Rattus norvegicus

46 known processes

Flna

filamin A, alpha

(Aliases: RGD1560614)

Flna biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of atp catabolic process GO:1903290 2 0.753
macromolecular complex subunit organization GO:0043933 339 0.590
single organism organelle organization GO:1902589 180 0.428
tissue development GO:0009888 252 0.426
protein complex subunit organization GO:0071822 302 0.416
organelle organization GO:0006996 266 0.378
cytoskeleton organization GO:0007010 111 0.373
cell motility GO:0048870 202 0.371
wound healing GO:0042060 122 0.358
actin filament based process GO:0030029 86 0.281
single organismal cell cell adhesion GO:0016337 42 0.254
blood coagulation GO:0007596 26 0.253
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.236
purine nucleoside monophosphate catabolic process GO:0009128 55 0.231
nucleoside monophosphate metabolic process GO:0009123 93 0.213
purine ribonucleoside metabolic process GO:0046128 168 0.199
regulation of purine nucleotide metabolic process GO:1900542 115 0.197
regulation of cellular component organization GO:0051128 368 0.178
cellular component movement GO:0006928 248 0.171
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.171
nucleoside catabolic process GO:0009164 126 0.169
muscle cell differentiation GO:0042692 52 0.168
cell adhesion GO:0007155 110 0.158
regulation of cellular component movement GO:0051270 150 0.153
atp metabolic process GO:0046034 72 0.152
cellular component assembly GO:0022607 360 0.146
muscle structure development GO:0061061 87 0.140
protein complex assembly GO:0006461 263 0.135
heterotypic cell cell adhesion GO:0034113 2 0.133
actin cytoskeleton organization GO:0030036 73 0.129
localization of cell GO:0051674 202 0.117
organonitrogen compound catabolic process GO:1901565 179 0.116
regulation of purine nucleotide catabolic process GO:0033121 65 0.110
nucleobase containing small molecule metabolic process GO:0055086 316 0.109
negative regulation of metabolic process GO:0009892 331 0.109
coagulation GO:0050817 28 0.106
response to wounding GO:0009611 254 0.100
regulation of nucleotide metabolic process GO:0006140 117 0.097
platelet aggregation GO:0070527 4 0.097
nucleotide metabolic process GO:0009117 279 0.094
platelet activation GO:0030168 8 0.094
biological adhesion GO:0022610 110 0.094
atp catabolic process GO:0006200 54 0.091
purine nucleoside monophosphate metabolic process GO:0009126 84 0.091
aging GO:0007568 241 0.084
negative regulation of macromolecule metabolic process GO:0010605 260 0.082
ribonucleoside metabolic process GO:0009119 174 0.082
negative regulation of actin filament polymerization GO:0030837 4 0.082
purine containing compound metabolic process GO:0072521 253 0.080
regulation of cellular component biogenesis GO:0044087 86 0.076
digestive system development GO:0055123 41 0.076
ribonucleoside catabolic process GO:0042454 126 0.073
cell migration GO:0016477 197 0.072
epithelium development GO:0060429 96 0.072
cellular component biogenesis GO:0044085 368 0.071
purine containing compound catabolic process GO:0072523 138 0.071
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.071
ribonucleoside monophosphate metabolic process GO:0009161 88 0.070
cell substrate adhesion GO:0031589 29 0.069
negative regulation of atpase activity GO:0032780 2 0.067
actomyosin structure organization GO:0031032 22 0.067
ribonucleoside triphosphate catabolic process GO:0009203 122 0.065
positive regulation of biosynthetic process GO:0009891 319 0.064
heterocycle catabolic process GO:0046700 167 0.062
cellular response to endogenous stimulus GO:0071495 377 0.062
ribonucleoside monophosphate catabolic process GO:0009158 55 0.061
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.061
muscle cell development GO:0055001 26 0.061
single organism catabolic process GO:0044712 283 0.060
nucleoside metabolic process GO:0009116 179 0.055
purine nucleoside metabolic process GO:0042278 169 0.055
positive regulation of gene expression GO:0010628 244 0.055
nucleoside triphosphate metabolic process GO:0009141 144 0.055
purine nucleoside triphosphate metabolic process GO:0009144 141 0.054
actin filament based movement GO:0030048 16 0.054
purine ribonucleotide catabolic process GO:0009154 136 0.053
ribose phosphate metabolic process GO:0019693 235 0.052
cellular nitrogen compound catabolic process GO:0044270 163 0.052
purine nucleoside triphosphate catabolic process GO:0009146 122 0.052
embryo development GO:0009790 49 0.051
negative regulation of cellular metabolic process GO:0031324 281 0.051
anatomical structure morphogenesis GO:0009653 298 0.051
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.049
transcription from rna polymerase ii promoter GO:0006366 252 0.049
positive regulation of cellular component organization GO:0051130 200 0.049
nucleoside phosphate metabolic process GO:0006753 283 0.048
purine nucleotide catabolic process GO:0006195 136 0.048
inflammatory response GO:0006954 150 0.048
negative regulation of gene expression GO:0010629 199 0.047
single organism reproductive process GO:0044702 297 0.046
positive regulation of nucleic acid templated transcription GO:1903508 197 0.046
response to growth factor GO:0070848 189 0.046
regulation of cell differentiation GO:0045595 320 0.045
organic substance catabolic process GO:1901575 316 0.045
nucleoside monophosphate catabolic process GO:0009125 56 0.045
transcription dna templated GO:0006351 377 0.044
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.044
intracellular signal transduction GO:0035556 314 0.044
regulation of rna metabolic process GO:0051252 391 0.044
cell morphogenesis GO:0000902 142 0.043
regulation of hydrolase activity GO:0051336 143 0.043
locomotion GO:0040011 237 0.043
programmed cell death GO:0012501 392 0.042
response to ionizing radiation GO:0010212 59 0.042
hemostasis GO:0007599 26 0.042
anterior posterior pattern specification GO:0009952 1 0.042
actin filament bundle assembly GO:0051017 19 0.041
regulation of actin filament depolymerization GO:0030834 2 0.041
macromolecular complex assembly GO:0065003 273 0.040
cell activation GO:0001775 97 0.040
aromatic compound catabolic process GO:0019439 168 0.040
actin filament organization GO:0007015 42 0.039
regulation of cell motility GO:2000145 131 0.039
regulation of rna biosynthetic process GO:2001141 381 0.039
catabolic process GO:0009056 351 0.039
nucleobase containing compound catabolic process GO:0034655 152 0.038
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.038
regulation of phosphorus metabolic process GO:0051174 349 0.038
regulation of schwann cell migration GO:1900147 2 0.038
gastrulation GO:0007369 2 0.037
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.037
purine nucleotide metabolic process GO:0006163 229 0.037
schwann cell migration GO:0036135 2 0.037
striated muscle cell development GO:0055002 26 0.037
connective tissue development GO:0061448 33 0.036
cellular component morphogenesis GO:0032989 155 0.036
regulation of molecular function GO:0065009 398 0.036
cellular component assembly involved in morphogenesis GO:0010927 17 0.036
purine ribonucleoside catabolic process GO:0046130 124 0.036
carbohydrate derivative metabolic process GO:1901135 346 0.035
cellular response to abiotic stimulus GO:0071214 85 0.034
cellular macromolecule localization GO:0070727 122 0.034
elastic fiber assembly GO:0048251 1 0.034
ribonucleotide catabolic process GO:0009261 136 0.033
glycosyl compound metabolic process GO:1901657 182 0.033
regulation of catalytic activity GO:0050790 304 0.033
actin filament depolymerization GO:0030042 3 0.032
regulation of nucleic acid templated transcription GO:1903506 380 0.032
glycosyl compound catabolic process GO:1901658 126 0.032
protein complex biogenesis GO:0070271 263 0.031
response to radiation GO:0009314 137 0.031
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.030
regulation of body fluid levels GO:0050878 90 0.030
cellular ketone metabolic process GO:0042180 51 0.030
purine ribonucleotide metabolic process GO:0009150 227 0.029
negative regulation of purine nucleotide metabolic process GO:1900543 23 0.029
carbohydrate derivative catabolic process GO:1901136 147 0.029
negative regulation of rna metabolic process GO:0051253 123 0.028
heart development GO:0007507 72 0.028
inorganic ion transmembrane transport GO:0098660 229 0.028
negative regulation of cellular biosynthetic process GO:0031327 161 0.028
reproduction GO:0000003 245 0.028
regulation of transcription dna templated GO:0006355 374 0.028
purine nucleoside catabolic process GO:0006152 124 0.028
reproductive process GO:0022414 372 0.028
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.027
response to fluoride GO:1902617 3 0.027
nucleotide catabolic process GO:0009166 139 0.027
cell cycle GO:0007049 101 0.027
response to mechanical stimulus GO:0009612 134 0.026
cell aging GO:0007569 14 0.026
single organism biosynthetic process GO:0044711 342 0.026
regulation of cell development GO:0060284 263 0.025
amine metabolic process GO:0009308 38 0.025
head development GO:0060322 247 0.025
epithelial cell differentiation GO:0030855 71 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
tissue morphogenesis GO:0048729 22 0.024
regulation of nucleoside metabolic process GO:0009118 66 0.024
protein oligomerization GO:0051259 191 0.024
regulation of multicellular organismal development GO:2000026 376 0.024
axis specification GO:0009798 4 0.024
protein heterooligomerization GO:0051291 89 0.024
muscle organ morphogenesis GO:0048644 1 0.023
positive regulation of developmental process GO:0051094 283 0.023
positive regulation of cell communication GO:0010647 271 0.023
organophosphate metabolic process GO:0019637 370 0.023
triglyceride homeostasis GO:0070328 2 0.023
regulation of humoral immune response mediated by circulating immunoglobulin GO:0002923 1 0.023
developmental maturation GO:0021700 25 0.023
negative regulation of cell communication GO:0010648 158 0.023
cellular catabolic process GO:0044248 295 0.023
neuron differentiation GO:0030182 368 0.022
regulation of programmed cell death GO:0043067 341 0.022
negative regulation of nucleotide metabolic process GO:0045980 23 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.022
regulation of organelle organization GO:0033043 80 0.022
cellular amine metabolic process GO:0044106 38 0.022
cellular response to stress GO:0033554 269 0.022
positive regulation of phosphorus metabolic process GO:0010562 262 0.022
response to other organism GO:0051707 220 0.021
organic acid metabolic process GO:0006082 292 0.021
positive regulation of transcription dna templated GO:0045893 197 0.021
regulation of apoptotic process GO:0042981 335 0.021
actin crosslink formation GO:0051764 3 0.021
multi organism reproductive process GO:0044703 262 0.021
spermatogenesis GO:0007283 99 0.021
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.021
small gtpase mediated signal transduction GO:0007264 36 0.021
growth GO:0040007 165 0.021
nucleoside phosphate catabolic process GO:1901292 140 0.020
regulation of phosphate metabolic process GO:0019220 349 0.020
chromatin organization GO:0006325 34 0.020
cardiovascular system development GO:0072358 134 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
negative regulation of biosynthetic process GO:0009890 168 0.020
organic cyclic compound catabolic process GO:1901361 175 0.020
response to inorganic substance GO:0010035 377 0.020
transmembrane transport GO:0055085 412 0.019
ribonucleoside triphosphate metabolic process GO:0009199 141 0.019
muscle tissue development GO:0060537 58 0.019
apoptotic process GO:0006915 381 0.019
gamete generation GO:0007276 124 0.019
digestive tract development GO:0048565 39 0.019
regulation of nucleotide catabolic process GO:0030811 65 0.018
muscle organ development GO:0007517 50 0.018
response to oxygen levels GO:0070482 265 0.018
nucleoside triphosphate catabolic process GO:0009143 123 0.018
endothelium development GO:0003158 12 0.018
regulation of cellular protein metabolic process GO:0032268 267 0.018
cell morphogenesis involved in differentiation GO:0000904 119 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
multicellular organismal reproductive process GO:0048609 233 0.018
nucleic acid templated transcription GO:0097659 379 0.018
regulation of catabolic process GO:0009894 113 0.018
regulation of protein modification process GO:0031399 194 0.018
reactive nitrogen species metabolic process GO:2001057 1 0.018
response to extracellular stimulus GO:0009991 380 0.018
positive regulation of stem cell differentiation GO:2000738 2 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
single organism cell adhesion GO:0098602 46 0.017
response to metal ion GO:0010038 253 0.017
positive regulation of molecular function GO:0044093 230 0.017
developmental process involved in reproduction GO:0003006 159 0.017
regulation of cell projection organization GO:0031344 175 0.017
chromosome organization GO:0051276 36 0.017
rna biosynthetic process GO:0032774 380 0.017
response to zinc ion GO:0010043 39 0.017
positive regulation of cell differentiation GO:0045597 217 0.016
wound healing spreading of cells GO:0044319 2 0.016
epiboly involved in wound healing GO:0090505 2 0.016
regulation of atp metabolic process GO:1903578 9 0.016
cell matrix adhesion GO:0007160 19 0.016
homotypic cell cell adhesion GO:0034109 8 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
regulation of locomotion GO:0040012 148 0.016
central nervous system development GO:0007417 311 0.016
positive regulation of cellular protein metabolic process GO:0032270 167 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
oxoacid metabolic process GO:0043436 290 0.015
response to reactive oxygen species GO:0000302 120 0.015
adult locomotory behavior GO:0008344 4 0.015
mrna transcription from rna polymerase ii promoter GO:0042789 1 0.015
regulation of cell adhesion GO:0030155 52 0.015
cellular homeostasis GO:0019725 252 0.015
cell projection organization GO:0030030 302 0.015
cellular response to oxygen containing compound GO:1901701 386 0.015
ion transmembrane transport GO:0034220 365 0.015
anatomical structure formation involved in morphogenesis GO:0048646 83 0.015
ribonucleotide metabolic process GO:0009259 231 0.015
myofibril assembly GO:0030239 6 0.014
endocytosis GO:0006897 84 0.014
response to decreased oxygen levels GO:0036293 237 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
carboxylic acid metabolic process GO:0019752 289 0.014
creatine transport GO:0015881 1 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
negative regulation of catalytic activity GO:0043086 103 0.014
negative regulation of transcription dna templated GO:0045892 116 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
ras protein signal transduction GO:0007265 29 0.014
immune system process GO:0002376 204 0.014
negative regulation of cellular component organization GO:0051129 83 0.014
regulation of response to stress GO:0080134 126 0.014
regulation of cell migration GO:0030334 128 0.013
regulation of anatomical structure morphogenesis GO:0022603 141 0.013
positive regulation of signaling GO:0023056 270 0.013
regulation of atpase activity GO:0043462 7 0.013
smad protein import into nucleus GO:0007184 3 0.013
defense response GO:0006952 194 0.013
male gamete generation GO:0048232 99 0.013
acylglycerol homeostasis GO:0055090 2 0.013
negative regulation of cell death GO:0060548 229 0.012
cellular protein complex assembly GO:0043623 44 0.012
neuron projection morphogenesis GO:0048812 122 0.012
regulation of cellular catabolic process GO:0031329 101 0.012
rna metabolic process GO:0016070 406 0.012
regulation of cellular ketone metabolic process GO:0010565 27 0.012
response to amino acid GO:0043200 75 0.012
protein localization GO:0008104 191 0.011
immune response GO:0006955 104 0.011
neuron projection development GO:0031175 273 0.011
myoblast fusion GO:0007520 2 0.011
response to nutrient levels GO:0031667 370 0.011
regulation of cell proliferation GO:0042127 359 0.011
wnt signaling pathway GO:0016055 17 0.011
positive regulation of atpase activity GO:0032781 6 0.011
regulation of actin filament bundle assembly GO:0032231 13 0.011
regulation of cell morphogenesis GO:0022604 77 0.011
cellular macromolecular complex assembly GO:0034622 58 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
negative regulation of nucleic acid templated transcription GO:1903507 117 0.011
positive regulation of apoptotic process GO:0043065 154 0.011
positive regulation of cellular component movement GO:0051272 102 0.011
skeletal system development GO:0001501 41 0.011
regulation of nervous system development GO:0051960 264 0.010
regulation of signal transduction GO:0009966 318 0.010
negative regulation of apoptotic process GO:0043066 181 0.010
proline transport GO:0015824 3 0.010
syncytium formation by plasma membrane fusion GO:0000768 3 0.010
regulation of neurogenesis GO:0050767 247 0.010

Flna disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.075
musculoskeletal system disease DOID:17 0 0.075
sensory system disease DOID:0050155 0 0.059
nervous system disease DOID:863 0 0.059
muscular disease DOID:0080000 0 0.038
muscle tissue disease DOID:66 0 0.038
myopathy DOID:423 0 0.037
heart disease DOID:114 0 0.037
cardiomyopathy DOID:0050700 0 0.037
dilated cardiomyopathy DOID:12930 0 0.037
intrinsic cardiomyopathy DOID:0060036 0 0.037
cardiovascular system disease DOID:1287 0 0.037
lipodystrophy DOID:811 0 0.014
skin disease DOID:37 0 0.014
integumentary system disease DOID:16 0 0.014