Rattus norvegicus

0 known processes

Sp140

SP140 nuclear body protein

Sp140 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular component assembly GO:0022607 360 0.210
macromolecule localization GO:0033036 252 0.186
regulation of cell proliferation GO:0042127 359 0.119
apoptotic process GO:0006915 381 0.115
immune response activating signal transduction GO:0002757 15 0.113
macromolecular complex assembly GO:0065003 273 0.103
regulation of programmed cell death GO:0043067 341 0.094
protein complex subunit organization GO:0071822 302 0.085
positive regulation of cell death GO:0010942 184 0.084
cellular component biogenesis GO:0044085 368 0.084
regulation of rna metabolic process GO:0051252 391 0.084
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.084
positive regulation of signal transduction GO:0009967 175 0.083
macromolecular complex subunit organization GO:0043933 339 0.083
protein complex assembly GO:0006461 263 0.076
immune system process GO:0002376 204 0.069
response to biotic stimulus GO:0009607 226 0.069
regulation of protein metabolic process GO:0051246 289 0.068
protein complex biogenesis GO:0070271 263 0.066
cation transport GO:0006812 382 0.065
carbohydrate derivative metabolic process GO:1901135 346 0.062
programmed cell death GO:0012501 392 0.060
regulation of phosphate metabolic process GO:0019220 349 0.059
nucleoside phosphate metabolic process GO:0006753 283 0.057
head development GO:0060322 247 0.057
positive regulation of signaling GO:0023056 270 0.056
regulation of protein modification process GO:0031399 194 0.056
organophosphate metabolic process GO:0019637 370 0.054
regulation of fc receptor mediated stimulatory signaling pathway GO:0060368 3 0.053
regulation of phosphorylation GO:0042325 248 0.053
positive regulation of cellular protein metabolic process GO:0032270 167 0.052
ribonucleoside metabolic process GO:0009119 174 0.051
brain development GO:0007420 247 0.050
purine nucleotide catabolic process GO:0006195 136 0.050
nucleotide metabolic process GO:0009117 279 0.050
positive regulation of programmed cell death GO:0043068 157 0.049
cellular nitrogen compound catabolic process GO:0044270 163 0.049
negative regulation of cellular metabolic process GO:0031324 281 0.049
purine ribonucleotide catabolic process GO:0009154 136 0.049
protein localization GO:0008104 191 0.048
protein oligomerization GO:0051259 191 0.047
regulation of phosphorus metabolic process GO:0051174 349 0.047
rna metabolic process GO:0016070 406 0.046
positive regulation of cell proliferation GO:0008284 249 0.044
regulation of nucleic acid templated transcription GO:1903506 380 0.043
organic substance catabolic process GO:1901575 316 0.043
organelle organization GO:0006996 266 0.043
negative regulation of metabolic process GO:0009892 331 0.042
multi organism reproductive process GO:0044703 262 0.041
actin filament based process GO:0030029 86 0.041
regulation of rna biosynthetic process GO:2001141 381 0.040
purine ribonucleoside catabolic process GO:0046130 124 0.039
positive regulation of multicellular organismal process GO:0051240 387 0.039
positive regulation of biosynthetic process GO:0009891 319 0.039
single organism cellular localization GO:1902580 102 0.038
regulation of intracellular signal transduction GO:1902531 218 0.038
response to external biotic stimulus GO:0043207 221 0.037
regulation of cellular component organization GO:0051128 368 0.037
catabolic process GO:0009056 351 0.037
regulation of molecular function GO:0065009 398 0.037
cellular amino acid metabolic process GO:0006520 107 0.036
ribonucleoside triphosphate metabolic process GO:0009199 141 0.036
purine nucleoside triphosphate metabolic process GO:0009144 141 0.036
nucleoside catabolic process GO:0009164 126 0.036
positive regulation of immune system process GO:0002684 90 0.035
defense response GO:0006952 194 0.035
positive regulation of developmental process GO:0051094 283 0.035
response to other organism GO:0051707 220 0.034
purine nucleotide metabolic process GO:0006163 229 0.034
protein phosphorylation GO:0006468 345 0.034
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.034
regulation of multicellular organismal development GO:2000026 376 0.034
ribonucleotide metabolic process GO:0009259 231 0.034
purine nucleoside triphosphate catabolic process GO:0009146 122 0.034
regulation of membrane potential GO:0042391 110 0.033
purine ribonucleotide metabolic process GO:0009150 227 0.032
response to transition metal nanoparticle GO:1990267 122 0.032
carbohydrate derivative catabolic process GO:1901136 147 0.032
immune response regulating signaling pathway GO:0002764 19 0.031
rna biosynthetic process GO:0032774 380 0.031
cellular ketone metabolic process GO:0042180 51 0.031
cytokine biosynthetic process GO:0042089 3 0.031
positive regulation of apoptotic process GO:0043065 154 0.031
ribonucleoside catabolic process GO:0042454 126 0.031
nucleoside metabolic process GO:0009116 179 0.030
cellular response to oxygen containing compound GO:1901701 386 0.030
regulation of cellular amino acid metabolic process GO:0006521 2 0.030
organic cyclic compound catabolic process GO:1901361 175 0.029
purine nucleoside monophosphate catabolic process GO:0009128 55 0.029
regulation of protein phosphorylation GO:0001932 183 0.029
regulation of catalytic activity GO:0050790 304 0.028
regulation of hydrolase activity GO:0051336 143 0.028
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.028
glycosyl compound catabolic process GO:1901658 126 0.028
regulation of immune response GO:0050776 55 0.028
anatomical structure morphogenesis GO:0009653 298 0.027
regulation of apoptotic process GO:0042981 335 0.027
organonitrogen compound catabolic process GO:1901565 179 0.027
response to ketone GO:1901654 182 0.027
regulation of transcription dna templated GO:0006355 374 0.026
purine nucleoside catabolic process GO:0006152 124 0.026
nucleobase containing compound catabolic process GO:0034655 152 0.026
metal ion transport GO:0030001 289 0.026
response to decreased oxygen levels GO:0036293 237 0.026
negative regulation of phosphorus metabolic process GO:0010563 80 0.026
amine metabolic process GO:0009308 38 0.026
heterocycle catabolic process GO:0046700 167 0.026
positive regulation of phosphorus metabolic process GO:0010562 262 0.026
regulation of cellular amine metabolic process GO:0033238 8 0.026
positive regulation of immune response GO:0050778 42 0.026
purine containing compound metabolic process GO:0072521 253 0.025
positive regulation of phosphate metabolic process GO:0045937 262 0.025
nucleic acid templated transcription GO:0097659 379 0.025
positive regulation of molecular function GO:0044093 230 0.025
purine containing compound catabolic process GO:0072523 138 0.025
transcription dna templated GO:0006351 377 0.024
response to oxygen levels GO:0070482 265 0.024
cellular amine metabolic process GO:0044106 38 0.024
cell part morphogenesis GO:0032990 123 0.024
single organism membrane organization GO:0044802 74 0.024
fc receptor mediated stimulatory signaling pathway GO:0002431 3 0.024
regulation of cellular localization GO:0060341 263 0.024
negative regulation of phosphate metabolic process GO:0045936 80 0.024
ribonucleotide catabolic process GO:0009261 136 0.023
cellular protein localization GO:0034613 122 0.023
positive regulation of transport GO:0051050 245 0.023
organophosphate catabolic process GO:0046434 148 0.023
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.023
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.023
muscle cell differentiation GO:0042692 52 0.023
protein heterooligomerization GO:0051291 89 0.023
carboxylic acid metabolic process GO:0019752 289 0.023
regulation of cellular ketone metabolic process GO:0010565 27 0.022
negative regulation of viral process GO:0048525 4 0.022
response to toxic substance GO:0009636 133 0.022
single organism reproductive process GO:0044702 297 0.022
establishment of protein localization GO:0045184 141 0.022
regulation of response to stress GO:0080134 126 0.022
response to bacterium GO:0009617 200 0.022
nucleoside phosphate catabolic process GO:1901292 140 0.022
membrane organization GO:0061024 94 0.022
ribonucleoside monophosphate metabolic process GO:0009161 88 0.022
intracellular signal transduction GO:0035556 314 0.022
neuron projection development GO:0031175 273 0.022
response to cytokine GO:0034097 215 0.021
positive regulation of cell communication GO:0010647 271 0.021
nucleoside triphosphate catabolic process GO:0009143 123 0.021
multicellular organismal reproductive process GO:0048609 233 0.021
positive regulation of intracellular signal transduction GO:1902533 138 0.021
cellular response to molecule of bacterial origin GO:0071219 56 0.021
negative regulation of cellular component organization GO:0051129 83 0.020
response to ethanol GO:0045471 162 0.020
regulation of signal transduction GO:0009966 318 0.020
organic acid metabolic process GO:0006082 292 0.020
reproductive process GO:0022414 372 0.020
purine ribonucleoside metabolic process GO:0046128 168 0.020
oxoacid metabolic process GO:0043436 290 0.020
neuron development GO:0048666 286 0.019
transmembrane transport GO:0055085 412 0.019
erythrocyte differentiation GO:0030218 1 0.019
cell motility GO:0048870 202 0.019
cell cell signaling GO:0007267 335 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
negative regulation of response to stimulus GO:0048585 155 0.019
homeostatic process GO:0042592 331 0.019
regulation of neuron differentiation GO:0045664 208 0.019
response to peptide GO:1901652 292 0.019
aromatic compound catabolic process GO:0019439 168 0.019
regulation of nervous system development GO:0051960 264 0.019
cellular catabolic process GO:0044248 295 0.019
regulation of neurogenesis GO:0050767 247 0.019
cellular macromolecular complex assembly GO:0034622 58 0.019
ribonucleoside triphosphate catabolic process GO:0009203 122 0.018
response to acid chemical GO:0001101 222 0.018
purine nucleoside metabolic process GO:0042278 169 0.018
positive regulation of gene expression GO:0010628 244 0.018
nucleotide catabolic process GO:0009166 139 0.018
action potential GO:0001508 54 0.018
immune response GO:0006955 104 0.018
response to hypoxia GO:0001666 231 0.018
neuron differentiation GO:0030182 368 0.018
endomembrane system organization GO:0010256 48 0.018
defense response to other organism GO:0098542 17 0.018
positive regulation of nucleic acid templated transcription GO:1903508 197 0.017
glycosyl compound metabolic process GO:1901657 182 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
cellular component morphogenesis GO:0032989 155 0.017
cardiovascular system development GO:0072358 134 0.017
positive regulation of protein metabolic process GO:0051247 178 0.017
cytoskeleton organization GO:0007010 111 0.017
cellular lipid metabolic process GO:0044255 208 0.017
forebrain development GO:0030900 98 0.017
neuronal action potential GO:0019228 35 0.017
protein transport GO:0015031 132 0.017
vasculogenesis GO:0001570 3 0.017
actin cytoskeleton organization GO:0030036 73 0.017
central nervous system development GO:0007417 311 0.016
regulation of system process GO:0044057 208 0.016
single organism organelle organization GO:1902589 180 0.016
regulation of neuron projection development GO:0010975 161 0.016
gamete generation GO:0007276 124 0.016
response to temperature stimulus GO:0009266 94 0.016
negative regulation of macromolecule metabolic process GO:0010605 260 0.016
cellular macromolecule localization GO:0070727 122 0.016
ribose phosphate metabolic process GO:0019693 235 0.015
gland development GO:0048732 155 0.015
inorganic ion transmembrane transport GO:0098660 229 0.015
ion homeostasis GO:0050801 212 0.015
cytokine production GO:0001816 61 0.015
positive regulation of protein modification process GO:0031401 142 0.015
single organism intracellular transport GO:1902582 166 0.015
cellular component movement GO:0006928 248 0.015
circulatory system development GO:0072359 134 0.015
regulation of cell development GO:0060284 263 0.015
regulation of protein transport GO:0051223 68 0.015
divalent inorganic cation transport GO:0072511 134 0.015
cellular response to stress GO:0033554 269 0.014
single organism biosynthetic process GO:0044711 342 0.014
synaptic transmission GO:0007268 235 0.014
regulation of cell differentiation GO:0045595 320 0.014
actin filament based movement GO:0030048 16 0.014
cation transmembrane transport GO:0098655 263 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.014
regulation of dna metabolic process GO:0051052 60 0.014
calcium ion homeostasis GO:0055074 162 0.014
actin filament organization GO:0007015 42 0.014
gtp catabolic process GO:0006184 71 0.014
anatomical structure formation involved in morphogenesis GO:0048646 83 0.014
protein import GO:0017038 37 0.014
regulation of organelle organization GO:0033043 80 0.014
cellular response to lipid GO:0071396 201 0.013
cellular ion homeostasis GO:0006873 184 0.013
response to reactive oxygen species GO:0000302 120 0.013
positive regulation of response to stimulus GO:0048584 285 0.013
positive regulation of cellular component organization GO:0051130 200 0.013
unsaturated fatty acid metabolic process GO:0033559 39 0.013
response to oxidative stress GO:0006979 186 0.013
nucleobase containing small molecule metabolic process GO:0055086 316 0.013
defense response to gram negative bacterium GO:0050829 3 0.013
syncytium formation by plasma membrane fusion GO:0000768 3 0.013
wound healing GO:0042060 122 0.013
response to radiation GO:0009314 137 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
negative regulation of programmed cell death GO:0043069 183 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
multicellular organism reproduction GO:0032504 233 0.013
nucleoside triphosphate metabolic process GO:0009141 144 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
regulation of response to external stimulus GO:0032101 106 0.012
locomotion GO:0040011 237 0.012
gliogenesis GO:0042063 93 0.012
negative regulation of protein phosphorylation GO:0001933 44 0.012
cytoplasmic transport GO:0016482 115 0.012
response to heat GO:0009408 60 0.012
response to nutrient levels GO:0031667 370 0.012
negative regulation of cellular protein metabolic process GO:0032269 106 0.012
aging GO:0007568 241 0.012
positive regulation of transferase activity GO:0051347 81 0.012
regeneration GO:0031099 163 0.012
maintenance of location GO:0051235 17 0.012
regulation of establishment of protein localization GO:0070201 69 0.012
activation of immune response GO:0002253 26 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
calcium ion transport GO:0006816 131 0.012
cellular homeostasis GO:0019725 252 0.012
metal ion homeostasis GO:0055065 186 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
rho protein signal transduction GO:0007266 11 0.012
viral genome replication GO:0019079 2 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
glial cell differentiation GO:0010001 65 0.012
cellular response to nitrogen compound GO:1901699 210 0.012
innate immune response GO:0045087 35 0.012
positive regulation of rna biosynthetic process GO:1902680 197 0.012
positive regulation of cellular biosynthetic process GO:0031328 295 0.011
negative regulation of innate immune response GO:0045824 4 0.011
peptide biosynthetic process GO:0043043 3 0.011
positive regulation of cell development GO:0010720 176 0.011
protein maturation GO:0051604 68 0.011
divalent metal ion transport GO:0070838 132 0.011
axis specification GO:0009798 4 0.011
negative regulation of cell communication GO:0010648 158 0.011
neurological system process GO:0050877 219 0.011
regulation of cellular component biogenesis GO:0044087 86 0.011
response to peptide hormone GO:0043434 278 0.011
positive regulation of rna metabolic process GO:0051254 203 0.011
regulation of secretion by cell GO:1903530 208 0.011
positive regulation of phosphorylation GO:0042327 177 0.011
interleukin 6 production GO:0032635 12 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
cell projection organization GO:0030030 302 0.011
regulation of neuron apoptotic process GO:0043523 83 0.011
regulation of transferase activity GO:0051338 123 0.011
dna metabolic process GO:0006259 96 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
secretion by cell GO:0032940 248 0.011
regulation of protein localization GO:0032880 81 0.011
ribonucleoside monophosphate catabolic process GO:0009158 55 0.011
intracellular transport GO:0046907 185 0.011
peptidyl tyrosine modification GO:0018212 72 0.010
lipid metabolic process GO:0006629 283 0.010
spermatogenesis GO:0007283 99 0.010
i kappab kinase nf kappab signaling GO:0007249 19 0.010
male gamete generation GO:0048232 99 0.010
negative regulation of gene expression GO:0010629 199 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.010
negative regulation of cellular amine metabolic process GO:0033239 3 0.010
muscle system process GO:0003012 115 0.010
carbohydrate derivative biosynthetic process GO:1901137 124 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.010
limbic system development GO:0021761 38 0.010
localization of cell GO:0051674 202 0.010
cellular response to abiotic stimulus GO:0071214 85 0.010
activation of cysteine type endopeptidase activity GO:0097202 4 0.010
negative regulation of viral genome replication GO:0045071 1 0.010
synaptic growth at neuromuscular junction GO:0051124 1 0.010
myoblast fusion GO:0007520 2 0.010
cardiac conduction GO:0061337 2 0.010
programmed necrotic cell death GO:0097300 2 0.010
regulation of ion transport GO:0043269 245 0.010

Sp140 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
sensory system disease DOID:0050155 0 0.014
disease of anatomical entity DOID:7 0 0.014
eye and adnexa disease DOID:1492 0 0.014
nervous system disease DOID:863 0 0.014
eye disease DOID:5614 0 0.014
organ system cancer DOID:0050686 0 0.014