Rattus norvegicus

10 known processes

Lrrk2

leucine-rich repeat kinase 2

Lrrk2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carbohydrate derivative metabolic process GO:1901135 346 0.068
nucleobase containing small molecule metabolic process GO:0055086 316 0.058
nucleoside phosphate metabolic process GO:0006753 283 0.055
aromatic compound catabolic process GO:0019439 168 0.053
single organism catabolic process GO:0044712 283 0.052
purine containing compound metabolic process GO:0072521 253 0.050
nucleotide metabolic process GO:0009117 279 0.048
organic acid metabolic process GO:0006082 292 0.048
purine ribonucleotide metabolic process GO:0009150 227 0.047
organophosphate metabolic process GO:0019637 370 0.047
cellular component biogenesis GO:0044085 368 0.047
purine nucleotide metabolic process GO:0006163 229 0.047
ribonucleotide metabolic process GO:0009259 231 0.046
organic substance catabolic process GO:1901575 316 0.046
oxoacid metabolic process GO:0043436 290 0.044
carboxylic acid metabolic process GO:0019752 289 0.043
nucleoside triphosphate metabolic process GO:0009141 144 0.043
catabolic process GO:0009056 351 0.042
protein phosphorylation GO:0006468 345 0.041
nucleoside metabolic process GO:0009116 179 0.041
organic cyclic compound catabolic process GO:1901361 175 0.040
cellular catabolic process GO:0044248 295 0.040
regulation of cellular component organization GO:0051128 368 0.039
locomotion GO:0040011 237 0.039
purine ribonucleotide catabolic process GO:0009154 136 0.038
organophosphate catabolic process GO:0046434 148 0.038
intracellular signal transduction GO:0035556 314 0.038
purine nucleotide catabolic process GO:0006195 136 0.037
purine nucleoside triphosphate metabolic process GO:0009144 141 0.037
cellular amino acid metabolic process GO:0006520 107 0.037
ribonucleotide catabolic process GO:0009261 136 0.037
ribonucleoside triphosphate metabolic process GO:0009199 141 0.037
purine ribonucleoside catabolic process GO:0046130 124 0.037
purine nucleoside triphosphate catabolic process GO:0009146 122 0.036
purine nucleoside metabolic process GO:0042278 169 0.036
ribose phosphate metabolic process GO:0019693 235 0.036
cellular component assembly GO:0022607 360 0.036
carbohydrate derivative catabolic process GO:1901136 147 0.036
cellular ketone metabolic process GO:0042180 51 0.035
ribonucleoside catabolic process GO:0042454 126 0.035
regulation of phosphate metabolic process GO:0019220 349 0.035
nucleotide catabolic process GO:0009166 139 0.034
regulation of phosphorus metabolic process GO:0051174 349 0.034
cellular component movement GO:0006928 248 0.033
ribonucleoside triphosphate catabolic process GO:0009203 122 0.033
regulation of cellular ketone metabolic process GO:0010565 27 0.033
nucleoside phosphate catabolic process GO:1901292 140 0.033
amine metabolic process GO:0009308 38 0.033
heterocycle catabolic process GO:0046700 167 0.033
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.033
nucleoside triphosphate catabolic process GO:0009143 123 0.033
regulation of cellular amino acid metabolic process GO:0006521 2 0.032
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
homeostatic process GO:0042592 331 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.032
regulation of cellular amine metabolic process GO:0033238 8 0.032
cellular amine metabolic process GO:0044106 38 0.031
nucleoside catabolic process GO:0009164 126 0.031
regulation of locomotion GO:0040012 148 0.031
purine containing compound catabolic process GO:0072523 138 0.031
regulation of cell differentiation GO:0045595 320 0.031
cellular nitrogen compound catabolic process GO:0044270 163 0.031
organonitrogen compound catabolic process GO:1901565 179 0.030
purine nucleoside catabolic process GO:0006152 124 0.030
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.030
macromolecular complex subunit organization GO:0043933 339 0.030
glycosyl compound catabolic process GO:1901658 126 0.029
regulation of multicellular organismal development GO:2000026 376 0.029
protein complex assembly GO:0006461 263 0.029
nucleobase containing compound catabolic process GO:0034655 152 0.029
immune system process GO:0002376 204 0.029
macromolecular complex assembly GO:0065003 273 0.028
ribonucleoside metabolic process GO:0009119 174 0.028
protein complex biogenesis GO:0070271 263 0.028
regulation of molecular function GO:0065009 398 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
regulation of signal transduction GO:0009966 318 0.027
vesicle mediated transport GO:0016192 181 0.027
regulation of apoptotic process GO:0042981 335 0.027
cell migration GO:0016477 197 0.026
organelle organization GO:0006996 266 0.026
programmed cell death GO:0012501 392 0.026
chemical homeostasis GO:0048878 292 0.026
rna metabolic process GO:0016070 406 0.025
purine ribonucleoside metabolic process GO:0046128 168 0.025
localization of cell GO:0051674 202 0.025
neuron projection development GO:0031175 273 0.025
positive regulation of developmental process GO:0051094 283 0.025
regulation of programmed cell death GO:0043067 341 0.025
regulation of cell development GO:0060284 263 0.025
guanosine containing compound catabolic process GO:1901069 71 0.025
cellular response to oxygen containing compound GO:1901701 386 0.025
regulation of phosphorylation GO:0042325 248 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.025
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
single organism biosynthetic process GO:0044711 342 0.024
cell cell signaling GO:0007267 335 0.024
neuron differentiation GO:0030182 368 0.024
negative regulation of metabolic process GO:0009892 331 0.024
small gtpase mediated signal transduction GO:0007264 36 0.024
regulation of intracellular signal transduction GO:1902531 218 0.024
glycosyl compound metabolic process GO:1901657 182 0.024
response to nutrient levels GO:0031667 370 0.024
positive regulation of phosphorylation GO:0042327 177 0.024
macromolecule localization GO:0033036 252 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.023
regulation of neurogenesis GO:0050767 247 0.023
regulation of nervous system development GO:0051960 264 0.023
ras protein signal transduction GO:0007265 29 0.023
nucleic acid templated transcription GO:0097659 379 0.023
gtp metabolic process GO:0046039 72 0.023
regulation of nucleic acid templated transcription GO:1903506 380 0.023
positive regulation of response to stimulus GO:0048584 285 0.023
regulation of cell proliferation GO:0042127 359 0.022
protein complex subunit organization GO:0071822 302 0.022
response to inorganic substance GO:0010035 377 0.022
guanosine containing compound metabolic process GO:1901068 74 0.022
cell motility GO:0048870 202 0.022
response to extracellular stimulus GO:0009991 380 0.022
positive regulation of multicellular organismal process GO:0051240 387 0.022
positive regulation of cell proliferation GO:0008284 249 0.022
protein localization GO:0008104 191 0.022
synaptic transmission GO:0007268 235 0.022
protein oligomerization GO:0051259 191 0.021
positive regulation of cell development GO:0010720 176 0.021
positive regulation of nervous system development GO:0051962 178 0.021
reproductive process GO:0022414 372 0.021
rna biosynthetic process GO:0032774 380 0.021
regulation of catalytic activity GO:0050790 304 0.021
gtp catabolic process GO:0006184 71 0.021
regulation of rna metabolic process GO:0051252 391 0.021
regulation of rna biosynthetic process GO:2001141 381 0.021
cell projection organization GO:0030030 302 0.020
regulation of transcription dna templated GO:0006355 374 0.020
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
lipid metabolic process GO:0006629 283 0.020
positive regulation of cell communication GO:0010647 271 0.020
single organism reproductive process GO:0044702 297 0.020
apoptotic process GO:0006915 381 0.020
positive regulation of biosynthetic process GO:0009891 319 0.020
positive regulation of cell migration GO:0030335 96 0.020
transmembrane transport GO:0055085 412 0.020
negative regulation of multicellular organismal process GO:0051241 203 0.020
regulation of protein modification process GO:0031399 194 0.020
ion transmembrane transport GO:0034220 365 0.020
ion homeostasis GO:0050801 212 0.020
positive regulation of neurogenesis GO:0050769 165 0.019
cellular homeostasis GO:0019725 252 0.019
regulation of neuron differentiation GO:0045664 208 0.019
regulation of protein metabolic process GO:0051246 289 0.019
positive regulation of cell differentiation GO:0045597 217 0.019
regulation of cell motility GO:2000145 131 0.019
secretion GO:0046903 307 0.019
anatomical structure morphogenesis GO:0009653 298 0.019
single organism intracellular transport GO:1902582 166 0.019
regulation of protein phosphorylation GO:0001932 183 0.019
multi organism reproductive process GO:0044703 262 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
intracellular transport GO:0046907 185 0.019
neuron development GO:0048666 286 0.018
cation transport GO:0006812 382 0.018
negative regulation of innate immune response GO:0045824 4 0.018
negative regulation of cellular metabolic process GO:0031324 281 0.018
neurological system process GO:0050877 219 0.018
behavior GO:0007610 205 0.018
regulation of cell projection organization GO:0031344 175 0.018
cellular chemical homeostasis GO:0055082 247 0.018
cellular response to endogenous stimulus GO:0071495 377 0.018
positive regulation of protein modification process GO:0031401 142 0.018
multicellular organism reproduction GO:0032504 233 0.018
positive regulation of molecular function GO:0044093 230 0.018
transcription dna templated GO:0006351 377 0.018
positive regulation of cellular component organization GO:0051130 200 0.018
central nervous system development GO:0007417 311 0.017
oxidation reduction process GO:0055114 304 0.017
response to acid chemical GO:0001101 222 0.017
anterior posterior pattern specification GO:0009952 1 0.017
nitrogen compound transport GO:0071705 229 0.017
regulation of cellular component movement GO:0051270 150 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
negative regulation of macromolecule metabolic process GO:0010605 260 0.017
metal ion transport GO:0030001 289 0.017
response to oxidative stress GO:0006979 186 0.017
cellular lipid metabolic process GO:0044255 208 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.017
regulation of neuron projection development GO:0010975 161 0.017
regulation of nucleotide metabolic process GO:0006140 117 0.017
positive regulation of protein metabolic process GO:0051247 178 0.016
muscle system process GO:0003012 115 0.016
response to growth factor GO:0070848 189 0.016
establishment of protein localization GO:0045184 141 0.016
reproduction GO:0000003 245 0.016
positive regulation of gene expression GO:0010628 244 0.016
head development GO:0060322 247 0.016
positive regulation of rna metabolic process GO:0051254 203 0.016
response to peptide GO:1901652 292 0.016
inorganic ion transmembrane transport GO:0098660 229 0.016
regulation of cellular localization GO:0060341 263 0.016
negative regulation of signaling GO:0023057 157 0.016
synaptic growth at neuromuscular junction GO:0051124 1 0.016
positive regulation of signaling GO:0023056 270 0.016
response to molecule of bacterial origin GO:0002237 194 0.016
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.016
positive regulation of locomotion GO:0040017 102 0.016
cellular response to stress GO:0033554 269 0.016
response to decreased oxygen levels GO:0036293 237 0.016
blood circulation GO:0008015 183 0.016
smooth muscle cell proliferation GO:0048659 77 0.016
tissue development GO:0009888 252 0.016
positive regulation of cell motility GO:2000147 97 0.016
response to peptide hormone GO:0043434 278 0.016
response to ethanol GO:0045471 162 0.016
circulatory system development GO:0072359 134 0.016
cellular protein localization GO:0034613 122 0.016
regulation of system process GO:0044057 208 0.016
positive regulation of cellular component movement GO:0051272 102 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.015
cellular macromolecule localization GO:0070727 122 0.015
antigen processing and presentation GO:0019882 2 0.015
regulation of kinase activity GO:0043549 117 0.015
regulation of synaptic transmission GO:0050804 141 0.015
positive regulation of cellular protein metabolic process GO:0032270 167 0.015
cardiovascular system development GO:0072358 134 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
response to metal ion GO:0010038 253 0.015
positive regulation of signal transduction GO:0009967 175 0.015
response to external biotic stimulus GO:0043207 221 0.015
regulation of vesicle mediated transport GO:0060627 81 0.015
response to nutrient GO:0007584 248 0.015
cation homeostasis GO:0055080 195 0.015
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.015
regulation of membrane potential GO:0042391 110 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.015
circulatory system process GO:0003013 183 0.015
negative regulation of cell communication GO:0010648 158 0.015
axis specification GO:0009798 4 0.014
response to oxygen levels GO:0070482 265 0.014
regulation of purine nucleotide metabolic process GO:1900542 115 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
response to biotic stimulus GO:0009607 226 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
transcription from rna polymerase ii promoter GO:0006366 252 0.014
response to ketone GO:1901654 182 0.014
metal ion homeostasis GO:0055065 186 0.014
cellular response to nitrogen compound GO:1901699 210 0.014
cellular response to organonitrogen compound GO:0071417 197 0.014
peptidyl amino acid modification GO:0018193 126 0.014
response to hypoxia GO:0001666 231 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
regulation of mapk cascade GO:0043408 116 0.014
divalent inorganic cation homeostasis GO:0072507 165 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
negative regulation of cell death GO:0060548 229 0.013
brain development GO:0007420 247 0.013
regeneration GO:0031099 163 0.013
regulation of transferase activity GO:0051338 123 0.013
regulation of hormone levels GO:0010817 187 0.013
response to bacterium GO:0009617 200 0.013
cytoplasmic transport GO:0016482 115 0.013
positive regulation of transport GO:0051050 245 0.013
signal transduction by phosphorylation GO:0023014 144 0.013
negative regulation of developmental process GO:0051093 125 0.013
regulation of secretion by cell GO:1903530 208 0.013
single organism carbohydrate metabolic process GO:0044723 118 0.013
calcium ion homeostasis GO:0055074 162 0.013
cellular response to hormone stimulus GO:0032870 247 0.013
anion transport GO:0006820 178 0.013
regulation of catabolic process GO:0009894 113 0.013
endocytosis GO:0006897 84 0.013
embryonic pattern specification GO:0009880 1 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
regulation of smooth muscle cell proliferation GO:0048660 75 0.013
muscle cell proliferation GO:0033002 84 0.013
response to wounding GO:0009611 254 0.013
protein transport GO:0015031 132 0.013
response to carbohydrate GO:0009743 183 0.013
response to glucocorticoid GO:0051384 223 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.013
mapk cascade GO:0000165 140 0.013
cellular response to lipid GO:0071396 201 0.013
cellular component morphogenesis GO:0032989 155 0.013
golgi vesicle transport GO:0048193 22 0.013
salivary gland development GO:0007431 3 0.012
aging GO:0007568 241 0.012
single organism cellular localization GO:1902580 102 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
cellular cation homeostasis GO:0030003 180 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
response to hexose GO:0009746 144 0.012
positive regulation of neuron projection development GO:0010976 99 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
positive regulation of cell death GO:0010942 184 0.012
chromosome segregation GO:0007059 2 0.012
carbohydrate metabolic process GO:0005975 130 0.012
intracellular protein transport GO:0006886 79 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
regulation of protein kinase activity GO:0045859 105 0.012
regulation of homeostatic process GO:0032844 101 0.012
response to glucose GO:0009749 136 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
spindle organization GO:0007051 2 0.012
cellular ion homeostasis GO:0006873 184 0.012
negative regulation of programmed cell death GO:0043069 183 0.012
vascular process in circulatory system GO:0003018 96 0.012
growth GO:0040007 165 0.012
defense response GO:0006952 194 0.012
cation transmembrane transport GO:0098655 263 0.012
cell projection morphogenesis GO:0048858 123 0.012
lipid storage GO:0019915 1 0.012
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.012
cell morphogenesis GO:0000902 142 0.012
divalent inorganic cation transport GO:0072511 134 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
response to corticosteroid GO:0031960 235 0.012
regulation of anatomical structure size GO:0090066 135 0.012
regulation of cell migration GO:0030334 128 0.012
positive regulation of nucleotide metabolic process GO:0045981 91 0.012
negative regulation of apoptotic process GO:0043066 181 0.012
regulation of immune system process GO:0002682 123 0.012
positive regulation of mapk cascade GO:0043410 92 0.012
chemosensory behavior GO:0007635 2 0.012
regulation of hydrolase activity GO:0051336 143 0.012
regulation of neuron death GO:1901214 115 0.011
peptide transport GO:0015833 97 0.011
inflammatory response GO:0006954 150 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
sexual reproduction GO:0019953 148 0.011
response to lipopolysaccharide GO:0032496 191 0.011
monocarboxylic acid metabolic process GO:0032787 152 0.011
immune response GO:0006955 104 0.011
secretion by cell GO:0032940 248 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
rho protein signal transduction GO:0007266 11 0.011
single organism behavior GO:0044708 130 0.011
inorganic cation transmembrane transport GO:0098662 202 0.011
neuron death GO:0070997 127 0.011
membrane organization GO:0061024 94 0.011
regulation of secretion GO:0051046 224 0.011
signal release GO:0023061 145 0.011
eye morphogenesis GO:0048592 4 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
regulation of synaptic plasticity GO:0048167 70 0.011
single organism organelle organization GO:1902589 180 0.011
response to cytokine GO:0034097 215 0.011
developmental process involved in reproduction GO:0003006 159 0.011
response to monosaccharide GO:0034284 159 0.011
female pregnancy GO:0007565 122 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
hormone transport GO:0009914 121 0.011
regulation of ion transport GO:0043269 245 0.011
amide transport GO:0042886 105 0.011
dephosphorylation GO:0016311 98 0.011
leukocyte cell cell adhesion GO:0007159 4 0.011
rhythmic process GO:0048511 156 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.011
multi multicellular organism process GO:0044706 138 0.011
mitotic spindle organization GO:0007052 2 0.011
maintenance of location GO:0051235 17 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
negative regulation of gene expression GO:0010629 199 0.011
regulation of response to stress GO:0080134 126 0.011
actin filament based process GO:0030029 86 0.011
negative regulation of cellular biosynthetic process GO:0031327 161 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
gastrulation GO:0007369 2 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
organic anion transport GO:0015711 132 0.011
peptidyl tyrosine phosphorylation GO:0018108 72 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
cytokine biosynthetic process GO:0042089 3 0.011
smooth muscle cell migration GO:0014909 36 0.011
gland development GO:0048732 155 0.011
development of primary sexual characteristics GO:0045137 107 0.011
regulation of anatomical structure morphogenesis GO:0022603 141 0.010
action potential GO:0001508 54 0.010
negative regulation of biosynthetic process GO:0009890 168 0.010
sequestering of metal ion GO:0051238 9 0.010
sequestering of calcium ion GO:0051208 8 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.010
negative regulation of secretion GO:0051048 82 0.010
regulation of reactive oxygen species metabolic process GO:2000377 26 0.010
cellular macromolecular complex assembly GO:0034622 58 0.010
olfactory learning GO:0008355 1 0.010
hormone secretion GO:0046879 115 0.010
response to vitamin GO:0033273 131 0.010
response to radiation GO:0009314 137 0.010
sex differentiation GO:0007548 113 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.010
cell adhesion GO:0007155 110 0.010
rna localization GO:0006403 4 0.010
positive regulation of immune system process GO:0002684 90 0.010
regulation of purine nucleotide catabolic process GO:0033121 65 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
response to estrogen GO:0043627 232 0.010
cellular metal ion homeostasis GO:0006875 172 0.010

Lrrk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027
nervous system disease DOID:863 0 0.027
musculoskeletal system disease DOID:17 0 0.015
cardiovascular system disease DOID:1287 0 0.014
central nervous system disease DOID:331 0 0.013
sensory system disease DOID:0050155 0 0.013
disease of metabolism DOID:0014667 0 0.012