Rattus norvegicus

0 known processes

Lrrk1

leucine-rich repeat kinase 1

Lrrk1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to hormone stimulus GO:0032870 247 0.090
intracellular signal transduction GO:0035556 314 0.088
protein complex subunit organization GO:0071822 302 0.065
response to acid chemical GO:0001101 222 0.062
macromolecular complex subunit organization GO:0043933 339 0.062
protein phosphorylation GO:0006468 345 0.061
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.061
organic acid metabolic process GO:0006082 292 0.058
cellular component assembly GO:0022607 360 0.057
regulation of rna metabolic process GO:0051252 391 0.056
response to peptide GO:1901652 292 0.056
response to ketone GO:1901654 182 0.054
response to estrogen GO:0043627 232 0.053
cellular component biogenesis GO:0044085 368 0.050
response to inorganic substance GO:0010035 377 0.050
cellular response to oxygen containing compound GO:1901701 386 0.048
response to extracellular stimulus GO:0009991 380 0.048
response to metal ion GO:0010038 253 0.046
response to peptide hormone GO:0043434 278 0.046
regulation of apoptotic process GO:0042981 335 0.046
apoptotic process GO:0006915 381 0.046
carboxylic acid metabolic process GO:0019752 289 0.044
response to oxidative stress GO:0006979 186 0.044
cellular catabolic process GO:0044248 295 0.044
anatomical structure morphogenesis GO:0009653 298 0.044
regulation of multicellular organismal development GO:2000026 376 0.043
response to nutrient levels GO:0031667 370 0.043
catabolic process GO:0009056 351 0.043
oxoacid metabolic process GO:0043436 290 0.042
response to corticosteroid GO:0031960 235 0.042
protein complex biogenesis GO:0070271 263 0.042
central nervous system development GO:0007417 311 0.042
cellular response to organic cyclic compound GO:0071407 202 0.040
cellular response to nitrogen compound GO:1901699 210 0.040
cellular component movement GO:0006928 248 0.039
programmed cell death GO:0012501 392 0.039
negative regulation of gene expression GO:0010629 199 0.038
brain development GO:0007420 247 0.038
macromolecular complex assembly GO:0065003 273 0.038
regulation of programmed cell death GO:0043067 341 0.038
regulation of phosphate metabolic process GO:0019220 349 0.037
protein oligomerization GO:0051259 191 0.037
tissue development GO:0009888 252 0.037
response to organophosphorus GO:0046683 102 0.036
protein complex assembly GO:0006461 263 0.035
response to oxygen levels GO:0070482 265 0.035
cellular response to endogenous stimulus GO:0071495 377 0.034
multi organism reproductive process GO:0044703 262 0.034
single organism reproductive process GO:0044702 297 0.034
negative regulation of metabolic process GO:0009892 331 0.034
rna biosynthetic process GO:0032774 380 0.033
positive regulation of cellular biosynthetic process GO:0031328 295 0.033
reproduction GO:0000003 245 0.033
female gonad development GO:0008585 53 0.033
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.033
reproductive process GO:0022414 372 0.033
enzyme linked receptor protein signaling pathway GO:0007167 116 0.032
transcription dna templated GO:0006351 377 0.032
response to transition metal nanoparticle GO:1990267 122 0.032
response to growth factor GO:0070848 189 0.031
cellular response to stress GO:0033554 269 0.031
response to external biotic stimulus GO:0043207 221 0.031
eye morphogenesis GO:0048592 4 0.030
nucleic acid templated transcription GO:0097659 379 0.030
rhythmic process GO:0048511 156 0.030
regulation of molecular function GO:0065009 398 0.030
regulation of cellular localization GO:0060341 263 0.030
cellular response to organonitrogen compound GO:0071417 197 0.029
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.029
multicellular organism reproduction GO:0032504 233 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.029
cellular response to lipid GO:0071396 201 0.029
organic substance catabolic process GO:1901575 316 0.029
regulation of cellular ketone metabolic process GO:0010565 27 0.028
regulation of signal transduction GO:0009966 318 0.027
regulation of protein metabolic process GO:0051246 289 0.027
regulation of cell differentiation GO:0045595 320 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.026
regeneration GO:0031099 163 0.026
cellular component morphogenesis GO:0032989 155 0.026
positive regulation of nucleic acid templated transcription GO:1903508 197 0.026
positive regulation of rna metabolic process GO:0051254 203 0.025
regulation of rna biosynthetic process GO:2001141 381 0.025
organonitrogen compound catabolic process GO:1901565 179 0.025
cellular amine metabolic process GO:0044106 38 0.025
single organism catabolic process GO:0044712 283 0.025
transmembrane transport GO:0055085 412 0.025
head development GO:0060322 247 0.025
response to nutrient GO:0007584 248 0.025
positive regulation of gene expression GO:0010628 244 0.025
aging GO:0007568 241 0.025
positive regulation of biosynthetic process GO:0009891 319 0.024
positive regulation of rna biosynthetic process GO:1902680 197 0.024
response to alkaloid GO:0043279 132 0.024
regulation of protein modification process GO:0031399 194 0.024
transcription from rna polymerase ii promoter GO:0006366 252 0.024
response to hypoxia GO:0001666 231 0.024
cellular amino acid metabolic process GO:0006520 107 0.024
response to ethanol GO:0045471 162 0.024
single organism biosynthetic process GO:0044711 342 0.023
development of primary female sexual characteristics GO:0046545 56 0.023
positive regulation of transport GO:0051050 245 0.023
secretion by cell GO:0032940 248 0.023
response to hydrogen peroxide GO:0042542 89 0.023
lipid metabolic process GO:0006629 283 0.023
positive regulation of cell proliferation GO:0008284 249 0.023
response to glucocorticoid GO:0051384 223 0.023
cellular ketone metabolic process GO:0042180 51 0.023
regulation of cell adhesion GO:0030155 52 0.023
immune system process GO:0002376 204 0.023
rna metabolic process GO:0016070 406 0.023
regulation of secretion by cell GO:1903530 208 0.022
negative regulation of programmed cell death GO:0043069 183 0.022
regulation of nervous system development GO:0051960 264 0.022
regulation of secretion GO:0051046 224 0.022
regulation of cellular component organization GO:0051128 368 0.022
positive regulation of cell death GO:0010942 184 0.022
monocarboxylic acid metabolic process GO:0032787 152 0.021
response to reactive oxygen species GO:0000302 120 0.021
response to other organism GO:0051707 220 0.021
positive regulation of developmental process GO:0051094 283 0.021
organophosphate metabolic process GO:0019637 370 0.021
response to vitamin GO:0033273 131 0.021
response to insulin GO:0032868 133 0.021
cellular response to steroid hormone stimulus GO:0071383 93 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.021
amine metabolic process GO:0009308 38 0.021
secretion GO:0046903 307 0.021
localization of cell GO:0051674 202 0.021
negative regulation of response to stimulus GO:0048585 155 0.020
response to decreased oxygen levels GO:0036293 237 0.020
negative regulation of cellular metabolic process GO:0031324 281 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
positive regulation of molecular function GO:0044093 230 0.020
regulation of cell proliferation GO:0042127 359 0.020
nucleotide metabolic process GO:0009117 279 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.020
positive regulation of cell communication GO:0010647 271 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
cellular response to growth factor stimulus GO:0071363 162 0.020
multicellular organismal reproductive process GO:0048609 233 0.019
negative regulation of multicellular organismal process GO:0051241 203 0.019
cellular response to peptide GO:1901653 133 0.019
positive regulation of transcription dna templated GO:0045893 197 0.019
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
response to carbohydrate GO:0009743 183 0.019
forebrain development GO:0030900 98 0.019
response to cytokine GO:0034097 215 0.019
positive regulation of cellular component organization GO:0051130 200 0.019
response to wounding GO:0009611 254 0.019
cellular lipid metabolic process GO:0044255 208 0.018
negative regulation of apoptotic process GO:0043066 181 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
regulation of anatomical structure morphogenesis GO:0022603 141 0.018
response to purine containing compound GO:0014074 126 0.018
regulation of catalytic activity GO:0050790 304 0.018
organ regeneration GO:0031100 101 0.018
negative regulation of cell death GO:0060548 229 0.018
positive regulation of programmed cell death GO:0043068 157 0.017
macromolecule localization GO:0033036 252 0.017
response to bacterium GO:0009617 200 0.017
regulation of transcription dna templated GO:0006355 374 0.017
positive regulation of protein metabolic process GO:0051247 178 0.017
protein localization GO:0008104 191 0.017
positive regulation of cell differentiation GO:0045597 217 0.017
regulation of neurogenesis GO:0050767 247 0.017
cellular response to acid chemical GO:0071229 75 0.017
nitrogen compound transport GO:0071705 229 0.017
regulation of phosphorylation GO:0042325 248 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.017
cell adhesion GO:0007155 110 0.017
negative regulation of signaling GO:0023057 157 0.017
neurological system process GO:0050877 219 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.017
ras protein signal transduction GO:0007265 29 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
carbohydrate derivative metabolic process GO:1901135 346 0.016
negative regulation of cell communication GO:0010648 158 0.016
gamete generation GO:0007276 124 0.016
vesicle mediated transport GO:0016192 181 0.016
oxidation reduction process GO:0055114 304 0.016
proteolysis GO:0006508 175 0.016
response to radiation GO:0009314 137 0.016
negative regulation of macromolecule metabolic process GO:0010605 260 0.015
reproductive structure development GO:0048608 128 0.015
cellular response to peptide hormone stimulus GO:0071375 120 0.015
gastrulation GO:0007369 2 0.015
sex differentiation GO:0007548 113 0.015
axis specification GO:0009798 4 0.015
response to monosaccharide GO:0034284 159 0.015
organic anion transport GO:0015711 132 0.015
developmental process involved in reproduction GO:0003006 159 0.015
epithelium development GO:0060429 96 0.015
growth GO:0040007 165 0.015
cardiovascular system development GO:0072358 134 0.015
action potential GO:0001508 54 0.015
gland development GO:0048732 155 0.015
reproductive system development GO:0061458 128 0.015
ossification GO:0001503 70 0.015
regulation of nucleic acid templated transcription GO:1903506 380 0.015
protein heterooligomerization GO:0051291 89 0.015
biological adhesion GO:0022610 110 0.015
negative regulation of cellular biosynthetic process GO:0031327 161 0.015
dna metabolic process GO:0006259 96 0.015
small gtpase mediated signal transduction GO:0007264 36 0.015
wound healing GO:0042060 122 0.015
anterior posterior pattern specification GO:0009952 1 0.015
organ morphogenesis GO:0009887 75 0.015
cellular homeostasis GO:0019725 252 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
skeletal system development GO:0001501 41 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.015
chemical homeostasis GO:0048878 292 0.014
ovulation cycle GO:0042698 67 0.014
positive regulation of response to stimulus GO:0048584 285 0.014
protein transport GO:0015031 132 0.014
neuron development GO:0048666 286 0.014
ribonucleotide metabolic process GO:0009259 231 0.014
organelle organization GO:0006996 266 0.014
establishment of protein localization GO:0045184 141 0.014
regulation of embryonic development GO:0045995 2 0.014
response to amino acid GO:0043200 75 0.014
metal ion homeostasis GO:0055065 186 0.014
regulation of cell development GO:0060284 263 0.014
cation homeostasis GO:0055080 195 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
single organism organelle organization GO:1902589 180 0.014
female sex differentiation GO:0046660 59 0.014
regulation of hormone levels GO:0010817 187 0.014
sexual reproduction GO:0019953 148 0.014
response to toxic substance GO:0009636 133 0.014
regulation of immune system process GO:0002682 123 0.014
neuron projection development GO:0031175 273 0.014
neuron differentiation GO:0030182 368 0.014
regulation of neuron projection development GO:0010975 161 0.013
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.013
response to molecule of bacterial origin GO:0002237 194 0.013
cellular cation homeostasis GO:0030003 180 0.013
liver development GO:0001889 90 0.013
regulation of response to stress GO:0080134 126 0.013
vasculogenesis GO:0001570 3 0.013
regulation of cell migration GO:0030334 128 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
single organism intracellular transport GO:1902582 166 0.013
response to retinoic acid GO:0032526 63 0.013
cell morphogenesis GO:0000902 142 0.013
urogenital system development GO:0001655 78 0.013
negative regulation of cell differentiation GO:0045596 99 0.013
cell motility GO:0048870 202 0.013
ion homeostasis GO:0050801 212 0.013
digestive system development GO:0055123 41 0.013
homeostatic process GO:0042592 331 0.013
positive regulation of immune system process GO:0002684 90 0.013
response to lipopolysaccharide GO:0032496 191 0.013
regulation of transferase activity GO:0051338 123 0.012
limbic system development GO:0021761 38 0.012
cellular chemical homeostasis GO:0055082 247 0.012
regulation of bmp signaling pathway GO:0030510 2 0.012
salivary gland development GO:0007431 3 0.012
telencephalon development GO:0021537 62 0.012
response to estradiol GO:0032355 164 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
inorganic ion transmembrane transport GO:0098660 229 0.012
digestive tract development GO:0048565 39 0.012
positive regulation of nervous system development GO:0051962 178 0.012
embryonic skeletal system development GO:0048706 3 0.012
circulatory system development GO:0072359 134 0.012
tube development GO:0035295 89 0.012
positive regulation of lipid kinase activity GO:0090218 2 0.012
regulation of phosphorus metabolic process GO:0051174 349 0.012
cell cell signaling GO:0007267 335 0.012
spermatogenesis GO:0007283 99 0.012
positive regulation of phosphate metabolic process GO:0045937 262 0.012
response to hyperoxia GO:0055093 45 0.012
defense response to gram negative bacterium GO:0050829 3 0.012
response to biotic stimulus GO:0009607 226 0.012
cation transport GO:0006812 382 0.012
fatty acid metabolic process GO:0006631 99 0.012
cellular ion homeostasis GO:0006873 184 0.012
negative regulation of molecular function GO:0044092 133 0.012
carbohydrate metabolic process GO:0005975 130 0.012
learning or memory GO:0007611 90 0.012
regulation of growth GO:0040008 105 0.012
behavior GO:0007610 205 0.012
positive regulation of protein modification process GO:0031401 142 0.012
female pregnancy GO:0007565 122 0.012
regulation of cellular component movement GO:0051270 150 0.011
regulation of dna metabolic process GO:0051052 60 0.011
embryonic pattern specification GO:0009880 1 0.011
positive regulation of secretion GO:0051047 140 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
negative regulation of developmental process GO:0051093 125 0.011
cytoplasmic transport GO:0016482 115 0.011
cell growth GO:0016049 104 0.011
gonad development GO:0008406 104 0.011
male gamete generation GO:0048232 99 0.011
response to camp GO:0051591 91 0.011
negative regulation of signal transduction GO:0009968 83 0.011
anatomical structure formation involved in morphogenesis GO:0048646 83 0.011
response to testosterone GO:0033574 55 0.011
kidney development GO:0001822 67 0.011
rho protein signal transduction GO:0007266 11 0.011
regulation of stem cell differentiation GO:2000736 2 0.011
regulation of body fluid levels GO:0050878 90 0.011
lipid localization GO:0010876 62 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
negative regulation of transport GO:0051051 136 0.011
peptidyl tyrosine modification GO:0018212 72 0.011
response to nicotine GO:0035094 51 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
formation of primary germ layer GO:0001704 1 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
positive regulation of secretion by cell GO:1903532 128 0.011
anion transport GO:0006820 178 0.011
positive regulation of signal transduction GO:0009967 175 0.011
regulation of hydrolase activity GO:0051336 143 0.011
limb morphogenesis GO:0035108 4 0.011
organic hydroxy compound transport GO:0015850 77 0.011
positive regulation of phosphorus metabolic process GO:0010562 262 0.010
cellular response to abiotic stimulus GO:0071214 85 0.010
cellular divalent inorganic cation homeostasis GO:0072503 162 0.010
cellular calcium ion homeostasis GO:0006874 160 0.010
b cell differentiation GO:0030183 2 0.010
heart development GO:0007507 72 0.010
regulation of membrane potential GO:0042391 110 0.010
camera type eye morphogenesis GO:0048593 2 0.010
regulation of protein localization GO:0032880 81 0.010
response to fatty acid GO:0070542 65 0.010
ion transmembrane transport GO:0034220 365 0.010
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.010
positive regulation of signaling GO:0023056 270 0.010
response to glucose GO:0009749 136 0.010
organonitrogen compound biosynthetic process GO:1901566 167 0.010
embryonic axis specification GO:0000578 1 0.010

Lrrk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
musculoskeletal system disease DOID:17 0 0.025
connective tissue disease DOID:65 0 0.014
nervous system disease DOID:863 0 0.014
disease of metabolism DOID:0014667 0 0.013
myopathy DOID:423 0 0.011
muscular disease DOID:0080000 0 0.011
muscle tissue disease DOID:66 0 0.011
central nervous system disease DOID:331 0 0.010