Rattus norvegicus

23 known processes

Klhl17

kelch-like 17 (Drosophila)

Klhl17 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transmembrane transport GO:0055085 412 0.089
single organism cellular localization GO:1902580 102 0.083
Rat
regulation of intracellular signal transduction GO:1902531 218 0.077
regulation of signal transduction GO:0009966 318 0.074
intracellular signal transduction GO:0035556 314 0.070
negative regulation of signaling GO:0023057 157 0.068
response to inorganic substance GO:0010035 377 0.063
Rat
macromolecular complex subunit organization GO:0043933 339 0.061
Rat
regulation of cellular component organization GO:0051128 368 0.057
Rat
cell cell signaling GO:0007267 335 0.055
cellular response to oxygen containing compound GO:1901701 386 0.053
single organism membrane organization GO:0044802 74 0.052
apoptotic process GO:0006915 381 0.049
cellular response to endogenous stimulus GO:0071495 377 0.048
negative regulation of cell communication GO:0010648 158 0.048
cellular response to stress GO:0033554 269 0.047
regulation of synaptic transmission GO:0050804 141 0.047
secretion by cell GO:0032940 248 0.046
synaptic transmission GO:0007268 235 0.046
protein localization GO:0008104 191 0.045
Rat
cellular catabolic process GO:0044248 295 0.044
organic acid metabolic process GO:0006082 292 0.043
Rat
neuron death GO:0070997 127 0.043
macromolecular complex assembly GO:0065003 273 0.042
Rat
macromolecule localization GO:0033036 252 0.041
Rat
single organism organelle organization GO:1902589 180 0.041
rna metabolic process GO:0016070 406 0.041
central nervous system development GO:0007417 311 0.040
negative regulation of response to stimulus GO:0048585 155 0.040
anterior posterior pattern specification GO:0009952 1 0.039
protein complex subunit organization GO:0071822 302 0.038
Rat
chemical homeostasis GO:0048878 292 0.038
regulation of synaptic plasticity GO:0048167 70 0.038
regulation of apoptotic process GO:0042981 335 0.038
cation transport GO:0006812 382 0.036
regulation of phosphorus metabolic process GO:0051174 349 0.036
small gtpase mediated signal transduction GO:0007264 36 0.036
cellular response to nitrogen compound GO:1901699 210 0.036
regulation of programmed cell death GO:0043067 341 0.035
glutamate receptor signaling pathway GO:0007215 43 0.035
single organism biosynthetic process GO:0044711 342 0.035
response to extracellular stimulus GO:0009991 380 0.035
neuron development GO:0048666 286 0.034
Rat
single organism intracellular transport GO:1902582 166 0.034
Rat
transcription dna templated GO:0006351 377 0.034
secretion GO:0046903 307 0.034
positive regulation of cell death GO:0010942 184 0.033
cellular amino acid metabolic process GO:0006520 107 0.033
cell cycle GO:0007049 101 0.033
neuron differentiation GO:0030182 368 0.032
Rat
enzyme linked receptor protein signaling pathway GO:0007167 116 0.032
oxoacid metabolic process GO:0043436 290 0.032
Rat
protein complex biogenesis GO:0070271 263 0.031
Rat
multi organism reproductive process GO:0044703 262 0.031
cytoskeleton organization GO:0007010 111 0.031
positive regulation of apoptotic process GO:0043065 154 0.031
organophosphate metabolic process GO:0019637 370 0.031
neuron projection development GO:0031175 273 0.031
Rat
programmed cell death GO:0012501 392 0.031
organelle organization GO:0006996 266 0.030
catabolic process GO:0009056 351 0.030
regulation of multicellular organismal development GO:2000026 376 0.030
Rat
cellular protein localization GO:0034613 122 0.030
Rat
inorganic ion transmembrane transport GO:0098660 229 0.030
cell growth GO:0016049 104 0.029
ras protein signal transduction GO:0007265 29 0.029
reproductive process GO:0022414 372 0.029
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.028
protein complex assembly GO:0006461 263 0.028
Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.028
head development GO:0060322 247 0.028
cellular component assembly GO:0022607 360 0.028
Rat
axis specification GO:0009798 4 0.028
positive regulation of synaptic transmission GO:0050806 62 0.028
intracellular transport GO:0046907 185 0.028
Rat
chromosome segregation GO:0007059 2 0.028
membrane organization GO:0061024 94 0.027
purine containing compound metabolic process GO:0072521 253 0.027
positive regulation of programmed cell death GO:0043068 157 0.027
organic substance catabolic process GO:1901575 316 0.027
cellular ketone metabolic process GO:0042180 51 0.026
nucleobase containing small molecule metabolic process GO:0055086 316 0.026
regulation of protein metabolic process GO:0051246 289 0.026
synaptic transmission glutamatergic GO:0035249 33 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
monovalent inorganic cation transport GO:0015672 172 0.026
growth GO:0040007 165 0.026
negative regulation of metabolic process GO:0009892 331 0.025
Rat
negative regulation of signal transduction GO:0009968 83 0.025
regulation of cellular ketone metabolic process GO:0010565 27 0.025
positive regulation of biosynthetic process GO:0009891 319 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.025
divalent inorganic cation homeostasis GO:0072507 165 0.025
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.025
regulation of ion transmembrane transport GO:0034765 121 0.025
establishment of protein localization GO:0045184 141 0.025
Rat
rna biosynthetic process GO:0032774 380 0.025
nucleoside phosphate metabolic process GO:0006753 283 0.025
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.024
positive regulation of developmental process GO:0051094 283 0.024
Rat
transcription from rna polymerase ii promoter GO:0006366 252 0.024
response to metal ion GO:0010038 253 0.024
Rat
regulation of transcription dna templated GO:0006355 374 0.024
male mating behavior GO:0060179 3 0.024
regulation of neuron projection development GO:0010975 161 0.024
Rat
carbohydrate derivative metabolic process GO:1901135 346 0.024
regulation of neuron death GO:1901214 115 0.024
response to ethanol GO:0045471 162 0.024
response to peptide hormone GO:0043434 278 0.023
regulation of secretion by cell GO:1903530 208 0.023
inorganic cation transmembrane transport GO:0098662 202 0.023
regulation of cellular localization GO:0060341 263 0.023
Rat
regulation of cellular amine metabolic process GO:0033238 8 0.023
calcium ion homeostasis GO:0055074 162 0.023
amine metabolic process GO:0009308 38 0.023
brain development GO:0007420 247 0.023
response to nutrient levels GO:0031667 370 0.023
negative regulation of cellular metabolic process GO:0031324 281 0.022
cellular homeostasis GO:0019725 252 0.022
cellular component movement GO:0006928 248 0.022
cellular amine metabolic process GO:0044106 38 0.022
regulation of rna biosynthetic process GO:2001141 381 0.022
protein transport GO:0015031 132 0.022
Rat
multicellular organism reproduction GO:0032504 233 0.022
lipid metabolic process GO:0006629 283 0.021
regulation of small gtpase mediated signal transduction GO:0051056 48 0.021
nucleic acid templated transcription GO:0097659 379 0.021
regulation of neuron differentiation GO:0045664 208 0.021
Rat
cell projection organization GO:0030030 302 0.021
Rat
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
positive regulation of protein metabolic process GO:0051247 178 0.021
cell cycle process GO:0022402 57 0.021
positive regulation of cell communication GO:0010647 271 0.021
cellular ion homeostasis GO:0006873 184 0.021
response to growth factor GO:0070848 189 0.021
ion transmembrane transport GO:0034220 365 0.021
metal ion homeostasis GO:0055065 186 0.021
cation homeostasis GO:0055080 195 0.021
regulation of nervous system development GO:0051960 264 0.021
Rat
cell morphogenesis involved in differentiation GO:0000904 119 0.021
signal transduction by phosphorylation GO:0023014 144 0.020
cellular response to hormone stimulus GO:0032870 247 0.020
positive regulation of response to stimulus GO:0048584 285 0.020
negative regulation of intracellular signal transduction GO:1902532 38 0.020
regulation of phosphorylation GO:0042325 248 0.020
proteolysis GO:0006508 175 0.020
organonitrogen compound biosynthetic process GO:1901566 167 0.020
regulation of molecular function GO:0065009 398 0.020
single organism catabolic process GO:0044712 283 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
positive regulation of transport GO:0051050 245 0.020
endocytosis GO:0006897 84 0.020
embryonic pattern specification GO:0009880 1 0.020
cytosolic calcium ion homeostasis GO:0051480 140 0.020
cellular chemical homeostasis GO:0055082 247 0.020
regulation of rna metabolic process GO:0051252 391 0.020
neuron apoptotic process GO:0051402 88 0.020
receptor clustering GO:0043113 13 0.019
response to corticosteroid GO:0031960 235 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
carboxylic acid metabolic process GO:0019752 289 0.019
Rat
positive regulation of nucleic acid templated transcription GO:1903508 197 0.019
sexual reproduction GO:0019953 148 0.019
regulation of transmembrane transport GO:0034762 122 0.019
positive regulation of rna metabolic process GO:0051254 203 0.019
metal ion transport GO:0030001 289 0.019
receptor internalization GO:0031623 14 0.018
negative regulation of cell death GO:0060548 229 0.018
cation transmembrane transport GO:0098655 263 0.018
homeostatic process GO:0042592 331 0.018
regulation of membrane potential GO:0042391 110 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
axonogenesis GO:0007409 71 0.018
cellular calcium ion homeostasis GO:0006874 160 0.018
regulation of cellular protein metabolic process GO:0032268 267 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.018
cellular lipid metabolic process GO:0044255 208 0.018
regulation of cell differentiation GO:0045595 320 0.018
Rat
single organism reproductive process GO:0044702 297 0.018
negative regulation of apoptotic process GO:0043066 181 0.018
neuromuscular process GO:0050905 2 0.017
protein oligomerization GO:0051259 191 0.017
Rat
regulation of cell projection organization GO:0031344 175 0.017
Rat
rhythmic process GO:0048511 156 0.017
cell projection morphogenesis GO:0048858 123 0.017
blood circulation GO:0008015 183 0.017
response to toxic substance GO:0009636 133 0.017
response to calcium ion GO:0051592 59 0.017
neurological system process GO:0050877 219 0.017
axon development GO:0061564 96 0.017
response to monosaccharide GO:0034284 159 0.017
regulation of cell development GO:0060284 263 0.017
Rat
regulation of ion transport GO:0043269 245 0.017
regulation of cell cycle GO:0051726 73 0.017
ionotropic glutamate receptor signaling pathway GO:0035235 34 0.017
negative regulation of macromolecule metabolic process GO:0010605 260 0.016
Rat
positive regulation of neurogenesis GO:0050769 165 0.016
Rat
chromosome organization GO:0051276 36 0.016
response to vitamin GO:0033273 131 0.016
cell part morphogenesis GO:0032990 123 0.016
positive regulation of phosphate metabolic process GO:0045937 262 0.016
cell motility GO:0048870 202 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.016
positive regulation of nervous system development GO:0051962 178 0.016
Rat
cellular response to peptide GO:1901653 133 0.016
regulation of catalytic activity GO:0050790 304 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
Rat
negative regulation of rna metabolic process GO:0051253 123 0.016
cell migration GO:0016477 197 0.016
response to wounding GO:0009611 254 0.016
vesicle mediated transport GO:0016192 181 0.016
localization of cell GO:0051674 202 0.016
peptidyl amino acid modification GO:0018193 126 0.016
regulation of proteasomal protein catabolic process GO:0061136 4 0.016
positive regulation of gene expression GO:0010628 244 0.016
cellular response to organic cyclic compound GO:0071407 202 0.016
Rat
protein localization to membrane GO:0072657 36 0.015
positive regulation of neuron apoptotic process GO:0043525 33 0.015
response to hexose GO:0009746 144 0.015
ribonucleotide metabolic process GO:0009259 231 0.015
regulation of metal ion transport GO:0010959 118 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
response to other organism GO:0051707 220 0.015
regulation of neuronal synaptic plasticity GO:0048168 31 0.015
embryonic axis specification GO:0000578 1 0.015
negative regulation of nucleic acid templated transcription GO:1903507 117 0.015
response to peptide GO:1901652 292 0.015
cell morphogenesis GO:0000902 142 0.015
cellular response to organonitrogen compound GO:0071417 197 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
Rat
negative regulation of programmed cell death GO:0043069 183 0.015
regulation of neuron apoptotic process GO:0043523 83 0.015
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.015
positive regulation of cell proliferation GO:0008284 249 0.015
ion homeostasis GO:0050801 212 0.015
cellular component biogenesis GO:0044085 368 0.015
Rat
positive regulation of transcription dna templated GO:0045893 197 0.015
regulation of secretion GO:0051046 224 0.015
muscle system process GO:0003012 115 0.015
response to carbohydrate GO:0009743 183 0.015
positive regulation of neuron differentiation GO:0045666 126 0.015
Rat
locomotor rhythm GO:0045475 1 0.014
negative regulation of molecular function GO:0044092 133 0.014
macromolecule catabolic process GO:0009057 58 0.014
regulation of cellular catabolic process GO:0031329 101 0.014
positive regulation of ion transport GO:0043270 94 0.014
reactive nitrogen species metabolic process GO:2001057 1 0.014
single organism behavior GO:0044708 130 0.014
organelle localization GO:0051640 55 0.014
sister chromatid segregation GO:0000819 1 0.014
negative regulation of cellular component organization GO:0051129 83 0.014
cell cycle checkpoint GO:0000075 2 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
actin cytoskeleton organization GO:0030036 73 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
sensory perception of pain GO:0019233 73 0.013
regulation of ras protein signal transduction GO:0046578 45 0.013
telencephalon development GO:0021537 62 0.013
regulation of growth GO:0040008 105 0.013
regulation of vesicle mediated transport GO:0060627 81 0.013
dna metabolic process GO:0006259 96 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.013
neuron projection morphogenesis GO:0048812 122 0.013
anatomical structure morphogenesis GO:0009653 298 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.013
regulation of neurogenesis GO:0050767 247 0.013
Rat
mitotic sister chromatid segregation GO:0000070 1 0.013
nucleoside phosphate biosynthetic process GO:1901293 102 0.013
carboxylic acid transport GO:0046942 115 0.013
nucleotide metabolic process GO:0009117 279 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
mitotic cell cycle GO:0000278 49 0.013
negative regulation of innate immune response GO:0045824 4 0.013
positive regulation of cellular component organization GO:0051130 200 0.013
Rat
positive regulation of signaling GO:0023056 270 0.013
negative regulation of cell cycle phase transition GO:1901988 4 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
regulation of chromosome segregation GO:0051983 1 0.013
response to acid chemical GO:0001101 222 0.013
epidermal growth factor receptor signaling pathway GO:0007173 23 0.013
cellular nitrogen compound catabolic process GO:0044270 163 0.013
neuron neuron synaptic transmission GO:0007270 60 0.013
chemosensory behavior GO:0007635 2 0.013
reproduction GO:0000003 245 0.013
glycosyl compound metabolic process GO:1901657 182 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
asymmetric protein localization GO:0008105 2 0.012
regulation of system process GO:0044057 208 0.012
rho protein signal transduction GO:0007266 11 0.012
response to decreased oxygen levels GO:0036293 237 0.012
positive regulation of molecular function GO:0044093 230 0.012
response to ketone GO:1901654 182 0.012
dna integrity checkpoint GO:0031570 2 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
response to external biotic stimulus GO:0043207 221 0.012
cellular response to peptide hormone stimulus GO:0071375 120 0.012
cellular response to lipid GO:0071396 201 0.012
regulation of catabolic process GO:0009894 113 0.012
heterocycle catabolic process GO:0046700 167 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
cytokine biosynthetic process GO:0042089 3 0.012
response to glucose GO:0009749 136 0.012
positive regulation of neuron death GO:1901216 43 0.012
protein modification by small protein conjugation GO:0032446 31 0.012
negative regulation of gene expression GO:0010629 199 0.012
Rat
organonitrogen compound catabolic process GO:1901565 179 0.012
wound healing GO:0042060 122 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.012
protein catabolic process GO:0030163 30 0.012
organic anion transport GO:0015711 132 0.012
regulation of mapk cascade GO:0043408 116 0.012
divalent inorganic cation transport GO:0072511 134 0.012
regulation of protein modification process GO:0031399 194 0.012
protein ubiquitination GO:0016567 28 0.012
purine ribonucleotide metabolic process GO:0009150 227 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
Rat
response to oxidative stress GO:0006979 186 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
cellular macromolecule localization GO:0070727 122 0.011
Rat
carbohydrate homeostasis GO:0033500 75 0.011
negative regulation of biosynthetic process GO:0009890 168 0.011
response to nutrient GO:0007584 248 0.011
oxidation reduction process GO:0055114 304 0.011
sodium ion transmembrane transport GO:0035725 67 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
glucose homeostasis GO:0042593 75 0.011
cell adhesion GO:0007155 110 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
response to lithium ion GO:0010226 28 0.011
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.011
lipid storage GO:0019915 1 0.011
male gamete generation GO:0048232 99 0.011
response to cytokine GO:0034097 215 0.011
response to insulin GO:0032868 133 0.011
synaptic growth at neuromuscular junction GO:0051124 1 0.011
regeneration GO:0031099 163 0.011
eye morphogenesis GO:0048592 4 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.011
multi multicellular organism process GO:0044706 138 0.011
potassium ion transport GO:0006813 97 0.011
organic cyclic compound catabolic process GO:1901361 175 0.011
immune system process GO:0002376 204 0.011
regulation of cell growth GO:0001558 85 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
divalent metal ion transport GO:0070838 132 0.011
cellular cation homeostasis GO:0030003 180 0.011
locomotion GO:0040011 237 0.011
cellular component morphogenesis GO:0032989 155 0.011
response to oxygen levels GO:0070482 265 0.011
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
circulatory system process GO:0003013 183 0.011
cyclic nucleotide metabolic process GO:0009187 80 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
organic hydroxy compound metabolic process GO:1901615 115 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
response to radiation GO:0009314 137 0.011
cytoplasmic transport GO:0016482 115 0.011
Rat
positive regulation of secretion by cell GO:1903532 128 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
positive regulation of cell development GO:0010720 176 0.011
Rat
cellular response to glucose stimulus GO:0071333 65 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
cellular response to insulin stimulus GO:0032869 81 0.011
ribose phosphate metabolic process GO:0019693 235 0.011
aromatic compound catabolic process GO:0019439 168 0.010
purine nucleotide catabolic process GO:0006195 136 0.010
action potential GO:0001508 54 0.010
forebrain development GO:0030900 98 0.010
hormone metabolic process GO:0042445 69 0.010
sequestering of metal ion GO:0051238 9 0.010
negative regulation of transcription dna templated GO:0045892 116 0.010
receptor mediated endocytosis GO:0006898 42 0.010
dephosphorylation GO:0016311 98 0.010
spindle organization GO:0007051 2 0.010
insulin receptor signaling pathway GO:0008286 24 0.010
spermatogenesis GO:0007283 99 0.010
response to ammonium ion GO:0060359 71 0.010
nucleotide catabolic process GO:0009166 139 0.010
gastrulation GO:0007369 2 0.010
gamete generation GO:0007276 124 0.010
negative regulation of cell differentiation GO:0045596 99 0.010
cell type specific apoptotic process GO:0097285 134 0.010
regulation of cytokine biosynthetic process GO:0042035 3 0.010
protein modification by small protein conjugation or removal GO:0070647 35 0.010
striated muscle contraction GO:0006941 44 0.010
monocarboxylic acid metabolic process GO:0032787 152 0.010
erbb signaling pathway GO:0038127 23 0.010
rna localization GO:0006403 4 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.010
regulation of protein phosphorylation GO:0001932 183 0.010
mapk cascade GO:0000165 140 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010

Klhl17 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
disease of metabolism DOID:0014667 0 0.016
sensory system disease DOID:0050155 0 0.016
musculoskeletal system disease DOID:17 0 0.011
central nervous system disease DOID:331 0 0.011
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010
muscular disease DOID:0080000 0 0.010
muscle tissue disease DOID:66 0 0.010