Rattus norvegicus

45 known processes

Thbs4

thrombospondin 4

Thbs4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to oxygen levels GO:0070482 265 0.138
reproductive process GO:0022414 372 0.102
response to wounding GO:0009611 254 0.081
macromolecular complex subunit organization GO:0043933 339 0.078
intracellular signal transduction GO:0035556 314 0.076
protein phosphorylation GO:0006468 345 0.073
Human
regulation of multicellular organismal development GO:2000026 376 0.060
Human
negative regulation of cell death GO:0060548 229 0.055
regulation of phosphorylation GO:0042325 248 0.054
Human
immune system process GO:0002376 204 0.053
Human
regulation of signal transduction GO:0009966 318 0.053
divalent inorganic cation transport GO:0072511 134 0.053
anatomical structure morphogenesis GO:0009653 298 0.050
regulation of cell proliferation GO:0042127 359 0.049
Human
defense response GO:0006952 194 0.049
negative regulation of metabolic process GO:0009892 331 0.048
negative regulation of programmed cell death GO:0043069 183 0.043
single organism biosynthetic process GO:0044711 342 0.042
cellular response to growth factor stimulus GO:0071363 162 0.041
homeostatic process GO:0042592 331 0.041
regulation of phosphate metabolic process GO:0019220 349 0.041
Human
secretion GO:0046903 307 0.039
organophosphate metabolic process GO:0019637 370 0.038
regulation of apoptotic process GO:0042981 335 0.038
response to extracellular stimulus GO:0009991 380 0.038
carbohydrate derivative metabolic process GO:1901135 346 0.037
cellular response to oxygen containing compound GO:1901701 386 0.036
positive regulation of multicellular organismal process GO:0051240 387 0.036
nucleic acid templated transcription GO:0097659 379 0.036
calcium ion transport GO:0006816 131 0.035
rna biosynthetic process GO:0032774 380 0.035
apoptotic process GO:0006915 381 0.035
regulation of cell development GO:0060284 263 0.034
metal ion homeostasis GO:0055065 186 0.033
regulation of secretion by cell GO:1903530 208 0.033
regulation of cellular protein metabolic process GO:0032268 267 0.033
Human
divalent metal ion transport GO:0070838 132 0.032
negative regulation of macromolecule metabolic process GO:0010605 260 0.031
regulation of transcription dna templated GO:0006355 374 0.031
response to decreased oxygen levels GO:0036293 237 0.031
neural crest cell differentiation GO:0014033 2 0.031
regulation of cell differentiation GO:0045595 320 0.030
negative regulation of signaling GO:0023057 157 0.030
positive regulation of cell death GO:0010942 184 0.030
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.029
response to nutrient GO:0007584 248 0.029
proteolysis GO:0006508 175 0.029
tissue remodeling GO:0048771 40 0.029
Mouse
localization of cell GO:0051674 202 0.029
Human
negative regulation of cell communication GO:0010648 158 0.028
positive regulation of gene expression GO:0010628 244 0.028
single organism intracellular transport GO:1902582 166 0.028
eye morphogenesis GO:0048592 4 0.028
regulation of protein phosphorylation GO:0001932 183 0.028
Human
blood circulation GO:0008015 183 0.028
transcription dna templated GO:0006351 377 0.028
cell morphogenesis GO:0000902 142 0.028
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
negative regulation of cellular metabolic process GO:0031324 281 0.027
regulation of cellular localization GO:0060341 263 0.027
regulation of neuron projection development GO:0010975 161 0.027
positive regulation of cell development GO:0010720 176 0.026
positive regulation of cell differentiation GO:0045597 217 0.026
mast cell migration GO:0097531 4 0.025
cellular homeostasis GO:0019725 252 0.025
tissue development GO:0009888 252 0.025
Zebrafish
regulation of hydrolase activity GO:0051336 143 0.024
response to hypoxia GO:0001666 231 0.024
regulation of neuron apoptotic process GO:0043523 83 0.024
negative regulation of protein metabolic process GO:0051248 114 0.024
negative regulation of multicellular organismal process GO:0051241 203 0.024
Human
regulation of cellular amino acid metabolic process GO:0006521 2 0.024
cellular component movement GO:0006928 248 0.024
Human
negative regulation of cellular protein metabolic process GO:0032269 106 0.024
intracellular transport GO:0046907 185 0.023
muscle system process GO:0003012 115 0.023
cellular calcium ion homeostasis GO:0006874 160 0.023
regulation of mapk cascade GO:0043408 116 0.023
protein complex assembly GO:0006461 263 0.023
neuron projection development GO:0031175 273 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.023
regulation of phosphorus metabolic process GO:0051174 349 0.023
Human
head development GO:0060322 247 0.022
positive regulation of developmental process GO:0051094 283 0.022
regulation of molecular function GO:0065009 398 0.022
cellular amino acid metabolic process GO:0006520 107 0.022
response to interleukin 1 GO:0070555 55 0.022
regulation of protein modification process GO:0031399 194 0.022
Human
rna metabolic process GO:0016070 406 0.022
amine metabolic process GO:0009308 38 0.022
positive regulation of neuron projection development GO:0010976 99 0.022
positive regulation of transcription dna templated GO:0045893 197 0.022
regulation of catalytic activity GO:0050790 304 0.022
negative regulation of phosphorus metabolic process GO:0010563 80 0.021
positive regulation of biosynthetic process GO:0009891 319 0.021
nucleoside phosphate metabolic process GO:0006753 283 0.021
t helper 1 type immune response GO:0042088 1 0.021
chemical homeostasis GO:0048878 292 0.021
purine ribonucleotide metabolic process GO:0009150 227 0.021
cation transport GO:0006812 382 0.021
regulation of cellular component organization GO:0051128 368 0.021
positive regulation of cell proliferation GO:0008284 249 0.021
Human
circulatory system process GO:0003013 183 0.021
limb morphogenesis GO:0035108 4 0.021
cellular cation homeostasis GO:0030003 180 0.020
g protein coupled receptor signaling pathway GO:0007186 242 0.020
regulation of nervous system development GO:0051960 264 0.020
regulation of neuron differentiation GO:0045664 208 0.020
negative regulation of response to stimulus GO:0048585 155 0.020
regulation of neurogenesis GO:0050767 247 0.020
cellular ketone metabolic process GO:0042180 51 0.020
cellular response to endogenous stimulus GO:0071495 377 0.020
nucleotide metabolic process GO:0009117 279 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
Human
multicellular organismal signaling GO:0035637 44 0.019
positive regulation of immune system process GO:0002684 90 0.019
Human
cellular component biogenesis GO:0044085 368 0.019
transmembrane transport GO:0055085 412 0.019
protein complex subunit organization GO:0071822 302 0.019
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.019
muscle structure development GO:0061061 87 0.019
Fly
regulation of cellular component movement GO:0051270 150 0.019
Human
response to mechanical stimulus GO:0009612 134 0.019
small gtpase mediated signal transduction GO:0007264 36 0.019
transcription from rna polymerase ii promoter GO:0006366 252 0.019
negative regulation of phosphate metabolic process GO:0045936 80 0.019
positive regulation of signaling GO:0023056 270 0.018
regulation of programmed cell death GO:0043067 341 0.018
negative regulation of gene expression GO:0010629 199 0.018
regulation of cellular ketone metabolic process GO:0010565 27 0.018
neuron development GO:0048666 286 0.018
ribonucleotide metabolic process GO:0009259 231 0.018
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.018
regulation of anatomical structure size GO:0090066 135 0.018
cellular component morphogenesis GO:0032989 155 0.018
cellular response to tumor necrosis factor GO:0071356 46 0.018
multi organism reproductive process GO:0044703 262 0.018
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.018
positive regulation of phosphorylation GO:0042327 177 0.017
Human
growth GO:0040007 165 0.017
positive regulation of cellular component organization GO:0051130 200 0.017
protein complex biogenesis GO:0070271 263 0.017
purine nucleotide metabolic process GO:0006163 229 0.017
regulation of membrane potential GO:0042391 110 0.017
cellular chemical homeostasis GO:0055082 247 0.017
regulation of secretion GO:0051046 224 0.017
inflammatory response GO:0006954 150 0.017
positive regulation of nucleic acid templated transcription GO:1903508 197 0.017
response to biotic stimulus GO:0009607 226 0.017
cellular amine metabolic process GO:0044106 38 0.017
positive regulation of cellular biosynthetic process GO:0031328 295 0.017
metal ion transport GO:0030001 289 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
enzyme linked receptor protein signaling pathway GO:0007167 116 0.016
response to vitamin GO:0033273 131 0.016
nucleoside metabolic process GO:0009116 179 0.016
muscle organ morphogenesis GO:0048644 1 0.016
secretion by cell GO:0032940 248 0.016
wound healing GO:0042060 122 0.016
cellular component assembly GO:0022607 360 0.016
regulation of homeostatic process GO:0032844 101 0.016
positive regulation of neuron differentiation GO:0045666 126 0.016
male sex differentiation GO:0046661 64 0.016
dendrite development GO:0016358 72 0.016
heart morphogenesis GO:0003007 3 0.016
macromolecular complex assembly GO:0065003 273 0.016
cellular metal ion homeostasis GO:0006875 172 0.016
regulation of transferase activity GO:0051338 123 0.016
cardiac chamber development GO:0003205 1 0.015
multicellular organismal reproductive process GO:0048609 233 0.015
development of primary sexual characteristics GO:0045137 107 0.015
positive regulation of response to stimulus GO:0048584 285 0.015
Human
ion homeostasis GO:0050801 212 0.015
positive regulation of molecular function GO:0044093 230 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
macromolecule localization GO:0033036 252 0.015
cardiac muscle tissue morphogenesis GO:0055008 1 0.015
organonitrogen compound biosynthetic process GO:1901566 167 0.015
negative regulation of molecular function GO:0044092 133 0.015
positive regulation of nervous system development GO:0051962 178 0.015
cytoplasmic transport GO:0016482 115 0.015
regulation of immune system process GO:0002682 123 0.015
Human
positive regulation of response to external stimulus GO:0032103 51 0.015
Human
adiponectin secretion GO:0070162 1 0.015
cell motility GO:0048870 202 0.015
Human
cardiovascular system development GO:0072358 134 0.015
Human
aging GO:0007568 241 0.015
establishment of synaptic specificity at neuromuscular junction GO:0007529 1 0.015
regulation of protein kinase activity GO:0045859 105 0.015
transmission of nerve impulse GO:0019226 42 0.015
response to peptide hormone GO:0043434 278 0.015
response to radiation GO:0009314 137 0.014
sequestering of calcium ion GO:0051208 8 0.014
cytosolic calcium ion homeostasis GO:0051480 140 0.014
multicellular organism reproduction GO:0032504 233 0.014
protein localization GO:0008104 191 0.014
negative regulation of developmental process GO:0051093 125 0.014
Human
organelle organization GO:0006996 266 0.014
regulation of stem cell differentiation GO:2000736 2 0.014
cell projection organization GO:0030030 302 0.014
negative regulation of catalytic activity GO:0043086 103 0.014
gastrulation GO:0007369 2 0.014
positive regulation of signal transduction GO:0009967 175 0.014
regulation of peptidase activity GO:0052547 55 0.014
regulation of cell activation GO:0050865 50 0.014
reproductive structure development GO:0048608 128 0.014
positive regulation of cell communication GO:0010647 271 0.014
central nervous system development GO:0007417 311 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
regulation of cell morphogenesis GO:0022604 77 0.014
regulation of blood pressure GO:0008217 83 0.014
regulation of nucleic acid templated transcription GO:1903506 380 0.014
single organism catabolic process GO:0044712 283 0.014
negative regulation of signal transduction GO:0009968 83 0.014
cellular response to stress GO:0033554 269 0.013
Mouse
aromatic compound catabolic process GO:0019439 168 0.013
lipid metabolic process GO:0006629 283 0.013
skeletal system development GO:0001501 41 0.013
sequestering of metal ion GO:0051238 9 0.013
neural crest cell development GO:0014032 2 0.013
muscle organ development GO:0007517 50 0.013
Fly
single organism cellular localization GO:1902580 102 0.013
oxoacid metabolic process GO:0043436 290 0.013
positive regulation of rna biosynthetic process GO:1902680 197 0.013
morphogenesis of embryonic epithelium GO:0016331 3 0.013
mapk cascade GO:0000165 140 0.013
multi multicellular organism process GO:0044706 138 0.013
cell part morphogenesis GO:0032990 123 0.013
muscle contraction GO:0006936 88 0.013
regulation of protein metabolic process GO:0051246 289 0.013
Human
regulation of cell projection organization GO:0031344 175 0.013
female pregnancy GO:0007565 122 0.013
negative regulation of protein phosphorylation GO:0001933 44 0.013
cell type specific apoptotic process GO:0097285 134 0.013
muscle filament sliding GO:0030049 2 0.013
establishment of protein localization GO:0045184 141 0.013
cellular response to interleukin 1 GO:0071347 37 0.013
response to nutrient levels GO:0031667 370 0.013
response to fibroblast growth factor GO:0071774 29 0.013
formation of primary germ layer GO:0001704 1 0.013
organic substance catabolic process GO:1901575 316 0.012
organic acid metabolic process GO:0006082 292 0.012
muscle tissue morphogenesis GO:0060415 1 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
response to axon injury GO:0048678 59 0.012
purine containing compound biosynthetic process GO:0072522 85 0.012
cellular response to hormone stimulus GO:0032870 247 0.012
programmed cell death GO:0012501 392 0.012
vascular process in circulatory system GO:0003018 96 0.012
neuronal action potential GO:0019228 35 0.012
cardiac ventricle development GO:0003231 1 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
vesicle mediated transport GO:0016192 181 0.012
striated muscle tissue development GO:0014706 58 0.012
response to metal ion GO:0010038 253 0.012
ras protein signal transduction GO:0007265 29 0.012
positive regulation of cell migration GO:0030335 96 0.012
Human
response to ketone GO:1901654 182 0.012
catabolic process GO:0009056 351 0.012
regulation of cellular amine metabolic process GO:0033238 8 0.012
single organism organelle organization GO:1902589 180 0.012
purine containing compound metabolic process GO:0072521 253 0.012
organ senescence GO:0010260 2 0.012
positive regulation of rna metabolic process GO:0051254 203 0.011
dna metabolic process GO:0006259 96 0.011
signal release GO:0023061 145 0.011
regulation of synaptic plasticity GO:0048167 70 0.011
response to bacterium GO:0009617 200 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
axis specification GO:0009798 4 0.011
embryonic skeletal system morphogenesis GO:0048704 3 0.011
gonad development GO:0008406 104 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
cellular response to external stimulus GO:0071496 118 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
positive regulation of bone mineralization GO:0030501 4 0.011
calcium ion homeostasis GO:0055074 162 0.011
positive regulation of cell motility GO:2000147 97 0.011
Human
regulation of response to wounding GO:1903034 69 0.011
neurological system process GO:0050877 219 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
protein maturation GO:0051604 68 0.011
behavior GO:0007610 205 0.011
neuron death GO:0070997 127 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
negative regulation of protein modification process GO:0031400 52 0.011
ion transmembrane transport GO:0034220 365 0.011
ossification GO:0001503 70 0.011
autonomic nervous system development GO:0048483 3 0.011
cellular macromolecule localization GO:0070727 122 0.011
protein transport GO:0015031 132 0.011
muscle tissue development GO:0060537 58 0.011
single organism reproductive process GO:0044702 297 0.010
cell activation GO:0001775 97 0.010
regulation of rna biosynthetic process GO:2001141 381 0.010
negative regulation of homeostatic process GO:0032845 47 0.010
positive regulation of cellular amine metabolic process GO:0033240 3 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.010
circulatory system development GO:0072359 134 0.010
Human
negative regulation of cellular biosynthetic process GO:0031327 161 0.010
carbohydrate derivative catabolic process GO:1901136 147 0.010
brain development GO:0007420 247 0.010
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.010
positive regulation of cell activation GO:0050867 34 0.010
organophosphate biosynthetic process GO:0090407 143 0.010
positive regulation of programmed cell death GO:0043068 157 0.010
positive regulation of secretion GO:0051047 140 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
regulation of muscle system process GO:0090257 79 0.010
nucleotide biosynthetic process GO:0009165 98 0.010
regulation of protein transport GO:0051223 68 0.010
neuron projection morphogenesis GO:0048812 122 0.010
response to external biotic stimulus GO:0043207 221 0.010
regulation of cytokine biosynthetic process GO:0042035 3 0.010

Thbs4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
nervous system disease DOID:863 0 0.029
muscular disease DOID:0080000 0 0.019
musculoskeletal system disease DOID:17 0 0.019
myopathy DOID:423 0 0.018
muscle tissue disease DOID:66 0 0.018
heart disease DOID:114 0 0.014
cardiovascular system disease DOID:1287 0 0.014
cardiomyopathy DOID:0050700 0 0.014
dilated cardiomyopathy DOID:12930 0 0.014
intrinsic cardiomyopathy DOID:0060036 0 0.014
central nervous system disease DOID:331 0 0.013