Rattus norvegicus

124 known processes

Hsd11b1

hydroxysteroid 11-beta dehydrogenase 1

(Aliases: LRRGT00065)

Hsd11b1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell proliferation GO:0042127 359 0.149
response to bacterium GO:0009617 200 0.105
oxoacid metabolic process GO:0043436 290 0.097
response to extracellular stimulus GO:0009991 380 0.095
cellular response to oxygen containing compound GO:1901701 386 0.087
regulation of protein metabolic process GO:0051246 289 0.084
response to biotic stimulus GO:0009607 226 0.082
apoptotic process GO:0006915 381 0.082
response to nutrient levels GO:0031667 370 0.081
response to inorganic substance GO:0010035 377 0.080
carboxylic acid metabolic process GO:0019752 289 0.080
response to metal ion GO:0010038 253 0.079
catabolic process GO:0009056 351 0.078
cellular component biogenesis GO:0044085 368 0.076
organic acid metabolic process GO:0006082 292 0.072
regulation of catalytic activity GO:0050790 304 0.068
organic substance catabolic process GO:1901575 316 0.067
response to glucocorticoid GO:0051384 223 0.067
lipid metabolic process GO:0006629 283 0.067
regulation of phosphate metabolic process GO:0019220 349 0.067
cellular response to stress GO:0033554 269 0.062
cellular component assembly GO:0022607 360 0.062
programmed cell death GO:0012501 392 0.062
single organism reproductive process GO:0044702 297 0.062
multicellular organism reproduction GO:0032504 233 0.059
cellular amino acid metabolic process GO:0006520 107 0.057
protein complex assembly GO:0006461 263 0.055
single organism biosynthetic process GO:0044711 342 0.054
regulation of molecular function GO:0065009 398 0.054
positive regulation of programmed cell death GO:0043068 157 0.054
positive regulation of molecular function GO:0044093 230 0.054
regulation of programmed cell death GO:0043067 341 0.053
cellular catabolic process GO:0044248 295 0.053
positive regulation of apoptotic process GO:0043065 154 0.053
proteolysis GO:0006508 175 0.053
reproductive process GO:0022414 372 0.052
negative regulation of metabolic process GO:0009892 331 0.052
reproduction GO:0000003 245 0.051
circulatory system development GO:0072359 134 0.049
regulation of cellular protein metabolic process GO:0032268 267 0.049
positive regulation of response to stimulus GO:0048584 285 0.049
response to hypoxia GO:0001666 231 0.049
positive regulation of cell proliferation GO:0008284 249 0.049
cation transport GO:0006812 382 0.046
central nervous system development GO:0007417 311 0.045
cellular response to external stimulus GO:0071496 118 0.044
growth GO:0040007 165 0.044
negative regulation of response to stimulus GO:0048585 155 0.043
protein phosphorylation GO:0006468 345 0.042
aging GO:0007568 241 0.042
multi organism reproductive process GO:0044703 262 0.042
protein maturation GO:0051604 68 0.040
negative regulation of cell proliferation GO:0008285 119 0.040
anatomical structure morphogenesis GO:0009653 298 0.040
regulation of signal transduction GO:0009966 318 0.040
cellular response to endogenous stimulus GO:0071495 377 0.039
regulation of cell differentiation GO:0045595 320 0.039
positive regulation of cell death GO:0010942 184 0.039
reproductive structure development GO:0048608 128 0.039
homeostatic process GO:0042592 331 0.039
cellular lipid metabolic process GO:0044255 208 0.039
organophosphate metabolic process GO:0019637 370 0.038
cellular response to lipid GO:0071396 201 0.038
cellular component movement GO:0006928 248 0.038
positive regulation of catalytic activity GO:0043085 184 0.038
defense response GO:0006952 194 0.037
response to nutrient GO:0007584 248 0.037
metal ion transport GO:0030001 289 0.037
response to corticosteroid GO:0031960 235 0.037
positive regulation of developmental process GO:0051094 283 0.036
negative regulation of macromolecule metabolic process GO:0010605 260 0.036
organ morphogenesis GO:0009887 75 0.036
regulation of response to stress GO:0080134 126 0.036
multicellular organismal reproductive process GO:0048609 233 0.036
neurological system process GO:0050877 219 0.035
regulation of phosphorus metabolic process GO:0051174 349 0.035
locomotion GO:0040011 237 0.035
regulation of apoptotic process GO:0042981 335 0.035
macromolecule localization GO:0033036 252 0.035
negative regulation of gene expression GO:0010629 199 0.035
organelle organization GO:0006996 266 0.035
positive regulation of multicellular organismal process GO:0051240 387 0.034
response to molecule of bacterial origin GO:0002237 194 0.034
reproductive system development GO:0061458 128 0.034
organonitrogen compound catabolic process GO:1901565 179 0.034
response to peptide GO:1901652 292 0.034
protein complex biogenesis GO:0070271 263 0.034
cardiovascular system development GO:0072358 134 0.033
response to ethanol GO:0045471 162 0.033
nucleobase containing small molecule metabolic process GO:0055086 316 0.032
immune system process GO:0002376 204 0.032
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
regulation of multicellular organismal development GO:2000026 376 0.032
cell projection organization GO:0030030 302 0.032
positive regulation of signaling GO:0023056 270 0.032
tissue development GO:0009888 252 0.032
regulation of cellular component organization GO:0051128 368 0.031
response to decreased oxygen levels GO:0036293 237 0.031
amine metabolic process GO:0009308 38 0.031
brain development GO:0007420 247 0.031
cellular amine metabolic process GO:0044106 38 0.031
neuron differentiation GO:0030182 368 0.031
lipid biosynthetic process GO:0008610 128 0.031
epithelium development GO:0060429 96 0.031
regulation of anatomical structure morphogenesis GO:0022603 141 0.030
protein complex subunit organization GO:0071822 302 0.030
head development GO:0060322 247 0.030
regulation of phosphorylation GO:0042325 248 0.029
regulation of protein phosphorylation GO:0001932 183 0.029
regulation of ion transport GO:0043269 245 0.028
response to acid chemical GO:0001101 222 0.028
positive regulation of phosphate metabolic process GO:0045937 262 0.028
purine containing compound metabolic process GO:0072521 253 0.028
regulation of cell projection organization GO:0031344 175 0.028
response to retinoic acid GO:0032526 63 0.028
cellular response to organic cyclic compound GO:0071407 202 0.028
response to peptide hormone GO:0043434 278 0.028
negative regulation of protein metabolic process GO:0051248 114 0.027
developmental process involved in reproduction GO:0003006 159 0.027
anion transport GO:0006820 178 0.027
response to wounding GO:0009611 254 0.027
neuron projection development GO:0031175 273 0.027
positive regulation of transport GO:0051050 245 0.027
response to amino acid GO:0043200 75 0.027
ion transmembrane transport GO:0034220 365 0.026
cellular component morphogenesis GO:0032989 155 0.026
negative regulation of cellular metabolic process GO:0031324 281 0.026
response to external biotic stimulus GO:0043207 221 0.026
chemical homeostasis GO:0048878 292 0.026
regulation of cellular localization GO:0060341 263 0.026
organic hydroxy compound metabolic process GO:1901615 115 0.026
regulation of cell development GO:0060284 263 0.026
macromolecular complex subunit organization GO:0043933 339 0.026
regulation of nervous system development GO:0051960 264 0.026
rna metabolic process GO:0016070 406 0.026
carbohydrate derivative metabolic process GO:1901135 346 0.026
secretion GO:0046903 307 0.025
protein oligomerization GO:0051259 191 0.025
positive regulation of biosynthetic process GO:0009891 319 0.025
negative regulation of programmed cell death GO:0043069 183 0.025
response to vitamin GO:0033273 131 0.025
response to ketone GO:1901654 182 0.025
sexual reproduction GO:0019953 148 0.025
protein processing GO:0016485 68 0.025
oxidation reduction process GO:0055114 304 0.025
response to lipopolysaccharide GO:0032496 191 0.025
response to growth factor GO:0070848 189 0.025
macromolecular complex assembly GO:0065003 273 0.025
neuron development GO:0048666 286 0.025
hormone metabolic process GO:0042445 69 0.025
single organism catabolic process GO:0044712 283 0.024
calcium ion transport GO:0006816 131 0.024
secretion by cell GO:0032940 248 0.024
transmembrane transport GO:0055085 412 0.024
regulation of immune system process GO:0002682 123 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.024
response to transition metal nanoparticle GO:1990267 122 0.024
regulation of neuron differentiation GO:0045664 208 0.023
mapk cascade GO:0000165 140 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
intracellular signal transduction GO:0035556 314 0.023
regulation of proteasomal protein catabolic process GO:0061136 4 0.023
regulation of hydrolase activity GO:0051336 143 0.023
gamete generation GO:0007276 124 0.023
cellular chemical homeostasis GO:0055082 247 0.023
cellular modified amino acid metabolic process GO:0006575 61 0.023
gonad development GO:0008406 104 0.023
cell motility GO:0048870 202 0.023
positive regulation of cellular amine metabolic process GO:0033240 3 0.023
multicellular organismal homeostasis GO:0048871 49 0.022
multicellular organismal signaling GO:0035637 44 0.022
cellular response to growth factor stimulus GO:0071363 162 0.022
localization of cell GO:0051674 202 0.022
regulation of hormone levels GO:0010817 187 0.022
glial cell differentiation GO:0010001 65 0.022
response to other organism GO:0051707 220 0.022
cellular ketone metabolic process GO:0042180 51 0.022
positive regulation of phosphorylation GO:0042327 177 0.022
cellular response to extracellular stimulus GO:0031668 73 0.021
cell migration GO:0016477 197 0.021
regulation of homeostatic process GO:0032844 101 0.021
regulation of cell growth GO:0001558 85 0.021
heart morphogenesis GO:0003007 3 0.021
positive regulation of cellular component organization GO:0051130 200 0.021
response to cytokine GO:0034097 215 0.021
single organism organelle organization GO:1902589 180 0.021
response to oxygen levels GO:0070482 265 0.021
negative regulation of cell death GO:0060548 229 0.021
heart development GO:0007507 72 0.021
signal transduction by phosphorylation GO:0023014 144 0.021
cell activation GO:0001775 97 0.020
negative regulation of molecular function GO:0044092 133 0.020
regulation of neurogenesis GO:0050767 247 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
development of primary sexual characteristics GO:0045137 107 0.020
wound healing GO:0042060 122 0.020
negative regulation of developmental process GO:0051093 125 0.020
regulation of secretion GO:0051046 224 0.020
rna biosynthetic process GO:0032774 380 0.020
cell cell signaling GO:0007267 335 0.020
positive regulation of cell differentiation GO:0045597 217 0.020
immune response GO:0006955 104 0.019
cellular response to alcohol GO:0097306 87 0.019
response to oxidative stress GO:0006979 186 0.019
transmission of nerve impulse GO:0019226 42 0.019
acute inflammatory response GO:0002526 58 0.019
positive regulation of cell communication GO:0010647 271 0.019
response to estrogen GO:0043627 232 0.019
cellular hormone metabolic process GO:0034754 49 0.019
response to insulin GO:0032868 133 0.019
epithelial cell proliferation GO:0050673 54 0.019
regulation of protein modification process GO:0031399 194 0.019
negative regulation of multicellular organismal process GO:0051241 203 0.019
regeneration GO:0031099 163 0.019
regulation of neuron projection development GO:0010975 161 0.018
negative regulation of cellular protein metabolic process GO:0032269 106 0.018
g protein coupled receptor signaling pathway GO:0007186 242 0.018
gliogenesis GO:0042063 93 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.018
response to estradiol GO:0032355 164 0.018
leukocyte activation GO:0045321 76 0.018
negative regulation of cell communication GO:0010648 158 0.018
chromosome segregation GO:0007059 2 0.018
inorganic ion transmembrane transport GO:0098660 229 0.018
ion homeostasis GO:0050801 212 0.018
nucleoside phosphate metabolic process GO:0006753 283 0.017
cellular nitrogen compound catabolic process GO:0044270 163 0.017
cell projection morphogenesis GO:0048858 123 0.017
behavior GO:0007610 205 0.017
cell adhesion GO:0007155 110 0.017
negative regulation of signaling GO:0023057 157 0.017
regulation of intracellular signal transduction GO:1902531 218 0.017
glycosyl compound metabolic process GO:1901657 182 0.017
regulation of locomotion GO:0040012 148 0.017
activation of cysteine type endopeptidase activity GO:0097202 4 0.017
cytoskeleton organization GO:0007010 111 0.017
organic cyclic compound catabolic process GO:1901361 175 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
regulation of lipid metabolic process GO:0019216 68 0.016
regulation of transcription dna templated GO:0006355 374 0.016
transcription from rna polymerase ii promoter GO:0006366 252 0.016
cellular homeostasis GO:0019725 252 0.016
regulation of nucleic acid templated transcription GO:1903506 380 0.016
regulation of rna biosynthetic process GO:2001141 381 0.016
cellular cation homeostasis GO:0030003 180 0.016
positive regulation of cell development GO:0010720 176 0.016
heterocycle catabolic process GO:0046700 167 0.016
actin filament based process GO:0030029 86 0.016
tissue remodeling GO:0048771 40 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
monovalent inorganic cation transport GO:0015672 172 0.015
intracellular transport GO:0046907 185 0.015
response to hexose GO:0009746 144 0.015
metal ion homeostasis GO:0055065 186 0.015
single organism behavior GO:0044708 130 0.015
female pregnancy GO:0007565 122 0.015
sex differentiation GO:0007548 113 0.015
response to aluminum ion GO:0010044 10 0.015
vesicle mediated transport GO:0016192 181 0.015
positive regulation of nervous system development GO:0051962 178 0.015
regulation of growth GO:0040008 105 0.015
inorganic cation transmembrane transport GO:0098662 202 0.015
spermatogenesis GO:0007283 99 0.015
cell cycle checkpoint GO:0000075 2 0.015
cell growth GO:0016049 104 0.015
nitrogen compound transport GO:0071705 229 0.015
regulation of membrane potential GO:0042391 110 0.015
response to carbohydrate GO:0009743 183 0.015
small gtpase mediated signal transduction GO:0007264 36 0.015
small molecule biosynthetic process GO:0044283 124 0.015
response to monosaccharide GO:0034284 159 0.015
alcohol metabolic process GO:0006066 77 0.015
negative regulation of apoptotic process GO:0043066 181 0.014
regulation of cell motility GO:2000145 131 0.014
action potential GO:0001508 54 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
negative regulation of signal transduction GO:0009968 83 0.014
single organism intracellular transport GO:1902582 166 0.014
cellular ion homeostasis GO:0006873 184 0.014
fatty acid metabolic process GO:0006631 99 0.014
steroid metabolic process GO:0008202 73 0.014
lipid localization GO:0010876 62 0.014
regulation of cellular component movement GO:0051270 150 0.014
blood vessel morphogenesis GO:0048514 58 0.014
vasculogenesis GO:0001570 3 0.014
male gamete generation GO:0048232 99 0.014
response to glucose GO:0009749 136 0.014
regulation of metal ion transport GO:0010959 118 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
nucleic acid templated transcription GO:0097659 379 0.014
positive regulation of hydrolase activity GO:0051345 86 0.014
regulation of system process GO:0044057 208 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.014
cation homeostasis GO:0055080 195 0.014
response to activity GO:0014823 73 0.014
organic anion transport GO:0015711 132 0.014
protein localization GO:0008104 191 0.014
vasculature development GO:0001944 70 0.014
cellular response to peptide hormone stimulus GO:0071375 120 0.013
regulation of catabolic process GO:0009894 113 0.013
cellular response to nutrient levels GO:0031669 60 0.013
neuronal action potential GO:0019228 35 0.013
cell part morphogenesis GO:0032990 123 0.013
regulation of rna metabolic process GO:0051252 391 0.013
synaptic transmission GO:0007268 235 0.013
positive regulation of protein modification process GO:0031401 142 0.013
protein homooligomerization GO:0051260 91 0.013
developmental growth GO:0048589 100 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.013
negative regulation of protein maturation GO:1903318 47 0.013
peptide metabolic process GO:0006518 32 0.013
regulation of anatomical structure size GO:0090066 135 0.013
regulation of vasculature development GO:1901342 44 0.013
single organism carbohydrate metabolic process GO:0044723 118 0.013
cellular response to organonitrogen compound GO:0071417 197 0.013
anatomical structure formation involved in morphogenesis GO:0048646 83 0.013
multi multicellular organism process GO:0044706 138 0.013
nucleoside metabolic process GO:0009116 179 0.013
cellular macromolecule localization GO:0070727 122 0.013
ras protein signal transduction GO:0007265 29 0.013
regulation of response to wounding GO:1903034 69 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
positive regulation of cellular component movement GO:0051272 102 0.013
lipid transport GO:0006869 61 0.013
regulation of mapk cascade GO:0043408 116 0.012
regulation of defense response GO:0031347 68 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
cell morphogenesis GO:0000902 142 0.012
negative regulation of phosphate metabolic process GO:0045936 80 0.012
response to mechanical stimulus GO:0009612 134 0.012
p38mapk cascade GO:0038066 1 0.012
blood circulation GO:0008015 183 0.012
transcription dna templated GO:0006351 377 0.012
positive regulation of cellular biosynthetic process GO:0031328 295 0.012
regulation of epithelial cell proliferation GO:0050678 49 0.012
ribose phosphate metabolic process GO:0019693 235 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.012
ribonucleotide metabolic process GO:0009259 231 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.012
regulation of proteolysis GO:0030162 66 0.012
sulfur compound metabolic process GO:0006790 70 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
regulation of secretion by cell GO:1903530 208 0.012
epithelial cell differentiation GO:0030855 71 0.012
tube development GO:0035295 89 0.012
Mouse
divalent inorganic cation transport GO:0072511 134 0.012
divalent metal ion transport GO:0070838 132 0.012
amide transport GO:0042886 105 0.012
carbohydrate metabolic process GO:0005975 130 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
response to purine containing compound GO:0014074 126 0.012
aromatic compound catabolic process GO:0019439 168 0.012
cellular response to hormone stimulus GO:0032870 247 0.011
regulation of response to external stimulus GO:0032101 106 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
regulation of kinase activity GO:0043549 117 0.011
inflammatory response GO:0006954 150 0.011
regulation of transferase activity GO:0051338 123 0.011
response to radiation GO:0009314 137 0.011
cellular amide metabolic process GO:0043603 44 0.011
response to camp GO:0051591 91 0.011
regulation of protein maturation GO:1903317 50 0.011
regulation of protein processing GO:0070613 50 0.011
sensory perception GO:0007600 101 0.011
positive regulation of immune system process GO:0002684 90 0.011
calcium ion homeostasis GO:0055074 162 0.011
cation transmembrane transport GO:0098655 263 0.011
biological adhesion GO:0022610 110 0.011
mesoderm development GO:0007498 2 0.011
positive regulation of gene expression GO:0010628 244 0.011
cellular response to acid chemical GO:0071229 75 0.011
tissue morphogenesis GO:0048729 22 0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
regulation of inflammatory response GO:0050727 48 0.011
complement activation GO:0006956 11 0.011
renal system development GO:0072001 67 0.011
cardiac chamber development GO:0003205 1 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.010
cell cycle GO:0007049 101 0.010
kidney development GO:0001822 67 0.010
response to zinc ion GO:0010043 39 0.010
negative regulation of protein processing GO:0010955 47 0.010
response to toxic substance GO:0009636 133 0.010
circulatory system process GO:0003013 183 0.010
negative regulation of catalytic activity GO:0043086 103 0.010
regulation of p38mapk cascade GO:1900744 1 0.010
neuron projection morphogenesis GO:0048812 122 0.010
carbohydrate derivative biosynthetic process GO:1901137 124 0.010
purine containing compound catabolic process GO:0072523 138 0.010
negative regulation of rna biosynthetic process GO:1902679 118 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.010
cellular response to vascular endothelial growth factor stimulus GO:0035924 6 0.010
erk1 and erk2 cascade GO:0070371 48 0.010
response to starvation GO:0042594 59 0.010
dna metabolic process GO:0006259 96 0.010
multicellular organism growth GO:0035264 1 0.010
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 4 0.010
skeletal system development GO:0001501 41 0.010
organophosphate catabolic process GO:0046434 148 0.010
positive regulation of secretion GO:0051047 140 0.010

Hsd11b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.037
nervous system disease DOID:863 0 0.037
sensory system disease DOID:0050155 0 0.018
disease of metabolism DOID:0014667 0 0.013
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
hypertension DOID:10763 0 0.010
artery disease DOID:0050828 0 0.010
vascular disease DOID:178 0 0.010
essential hypertension DOID:10825 0 0.010
cardiovascular system disease DOID:1287 0 0.010