Rattus norvegicus

0 known processes

Adam1a

a disintegrin and metallopeptidase domain 1a

(Aliases: MGC93473,PH-30a,Adam1)

Adam1a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cation transport GO:0006812 382 0.345
negative regulation of signaling GO:0023057 157 0.204
ion transmembrane transport GO:0034220 365 0.201
regulation of multicellular organismal development GO:2000026 376 0.159
regulation of secretion by cell GO:1903530 208 0.145
cellular response to endogenous stimulus GO:0071495 377 0.143
intracellular signal transduction GO:0035556 314 0.142
inorganic cation transmembrane transport GO:0098662 202 0.137
secretion by cell GO:0032940 248 0.132
metal ion transport GO:0030001 289 0.125
nucleic acid templated transcription GO:0097659 379 0.121
nitrogen compound transport GO:0071705 229 0.115
rna metabolic process GO:0016070 406 0.103
regulation of cell proliferation GO:0042127 359 0.103
central nervous system development GO:0007417 311 0.093
hormone transport GO:0009914 121 0.093
cation transmembrane transport GO:0098655 263 0.092
hormone secretion GO:0046879 115 0.091
homeostatic process GO:0042592 331 0.089
organic acid metabolic process GO:0006082 292 0.089
secretion GO:0046903 307 0.088
negative regulation of response to external stimulus GO:0032102 37 0.085
regulation of cell differentiation GO:0045595 320 0.085
cellular component movement GO:0006928 248 0.084
sensory perception GO:0007600 101 0.082
response to inorganic substance GO:0010035 377 0.080
regulation of secretion GO:0051046 224 0.078
regulation of programmed cell death GO:0043067 341 0.077
peptide secretion GO:0002790 86 0.076
regulation of peptide secretion GO:0002791 82 0.075
reproduction GO:0000003 245 0.075
chemical homeostasis GO:0048878 292 0.074
regulation of peptide hormone secretion GO:0090276 80 0.074
oxoacid metabolic process GO:0043436 290 0.071
regulation of defecation GO:2000292 1 0.070
negative regulation of response to extracellular stimulus GO:0032105 7 0.070
neuron projection development GO:0031175 273 0.069
regulation of hormone secretion GO:0046883 106 0.069
regulation of hormone levels GO:0010817 187 0.069
transmembrane transport GO:0055085 412 0.068
organelle organization GO:0006996 266 0.068
regulation of rna metabolic process GO:0051252 391 0.068
regulation of vesicle mediated transport GO:0060627 81 0.068
signal transduction by phosphorylation GO:0023014 144 0.065
negative regulation of response to stimulus GO:0048585 155 0.064
neuron differentiation GO:0030182 368 0.064
cell cell signaling GO:0007267 335 0.064
amino acid transport GO:0006865 70 0.063
signal release GO:0023061 145 0.062
circulatory system process GO:0003013 183 0.062
multicellular organismal reproductive process GO:0048609 233 0.059
calcium ion homeostasis GO:0055074 162 0.059
cell projection organization GO:0030030 302 0.059
positive regulation of transport GO:0051050 245 0.057
cellular response to organonitrogen compound GO:0071417 197 0.057
mapk cascade GO:0000165 140 0.055
inorganic ion transmembrane transport GO:0098660 229 0.054
regulation of cell development GO:0060284 263 0.053
regulation of postsynaptic membrane potential GO:0060078 25 0.053
regulation of lyase activity GO:0051339 22 0.052
carboxylic acid metabolic process GO:0019752 289 0.051
response to nutrient levels GO:0031667 370 0.050
regulation of system process GO:0044057 208 0.050
heart process GO:0003015 57 0.050
negative regulation of hormone secretion GO:0046888 46 0.049
positive regulation of ion transport GO:0043270 94 0.048
blood circulation GO:0008015 183 0.048
striated muscle contraction GO:0006941 44 0.047
neurological system process GO:0050877 219 0.047
cellular response to oxygen containing compound GO:1901701 386 0.046
peptide transport GO:0015833 97 0.045
response to peptide hormone GO:0043434 278 0.045
divalent metal ion transport GO:0070838 132 0.045
response to wounding GO:0009611 254 0.045
positive regulation of multicellular organismal process GO:0051240 387 0.044
response to metal ion GO:0010038 253 0.044
neuron development GO:0048666 286 0.043
regulation of transcription dna templated GO:0006355 374 0.043
cellular amino acid metabolic process GO:0006520 107 0.042
organophosphate metabolic process GO:0019637 370 0.042
reproductive process GO:0022414 372 0.042
vesicle mediated transport GO:0016192 181 0.042
negative regulation of response to wounding GO:1903035 23 0.041
positive regulation of synaptic transmission GO:0050806 62 0.040
regulation of neurogenesis GO:0050767 247 0.040
positive regulation of cell communication GO:0010647 271 0.038
response to extracellular stimulus GO:0009991 380 0.038
regulation of cellular localization GO:0060341 263 0.038
macromolecule localization GO:0033036 252 0.038
cellular chemical homeostasis GO:0055082 247 0.037
anion transport GO:0006820 178 0.037
cellular homeostasis GO:0019725 252 0.037
multicellular organism reproduction GO:0032504 233 0.037
calcium ion import GO:0070509 22 0.037
rna biosynthetic process GO:0032774 380 0.037
positive regulation of serotonin secretion GO:0014064 1 0.036
response to insulin GO:0032868 133 0.035
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.035
regulation of cellular amine metabolic process GO:0033238 8 0.034
single organism reproductive process GO:0044702 297 0.034
cellular cation homeostasis GO:0030003 180 0.034
neuromuscular process GO:0050905 2 0.034
organic anion transport GO:0015711 132 0.034
negative regulation of apoptotic process GO:0043066 181 0.033
positive regulation of secretion GO:0051047 140 0.033
regulation of blood circulation GO:1903522 110 0.033
regulation of neuron differentiation GO:0045664 208 0.032
locomotion GO:0040011 237 0.032
heart contraction GO:0060047 57 0.032
synaptic transmission GO:0007268 235 0.032
nucleoside phosphate biosynthetic process GO:1901293 102 0.032
regulation of ion transmembrane transport GO:0034765 121 0.031
organic acid transport GO:0015849 116 0.031
negative regulation of cell communication GO:0010648 158 0.031
response to acid chemical GO:0001101 222 0.031
cellular response to nitrogen compound GO:1901699 210 0.030
regulation of heart contraction GO:0008016 48 0.030
metal ion homeostasis GO:0055065 186 0.030
regulation of inflammatory response GO:0050727 48 0.030
regulation of intracellular signal transduction GO:1902531 218 0.030
regulation of phosphorylation GO:0042325 248 0.030
transcription dna templated GO:0006351 377 0.030
positive regulation of cell death GO:0010942 184 0.030
regulation of rna biosynthetic process GO:2001141 381 0.029
regulation of response to wounding GO:1903034 69 0.029
single organism biosynthetic process GO:0044711 342 0.029
negative regulation of cell proliferation GO:0008285 119 0.029
response to peptide GO:1901652 292 0.029
regulation of apoptotic process GO:0042981 335 0.029
regulation of protein metabolic process GO:0051246 289 0.029
regulation of locomotion GO:0040012 148 0.029
cell projection morphogenesis GO:0048858 123 0.029
potassium ion transmembrane transport GO:0071805 71 0.029
regulation of nucleic acid templated transcription GO:1903506 380 0.029
positive regulation of peptide hormone secretion GO:0090277 50 0.029
positive regulation of neurogenesis GO:0050769 165 0.028
regulation of neuron projection development GO:0010975 161 0.028
positive regulation of signaling GO:0023056 270 0.028
response to cocaine GO:0042220 39 0.028
regulation of membrane potential GO:0042391 110 0.028
cellular response to acid chemical GO:0071229 75 0.028
negative regulation of transport GO:0051051 136 0.028
calcium ion transport GO:0006816 131 0.028
positive regulation of developmental process GO:0051094 283 0.028
response to carbohydrate GO:0009743 183 0.028
brain development GO:0007420 247 0.027
positive regulation of peptide secretion GO:0002793 52 0.027
regulation of peptide transport GO:0090087 87 0.027
cell adhesion GO:0007155 110 0.027
response to glucose GO:0009749 136 0.027
response to alkaloid GO:0043279 132 0.027
insulin secretion GO:0030073 69 0.027
carbohydrate derivative metabolic process GO:1901135 346 0.027
peptide hormone secretion GO:0030072 84 0.027
regulation of insulin secretion GO:0050796 65 0.027
protein phosphorylation GO:0006468 345 0.027
positive regulation of blood circulation GO:1903524 65 0.027
negative regulation of response to food GO:0032096 7 0.027
cellular response to organic cyclic compound GO:0071407 202 0.027
regulation of synaptic transmission GO:0050804 141 0.027
inflammatory response GO:0006954 150 0.027
negative regulation of phosphate metabolic process GO:0045936 80 0.026
head development GO:0060322 247 0.026
regulation of response to external stimulus GO:0032101 106 0.026
regulation of phosphorus metabolic process GO:0051174 349 0.026
regulation of muscle contraction GO:0006937 53 0.026
lipid metabolic process GO:0006629 283 0.026
negative regulation of cellular metabolic process GO:0031324 281 0.026
regulation of follicle stimulating hormone secretion GO:0046880 5 0.026
synaptic vesicle priming GO:0016082 4 0.025
amide transport GO:0042886 105 0.025
regulation of cell projection organization GO:0031344 175 0.025
defecation GO:0030421 1 0.025
tissue development GO:0009888 252 0.025
organic hydroxy compound metabolic process GO:1901615 115 0.025
negative regulation of luteinizing hormone secretion GO:0033685 4 0.025
neurotrophin production GO:0032898 2 0.025
cardiac muscle contraction GO:0060048 27 0.025
positive regulation of cell differentiation GO:0045597 217 0.024
negative regulation of secretion by cell GO:1903531 72 0.024
regulation of signal transduction GO:0009966 318 0.024
positive regulation of gene expression GO:0010628 244 0.024
positive regulation of response to stimulus GO:0048584 285 0.024
behavior GO:0007610 205 0.024
response to hexose GO:0009746 144 0.023
regulation of cell migration GO:0030334 128 0.023
divalent inorganic cation homeostasis GO:0072507 165 0.023
cellular amine metabolic process GO:0044106 38 0.023
small molecule biosynthetic process GO:0044283 124 0.023
cyclic purine nucleotide metabolic process GO:0052652 62 0.023
relaxation of muscle GO:0090075 4 0.023
purine nucleotide biosynthetic process GO:0006164 83 0.023
negative regulation of gene expression GO:0010629 199 0.023
immune system process GO:0002376 204 0.023
cellular ketone metabolic process GO:0042180 51 0.023
negative regulation of cell death GO:0060548 229 0.022
nucleoside phosphate metabolic process GO:0006753 283 0.022
negative regulation of multicellular organismal process GO:0051241 203 0.022
response to ketone GO:1901654 182 0.022
g protein coupled receptor signaling pathway GO:0007186 242 0.022
negative regulation of metabolic process GO:0009892 331 0.022
forebrain development GO:0030900 98 0.022
second messenger mediated signaling GO:0019932 51 0.022
regulation of ion transport GO:0043269 245 0.022
regulation of nervous system development GO:0051960 264 0.022
sexual reproduction GO:0019953 148 0.021
regulation of anion transport GO:0044070 43 0.021
amine metabolic process GO:0009308 38 0.021
response to decreased oxygen levels GO:0036293 237 0.021
acid secretion GO:0046717 48 0.021
multi organism reproductive process GO:0044703 262 0.021
positive regulation of phosphorylation GO:0042327 177 0.021
organophosphate biosynthetic process GO:0090407 143 0.021
negative regulation of follicle stimulating hormone secretion GO:0046882 3 0.021
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.021
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
regulation of protein phosphorylation GO:0001932 183 0.020
single organism organelle organization GO:1902589 180 0.020
negative regulation of secretion GO:0051048 82 0.020
purine containing compound metabolic process GO:0072521 253 0.020
response to amine GO:0014075 46 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
muscle system process GO:0003012 115 0.020
ion homeostasis GO:0050801 212 0.020
cellular response to peptide GO:1901653 133 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
smooth muscle cell proliferation GO:0048659 77 0.020
catabolic process GO:0009056 351 0.019
carboxylic acid biosynthetic process GO:0046394 83 0.019
positive regulation of signal transduction GO:0009967 175 0.019
positive regulation of rna metabolic process GO:0051254 203 0.019
negative regulation of phosphorus metabolic process GO:0010563 80 0.019
anatomical structure morphogenesis GO:0009653 298 0.019
acute inflammatory response GO:0002526 58 0.019
regulation of muscle system process GO:0090257 79 0.019
carbohydrate derivative biosynthetic process GO:1901137 124 0.019
regulation of striated muscle contraction GO:0006942 21 0.019
cellular metal ion homeostasis GO:0006875 172 0.019
regulation of metal ion transport GO:0010959 118 0.019
establishment of tissue polarity GO:0007164 2 0.019
programmed cell death GO:0012501 392 0.019
cyclic nucleotide metabolic process GO:0009187 80 0.018
negative regulation of response to nutrient levels GO:0032108 7 0.018
regulation of cell morphogenesis GO:0022604 77 0.018
action potential GO:0001508 54 0.018
defense response GO:0006952 194 0.018
apoptotic process GO:0006915 381 0.017
gamete generation GO:0007276 124 0.017
nucleobase containing small molecule metabolic process GO:0055086 316 0.017
positive regulation of nervous system development GO:0051962 178 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.017
exploration behavior GO:0035640 1 0.017
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.017
reproductive system development GO:0061458 128 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.017
cellular response to stress GO:0033554 269 0.016
negative regulation of programmed cell death GO:0043069 183 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
single organism intracellular transport GO:1902582 166 0.016
positive regulation of biosynthetic process GO:0009891 319 0.016
enzyme linked receptor protein signaling pathway GO:0007167 116 0.016
nucleotide biosynthetic process GO:0009165 98 0.016
regulation of cellular component movement GO:0051270 150 0.016
reproductive structure development GO:0048608 128 0.016
amine transport GO:0015837 57 0.016
lipid transport GO:0006869 61 0.016
regulation of response to stress GO:0080134 126 0.016
spermatogenesis GO:0007283 99 0.016
neuron death GO:0070997 127 0.015
cell morphogenesis involved in differentiation GO:0000904 119 0.015
positive regulation of mapk cascade GO:0043410 92 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.015
regulation of exocytosis GO:0017157 37 0.015
response to monosaccharide GO:0034284 159 0.015
regulation of protein modification process GO:0031399 194 0.015
positive regulation of kinase activity GO:0033674 77 0.015
regeneration GO:0031099 163 0.015
response to fatty acid GO:0070542 65 0.015
cell part morphogenesis GO:0032990 123 0.015
regulation of homeostatic process GO:0032844 101 0.015
negative regulation of synaptic transmission dopaminergic GO:0032227 4 0.015
cytoplasmic transport GO:0016482 115 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.014
regulation of cellular ketone metabolic process GO:0010565 27 0.014
transcription from rna polymerase ii promoter GO:0006366 252 0.014
negative regulation of collagen metabolic process GO:0010713 4 0.014
negative regulation of calcium ion import GO:0090281 2 0.014
male gamete generation GO:0048232 99 0.014
negative regulation of defecation GO:2000293 1 0.014
positive regulation of calcium ion transport GO:0051928 36 0.014
immune response GO:0006955 104 0.014
telencephalon development GO:0021537 62 0.014
cellular ion homeostasis GO:0006873 184 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
carbohydrate homeostasis GO:0033500 75 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
response to ethanol GO:0045471 162 0.014
negative regulation of peptide hormone secretion GO:0090278 30 0.014
macromolecule catabolic process GO:0009057 58 0.013
monoamine transport GO:0015844 43 0.013
positive regulation of camp metabolic process GO:0030816 31 0.013
regulation of mapk cascade GO:0043408 116 0.013
taxis GO:0042330 67 0.013
chemotaxis GO:0006935 66 0.013
regulation of cardiac muscle contraction GO:0055117 17 0.013
negative regulation of collagen biosynthetic process GO:0032966 4 0.013
regulation of cell activation GO:0050865 50 0.013
positive regulation of transcription dna templated GO:0045893 197 0.013
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.013
coenzyme metabolic process GO:0006732 86 0.013
response to growth factor GO:0070848 189 0.013
positive regulation of cell projection organization GO:0031346 111 0.013
response to radiation GO:0009314 137 0.013
cellular catabolic process GO:0044248 295 0.013
developmental process involved in reproduction GO:0003006 159 0.013
cellular response to hormone stimulus GO:0032870 247 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
neuropeptide signaling pathway GO:0007218 29 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.013
regulation of phosphate metabolic process GO:0019220 349 0.013
growth GO:0040007 165 0.012
response to hypoxia GO:0001666 231 0.012
oxidation reduction process GO:0055114 304 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
membrane organization GO:0061024 94 0.012
cell cycle GO:0007049 101 0.012
positive regulation of phosphorus metabolic process GO:0010562 262 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
nitrogen cycle metabolic process GO:0071941 5 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
cation homeostasis GO:0055080 195 0.012
cellular response to oxygen levels GO:0071453 60 0.012
carbohydrate metabolic process GO:0005975 130 0.012
response to calcium ion GO:0051592 59 0.012
response to corticosteroid GO:0031960 235 0.012
response to interleukin 15 GO:0070672 4 0.012
cellular response to ketone GO:1901655 51 0.012
positive regulation of blood pressure GO:0045777 31 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
positive regulation of cell development GO:0010720 176 0.012
neurotransmitter uptake GO:0001504 3 0.012
inner ear receptor cell differentiation GO:0060113 2 0.012
multicellular organism growth GO:0035264 1 0.012
positive regulation of protein modification process GO:0031401 142 0.012
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
response to electrical stimulus GO:0051602 56 0.012
maternal process involved in female pregnancy GO:0060135 38 0.012
embryonic pattern specification GO:0009880 1 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
ribonucleotide metabolic process GO:0009259 231 0.011
regulation of heart rate GO:0002027 16 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
lipid localization GO:0010876 62 0.011
positive regulation of insulin secretion GO:0032024 36 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
response to nutrient GO:0007584 248 0.011
axis specification GO:0009798 4 0.011
mechanoreceptor differentiation GO:0042490 2 0.011
divalent inorganic cation transport GO:0072511 134 0.011
organ regeneration GO:0031100 101 0.011
regulation of cellular component organization GO:0051128 368 0.011
neuron projection morphogenesis GO:0048812 122 0.011
single organism behavior GO:0044708 130 0.011
glucose homeostasis GO:0042593 75 0.011
leukocyte activation GO:0045321 76 0.011
erk1 and erk2 cascade GO:0070371 48 0.011
nucleotide metabolic process GO:0009117 279 0.011
actin mediated cell contraction GO:0070252 12 0.011
cytoskeleton dependent cytokinesis GO:0061640 2 0.011
cell morphogenesis GO:0000902 142 0.011
sex differentiation GO:0007548 113 0.011
negative regulation of synaptic transmission GO:0050805 29 0.011
regulation of transmembrane transport GO:0034762 122 0.011
negative regulation of phosphorylation GO:0042326 57 0.011
neuronal action potential GO:0019228 35 0.010
organic substance catabolic process GO:1901575 316 0.010
alcohol biosynthetic process GO:0046165 38 0.010
retinal ganglion cell axon guidance GO:0031290 1 0.010
purine containing compound biosynthetic process GO:0072522 85 0.010
actin filament based movement GO:0030048 16 0.010
cellular response to glucose stimulus GO:0071333 65 0.010
cellular divalent inorganic cation homeostasis GO:0072503 162 0.010
biological adhesion GO:0022610 110 0.010
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.010
cyclic nucleotide biosynthetic process GO:0009190 63 0.010
alpha amino acid metabolic process GO:1901605 71 0.010
multicellular organismal homeostasis GO:0048871 49 0.010
digestive system process GO:0022600 24 0.010
positive regulation of isotype switching GO:0045830 1 0.010
fatty acid metabolic process GO:0006631 99 0.010
non canonical wnt signaling pathway GO:0035567 3 0.010
regulation of cellular protein metabolic process GO:0032268 267 0.010

Adam1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.056
disease of anatomical entity DOID:7 0 0.056
sensory system disease DOID:0050155 0 0.035
central nervous system disease DOID:331 0 0.023
disease of cellular proliferation DOID:14566 0 0.013
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.010