Rattus norvegicus

0 known processes

Pnpla2

patatin-like phospholipase domain containing 2

(Aliases: RGD1309044)

Pnpla2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular lipid metabolic process GO:0044255 208 0.762
Human Fly
lipid metabolic process GO:0006629 283 0.521
Human Fly
triglyceride metabolic process GO:0006641 21 0.339
Human Fly
lipid biosynthetic process GO:0008610 128 0.319
neutral lipid metabolic process GO:0006638 21 0.222
Human Fly
single organism biosynthetic process GO:0044711 342 0.215
glycerolipid metabolic process GO:0046486 67 0.210
Human Fly
apoptotic process GO:0006915 381 0.208
carboxylic acid metabolic process GO:0019752 289 0.181
organophosphate metabolic process GO:0019637 370 0.161
acylglycerol metabolic process GO:0006639 21 0.151
Human Fly
oxoacid metabolic process GO:0043436 290 0.148
intracellular signal transduction GO:0035556 314 0.116
secretion GO:0046903 307 0.111
amine metabolic process GO:0009308 38 0.107
cellular response to endogenous stimulus GO:0071495 377 0.102
regulation of programmed cell death GO:0043067 341 0.095
cellular ketone metabolic process GO:0042180 51 0.092
small molecule biosynthetic process GO:0044283 124 0.092
programmed cell death GO:0012501 392 0.090
response to oxygen levels GO:0070482 265 0.089
monocarboxylic acid metabolic process GO:0032787 152 0.085
response to oxidative stress GO:0006979 186 0.078
alcohol metabolic process GO:0006066 77 0.077
negative regulation of programmed cell death GO:0043069 183 0.076
cellular response to lipid GO:0071396 201 0.075
regulation of protein modification process GO:0031399 194 0.072
cellular amine metabolic process GO:0044106 38 0.071
regulation of cellular ketone metabolic process GO:0010565 27 0.069
regulation of apoptotic process GO:0042981 335 0.069
cellular lipid catabolic process GO:0044242 37 0.068
Human Fly
positive regulation of signaling GO:0023056 270 0.064
response to nutrient levels GO:0031667 370 0.060
cellular response to oxygen containing compound GO:1901701 386 0.060
macromolecular complex assembly GO:0065003 273 0.060
protein complex subunit organization GO:0071822 302 0.060
organic acid metabolic process GO:0006082 292 0.059
nucleobase containing small molecule metabolic process GO:0055086 316 0.058
regulation of lipid metabolic process GO:0019216 68 0.058
Human
secretion by cell GO:0032940 248 0.058
cellular response to hormone stimulus GO:0032870 247 0.058
protein complex assembly GO:0006461 263 0.056
nitrogen compound transport GO:0071705 229 0.056
cellular catabolic process GO:0044248 295 0.055
Human Fly
regulation of signal transduction GO:0009966 318 0.055
cellular response to stress GO:0033554 269 0.054
positive regulation of multicellular organismal process GO:0051240 387 0.053
positive regulation of cell communication GO:0010647 271 0.051
macromolecular complex subunit organization GO:0043933 339 0.049
cellular component assembly GO:0022607 360 0.048
response to extracellular stimulus GO:0009991 380 0.048
phospholipid metabolic process GO:0006644 61 0.047
carbohydrate derivative metabolic process GO:1901135 346 0.047
regulation of cellular localization GO:0060341 263 0.047
cellular response to oxidative stress GO:0034599 76 0.046
neutral lipid biosynthetic process GO:0046460 7 0.045
negative regulation of metabolic process GO:0009892 331 0.045
signal release GO:0023061 145 0.045
organophosphate biosynthetic process GO:0090407 143 0.045
cellular component biogenesis GO:0044085 368 0.044
positive regulation of intracellular signal transduction GO:1902533 138 0.044
organonitrogen compound biosynthetic process GO:1901566 167 0.042
anion transport GO:0006820 178 0.042
protein phosphorylation GO:0006468 345 0.042
regulation of phosphorylation GO:0042325 248 0.042
response to nutrient GO:0007584 248 0.042
negative regulation of apoptotic process GO:0043066 181 0.041
organic acid biosynthetic process GO:0016053 83 0.041
response to inorganic substance GO:0010035 377 0.041
phosphatidylethanolamine metabolic process GO:0046337 1 0.041
organic substance catabolic process GO:1901575 316 0.040
Human Fly
regulation of intracellular signal transduction GO:1902531 218 0.040
peptide secretion GO:0002790 86 0.038
negative regulation of cell death GO:0060548 229 0.038
regulation of cellular protein metabolic process GO:0032268 267 0.037
organic hydroxy compound metabolic process GO:1901615 115 0.037
carboxylic acid biosynthetic process GO:0046394 83 0.037
regulation of protein phosphorylation GO:0001932 183 0.037
response to decreased oxygen levels GO:0036293 237 0.037
regulation of molecular function GO:0065009 398 0.037
protein homooligomerization GO:0051260 91 0.036
antral ovarian follicle growth GO:0001547 3 0.036
peptide hormone secretion GO:0030072 84 0.036
single organism catabolic process GO:0044712 283 0.035
Human Fly
regulation of phosphate metabolic process GO:0019220 349 0.035
cellular homeostasis GO:0019725 252 0.035
cellular amino acid metabolic process GO:0006520 107 0.035
regulation of catalytic activity GO:0050790 304 0.035
acylglycerol biosynthetic process GO:0046463 7 0.035
regulation of cellular amino acid metabolic process GO:0006521 2 0.035
carnitine metabolic process GO:0009437 3 0.034
hormone transport GO:0009914 121 0.034
regulation of phosphorus metabolic process GO:0051174 349 0.034
cellular response to organonitrogen compound GO:0071417 197 0.033
regulation of secretion GO:0051046 224 0.033
oxidation reduction process GO:0055114 304 0.033
regulation of protein metabolic process GO:0051246 289 0.033
response to external biotic stimulus GO:0043207 221 0.032
protein oligomerization GO:0051259 191 0.032
macromolecule localization GO:0033036 252 0.032
Human Fly
negative regulation of biosynthetic process GO:0009890 168 0.032
response to hypoxia GO:0001666 231 0.032
regulation of cellular amine metabolic process GO:0033238 8 0.031
cellular response to nitrogen compound GO:1901699 210 0.031
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
negative regulation of signaling GO:0023057 157 0.030
regulation of hormone levels GO:0010817 187 0.030
establishment of protein localization GO:0045184 141 0.030
phosphatidic acid biosynthetic process GO:0006654 1 0.030
positive regulation of response to stimulus GO:0048584 285 0.029
regulation of secretion by cell GO:1903530 208 0.029
organic acid transport GO:0015849 116 0.029
cellular response to lipopolysaccharide GO:0071222 55 0.028
carboxylic acid transport GO:0046942 115 0.028
nucleoside phosphate metabolic process GO:0006753 283 0.028
cell cell signaling GO:0007267 335 0.028
nucleotide metabolic process GO:0009117 279 0.027
cellular response to organic cyclic compound GO:0071407 202 0.027
positive regulation of transport GO:0051050 245 0.027
response to purine containing compound GO:0014074 126 0.026
response to reactive oxygen species GO:0000302 120 0.026
positive regulation of phosphate metabolic process GO:0045937 262 0.026
phosphatidylcholine biosynthetic process GO:0006656 5 0.026
hormone secretion GO:0046879 115 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
nucleoside catabolic process GO:0009164 126 0.025
homeostatic process GO:0042592 331 0.025
Fly
long chain fatty acid metabolic process GO:0001676 32 0.025
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.025
organic anion transport GO:0015711 132 0.025
peptide transport GO:0015833 97 0.025
positive regulation of signal transduction GO:0009967 175 0.025
regulation of transferase activity GO:0051338 123 0.024
learning or memory GO:0007611 90 0.024
positive regulation of phosphorus metabolic process GO:0010562 262 0.024
negative regulation of phosphorus metabolic process GO:0010563 80 0.024
regulation of cell proliferation GO:0042127 359 0.024
response to transition metal nanoparticle GO:1990267 122 0.024
lipid catabolic process GO:0016042 46 0.024
Human Fly
insulin secretion GO:0030073 69 0.024
response to peptide GO:1901652 292 0.024
protein complex biogenesis GO:0070271 263 0.023
catabolic process GO:0009056 351 0.023
Human Fly
ribonucleotide metabolic process GO:0009259 231 0.023
neurotransmitter biosynthetic process GO:0042136 2 0.023
regulation of response to external stimulus GO:0032101 106 0.023
positive regulation of phosphorylation GO:0042327 177 0.023
regulation of multicellular organismal development GO:2000026 376 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.023
fatty acid beta oxidation GO:0006635 22 0.023
ras protein signal transduction GO:0007265 29 0.022
cellular nitrogen compound catabolic process GO:0044270 163 0.022
cation transport GO:0006812 382 0.022
amide transport GO:0042886 105 0.022
negative regulation of cellular metabolic process GO:0031324 281 0.022
positive regulation of cellular protein metabolic process GO:0032270 167 0.022
chemical homeostasis GO:0048878 292 0.022
Fly
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
small gtpase mediated signal transduction GO:0007264 36 0.022
positive regulation of defense response GO:0031349 37 0.021
response to hydrogen peroxide GO:0042542 89 0.021
fatty acid metabolic process GO:0006631 99 0.021
response to ethanol GO:0045471 162 0.021
organelle organization GO:0006996 266 0.020
nucleic acid templated transcription GO:0097659 379 0.020
regulation of transcription dna templated GO:0006355 374 0.020
positive regulation of molecular function GO:0044093 230 0.020
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.020
behavior GO:0007610 205 0.020
epithelial cell differentiation GO:0030855 71 0.020
neurological system process GO:0050877 219 0.020
regulation of nervous system development GO:0051960 264 0.020
monocarboxylic acid transport GO:0015718 52 0.020
reproductive process GO:0022414 372 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.020
positive regulation of lipid catabolic process GO:0050996 4 0.020
Human
regulation of cellular component organization GO:0051128 368 0.020
nicotinamide nucleotide metabolic process GO:0046496 28 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
response to acid chemical GO:0001101 222 0.019
positive regulation of secretion GO:0051047 140 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
response to biotic stimulus GO:0009607 226 0.019
negative regulation of multicellular organismal process GO:0051241 203 0.019
central nervous system development GO:0007417 311 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
fatty acid oxidation GO:0019395 29 0.019
g protein coupled receptor signaling pathway GO:0007186 242 0.019
reproduction GO:0000003 245 0.019
signal transduction by phosphorylation GO:0023014 144 0.019
regulation of defense response GO:0031347 68 0.019
carbohydrate derivative biosynthetic process GO:1901137 124 0.019
negative regulation of cellular biosynthetic process GO:0031327 161 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
positive regulation of catalytic activity GO:0043085 184 0.019
defense response GO:0006952 194 0.019
regulation of cellular catabolic process GO:0031329 101 0.019
Human
phospholipid biosynthetic process GO:0008654 29 0.019
tissue development GO:0009888 252 0.019
regulation of cell differentiation GO:0045595 320 0.019
cell type specific apoptotic process GO:0097285 134 0.019
response to bacterium GO:0009617 200 0.018
heterocycle catabolic process GO:0046700 167 0.018
cellular biogenic amine metabolic process GO:0006576 30 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
organophosphate catabolic process GO:0046434 148 0.018
multicellular organism reproduction GO:0032504 233 0.018
ion homeostasis GO:0050801 212 0.018
positive regulation of biosynthetic process GO:0009891 319 0.018
regulation of rna biosynthetic process GO:2001141 381 0.018
anion transmembrane transport GO:0098656 77 0.018
cofactor metabolic process GO:0051186 95 0.018
head development GO:0060322 247 0.018
regulation of proteasomal protein catabolic process GO:0061136 4 0.018
response to carbohydrate GO:0009743 183 0.018
circulatory system process GO:0003013 183 0.017
rna biosynthetic process GO:0032774 380 0.017
gland development GO:0048732 155 0.017
purine containing compound metabolic process GO:0072521 253 0.017
cognition GO:0050890 92 0.017
negative regulation of cell differentiation GO:0045596 99 0.017
positive regulation of nucleic acid templated transcription GO:1903508 197 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
regulation of peptide hormone secretion GO:0090276 80 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
brain development GO:0007420 247 0.017
lipid modification GO:0030258 52 0.017
blood circulation GO:0008015 183 0.017
positive regulation of protein modification process GO:0031401 142 0.017
neuron differentiation GO:0030182 368 0.017
rna metabolic process GO:0016070 406 0.016
multi organism reproductive process GO:0044703 262 0.016
negative regulation of gene expression GO:0010629 199 0.016
cellular chemical homeostasis GO:0055082 247 0.016
vascular process in circulatory system GO:0003018 96 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
positive regulation of catabolic process GO:0009896 78 0.016
Human
positive regulation of rna metabolic process GO:0051254 203 0.016
response to peptide hormone GO:0043434 278 0.016
negative regulation of cell communication GO:0010648 158 0.016
positive regulation of humoral immune response GO:0002922 2 0.016
cdp choline pathway GO:0006657 3 0.016
response to osmotic stress GO:0006970 42 0.016
fatty acid transport GO:0015908 25 0.016
positive regulation of protein phosphorylation GO:0001934 135 0.016
neuron death GO:0070997 127 0.016
transmembrane transport GO:0055085 412 0.016
cation homeostasis GO:0055080 195 0.016
peptidyl amino acid modification GO:0018193 126 0.016
regulation of nucleic acid templated transcription GO:1903506 380 0.015
defense response to other organism GO:0098542 17 0.015
chromosome segregation GO:0007059 2 0.015
glycerophospholipid metabolic process GO:0006650 47 0.015
negative regulation of response to stimulus GO:0048585 155 0.015
triglyceride biosynthetic process GO:0019432 7 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
response to estrogen GO:0043627 232 0.015
fatty acid biosynthetic process GO:0006633 33 0.015
regulation of tumor necrosis factor production GO:0032680 13 0.015
positive regulation of gene expression GO:0010628 244 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
intracellular transport GO:0046907 185 0.015
regulation of neurotransmitter levels GO:0001505 42 0.015
regulation of mapk cascade GO:0043408 116 0.015
acetate ester biosynthetic process GO:1900620 2 0.015
regulation of blood vessel size GO:0050880 89 0.014
cytokine production GO:0001816 61 0.014
regulation of catabolic process GO:0009894 113 0.014
Human
ion transmembrane transport GO:0034220 365 0.014
response to camp GO:0051591 91 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
positive regulation of cell death GO:0010942 184 0.014
single organism reproductive process GO:0044702 297 0.014
response to molecule of bacterial origin GO:0002237 194 0.014
coenzyme metabolic process GO:0006732 86 0.014
response to growth factor GO:0070848 189 0.014
regulation of hydrolase activity GO:0051336 143 0.014
negative regulation of developmental process GO:0051093 125 0.014
aging GO:0007568 241 0.014
Fly
response to metal ion GO:0010038 253 0.014
anatomical structure morphogenesis GO:0009653 298 0.014
response to alkaloid GO:0043279 132 0.014
response to other organism GO:0051707 220 0.014
cytokine mediated signaling pathway GO:0019221 43 0.014
lipid localization GO:0010876 62 0.014
Human Fly
reactive oxygen species metabolic process GO:0072593 37 0.014
protein transport GO:0015031 132 0.013
lipid oxidation GO:0034440 30 0.013
response to lipopolysaccharide GO:0032496 191 0.013
positive regulation of hydrolase activity GO:0051345 86 0.013
protein localization GO:0008104 191 0.013
amino acid betaine metabolic process GO:0006577 3 0.013
regulation of phagocytosis engulfment GO:0060099 4 0.013
axis specification GO:0009798 4 0.013
negative regulation of catalytic activity GO:0043086 103 0.013
negative regulation of phosphate metabolic process GO:0045936 80 0.013
positive regulation of cell differentiation GO:0045597 217 0.013
tube development GO:0035295 89 0.013
negative regulation of nervous system development GO:0051961 79 0.013
cellular amino acid biosynthetic process GO:0008652 32 0.013
purine nucleoside triphosphate catabolic process GO:0009146 122 0.013
nucleoside metabolic process GO:0009116 179 0.013
pyridine containing compound metabolic process GO:0072524 32 0.013
very long chain fatty acid metabolic process GO:0000038 3 0.013
response to toxic substance GO:0009636 133 0.013
organic hydroxy compound biosynthetic process GO:1901617 51 0.013
purine ribonucleoside catabolic process GO:0046130 124 0.013
regulation of reactive oxygen species metabolic process GO:2000377 26 0.013
regulation of tube size GO:0035150 89 0.013
positive regulation of nervous system development GO:0051962 178 0.013
regulation of response to stress GO:0080134 126 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
response to temperature stimulus GO:0009266 94 0.013
long chain fatty acid transport GO:0015909 14 0.013
immune system process GO:0002376 204 0.012
response to fatty acid GO:0070542 65 0.012
cellular response to biotic stimulus GO:0071216 59 0.012
regulation of neuron death GO:1901214 115 0.012
positive regulation of cell proliferation GO:0008284 249 0.012
transcription dna templated GO:0006351 377 0.012
regulation of neurogenesis GO:0050767 247 0.012
neurotransmitter uptake GO:0001504 3 0.012
ribonucleoside catabolic process GO:0042454 126 0.012
single organism intracellular transport GO:1902582 166 0.012
carbohydrate derivative catabolic process GO:1901136 147 0.012
carboxylic acid catabolic process GO:0046395 49 0.012
nucleotide catabolic process GO:0009166 139 0.012
urogenital system development GO:0001655 78 0.012
regulation of rna metabolic process GO:0051252 391 0.012
positive regulation of fatty acid beta oxidation GO:0032000 4 0.012
regulation of growth GO:0040008 105 0.012
kidney development GO:0001822 67 0.012
steroid metabolic process GO:0008202 73 0.012
regulation of fatty acid oxidation GO:0046320 10 0.012
neuron apoptotic process GO:0051402 88 0.012
sexual reproduction GO:0019953 148 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
neurotransmitter transport GO:0006836 42 0.012
triglyceride catabolic process GO:0019433 3 0.012
Human Fly
cellular response to reactive oxygen species GO:0034614 55 0.012
cellular response to alcohol GO:0097306 87 0.012
regulation of hormone secretion GO:0046883 106 0.012
cellular response to insulin stimulus GO:0032869 81 0.012
positive regulation of cellular component organization GO:0051130 200 0.011
ribonucleotide catabolic process GO:0009261 136 0.011
regulation of cell development GO:0060284 263 0.011
glycosyl compound metabolic process GO:1901657 182 0.011
regulation of response to wounding GO:1903034 69 0.011
regulation of lipid biosynthetic process GO:0046890 38 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
response to mechanical stimulus GO:0009612 134 0.011
carbohydrate metabolic process GO:0005975 130 0.011
acetyl coa metabolic process GO:0006084 17 0.011
regulation of protein kinase activity GO:0045859 105 0.011
positive regulation of kinase activity GO:0033674 77 0.011
single organism behavior GO:0044708 130 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.011
choline transport GO:0015871 4 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
renal system development GO:0072001 67 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
meiotic cell cycle process GO:1903046 3 0.011
metal ion transport GO:0030001 289 0.011
alcohol biosynthetic process GO:0046165 38 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
vesicle mediated transport GO:0016192 181 0.011
sterol metabolic process GO:0016125 18 0.011
negative regulation of lipid biosynthetic process GO:0051055 2 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.010
Human
response to monosaccharide GO:0034284 159 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.010
cellular response to molecule of bacterial origin GO:0071219 56 0.010
positive regulation of transferase activity GO:0051347 81 0.010
ribose phosphate biosynthetic process GO:0046390 87 0.010
cellular response to acid chemical GO:0071229 75 0.010
positive regulation of rna biosynthetic process GO:1902680 197 0.010
transcription from rna polymerase ii promoter GO:0006366 252 0.010
positive regulation of cytokine production GO:0001819 42 0.010
negative regulation of rna biosynthetic process GO:1902679 118 0.010
response to insulin GO:0032868 133 0.010
purine containing compound catabolic process GO:0072523 138 0.010
guanosine containing compound metabolic process GO:1901068 74 0.010
pattern recognition receptor signaling pathway GO:0002221 9 0.010
gastrulation GO:0007369 2 0.010
response to ammonium ion GO:0060359 71 0.010
response to estradiol GO:0032355 164 0.010
cellular response to abiotic stimulus GO:0071214 85 0.010

Pnpla2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
nervous system disease DOID:863 0 0.033
musculoskeletal system disease DOID:17 0 0.027
myopathy DOID:423 0 0.025
muscular disease DOID:0080000 0 0.025
muscle tissue disease DOID:66 0 0.025
muscular dystrophy DOID:9884 0 0.021
central nervous system disease DOID:331 0 0.016
disease of metabolism DOID:0014667 0 0.012
sensory system disease DOID:0050155 0 0.010