Rattus norvegicus

0 known processes

Duox2

dual oxidase 2

(Aliases: Thox2)

Duox2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
reproductive process GO:0022414 372 0.335
Mouse
response to peptide GO:1901652 292 0.227
programmed cell death GO:0012501 392 0.195
Fly
regulation of apoptotic process GO:0042981 335 0.187
Fly
regulation of programmed cell death GO:0043067 341 0.146
Fly
neurological system process GO:0050877 219 0.143
tissue development GO:0009888 252 0.140
Mouse
cellular response to endogenous stimulus GO:0071495 377 0.132
positive regulation of developmental process GO:0051094 283 0.131
response to oxygen levels GO:0070482 265 0.126
carboxylic acid metabolic process GO:0019752 289 0.102
Mouse
blood circulation GO:0008015 183 0.102
oxoacid metabolic process GO:0043436 290 0.101
Mouse
single organism reproductive process GO:0044702 297 0.092
Mouse
regulation of cell proliferation GO:0042127 359 0.091
cellular response to organic cyclic compound GO:0071407 202 0.090
response to other organism GO:0051707 220 0.089
Human Zebrafish Fly
regulation of blood vessel size GO:0050880 89 0.089
multicellular organismal reproductive process GO:0048609 233 0.086
vascular process in circulatory system GO:0003018 96 0.082
epithelium development GO:0060429 96 0.081
homeostatic process GO:0042592 331 0.073
monocarboxylic acid metabolic process GO:0032787 152 0.070
negative regulation of apoptotic process GO:0043066 181 0.063
Fly
response to decreased oxygen levels GO:0036293 237 0.063
lipid metabolic process GO:0006629 283 0.063
cellular response to biotic stimulus GO:0071216 59 0.062
circulatory system process GO:0003013 183 0.062
cellular response to lipid GO:0071396 201 0.062
regulation of system process GO:0044057 208 0.061
regulation of blood circulation GO:1903522 110 0.058
positive regulation of cell proliferation GO:0008284 249 0.057
reproduction GO:0000003 245 0.056
Mouse
response to corticosteroid GO:0031960 235 0.056
positive regulation of cellular biosynthetic process GO:0031328 295 0.055
cellular catabolic process GO:0044248 295 0.055
response to wounding GO:0009611 254 0.055
Zebrafish
neuron differentiation GO:0030182 368 0.054
response to acid chemical GO:0001101 222 0.053
response to biotic stimulus GO:0009607 226 0.053
Human Zebrafish Fly
ion homeostasis GO:0050801 212 0.053
behavior GO:0007610 205 0.052
aging GO:0007568 241 0.052
response to metal ion GO:0010038 253 0.051
chemical homeostasis GO:0048878 292 0.050
positive regulation of apoptotic process GO:0043065 154 0.050
sexual reproduction GO:0019953 148 0.050
Mouse
negative regulation of cell death GO:0060548 229 0.050
Fly
response to nutrient GO:0007584 248 0.049
intracellular signal transduction GO:0035556 314 0.048
catabolic process GO:0009056 351 0.047
small molecule biosynthetic process GO:0044283 124 0.046
response to estrogen GO:0043627 232 0.046
purine containing compound metabolic process GO:0072521 253 0.046
cytokine biosynthetic process GO:0042089 3 0.045
apoptotic process GO:0006915 381 0.045
Fly
somatostatin receptor signaling pathway GO:0038169 4 0.043
metal ion transport GO:0030001 289 0.043
carboxylic acid biosynthetic process GO:0046394 83 0.043
multicellular organism reproduction GO:0032504 233 0.043
cellular chemical homeostasis GO:0055082 247 0.042
multicellular organismal signaling GO:0035637 44 0.042
organelle organization GO:0006996 266 0.041
single organism catabolic process GO:0044712 283 0.041
regulation of cytokine biosynthetic process GO:0042035 3 0.041
cellular modified amino acid metabolic process GO:0006575 61 0.040
Mouse
response to peptide hormone GO:0043434 278 0.039
macromolecular complex subunit organization GO:0043933 339 0.039
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.039
nucleotide metabolic process GO:0009117 279 0.038
cell cell signaling GO:0007267 335 0.038
response to ketone GO:1901654 182 0.038
regulation of intracellular signal transduction GO:1902531 218 0.038
cation transport GO:0006812 382 0.038
cellular homeostasis GO:0019725 252 0.038
cellular ion homeostasis GO:0006873 184 0.038
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.037
ion transmembrane transport GO:0034220 365 0.037
cation homeostasis GO:0055080 195 0.036
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.035
cellular response to oxygen containing compound GO:1901701 386 0.035
g protein coupled receptor signaling pathway GO:0007186 242 0.035
positive regulation of multicellular organismal process GO:0051240 387 0.035
sex differentiation GO:0007548 113 0.035
response to extracellular stimulus GO:0009991 380 0.035
phasic smooth muscle contraction GO:0014821 3 0.035
regulation of cell migration GO:0030334 128 0.035
cellular response to nitrogen compound GO:1901699 210 0.035
metal ion homeostasis GO:0055065 186 0.034
organic substance catabolic process GO:1901575 316 0.034
organophosphate metabolic process GO:0019637 370 0.034
response to axon injury GO:0048678 59 0.034
organic acid biosynthetic process GO:0016053 83 0.033
multi organism reproductive process GO:0044703 262 0.033
Mouse
regulation of leukocyte migration GO:0002685 24 0.033
response to transition metal nanoparticle GO:1990267 122 0.033
central nervous system development GO:0007417 311 0.033
Mouse
gamete generation GO:0007276 124 0.032
positive regulation of cell communication GO:0010647 271 0.032
sensory perception of pain GO:0019233 73 0.032
positive regulation of rna metabolic process GO:0051254 203 0.032
regulation of cellular component movement GO:0051270 150 0.032
regulation of signal transduction GO:0009966 318 0.032
positive regulation of cell motility GO:2000147 97 0.031
cellular macromolecule localization GO:0070727 122 0.031
regulation of molecular function GO:0065009 398 0.030
axon development GO:0061564 96 0.030
single organism biosynthetic process GO:0044711 342 0.030
cellular cation homeostasis GO:0030003 180 0.030
cellular divalent inorganic cation homeostasis GO:0072503 162 0.029
cellular component movement GO:0006928 248 0.029
Zebrafish
response to vitamin GO:0033273 131 0.029
spermatogenesis GO:0007283 99 0.029
dna metabolic process GO:0006259 96 0.029
macromolecular complex assembly GO:0065003 273 0.029
hormone metabolic process GO:0042445 69 0.029
Mouse
purine nucleoside metabolic process GO:0042278 169 0.029
peristalsis GO:0030432 2 0.028
organic acid metabolic process GO:0006082 292 0.028
Mouse
transmission of nerve impulse GO:0019226 42 0.028
wound healing GO:0042060 122 0.028
proteolysis GO:0006508 175 0.028
cellular metal ion homeostasis GO:0006875 172 0.028
cell migration GO:0016477 197 0.028
Zebrafish
epithelial cell differentiation GO:0030855 71 0.028
positive regulation of protein metabolic process GO:0051247 178 0.027
positive regulation of gene expression GO:0010628 244 0.027
fat soluble vitamin biosynthetic process GO:0042362 2 0.027
divalent inorganic cation homeostasis GO:0072507 165 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
reproductive structure development GO:0048608 128 0.026
regulation of phosphorus metabolic process GO:0051174 349 0.026
response to hypoxia GO:0001666 231 0.026
regulation of cell differentiation GO:0045595 320 0.026
synaptic transmission gabaergic GO:0051932 22 0.025
regulation of heart contraction GO:0008016 48 0.025
monovalent inorganic cation transport GO:0015672 172 0.025
regulation of anatomical structure size GO:0090066 135 0.025
mapk cascade GO:0000165 140 0.025
response to inorganic substance GO:0010035 377 0.025
negative regulation of cell proliferation GO:0008285 119 0.025
regulation of leukocyte activation GO:0002694 45 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.025
positive regulation of phosphorus metabolic process GO:0010562 262 0.025
response to lipopolysaccharide GO:0032496 191 0.024
cellular response to stress GO:0033554 269 0.024
regulation of tube size GO:0035150 89 0.024
regulation of phosphorylation GO:0042325 248 0.024
negative regulation of multicellular organismal process GO:0051241 203 0.024
regulation of neurogenesis GO:0050767 247 0.024
head development GO:0060322 247 0.024
Mouse
purine ribonucleoside metabolic process GO:0046128 168 0.024
amine metabolic process GO:0009308 38 0.024
cellular response to metal ion GO:0071248 55 0.024
positive regulation of nucleoside metabolic process GO:0045979 55 0.023
positive regulation of biosynthetic process GO:0009891 319 0.023
carbohydrate derivative metabolic process GO:1901135 346 0.023
regulation of vasodilation GO:0042312 36 0.023
neuron projection development GO:0031175 273 0.023
cellular calcium ion homeostasis GO:0006874 160 0.023
development of primary sexual characteristics GO:0045137 107 0.023
regulation of cellular ketone metabolic process GO:0010565 27 0.023
cytokine production GO:0001816 61 0.023
cell adhesion GO:0007155 110 0.023
regulation of protein metabolic process GO:0051246 289 0.022
localization of cell GO:0051674 202 0.022
Zebrafish
single organism behavior GO:0044708 130 0.022
regulation of cell motility GO:2000145 131 0.022
rna biosynthetic process GO:0032774 380 0.022
regeneration GO:0031099 163 0.022
protein complex biogenesis GO:0070271 263 0.022
response to histamine GO:0034776 3 0.022
cellular amino acid metabolic process GO:0006520 107 0.022
Mouse
cellular response to alcohol GO:0097306 87 0.021
regulation of hormone secretion GO:0046883 106 0.021
cellular response to molecule of bacterial origin GO:0071219 56 0.021
nucleobase containing small molecule metabolic process GO:0055086 316 0.021
regulation of multicellular organismal development GO:2000026 376 0.021
regulation of establishment of planar polarity GO:0090175 2 0.021
regulation of catalytic activity GO:0050790 304 0.021
response to ethanol GO:0045471 162 0.021
positive regulation of nervous system development GO:0051962 178 0.021
organic hydroxy compound metabolic process GO:1901615 115 0.021
Mouse
nitrogen compound transport GO:0071705 229 0.021
inorganic ion transmembrane transport GO:0098660 229 0.021
somatostatin signaling pathway GO:0038170 4 0.021
hormone secretion GO:0046879 115 0.021
hormone transport GO:0009914 121 0.020
cellular component assembly GO:0022607 360 0.020
anion transport GO:0006820 178 0.020
regulation of cellular protein metabolic process GO:0032268 267 0.020
rhythmic process GO:0048511 156 0.020
regulation of proteolysis GO:0030162 66 0.020
regulation of secretion GO:0051046 224 0.020
cellular ketone metabolic process GO:0042180 51 0.019
regulation of locomotion GO:0040012 148 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
developmental process involved in reproduction GO:0003006 159 0.019
adenylate cyclase inhibiting opioid receptor signaling pathway GO:0031635 2 0.019
positive regulation of catalytic activity GO:0043085 184 0.019
transmembrane transport GO:0055085 412 0.019
cellular protein localization GO:0034613 122 0.019
regulation of neurological system process GO:0031644 43 0.019
synaptic transmission glycinergic GO:0060012 2 0.019
positive regulation of programmed cell death GO:0043068 157 0.019
purine nucleotide metabolic process GO:0006163 229 0.018
sensory perception GO:0007600 101 0.018
response to food GO:0032094 27 0.018
regulation of vasoconstriction GO:0019229 44 0.018
vasoconstriction GO:0042310 54 0.018
small gtpase mediated signal transduction GO:0007264 36 0.018
calcium ion homeostasis GO:0055074 162 0.018
carbohydrate metabolic process GO:0005975 130 0.018
positive regulation of ion transport GO:0043270 94 0.018
protein complex subunit organization GO:0071822 302 0.018
negative regulation of response to external stimulus GO:0032102 37 0.018
potassium ion transport GO:0006813 97 0.017
positive regulation of signaling GO:0023056 270 0.017
sodium ion transport GO:0006814 82 0.017
organonitrogen compound catabolic process GO:1901565 179 0.017
cell motility GO:0048870 202 0.017
Zebrafish
axis specification GO:0009798 4 0.017
inflammatory response to antigenic stimulus GO:0002437 18 0.017
neuronal action potential GO:0019228 35 0.017
regulation of metal ion transport GO:0010959 118 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.017
positive regulation of blood circulation GO:1903524 65 0.017
negative regulation of transport GO:0051051 136 0.017
regulation of cellular localization GO:0060341 263 0.017
ribonucleoside metabolic process GO:0009119 174 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.017
muscle cell proliferation GO:0033002 84 0.017
nucleic acid templated transcription GO:0097659 379 0.016
response to hexose GO:0009746 144 0.016
response to bacterium GO:0009617 200 0.016
Zebrafish Fly
protein complex assembly GO:0006461 263 0.016
cellular amine metabolic process GO:0044106 38 0.016
response to estradiol GO:0032355 164 0.016
female pregnancy GO:0007565 122 0.016
establishment of synaptic specificity at neuromuscular junction GO:0007529 1 0.016
response to amino acid GO:0043200 75 0.016
lipid biosynthetic process GO:0008610 128 0.016
negative regulation of secretion GO:0051048 82 0.016
peptide secretion GO:0002790 86 0.016
positive regulation of adiponectin secretion GO:0070165 1 0.016
response to external biotic stimulus GO:0043207 221 0.015
Human Zebrafish Fly
regulation of nucleotide metabolic process GO:0006140 117 0.015
regulation of nucleic acid templated transcription GO:1903506 380 0.015
regulation of smooth muscle cell proliferation GO:0048660 75 0.015
lymphocyte migration GO:0072676 3 0.015
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.015
positive regulation of cell migration GO:0030335 96 0.015
regulation of synaptic transmission GO:0050804 141 0.015
cell projection organization GO:0030030 302 0.015
positive regulation of molecular function GO:0044093 230 0.015
chemokine metabolic process GO:0050755 3 0.015
positive regulation of cell death GO:0010942 184 0.015
positive regulation of cellular component movement GO:0051272 102 0.015
response to alkaloid GO:0043279 132 0.015
secretion GO:0046903 307 0.015
positive regulation of cellular protein metabolic process GO:0032270 167 0.015
muscle contraction GO:0006936 88 0.015
muscle system process GO:0003012 115 0.015
reproductive system development GO:0061458 128 0.015
positive regulation of leukocyte migration GO:0002687 21 0.015
response to organophosphorus GO:0046683 102 0.015
Human
potassium ion transmembrane transport GO:0071805 71 0.015
regulation of hydrolase activity GO:0051336 143 0.014
peptide hormone secretion GO:0030072 84 0.014
sensory perception of bitter taste GO:0050913 4 0.014
protein phosphorylation GO:0006468 345 0.014
divalent metal ion transport GO:0070838 132 0.014
vesicle mediated transport GO:0016192 181 0.014
negative regulation of metabolic process GO:0009892 331 0.014
neuron development GO:0048666 286 0.014
regulation of neuron projection development GO:0010975 161 0.014
response to nutrient levels GO:0031667 370 0.014
amide transport GO:0042886 105 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
unsaturated fatty acid metabolic process GO:0033559 39 0.014
fatty acid derivative metabolic process GO:1901568 38 0.014
regulation of response to stress GO:0080134 126 0.014
ras protein signal transduction GO:0007265 29 0.014
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.014
positive regulation of cell differentiation GO:0045597 217 0.014
ribonucleotide metabolic process GO:0009259 231 0.014
cellular response to nutrient GO:0031670 30 0.014
gland development GO:0048732 155 0.014
Mouse
development of primary female sexual characteristics GO:0046545 56 0.014
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.013
regulation of establishment of protein localization GO:0070201 69 0.013
calcium ion transport GO:0006816 131 0.013
aromatic compound catabolic process GO:0019439 168 0.013
cellular component biogenesis GO:0044085 368 0.013
actin filament based process GO:0030029 86 0.013
cellular response to lipopolysaccharide GO:0071222 55 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.013
carbohydrate homeostasis GO:0033500 75 0.013
cellular response to acid chemical GO:0071229 75 0.013
regulation of neuron differentiation GO:0045664 208 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
reactive oxygen species metabolic process GO:0072593 37 0.013
Zebrafish Fly
gastrulation GO:0007369 2 0.013
anatomical structure morphogenesis GO:0009653 298 0.013
Mouse
male gamete generation GO:0048232 99 0.013
cellular response to low density lipoprotein particle stimulus GO:0071404 3 0.013
gonad development GO:0008406 104 0.013
regulation of response to wounding GO:1903034 69 0.013
regulation of ion transport GO:0043269 245 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
vasodilation GO:0042311 44 0.013
guanosine containing compound catabolic process GO:1901069 71 0.013
regulation of homeostatic process GO:0032844 101 0.013
signal transduction by phosphorylation GO:0023014 144 0.013
t cell migration GO:0072678 2 0.012
brain development GO:0007420 247 0.012
Mouse
regulation of small gtpase mediated signal transduction GO:0051056 48 0.012
regulation of immunoglobulin production GO:0002637 4 0.012
regulation of cellular amino acid metabolic process GO:0006521 2 0.012
protein oligomerization GO:0051259 191 0.012
multi multicellular organism process GO:0044706 138 0.012
negative regulation of calcium ion dependent exocytosis GO:0045955 5 0.012
response to electrical stimulus GO:0051602 56 0.012
glycosyl compound catabolic process GO:1901658 126 0.012
digestive system development GO:0055123 41 0.012
glycosyl compound metabolic process GO:1901657 182 0.012
cellular response to peptide GO:1901653 133 0.012
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
Zebrafish
regulation of cell activation GO:0050865 50 0.012
glutamate receptor signaling pathway GO:0007215 43 0.012
regulation of muscle contraction GO:0006937 53 0.012
regulation of sensory perception of pain GO:0051930 29 0.012
cellular lipid metabolic process GO:0044255 208 0.012
regulation of dna metabolic process GO:0051052 60 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.012
positive regulation of nucleotide metabolic process GO:0045981 91 0.012
regulation of rna biosynthetic process GO:2001141 381 0.012
cellular response to tumor necrosis factor GO:0071356 46 0.012
positive regulation of signal transduction GO:0009967 175 0.012
regulation of rna metabolic process GO:0051252 391 0.012
insulin secretion GO:0030073 69 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
t cell chemotaxis GO:0010818 2 0.012
positive regulation of protein phosphorylation GO:0001934 135 0.011
regulation of embryonic development GO:0045995 2 0.011
establishment of protein localization GO:0045184 141 0.011
response to oxidative stress GO:0006979 186 0.011
formation of primary germ layer GO:0001704 1 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
transcription dna templated GO:0006351 377 0.011
signal release GO:0023061 145 0.011
purine nucleoside triphosphate catabolic process GO:0009146 122 0.011
positive regulation of cell development GO:0010720 176 0.011
regulation of cellular amine metabolic process GO:0033238 8 0.011
response to growth factor GO:0070848 189 0.011
regulation of peptide hormone secretion GO:0090276 80 0.011
negative regulation of cellular metabolic process GO:0031324 281 0.011
response to glucocorticoid GO:0051384 223 0.011
response to ammonium ion GO:0060359 71 0.011
synaptic transmission GO:0007268 235 0.011
cellular response to extracellular stimulus GO:0031668 73 0.011
positive regulation of transport GO:0051050 245 0.011
epidermis development GO:0008544 11 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
regulation of secretion by cell GO:1903530 208 0.011
defense response GO:0006952 194 0.011
Zebrafish Fly
icosanoid metabolic process GO:0006690 38 0.011
keratinocyte differentiation GO:0030216 2 0.011
female sex differentiation GO:0046660 59 0.011
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.011
positive regulation of kinase activity GO:0033674 77 0.011
intracellular transport GO:0046907 185 0.011
negative regulation of oxidoreductase activity GO:0051354 4 0.011
response to carbohydrate GO:0009743 183 0.011
neuron neuron synaptic transmission GO:0007270 60 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
forebrain development GO:0030900 98 0.011
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
cellular response to nutrient levels GO:0031669 60 0.011
lymphocyte chemotaxis GO:0048247 3 0.010
phosphatidylinositol dephosphorylation GO:0046856 4 0.010
positive regulation of protein modification process GO:0031401 142 0.010
smooth muscle cell proliferation GO:0048659 77 0.010
response to calcium ion GO:0051592 59 0.010
ovulation cycle process GO:0022602 50 0.010
nucleoside phosphate metabolic process GO:0006753 283 0.010
regulation of anion transport GO:0044070 43 0.010
ribonucleoside triphosphate metabolic process GO:0009199 141 0.010
response to mechanical stimulus GO:0009612 134 0.010
regulation of transmembrane transport GO:0034762 122 0.010
regulation of phosphate metabolic process GO:0019220 349 0.010
positive regulation of phosphorylation GO:0042327 177 0.010
negative regulation of cell communication GO:0010648 158 0.010
gtp metabolic process GO:0046039 72 0.010
response to low density lipoprotein particle GO:0055098 4 0.010
ovulation cycle GO:0042698 67 0.010
positive regulation of angiogenesis GO:0045766 28 0.010

Duox2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
Human
nervous system disease DOID:863 0 0.016
musculoskeletal system disease DOID:17 0 0.016
connective tissue disease DOID:65 0 0.015