Rattus norvegicus

0 known processes

Hmgb4

high-mobility group box 4

Hmgb4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
single organism biosynthetic process GO:0044711 342 0.151
negative regulation of metabolic process GO:0009892 331 0.076
regulation of catalytic activity GO:0050790 304 0.070
regulation of molecular function GO:0065009 398 0.067
nucleobase containing small molecule metabolic process GO:0055086 316 0.062
purine ribonucleotide biosynthetic process GO:0009152 81 0.062
positive regulation of biosynthetic process GO:0009891 319 0.062
Rat
regulation of phosphate metabolic process GO:0019220 349 0.060
negative regulation of macromolecule metabolic process GO:0010605 260 0.059
negative regulation of cellular metabolic process GO:0031324 281 0.058
purine containing compound metabolic process GO:0072521 253 0.052
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.050
Rat
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.047
ribose phosphate metabolic process GO:0019693 235 0.046
nucleoside phosphate metabolic process GO:0006753 283 0.046
carbohydrate derivative metabolic process GO:1901135 346 0.045
negative regulation of gene expression GO:0010629 199 0.045
regulation of cell proliferation GO:0042127 359 0.044
regulation of phosphorus metabolic process GO:0051174 349 0.043
purine nucleotide metabolic process GO:0006163 229 0.041
purine nucleotide biosynthetic process GO:0006164 83 0.041
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.041
Rat
nucleotide metabolic process GO:0009117 279 0.040
regulation of apoptotic process GO:0042981 335 0.040
positive regulation of multicellular organismal process GO:0051240 387 0.040
nucleic acid templated transcription GO:0097659 379 0.039
Rat
apoptotic process GO:0006915 381 0.039
positive regulation of protein metabolic process GO:0051247 178 0.039
transmembrane transport GO:0055085 412 0.038
regulation of nucleic acid templated transcription GO:1903506 380 0.037
Rat
programmed cell death GO:0012501 392 0.037
positive regulation of cellular biosynthetic process GO:0031328 295 0.037
Rat
regulation of phosphorylation GO:0042325 248 0.035
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.035
Rat
cell projection organization GO:0030030 302 0.035
ribonucleotide biosynthetic process GO:0009260 85 0.034
cellular response to stress GO:0033554 269 0.033
multi organism reproductive process GO:0044703 262 0.033
purine ribonucleotide metabolic process GO:0009150 227 0.033
intracellular signal transduction GO:0035556 314 0.033
regulation of transcription dna templated GO:0006355 374 0.032
Rat
regulation of signal transduction GO:0009966 318 0.031
response to peptide GO:1901652 292 0.031
organophosphate biosynthetic process GO:0090407 143 0.031
transcription dna templated GO:0006351 377 0.030
Rat
cyclic nucleotide metabolic process GO:0009187 80 0.030
central nervous system development GO:0007417 311 0.029
reproductive process GO:0022414 372 0.029
positive regulation of response to stimulus GO:0048584 285 0.029
positive regulation of phosphate metabolic process GO:0045937 262 0.029
response to biotic stimulus GO:0009607 226 0.029
positive regulation of catalytic activity GO:0043085 184 0.029
regulation of intracellular signal transduction GO:1902531 218 0.028
response to oxidative stress GO:0006979 186 0.028
catabolic process GO:0009056 351 0.028
positive regulation of phosphorus metabolic process GO:0010562 262 0.028
rna metabolic process GO:0016070 406 0.028
Rat
response to bacterium GO:0009617 200 0.027
regulation of rna biosynthetic process GO:2001141 381 0.027
Rat
protein phosphorylation GO:0006468 345 0.027
protein complex assembly GO:0006461 263 0.027
tissue development GO:0009888 252 0.027
cellular response to hormone stimulus GO:0032870 247 0.027
vascular process in circulatory system GO:0003018 96 0.027
positive regulation of neurogenesis GO:0050769 165 0.026
organophosphate metabolic process GO:0019637 370 0.026
carbohydrate derivative biosynthetic process GO:1901137 124 0.026
intracellular transport GO:0046907 185 0.025
protein transport GO:0015031 132 0.025
neuron differentiation GO:0030182 368 0.025
regulation of transferase activity GO:0051338 123 0.025
positive regulation of nucleic acid templated transcription GO:1903508 197 0.024
Rat
regulation of nervous system development GO:0051960 264 0.023
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.023
positive regulation of phosphorylation GO:0042327 177 0.023
regulation of multicellular organismal development GO:2000026 376 0.023
positive regulation of developmental process GO:0051094 283 0.023
oxoacid metabolic process GO:0043436 290 0.023
response to external biotic stimulus GO:0043207 221 0.022
negative regulation of cellular biosynthetic process GO:0031327 161 0.022
ribonucleotide metabolic process GO:0009259 231 0.022
positive regulation of cell differentiation GO:0045597 217 0.022
response to molecule of bacterial origin GO:0002237 194 0.022
protein complex subunit organization GO:0071822 302 0.022
cellular response to oxygen containing compound GO:1901701 386 0.022
regulation of programmed cell death GO:0043067 341 0.022
homeostatic process GO:0042592 331 0.022
positive regulation of molecular function GO:0044093 230 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.022
regulation of growth GO:0040008 105 0.022
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.021
negative regulation of protein metabolic process GO:0051248 114 0.021
nucleoside phosphate biosynthetic process GO:1901293 102 0.021
blood circulation GO:0008015 183 0.021
cellular component assembly GO:0022607 360 0.021
positive regulation of rna biosynthetic process GO:1902680 197 0.021
Rat
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.021
positive regulation of rna metabolic process GO:0051254 203 0.021
Rat
regulation of cell development GO:0060284 263 0.021
cellular amine metabolic process GO:0044106 38 0.020
response to nutrient GO:0007584 248 0.020
brain development GO:0007420 247 0.020
macromolecular complex subunit organization GO:0043933 339 0.020
negative regulation of cellular protein metabolic process GO:0032269 106 0.020
regulation of protein metabolic process GO:0051246 289 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
inflammatory response GO:0006954 150 0.020
carboxylic acid metabolic process GO:0019752 289 0.020
protein maturation GO:0051604 68 0.020
purine ribonucleotide catabolic process GO:0009154 136 0.019
rna biosynthetic process GO:0032774 380 0.019
Rat
nucleotide biosynthetic process GO:0009165 98 0.019
negative regulation of transcription dna templated GO:0045892 116 0.019
regulation of neurogenesis GO:0050767 247 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
regulation of response to stress GO:0080134 126 0.019
response to corticosteroid GO:0031960 235 0.019
regeneration GO:0031099 163 0.019
Rat
nucleoside metabolic process GO:0009116 179 0.018
regulation of kinase activity GO:0043549 117 0.018
negative regulation of neuron death GO:1901215 69 0.018
negative regulation of biosynthetic process GO:0009890 168 0.018
macromolecular complex assembly GO:0065003 273 0.018
steroid metabolic process GO:0008202 73 0.018
cytoplasmic transport GO:0016482 115 0.018
head development GO:0060322 247 0.018
cellular response to peptide GO:1901653 133 0.018
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.018
response to peptide hormone GO:0043434 278 0.017
intracellular protein transport GO:0006886 79 0.017
regulation of neuron death GO:1901214 115 0.017
ribose phosphate biosynthetic process GO:0046390 87 0.017
circulatory system process GO:0003013 183 0.017
aromatic compound catabolic process GO:0019439 168 0.017
positive regulation of cell communication GO:0010647 271 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
positive regulation of signaling GO:0023056 270 0.016
positive regulation of protein kinase activity GO:0045860 73 0.016
organonitrogen compound biosynthetic process GO:1901566 167 0.016
regulation of neuron differentiation GO:0045664 208 0.016
reproduction GO:0000003 245 0.016
proteolysis GO:0006508 175 0.016
single organism organelle organization GO:1902589 180 0.016
single organism reproductive process GO:0044702 297 0.016
positive regulation of neuron differentiation GO:0045666 126 0.016
regulation of cellular ketone metabolic process GO:0010565 27 0.015
heterocycle catabolic process GO:0046700 167 0.015
neuron death GO:0070997 127 0.015
regulation of purine nucleotide metabolic process GO:1900542 115 0.015
cyclic purine nucleotide metabolic process GO:0052652 62 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.015
reactive oxygen species metabolic process GO:0072593 37 0.015
response to interleukin 1 GO:0070555 55 0.015
organ regeneration GO:0031100 101 0.015
Rat
ion transmembrane transport GO:0034220 365 0.015
negative regulation of rna metabolic process GO:0051253 123 0.015
multicellular organism growth GO:0035264 1 0.015
response to estrogen GO:0043627 232 0.015
protein complex biogenesis GO:0070271 263 0.015
positive regulation of nervous system development GO:0051962 178 0.015
cellular catabolic process GO:0044248 295 0.015
regulation of protein modification process GO:0031399 194 0.015
organophosphate catabolic process GO:0046434 148 0.014
neuron development GO:0048666 286 0.014
amine metabolic process GO:0009308 38 0.014
gastrulation GO:0007369 2 0.014
g protein coupled receptor signaling pathway GO:0007186 242 0.014
positive regulation of signal transduction GO:0009967 175 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
regulation of cellular component organization GO:0051128 368 0.014
regulation of system process GO:0044057 208 0.014
response to extracellular stimulus GO:0009991 380 0.014
response to glucocorticoid GO:0051384 223 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
Rat
carbohydrate derivative catabolic process GO:1901136 147 0.014
cell cycle checkpoint GO:0000075 2 0.014
positive regulation of gene expression GO:0010628 244 0.014
Rat
negative regulation of molecular function GO:0044092 133 0.014
cyclic nucleotide biosynthetic process GO:0009190 63 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
regulation of smooth muscle cell proliferation GO:0048660 75 0.014
positive regulation of intracellular signal transduction GO:1902533 138 0.014
organic substance catabolic process GO:1901575 316 0.014
negative regulation of cell death GO:0060548 229 0.013
regulation of rna metabolic process GO:0051252 391 0.013
Rat
multicellular organismal reproductive process GO:0048609 233 0.013
single organism intracellular transport GO:1902582 166 0.013
purine ribonucleoside metabolic process GO:0046128 168 0.013
lipid biosynthetic process GO:0008610 128 0.013
negative regulation of programmed cell death GO:0043069 183 0.013
response to inorganic substance GO:0010035 377 0.013
neuronal action potential GO:0019228 35 0.013
defense response GO:0006952 194 0.013
neuron projection development GO:0031175 273 0.013
cellular amino acid metabolic process GO:0006520 107 0.013
circadian rhythm GO:0007623 88 0.013
nucleobase containing compound catabolic process GO:0034655 152 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
macromolecule localization GO:0033036 252 0.013
cellular ketone metabolic process GO:0042180 51 0.013
response to insulin GO:0032868 133 0.013
ras protein signal transduction GO:0007265 29 0.013
regulation of blood vessel size GO:0050880 89 0.013
response to nutrient levels GO:0031667 370 0.013
positive regulation of cell development GO:0010720 176 0.013
negative regulation of catalytic activity GO:0043086 103 0.012
small molecule biosynthetic process GO:0044283 124 0.012
single organism catabolic process GO:0044712 283 0.012
jak stat cascade GO:0007259 26 0.012
fertilization GO:0009566 3 0.012
multicellular organism reproduction GO:0032504 233 0.012
regulation of anatomical structure size GO:0090066 135 0.012
protein autophosphorylation GO:0046777 66 0.012
regulation of protein kinase activity GO:0045859 105 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.012
metal ion transport GO:0030001 289 0.012
embryo development GO:0009790 49 0.012
single organism carbohydrate metabolic process GO:0044723 118 0.012
negative regulation of phosphate metabolic process GO:0045936 80 0.012
lipid metabolic process GO:0006629 283 0.012
negative regulation of protein phosphorylation GO:0001933 44 0.012
regulation of protein maturation GO:1903317 50 0.011
protein processing GO:0016485 68 0.011
regulation of neuron projection development GO:0010975 161 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
regulation of cellular amino acid metabolic process GO:0006521 2 0.011
negative regulation of nucleic acid templated transcription GO:1903507 117 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
cation transport GO:0006812 382 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.011
response to lipopolysaccharide GO:0032496 191 0.011
regulation of hydrolase activity GO:0051336 143 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
cellular response to glucocorticoid stimulus GO:0071385 68 0.011
negative regulation of rna biosynthetic process GO:1902679 118 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
response to ketone GO:1901654 182 0.011
nuclear transport GO:0051169 49 0.011
sulfur compound metabolic process GO:0006790 70 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
dendrite morphogenesis GO:0048813 43 0.011
muscle cell proliferation GO:0033002 84 0.011
nucleotide catabolic process GO:0009166 139 0.011
cation homeostasis GO:0055080 195 0.011
cellular carbohydrate metabolic process GO:0044262 72 0.011
regulation of hormone levels GO:0010817 187 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
regulation of cell projection organization GO:0031344 175 0.010
lipid transport GO:0006869 61 0.010
organic acid metabolic process GO:0006082 292 0.010
positive regulation of neuron projection development GO:0010976 99 0.010
establishment of protein localization GO:0045184 141 0.010
regulation of membrane potential GO:0042391 110 0.010
action potential GO:0001508 54 0.010
positive regulation of secretion GO:0051047 140 0.010
chromosome segregation GO:0007059 2 0.010
axis specification GO:0009798 4 0.010
response to hypoxia GO:0001666 231 0.010
regulation of cellular amine metabolic process GO:0033238 8 0.010

Hmgb4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
nervous system disease DOID:863 0 0.033
musculoskeletal system disease DOID:17 0 0.015
sensory system disease DOID:0050155 0 0.012
muscular disease DOID:0080000 0 0.011
muscle tissue disease DOID:66 0 0.011