 0.015
negative regulation of proteolysis GO:0045861 41 0.015
action potential GO:0001508 54 0.015
positive regulation of saliva secretion GO:0046878 3 0.015
somatostatin signaling pathway GO:0038170 4 0.015
positive regulation of cellular component organization GO:0051130 200 0.014
vasodilation by norepinephrine epinephrine involved in regulation of systemic arterial blood pressure GO:0002025 1 0.014
negative regulation of long term synaptic potentiation GO:1900272 1 0.014
negative regulation of membrane potential GO:0045837 5 0.014
phasic smooth muscle contraction GO:0014821 3 0.014
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.014
peptidyl tyrosine modification GO:0018212 72 0.014
fertilization GO:0009566 3 0.014
Mouse
regulation of cell proliferation GO:0042127 359 0.014
macromolecular complex assembly GO:0065003 273 0.014
regulation of excretion GO:0044062 21 0.014
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.014
innate immune response GO:0045087 35 0.014
regulation of proteolysis GO:0030162 66 0.014
negative regulation of signaling GO:0023057 157 0.014
response to interleukin 1 GO:0070555 55 0.014
regulation of glutamate secretion GO:0014048 17 0.014
positive regulation of the force of heart contraction by chemical signal GO:0003099 2 0.014
catabolic process GO:0009056 351 0.014
regulation of response to stress GO:0080134 126 0.014
positive regulation of programmed cell death GO:0043068 157 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
artery smooth muscle contraction GO:0014824 4 0.014
regulation of sensory perception of pain GO:0051930 29 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
angiotensin mediated drinking behavior GO:0003051 2 0.013
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.013
regulation of transmembrane transporter activity GO:0022898 49 0.013
organic hydroxy compound transport GO:0015850 77 0.013
cation transmembrane transport GO:0098655 263 0.013
protein localization GO:0008104 191 0.013
protein complex subunit organization GO:0071822 302 0.013
regulation of sensory perception GO:0051931 29 0.013
positive regulation of secretion by cell GO:1903532 128 0.013
regulation of locomotion GO:0040012 148 0.013
cellular catabolic process GO:0044248 295 0.013
eosinophil chemotaxis GO:0048245 3 0.013
regulation of protein maturation GO:1903317 50 0.013
positive regulation of transport GO:0051050 245 0.013
neuron differentiation GO:0030182 368 0.013
hormone metabolic process GO:0042445 69 0.013
single organism intracellular transport GO:1902582 166 0.013
intracellular protein transport GO:0006886 79 0.013
protein homooligomerization GO:0051260 91 0.013
regulation of body fluid levels GO:0050878 90 0.013
regulation of cytokine production GO:0001817 56 0.012
cellular response to acid chemical GO:0071229 75 0.012
positive regulation of ion transport GO:0043270 94 0.012
monovalent inorganic cation homeostasis GO:0055067 36 0.012
regulation of rna metabolic process GO:0051252 391 0.012
localization of cell GO:0051674 202 0.012
nucleotide metabolic process GO:0009117 279 0.012
single organism membrane organization GO:0044802 74 0.012
cellular response to interleukin 1 GO:0071347 37 0.012
positive regulation of cell migration GO:0030335 96 0.012
regulation of long term synaptic potentiation GO:1900271 5 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
purine ribonucleotide biosynthetic process GO:0009152 81 0.012
response to antibiotic GO:0046677 39 0.012
mast cell migration GO:0097531 4 0.012
cellular carbohydrate metabolic process GO:0044262 72 0.012
negative regulation of homeostatic process GO:0032845 47 0.012
positive regulation of locomotion GO:0040017 102 0.012
negative regulation of neuron death GO:1901215 69 0.012
glomerulus development GO:0032835 10 0.012
intracellular transport GO:0046907 185 0.012
cell projection organization GO:0030030 302 0.012
response to heat GO:0009408 60 0.012
dicarboxylic acid transport GO:0006835 34 0.011
regulation of muscle system process GO:0090257 79 0.011
positive regulation of nervous system development GO:0051962 178 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
regulation of hydrolase activity GO:0051336 143 0.011
male gamete generation GO:0048232 99 0.011
rho protein signal transduction GO:0007266 11 0.011
response to reactive oxygen species GO:0000302 120 0.011
regulation of regulatory t cell differentiation GO:0045589 2 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
rna biosynthetic process GO:0032774 380 0.011
eosinophil migration GO:0072677 3 0.011
s shaped body morphogenesis GO:0072050 2 0.011
spermatogenesis GO:0007283 99 0.011
cellular response to peptide GO:1901653 133 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
protein targeting GO:0006605 61 0.011
positive regulation of lipid metabolic process GO:0045834 33 0.011
positive regulation of glomerular mesangial cell proliferation GO:0072126 4 0.011
negative regulation of protein phosphorylation GO:0001933 44 0.011
neuron death GO:0070997 127 0.011
interferon gamma production GO:0032609 3 0.011
n methyl d aspartate receptor clustering GO:0097114 2 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
ras protein signal transduction GO:0007265 29 0.011
calcium mediated signaling GO:0019722 23 0.011
regulation of amine transport GO:0051952 54 0.010
ribonucleotide metabolic process GO:0009259 231 0.010
regulation of protein transport GO:0051223 68 0.010
negative regulation of peptidase activity GO:0010466 38 0.010
peptidyl tyrosine phosphorylation GO:0018108 72 0.010
organic cyclic compound catabolic process GO:1901361 175 0.010
positive regulation of interferon gamma production GO:0032729 2 0.010
epithelial cell proliferation GO:0050673 54 0.010
positive regulation of circadian sleep wake cycle wakefulness GO:0010841 2 0.010
cell adhesion GO:0007155 110 0.010
cell migration GO:0016477 197 0.010
response to dexamethasone GO:0071548 49 0.010
adenylate cyclase inhibiting serotonin receptor signaling pathway GO:0007198 1 0.010
positive regulation of cellular component movement GO:0051272 102 0.010
regulation of cell morphogenesis GO:0022604 77 0.010
regulation of cytokine biosynthetic process GO:0042035 3 0.010
regulation of metanephros development GO:0072215 4 0.010
vasoconstriction GO:0042310 54 0.010
negative regulation of response to stimulus GO:0048585 155 0.010
response to camp GO:0051591 91 0.010

Spam1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
substance related disorder DOID:303 0 0.012
disease of mental health DOID:150 0 0.012
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011