Rattus norvegicus

24 known processes

Bhlhe41

basic helix-loop-helix family, member e41

(Aliases: Bhlhb3,Sharp1,SHARP-1,Dec2)

Bhlhe41 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of nucleic acid templated transcription GO:1903506 380 0.153
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.151
regulation of transcription dna templated GO:0006355 374 0.125
transcription dna templated GO:0006351 377 0.120
transcription from rna polymerase ii promoter GO:0006366 252 0.119
oxoacid metabolic process GO:0043436 290 0.098
regulation of rna biosynthetic process GO:2001141 381 0.093
regulation of rna metabolic process GO:0051252 391 0.091
nucleic acid templated transcription GO:0097659 379 0.087
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.085
rna metabolic process GO:0016070 406 0.084
regulation of phosphate metabolic process GO:0019220 349 0.078
regulation of phosphorylation GO:0042325 248 0.076
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.073
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.067
negative regulation of gene expression GO:0010629 199 0.066
regulation of cell differentiation GO:0045595 320 0.060
rna biosynthetic process GO:0032774 380 0.059
programmed cell death GO:0012501 392 0.058
anatomical structure morphogenesis GO:0009653 298 0.057
positive regulation of rna biosynthetic process GO:1902680 197 0.056
regulation of nervous system development GO:0051960 264 0.051
organophosphate metabolic process GO:0019637 370 0.049
regulation of protein metabolic process GO:0051246 289 0.047
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.046
positive regulation of gene expression GO:0010628 244 0.046
catabolic process GO:0009056 351 0.046
positive regulation of nucleic acid templated transcription GO:1903508 197 0.045
organic acid metabolic process GO:0006082 292 0.045
cellular response to oxygen containing compound GO:1901701 386 0.044
positive regulation of cellular biosynthetic process GO:0031328 295 0.042
protein phosphorylation GO:0006468 345 0.039
organic substance catabolic process GO:1901575 316 0.038
regulation of phosphorus metabolic process GO:0051174 349 0.037
intracellular signal transduction GO:0035556 314 0.036
regulation of multicellular organismal development GO:2000026 376 0.035
cellular catabolic process GO:0044248 295 0.035
homeostatic process GO:0042592 331 0.035
positive regulation of transcription dna templated GO:0045893 197 0.034
positive regulation of rna metabolic process GO:0051254 203 0.034
cell projection organization GO:0030030 302 0.033
carboxylic acid metabolic process GO:0019752 289 0.033
regulation of hormone secretion GO:0046883 106 0.032
cellular amino acid metabolic process GO:0006520 107 0.032
oxidation reduction process GO:0055114 304 0.032
regulation of cell development GO:0060284 263 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
apoptotic process GO:0006915 381 0.031
regulation of signal transduction GO:0009966 318 0.031
neuron projection development GO:0031175 273 0.031
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.031
cell part morphogenesis GO:0032990 123 0.031
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
negative regulation of cellular metabolic process GO:0031324 281 0.030
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.030
regulation of cellular component organization GO:0051128 368 0.030
negative regulation of transcription dna templated GO:0045892 116 0.030
cellular amine metabolic process GO:0044106 38 0.030
negative regulation of metabolic process GO:0009892 331 0.030
organelle organization GO:0006996 266 0.029
regulation of intracellular signal transduction GO:1902531 218 0.029
cellular response to stress GO:0033554 269 0.029
cellular ketone metabolic process GO:0042180 51 0.029
neuron differentiation GO:0030182 368 0.029
regulation of molecular function GO:0065009 398 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.028
secretion GO:0046903 307 0.028
glycogen metabolic process GO:0005977 23 0.028
cellular lipid metabolic process GO:0044255 208 0.028
positive regulation of biosynthetic process GO:0009891 319 0.027
small molecule biosynthetic process GO:0044283 124 0.027
negative regulation of protein metabolic process GO:0051248 114 0.027
response to inorganic substance GO:0010035 377 0.027
negative regulation of cell communication GO:0010648 158 0.026
regulation of neurogenesis GO:0050767 247 0.026
carbohydrate derivative metabolic process GO:1901135 346 0.025
carboxylic acid biosynthetic process GO:0046394 83 0.025
response to glucose GO:0009749 136 0.025
neurological system process GO:0050877 219 0.024
ribonucleotide metabolic process GO:0009259 231 0.024
cellular component assembly GO:0022607 360 0.023
positive regulation of response to stimulus GO:0048584 285 0.023
regulation of protein modification process GO:0031399 194 0.023
positive regulation of cell death GO:0010942 184 0.023
response to oxygen levels GO:0070482 265 0.023
cell morphogenesis GO:0000902 142 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
protein complex assembly GO:0006461 263 0.023
macromolecular complex subunit organization GO:0043933 339 0.023
carboxylic acid transport GO:0046942 115 0.022
negative regulation of cell proliferation GO:0008285 119 0.022
amine metabolic process GO:0009308 38 0.022
response to wounding GO:0009611 254 0.022
positive regulation of phosphorylation GO:0042327 177 0.022
regulation of cellular amino acid metabolic process GO:0006521 2 0.022
metal ion transport GO:0030001 289 0.022
single organism organelle organization GO:1902589 180 0.022
response to decreased oxygen levels GO:0036293 237 0.022
rhythmic process GO:0048511 156 0.022
aging GO:0007568 241 0.021
regulation of neuron differentiation GO:0045664 208 0.021
positive regulation of programmed cell death GO:0043068 157 0.021
response to hypoxia GO:0001666 231 0.021
macromolecular complex assembly GO:0065003 273 0.021
regulation of apoptotic process GO:0042981 335 0.021
cellular homeostasis GO:0019725 252 0.021
nucleoside phosphate metabolic process GO:0006753 283 0.021
circulatory system development GO:0072359 134 0.020
circadian regulation of gene expression GO:0032922 3 0.020
head development GO:0060322 247 0.020
cellular response to endogenous stimulus GO:0071495 377 0.020
regulation of peptide transport GO:0090087 87 0.020
cellular component biogenesis GO:0044085 368 0.020
positive regulation of molecular function GO:0044093 230 0.020
purine containing compound metabolic process GO:0072521 253 0.020
single organism biosynthetic process GO:0044711 342 0.020
gland development GO:0048732 155 0.020
hormone transport GO:0009914 121 0.020
response to nutrient levels GO:0031667 370 0.019
lipid metabolic process GO:0006629 283 0.019
neuron development GO:0048666 286 0.019
negative regulation of cellular biosynthetic process GO:0031327 161 0.019
g protein coupled receptor signaling pathway GO:0007186 242 0.019
single organism catabolic process GO:0044712 283 0.019
positive regulation of neurogenesis GO:0050769 165 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
negative regulation of multicellular organismal process GO:0051241 203 0.019
intracellular transport GO:0046907 185 0.019
amide transport GO:0042886 105 0.019
nucleotide metabolic process GO:0009117 279 0.019
l glutamate import GO:0051938 2 0.019
protein complex subunit organization GO:0071822 302 0.019
cellular component movement GO:0006928 248 0.018
cellular response to growth factor stimulus GO:0071363 162 0.018
circulatory system process GO:0003013 183 0.018
regulation of cell proliferation GO:0042127 359 0.018
negative regulation of biosynthetic process GO:0009890 168 0.018
positive regulation of cell differentiation GO:0045597 217 0.018
organic acid biosynthetic process GO:0016053 83 0.018
regulation of cell projection organization GO:0031344 175 0.018
synaptic transmission GO:0007268 235 0.018
chemical homeostasis GO:0048878 292 0.017
positive regulation of phosphate metabolic process GO:0045937 262 0.017
transmembrane transport GO:0055085 412 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
nucleobase containing small molecule metabolic process GO:0055086 316 0.017
response to peptide hormone GO:0043434 278 0.017
multicellular organismal signaling GO:0035637 44 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
positive regulation of phosphorus metabolic process GO:0010562 262 0.017
regulation of cellular protein metabolic process GO:0032268 267 0.017
positive regulation of multicellular organismal process GO:0051240 387 0.017
ras protein signal transduction GO:0007265 29 0.016
cellular component morphogenesis GO:0032989 155 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.016
cation transport GO:0006812 382 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
anion transport GO:0006820 178 0.016
regulation of transferase activity GO:0051338 123 0.016
regulation of programmed cell death GO:0043067 341 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
organonitrogen compound catabolic process GO:1901565 179 0.016
reproductive process GO:0022414 372 0.016
response to metal ion GO:0010038 253 0.016
positive regulation of developmental process GO:0051094 283 0.016
central nervous system development GO:0007417 311 0.016
anterior posterior pattern specification GO:0009952 1 0.016
cardiovascular system development GO:0072358 134 0.016
response to monosaccharide GO:0034284 159 0.016
ion transmembrane transport GO:0034220 365 0.016
regulation of catalytic activity GO:0050790 304 0.016
organophosphate biosynthetic process GO:0090407 143 0.016
positive regulation of mapk cascade GO:0043410 92 0.016
vascular process in circulatory system GO:0003018 96 0.016
regulation of anatomical structure morphogenesis GO:0022603 141 0.016
response to carbohydrate GO:0009743 183 0.016
mapk cascade GO:0000165 140 0.016
negative regulation of response to stimulus GO:0048585 155 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.015
proteolysis GO:0006508 175 0.015
regulation of synaptic transmission GO:0050804 141 0.015
response to bacterium GO:0009617 200 0.015
regulation of protein phosphorylation GO:0001932 183 0.015
negative regulation of signaling GO:0023057 157 0.015
regulation of hormone levels GO:0010817 187 0.015
positive regulation of cell projection organization GO:0031346 111 0.015
regulation of ion transport GO:0043269 245 0.015
cation transmembrane transport GO:0098655 263 0.015
cellular response to nitrogen compound GO:1901699 210 0.015
ribose phosphate metabolic process GO:0019693 235 0.014
response to growth factor GO:0070848 189 0.014
organic hydroxy compound metabolic process GO:1901615 115 0.014
regulation of neuron projection development GO:0010975 161 0.014
positive regulation of catalytic activity GO:0043085 184 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
metal ion homeostasis GO:0055065 186 0.014
embryonic pattern specification GO:0009880 1 0.014
axis specification GO:0009798 4 0.014
response to extracellular stimulus GO:0009991 380 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.014
neuron death GO:0070997 127 0.014
protein complex biogenesis GO:0070271 263 0.014
positive regulation of nervous system development GO:0051962 178 0.014
response to ethanol GO:0045471 162 0.014
purine ribonucleoside metabolic process GO:0046128 168 0.014
multi organism reproductive process GO:0044703 262 0.014
negative regulation of developmental process GO:0051093 125 0.014
negative regulation of cell death GO:0060548 229 0.014
purine nucleotide metabolic process GO:0006163 229 0.013
regulation of mapk cascade GO:0043408 116 0.013
negative regulation of programmed cell death GO:0043069 183 0.013
transmission of nerve impulse GO:0019226 42 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
response to peptide GO:1901652 292 0.013
positive regulation of cell development GO:0010720 176 0.013
ribonucleoside metabolic process GO:0009119 174 0.013
brain development GO:0007420 247 0.013
anatomical structure formation involved in morphogenesis GO:0048646 83 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
aromatic compound catabolic process GO:0019439 168 0.013
regulation of system process GO:0044057 208 0.013
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.013
fatty acid metabolic process GO:0006631 99 0.013
cellular ion homeostasis GO:0006873 184 0.013
response to cytokine GO:0034097 215 0.013
cell projection morphogenesis GO:0048858 123 0.013
energy derivation by oxidation of organic compounds GO:0015980 46 0.013
carbohydrate derivative catabolic process GO:1901136 147 0.012
negative regulation of molecular function GO:0044092 133 0.012
cellular glucan metabolic process GO:0006073 23 0.012
glucan metabolic process GO:0044042 23 0.012
generation of precursor metabolites and energy GO:0006091 62 0.012
calcium ion homeostasis GO:0055074 162 0.012
blood vessel development GO:0001568 69 0.012
signal release GO:0023061 145 0.012
single organism reproductive process GO:0044702 297 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
regulation of membrane potential GO:0042391 110 0.012
nucleoside metabolic process GO:0009116 179 0.012
regulation of hydrolase activity GO:0051336 143 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
response to vitamin GO:0033273 131 0.012
positive regulation of signal transduction GO:0009967 175 0.012
response to insulin GO:0032868 133 0.012
cell migration GO:0016477 197 0.012
ion homeostasis GO:0050801 212 0.012
cell cycle GO:0007049 101 0.012
amino acid transport GO:0006865 70 0.012
tissue development GO:0009888 252 0.012
heterocycle catabolic process GO:0046700 167 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
negative regulation of signal transduction GO:0009968 83 0.012
cellular response to peptide GO:1901653 133 0.012
regulation of homeostatic process GO:0032844 101 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
positive regulation of cell communication GO:0010647 271 0.012
response to molecule of bacterial origin GO:0002237 194 0.011
organophosphate catabolic process GO:0046434 148 0.011
response to hexose GO:0009746 144 0.011
regulation of catabolic process GO:0009894 113 0.011
reproduction GO:0000003 245 0.011
regulation of neuron death GO:1901214 115 0.011
organic cyclic compound catabolic process GO:1901361 175 0.011
regulation of peptide secretion GO:0002791 82 0.011
macromolecule catabolic process GO:0009057 58 0.011
glucose metabolic process GO:0006006 52 0.011
organic acid transport GO:0015849 116 0.011
response to estradiol GO:0032355 164 0.011
cell cell signaling GO:0007267 335 0.011
cellular carbohydrate metabolic process GO:0044262 72 0.011
cellular macromolecule localization GO:0070727 122 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
regulation of response to stress GO:0080134 126 0.011
response to nutrient GO:0007584 248 0.011
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.011
enzyme linked receptor protein signaling pathway GO:0007167 116 0.011
regeneration GO:0031099 163 0.011
cell motility GO:0048870 202 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.011
positive regulation of transport GO:0051050 245 0.011
nucleotide catabolic process GO:0009166 139 0.011
multicellular organismal reproductive process GO:0048609 233 0.011
protein oligomerization GO:0051259 191 0.011
establishment of tissue polarity GO:0007164 2 0.011
regulation of insulin secretion GO:0050796 65 0.011
negative regulation of phosphorylation GO:0042326 57 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
macromolecule localization GO:0033036 252 0.011
gamete generation GO:0007276 124 0.011
purine ribonucleoside catabolic process GO:0046130 124 0.011
blood circulation GO:0008015 183 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
cellular chemical homeostasis GO:0055082 247 0.011
carbohydrate biosynthetic process GO:0016051 42 0.011
regulation of cellular component movement GO:0051270 150 0.011
regulation of canonical wnt signaling pathway GO:0060828 4 0.011
hematopoietic progenitor cell differentiation GO:0002244 2 0.011
positive regulation of protein modification process GO:0031401 142 0.011
cellular response to peptide hormone stimulus GO:0071375 120 0.011
positive regulation of cell proliferation GO:0008284 249 0.010
negative regulation of phosphate metabolic process GO:0045936 80 0.010
peptide hormone secretion GO:0030072 84 0.010
vasculature development GO:0001944 70 0.010
peptide transport GO:0015833 97 0.010
cardiac chamber development GO:0003205 1 0.010
ribose phosphate biosynthetic process GO:0046390 87 0.010
male sex differentiation GO:0046661 64 0.010
cellular cation homeostasis GO:0030003 180 0.010
response to lipopolysaccharide GO:0032496 191 0.010
organonitrogen compound biosynthetic process GO:1901566 167 0.010
alpha amino acid metabolic process GO:1901605 71 0.010
regulation of blood vessel size GO:0050880 89 0.010
cellular divalent inorganic cation homeostasis GO:0072503 162 0.010
eye morphogenesis GO:0048592 4 0.010
negative regulation of catalytic activity GO:0043086 103 0.010
cellular response to hexose stimulus GO:0071331 65 0.010
ribonucleoside catabolic process GO:0042454 126 0.010
response to glucocorticoid GO:0051384 223 0.010
cardiac ventricle development GO:0003231 1 0.010
anion transmembrane transport GO:0098656 77 0.010
carbohydrate derivative biosynthetic process GO:1901137 124 0.010
positive regulation of neuron projection development GO:0010976 99 0.010

Bhlhe41 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
disease of metabolism DOID:0014667 0 0.011
central nervous system disease DOID:331 0 0.010
sensory system disease DOID:0050155 0 0.010