Rattus norvegicus

18 known processes

Pde7a

phosphodiesterase 7A

(Aliases: PDE7-1)

Pde7a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cation transport GO:0006812 382 0.096
rna metabolic process GO:0016070 406 0.085
organophosphate metabolic process GO:0019637 370 0.085
Rat
cellular component movement GO:0006928 248 0.068
intracellular signal transduction GO:0035556 314 0.066
regulation of secretion GO:0051046 224 0.066
Rat
secretion GO:0046903 307 0.063
Rat
rna biosynthetic process GO:0032774 380 0.061
cell motility GO:0048870 202 0.061
cell cell signaling GO:0007267 335 0.061
Rat
regulation of cellular component organization GO:0051128 368 0.059
anatomical structure morphogenesis GO:0009653 298 0.056
regulation of transcription dna templated GO:0006355 374 0.055
regulation of secretion by cell GO:1903530 208 0.054
Rat
transcription dna templated GO:0006351 377 0.054
nucleic acid templated transcription GO:0097659 379 0.054
regulation of rna metabolic process GO:0051252 391 0.053
negative regulation of signaling GO:0023057 157 0.052
Rat
negative regulation of response to stimulus GO:0048585 155 0.050
transcription from rna polymerase ii promoter GO:0006366 252 0.049
cation transmembrane transport GO:0098655 263 0.049
regulation of signal transduction GO:0009966 318 0.048
cell migration GO:0016477 197 0.048
negative regulation of metabolic process GO:0009892 331 0.048
signal release GO:0023061 145 0.046
Rat
regulation of cell development GO:0060284 263 0.045
cellular component biogenesis GO:0044085 368 0.044
organelle organization GO:0006996 266 0.044
cellular chemical homeostasis GO:0055082 247 0.044
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.042
single organism organelle organization GO:1902589 180 0.040
protein phosphorylation GO:0006468 345 0.040
regulation of nucleic acid templated transcription GO:1903506 380 0.040
positive regulation of secretion GO:0051047 140 0.039
negative regulation of cell communication GO:0010648 158 0.039
Rat
regulation of rna biosynthetic process GO:2001141 381 0.038
negative regulation of multicellular organismal process GO:0051241 203 0.038
localization of cell GO:0051674 202 0.037
positive regulation of developmental process GO:0051094 283 0.037
positive regulation of multicellular organismal process GO:0051240 387 0.037
homeostatic process GO:0042592 331 0.036
ion transmembrane transport GO:0034220 365 0.036
reproductive process GO:0022414 372 0.036
regulation of cellular localization GO:0060341 263 0.036
Rat
negative regulation of cellular metabolic process GO:0031324 281 0.035
nitrogen compound transport GO:0071705 229 0.035
Rat
cellular ketone metabolic process GO:0042180 51 0.035
positive regulation of cellular biosynthetic process GO:0031328 295 0.035
regulation of phosphorus metabolic process GO:0051174 349 0.035
carboxylic acid metabolic process GO:0019752 289 0.035
regulation of hormone secretion GO:0046883 106 0.035
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.034
amine metabolic process GO:0009308 38 0.034
regulation of nervous system development GO:0051960 264 0.034
cation homeostasis GO:0055080 195 0.033
positive regulation of transport GO:0051050 245 0.033
oxoacid metabolic process GO:0043436 290 0.033
regulation of protein metabolic process GO:0051246 289 0.033
cellular homeostasis GO:0019725 252 0.033
macromolecule localization GO:0033036 252 0.033
regulation of cellular component movement GO:0051270 150 0.033
central nervous system development GO:0007417 311 0.033
inorganic ion transmembrane transport GO:0098660 229 0.032
response to wounding GO:0009611 254 0.032
positive regulation of signaling GO:0023056 270 0.031
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.031
organic acid metabolic process GO:0006082 292 0.031
purine nucleotide metabolic process GO:0006163 229 0.031
Rat
neuron projection development GO:0031175 273 0.030
cellular amine metabolic process GO:0044106 38 0.030
regulation of cellular amino acid metabolic process GO:0006521 2 0.030
locomotion GO:0040011 237 0.030
neurological system process GO:0050877 219 0.030
Rat
regulation of cellular ketone metabolic process GO:0010565 27 0.030
regulation of multicellular organismal development GO:2000026 376 0.030
macromolecular complex subunit organization GO:0043933 339 0.029
response to hypoxia GO:0001666 231 0.029
regulation of neurogenesis GO:0050767 247 0.029
positive regulation of cell development GO:0010720 176 0.029
regulation of catalytic activity GO:0050790 304 0.028
protein complex subunit organization GO:0071822 302 0.028
multi organism reproductive process GO:0044703 262 0.028
programmed cell death GO:0012501 392 0.028
positive regulation of biosynthetic process GO:0009891 319 0.028
cellular component morphogenesis GO:0032989 155 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.027
regulation of programmed cell death GO:0043067 341 0.027
regulation of cellular amine metabolic process GO:0033238 8 0.027
eye morphogenesis GO:0048592 4 0.027
cytoskeleton organization GO:0007010 111 0.027
negative regulation of macromolecule metabolic process GO:0010605 260 0.027
transmembrane transport GO:0055085 412 0.027
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.027
single organism biosynthetic process GO:0044711 342 0.027
cellular amino acid metabolic process GO:0006520 107 0.026
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.026
positive regulation of cellular component organization GO:0051130 200 0.026
positive regulation of neurogenesis GO:0050769 165 0.026
secretion by cell GO:0032940 248 0.026
Rat
positive regulation of transcription dna templated GO:0045893 197 0.026
regulation of hormone levels GO:0010817 187 0.026
Rat
regulation of neuron differentiation GO:0045664 208 0.025
lipid metabolic process GO:0006629 283 0.025
nucleobase containing small molecule metabolic process GO:0055086 316 0.025
Rat
nucleoside triphosphate metabolic process GO:0009141 144 0.025
regulation of apoptotic process GO:0042981 335 0.025
hormone secretion GO:0046879 115 0.025
Rat
chemical homeostasis GO:0048878 292 0.025
regulation of locomotion GO:0040012 148 0.025
action potential GO:0001508 54 0.025
cellular response to endogenous stimulus GO:0071495 377 0.025
cellular ion homeostasis GO:0006873 184 0.025
negative regulation of transport GO:0051051 136 0.025
Rat
divalent inorganic cation homeostasis GO:0072507 165 0.024
synaptic transmission GO:0007268 235 0.024
cell projection organization GO:0030030 302 0.024
positive regulation of gene expression GO:0010628 244 0.024
response to decreased oxygen levels GO:0036293 237 0.024
regulation of anatomical structure morphogenesis GO:0022603 141 0.024
ribonucleotide metabolic process GO:0009259 231 0.024
Rat
regulation of cell differentiation GO:0045595 320 0.023
response to inorganic substance GO:0010035 377 0.023
Rat
negative regulation of molecular function GO:0044092 133 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.023
metal ion homeostasis GO:0055065 186 0.023
hormone transport GO:0009914 121 0.023
Rat
response to oxygen levels GO:0070482 265 0.023
regulation of cell projection organization GO:0031344 175 0.022
small gtpase mediated signal transduction GO:0007264 36 0.022
ion homeostasis GO:0050801 212 0.022
positive regulation of cell differentiation GO:0045597 217 0.022
cellular response to oxygen containing compound GO:1901701 386 0.022
single organism reproductive process GO:0044702 297 0.022
positive regulation of nervous system development GO:0051962 178 0.022
heart morphogenesis GO:0003007 3 0.022
positive regulation of cell proliferation GO:0008284 249 0.022
cellular component assembly GO:0022607 360 0.021
regulation of intracellular signal transduction GO:1902531 218 0.021
carbohydrate derivative metabolic process GO:1901135 346 0.021
Rat
regulation of molecular function GO:0065009 398 0.021
ras protein signal transduction GO:0007265 29 0.021
regulation of ion transport GO:0043269 245 0.021
regulation of peptide transport GO:0090087 87 0.021
Rat
response to mechanical stimulus GO:0009612 134 0.021
metal ion transport GO:0030001 289 0.021
cell projection morphogenesis GO:0048858 123 0.021
regulation of cell migration GO:0030334 128 0.021
positive regulation of neuron differentiation GO:0045666 126 0.020
macromolecular complex assembly GO:0065003 273 0.020
regulation of protein modification process GO:0031399 194 0.020
forebrain development GO:0030900 98 0.020
positive regulation of rna biosynthetic process GO:1902680 197 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
cell morphogenesis GO:0000902 142 0.020
response to extracellular stimulus GO:0009991 380 0.020
negative regulation of nucleic acid templated transcription GO:1903507 117 0.020
positive regulation of neuron projection development GO:0010976 99 0.020
protein complex biogenesis GO:0070271 263 0.020
positive regulation of cell death GO:0010942 184 0.020
organonitrogen compound catabolic process GO:1901565 179 0.020
Rat
g protein coupled receptor signaling pathway GO:0007186 242 0.020
positive regulation of response to stimulus GO:0048584 285 0.020
regulation of protein phosphorylation GO:0001932 183 0.019
circulatory system process GO:0003013 183 0.019
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.019
regulation of hydrolase activity GO:0051336 143 0.019
single organism intracellular transport GO:1902582 166 0.019
regulation of phosphorylation GO:0042325 248 0.019
cellular response to growth factor stimulus GO:0071363 162 0.019
cellular divalent inorganic cation homeostasis GO:0072503 162 0.019
positive regulation of cell communication GO:0010647 271 0.019
multicellular organism reproduction GO:0032504 233 0.019
inorganic cation transmembrane transport GO:0098662 202 0.019
response to acid chemical GO:0001101 222 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.019
cytosolic calcium ion homeostasis GO:0051480 140 0.019
cellular lipid metabolic process GO:0044255 208 0.019
cellular protein localization GO:0034613 122 0.019
head development GO:0060322 247 0.019
organophosphate biosynthetic process GO:0090407 143 0.019
ribose phosphate metabolic process GO:0019693 235 0.018
Rat
catabolic process GO:0009056 351 0.018
Rat
purine ribonucleotide metabolic process GO:0009150 227 0.018
Rat
positive regulation of rna metabolic process GO:0051254 203 0.018
protein complex assembly GO:0006461 263 0.018
divalent metal ion transport GO:0070838 132 0.018
neuronal action potential GO:0019228 35 0.018
purine nucleotide catabolic process GO:0006195 136 0.018
Rat
mesoderm development GO:0007498 2 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
ribonucleoside triphosphate catabolic process GO:0009203 122 0.017
monovalent inorganic cation transport GO:0015672 172 0.017
regulation of system process GO:0044057 208 0.017
organic hydroxy compound metabolic process GO:1901615 115 0.017
negative regulation of gene expression GO:0010629 199 0.017
purine nucleoside triphosphate catabolic process GO:0009146 122 0.017
gland development GO:0048732 155 0.017
neural crest cell differentiation GO:0014033 2 0.017
regulation of cell proliferation GO:0042127 359 0.017
negative regulation of developmental process GO:0051093 125 0.017
response to growth factor GO:0070848 189 0.017
organic substance catabolic process GO:1901575 316 0.017
Rat
negative regulation of rna biosynthetic process GO:1902679 118 0.016
muscle system process GO:0003012 115 0.016
motor neuron axon guidance GO:0008045 1 0.016
developmental process involved in reproduction GO:0003006 159 0.016
positive regulation of hormone secretion GO:0046887 65 0.016
response to metal ion GO:0010038 253 0.016
Rat
peptide transport GO:0015833 97 0.016
Rat
gastrulation GO:0007369 2 0.016
cardiac ventricle development GO:0003231 1 0.016
regulation of metal ion transport GO:0010959 118 0.016
regulation of stem cell differentiation GO:2000736 2 0.016
brain development GO:0007420 247 0.016
regulation of body fluid levels GO:0050878 90 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
establishment of protein localization GO:0045184 141 0.016
response to carbohydrate GO:0009743 183 0.016
multicellular organismal reproductive process GO:0048609 233 0.016
regulation of peptide secretion GO:0002791 82 0.016
Rat
axis specification GO:0009798 4 0.016
centrosome organization GO:0051297 1 0.016
protein oligomerization GO:0051259 191 0.016
bmp signaling pathway GO:0030509 4 0.016
nucleoside phosphate catabolic process GO:1901292 140 0.016
Rat
intracellular transport GO:0046907 185 0.015
positive regulation of signal transduction GO:0009967 175 0.015
reproduction GO:0000003 245 0.015
apoptotic process GO:0006915 381 0.015
carbohydrate metabolic process GO:0005975 130 0.015
calcium ion homeostasis GO:0055074 162 0.015
carbohydrate derivative catabolic process GO:1901136 147 0.015
Rat
negative regulation of biosynthetic process GO:0009890 168 0.015
protein localization GO:0008104 191 0.015
multicellular organismal signaling GO:0035637 44 0.015
positive regulation of phosphate metabolic process GO:0045937 262 0.015
multicellular organism growth GO:0035264 1 0.015
negative regulation of catalytic activity GO:0043086 103 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
cellular macromolecule localization GO:0070727 122 0.015
cellular response to insulin stimulus GO:0032869 81 0.015
regulation of cell motility GO:2000145 131 0.015
positive regulation of secretion by cell GO:1903532 128 0.015
negative regulation of rna metabolic process GO:0051253 123 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
aging GO:0007568 241 0.015
negative regulation of protein metabolic process GO:0051248 114 0.015
regulation of neuron projection development GO:0010975 161 0.015
response to monosaccharide GO:0034284 159 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
blood circulation GO:0008015 183 0.015
negative regulation of apoptotic process GO:0043066 181 0.015
organic anion transport GO:0015711 132 0.015
neuron projection morphogenesis GO:0048812 122 0.015
microtubule based process GO:0007017 36 0.015
regulation of establishment of planar polarity GO:0090175 2 0.015
single organism carbohydrate metabolic process GO:0044723 118 0.015
negative regulation of phosphorus metabolic process GO:0010563 80 0.015
organophosphate catabolic process GO:0046434 148 0.014
Rat
divalent inorganic cation transport GO:0072511 134 0.014
heterocycle catabolic process GO:0046700 167 0.014
Rat
neuron development GO:0048666 286 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
membrane organization GO:0061024 94 0.014
defense response GO:0006952 194 0.014
cellular response to stress GO:0033554 269 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
response to oxidative stress GO:0006979 186 0.014
purine containing compound catabolic process GO:0072523 138 0.014
Rat
regulation of peptide hormone secretion GO:0090276 80 0.014
Rat
regulation of canonical wnt signaling pathway GO:0060828 4 0.014
negative regulation of transcription dna templated GO:0045892 116 0.014
sex differentiation GO:0007548 113 0.014
response to purine containing compound GO:0014074 126 0.014
cell morphogenesis involved in differentiation GO:0000904 119 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
regulation of bmp signaling pathway GO:0030510 2 0.014
hematopoietic progenitor cell differentiation GO:0002244 2 0.014
negative regulation of secretion GO:0051048 82 0.014
Rat
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.014
amine transport GO:0015837 57 0.014
negative regulation of secretion by cell GO:1903531 72 0.014
Rat
cardiovascular system development GO:0072358 134 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
sensory perception GO:0007600 101 0.014
Rat
cellular response to organonitrogen compound GO:0071417 197 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
protein homooligomerization GO:0051260 91 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
cardiac chamber development GO:0003205 1 0.013
sensory organ development GO:0007423 74 0.013
neuron differentiation GO:0030182 368 0.013
behavior GO:0007610 205 0.013
positive regulation of molecular function GO:0044093 230 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
purine ribonucleoside catabolic process GO:0046130 124 0.013
cell part morphogenesis GO:0032990 123 0.013
ossification GO:0001503 70 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
anion transport GO:0006820 178 0.013
negative regulation of phosphate metabolic process GO:0045936 80 0.013
oxidation reduction process GO:0055114 304 0.013
negative regulation of cellular biosynthetic process GO:0031327 161 0.013
gliogenesis GO:0042063 93 0.013
amide transport GO:0042886 105 0.013
Rat
response to peptide hormone GO:0043434 278 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
regulation of blood circulation GO:1903522 110 0.013
negative regulation of signal transduction GO:0009968 83 0.013
regulation of anatomical structure size GO:0090066 135 0.013
spindle organization GO:0007051 2 0.013
mitotic spindle organization GO:0007052 2 0.013
cellular catabolic process GO:0044248 295 0.013
Rat
organic cyclic compound catabolic process GO:1901361 175 0.013
Rat
nucleotide metabolic process GO:0009117 279 0.013
Rat
negative regulation of cell death GO:0060548 229 0.013
purine containing compound metabolic process GO:0072521 253 0.013
Rat
glycosyl compound catabolic process GO:1901658 126 0.013
transmission of nerve impulse GO:0019226 42 0.013
immune system process GO:0002376 204 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
embryonic pattern specification GO:0009880 1 0.013
regulation of response to wounding GO:1903034 69 0.013
circulatory system development GO:0072359 134 0.012
peptide secretion GO:0002790 86 0.012
Rat
response to insulin GO:0032868 133 0.012
regulation of membrane potential GO:0042391 110 0.012
nucleoside metabolic process GO:0009116 179 0.012
regulation of transmembrane transport GO:0034762 122 0.012
circadian rhythm GO:0007623 88 0.012
regulation of catabolic process GO:0009894 113 0.012
cell cycle GO:0007049 101 0.012
protein transport GO:0015031 132 0.012
ribonucleoside catabolic process GO:0042454 126 0.012
cellular cation homeostasis GO:0030003 180 0.012
neural crest cell development GO:0014032 2 0.012
positive regulation of locomotion GO:0040017 102 0.012
anterior posterior pattern specification GO:0009952 1 0.012
gamete generation GO:0007276 124 0.012
synaptic growth at neuromuscular junction GO:0051124 1 0.012
regulation of cell activation GO:0050865 50 0.012
tube development GO:0035295 89 0.012
regulation of homeostatic process GO:0032844 101 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
insulin secretion GO:0030073 69 0.012
Rat
positive regulation of ion transport GO:0043270 94 0.012
nucleoside catabolic process GO:0009164 126 0.012
liver development GO:0001889 90 0.012
spermatogenesis GO:0007283 99 0.012
calcium ion transport GO:0006816 131 0.012
single organism catabolic process GO:0044712 283 0.012
Rat
response to peptide GO:1901652 292 0.012
regulation of ion transmembrane transport GO:0034765 121 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
organic acid transport GO:0015849 116 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.012
regulation of calcium ion transport GO:0051924 77 0.012
nucleotide catabolic process GO:0009166 139 0.011
Rat
developmental growth GO:0048589 100 0.011
regulation of synaptic transmission GO:0050804 141 0.011
male gamete generation GO:0048232 99 0.011
positive regulation of phosphorus metabolic process GO:0010562 262 0.011
female pregnancy GO:0007565 122 0.011
purine nucleoside catabolic process GO:0006152 124 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
regulation of cytoskeleton organization GO:0051493 49 0.011
aromatic compound catabolic process GO:0019439 168 0.011
Rat
response to alkaloid GO:0043279 132 0.011
positive regulation of programmed cell death GO:0043068 157 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.011
b cell differentiation GO:0030183 2 0.011
lipid biosynthetic process GO:0008610 128 0.011
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.011
multi multicellular organism process GO:0044706 138 0.011
positive regulation of blood circulation GO:1903524 65 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
development of primary sexual characteristics GO:0045137 107 0.011
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
centrosome cycle GO:0007098 1 0.011
endoplasmic reticulum to cytosol transport GO:1903513 4 0.011
regulation of organelle organization GO:0033043 80 0.011
response to radiation GO:0009314 137 0.011
tissue development GO:0009888 252 0.011
response to glucose GO:0009749 136 0.011
regulation of transferase activity GO:0051338 123 0.011
positive regulation of peptide hormone secretion GO:0090277 50 0.011
alternative mrna splicing via spliceosome GO:0000380 4 0.011
glycerolipid metabolic process GO:0046486 67 0.011
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.011
peptide hormone secretion GO:0030072 84 0.011
Rat
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
ribonucleotide catabolic process GO:0009261 136 0.011
Rat
response to cocaine GO:0042220 39 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
epithelium development GO:0060429 96 0.011
response to ketone GO:1901654 182 0.011
gonad development GO:0008406 104 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
formation of primary germ layer GO:0001704 1 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.010
regulation of fat cell differentiation GO:0045598 3 0.010
actin filament based process GO:0030029 86 0.010
camera type eye morphogenesis GO:0048593 2 0.010
response to corticosteroid GO:0031960 235 0.010
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.010
cytoplasmic transport GO:0016482 115 0.010
insulin like growth factor receptor signaling pathway GO:0048009 3 0.010
regulation of response to external stimulus GO:0032101 106 0.010
vasculature development GO:0001944 70 0.010
kidney development GO:0001822 67 0.010
protein localization to membrane GO:0072657 36 0.010
mapk cascade GO:0000165 140 0.010
rho protein signal transduction GO:0007266 11 0.010
regulation of kinase activity GO:0043549 117 0.010
enzyme linked receptor protein signaling pathway GO:0007167 116 0.010
positive regulation of nucleoside metabolic process GO:0045979 55 0.010
cellular response to peptide GO:1901653 133 0.010

Pde7a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.023
central nervous system disease DOID:331 0 0.019
disease of metabolism DOID:0014667 0 0.011
sensory system disease DOID:0050155 0 0.010