Rattus norvegicus

0 known processes

Dkk2

dickkopf homolog 2 (Xenopus laevis)

(Aliases: Dkk4)

Dkk2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell proliferation GO:0042127 359 0.116
localization of cell GO:0051674 202 0.108
locomotion GO:0040011 237 0.098
anatomical structure morphogenesis GO:0009653 298 0.093
regulation of nucleic acid templated transcription GO:1903506 380 0.089
chemical homeostasis GO:0048878 292 0.088
organ morphogenesis GO:0009887 75 0.081
positive regulation of response to stimulus GO:0048584 285 0.079
Human
circulatory system development GO:0072359 134 0.078
single organism reproductive process GO:0044702 297 0.075
cell motility GO:0048870 202 0.072
cellular response to oxygen containing compound GO:1901701 386 0.072
response to extracellular stimulus GO:0009991 380 0.068
positive regulation of cell proliferation GO:0008284 249 0.066
oxoacid metabolic process GO:0043436 290 0.066
regulation of rna metabolic process GO:0051252 391 0.065
cellular component movement GO:0006928 248 0.065
secretion GO:0046903 307 0.064
wound healing GO:0042060 122 0.063
regulation of transcription dna templated GO:0006355 374 0.063
response to hypoxia GO:0001666 231 0.063
regulation of cellular component organization GO:0051128 368 0.063
reproductive process GO:0022414 372 0.062
positive regulation of multicellular organismal process GO:0051240 387 0.059
response to nutrient levels GO:0031667 370 0.057
immune system process GO:0002376 204 0.056
cardiovascular system development GO:0072358 134 0.056
carboxylic acid metabolic process GO:0019752 289 0.055
intracellular signal transduction GO:0035556 314 0.054
transcription dna templated GO:0006351 377 0.053
blood circulation GO:0008015 183 0.052
rna metabolic process GO:0016070 406 0.051
cellular response to lipid GO:0071396 201 0.050
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.050
response to wounding GO:0009611 254 0.050
regulation of immune system process GO:0002682 123 0.048
cellular chemical homeostasis GO:0055082 247 0.047
regulation of cellular ketone metabolic process GO:0010565 27 0.047
cell migration GO:0016477 197 0.045
multi organism reproductive process GO:0044703 262 0.045
nucleic acid templated transcription GO:0097659 379 0.045
positive regulation of immune system process GO:0002684 90 0.044
cellular response to endogenous stimulus GO:0071495 377 0.044
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.043
cellular response to organic cyclic compound GO:0071407 202 0.043
positive regulation of signal transduction GO:0009967 175 0.043
Human
regulation of signal transduction GO:0009966 318 0.043
Human
regulation of secretion GO:0051046 224 0.041
regeneration GO:0031099 163 0.041
regulation of hormone levels GO:0010817 187 0.041
positive regulation of cell communication GO:0010647 271 0.040
Human
regulation of cellular component movement GO:0051270 150 0.040
positive regulation of developmental process GO:0051094 283 0.040
positive regulation of nucleic acid templated transcription GO:1903508 197 0.040
positive regulation of signaling GO:0023056 270 0.039
Human
heart morphogenesis GO:0003007 3 0.039
response to estrogen GO:0043627 232 0.039
aging GO:0007568 241 0.039
ion homeostasis GO:0050801 212 0.038
multicellular organism reproduction GO:0032504 233 0.038
regulation of system process GO:0044057 208 0.038
regulation of protein metabolic process GO:0051246 289 0.038
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.037
organic acid metabolic process GO:0006082 292 0.037
homeostatic process GO:0042592 331 0.037
regulation of cellular localization GO:0060341 263 0.036
positive regulation of cell differentiation GO:0045597 217 0.035
circulatory system process GO:0003013 183 0.035
cellular homeostasis GO:0019725 252 0.035
regulation of locomotion GO:0040012 148 0.035
gonad development GO:0008406 104 0.035
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.035
immune response GO:0006955 104 0.034
regulation of programmed cell death GO:0043067 341 0.034
rna biosynthetic process GO:0032774 380 0.034
cell projection organization GO:0030030 302 0.034
brain development GO:0007420 247 0.034
tissue development GO:0009888 252 0.034
response to external biotic stimulus GO:0043207 221 0.033
negative regulation of gene expression GO:0010629 199 0.033
cellular catabolic process GO:0044248 295 0.033
cellular response to hormone stimulus GO:0032870 247 0.033
developmental process involved in reproduction GO:0003006 159 0.033
cation homeostasis GO:0055080 195 0.032
catabolic process GO:0009056 351 0.032
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.032
negative regulation of nucleic acid templated transcription GO:1903507 117 0.032
cellular cation homeostasis GO:0030003 180 0.032
response to nutrient GO:0007584 248 0.032
response to oxygen levels GO:0070482 265 0.032
response to inorganic substance GO:0010035 377 0.032
cytosolic calcium ion homeostasis GO:0051480 140 0.032
enzyme linked receptor protein signaling pathway GO:0007167 116 0.032
response to bacterium GO:0009617 200 0.032
response to mechanical stimulus GO:0009612 134 0.031
cell cell signaling GO:0007267 335 0.031
transmembrane transport GO:0055085 412 0.031
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.031
vasculature development GO:0001944 70 0.031
g protein coupled receptor signaling pathway GO:0007186 242 0.031
carbohydrate metabolic process GO:0005975 130 0.031
cellular amine metabolic process GO:0044106 38 0.031
neuron development GO:0048666 286 0.031
head development GO:0060322 247 0.030
regulation of cell differentiation GO:0045595 320 0.030
divalent metal ion transport GO:0070838 132 0.030
regulation of apoptotic process GO:0042981 335 0.030
positive regulation of rna biosynthetic process GO:1902680 197 0.030
positive regulation of cell development GO:0010720 176 0.030
cellular ketone metabolic process GO:0042180 51 0.029
cellular response to growth factor stimulus GO:0071363 162 0.029
positive regulation of transport GO:0051050 245 0.029
response to metal ion GO:0010038 253 0.029
negative regulation of macromolecule metabolic process GO:0010605 260 0.029
neuron differentiation GO:0030182 368 0.029
secretion by cell GO:0032940 248 0.029
cellular ion homeostasis GO:0006873 184 0.029
positive regulation of phosphorus metabolic process GO:0010562 262 0.029
carbohydrate derivative metabolic process GO:1901135 346 0.028
regulation of cellular amino acid metabolic process GO:0006521 2 0.028
cellular response to organonitrogen compound GO:0071417 197 0.028
transcription from rna polymerase ii promoter GO:0006366 252 0.028
organ regeneration GO:0031100 101 0.028
regulation of secretion by cell GO:1903530 208 0.028
response to decreased oxygen levels GO:0036293 237 0.027
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.027
amine metabolic process GO:0009308 38 0.027
angiogenesis GO:0001525 53 0.027
positive regulation of rna metabolic process GO:0051254 203 0.027
taxis GO:0042330 67 0.027
defense response GO:0006952 194 0.026
regulation of cellular protein metabolic process GO:0032268 267 0.026
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.026
regulation of cellular amine metabolic process GO:0033238 8 0.026
inflammatory response GO:0006954 150 0.026
regulation of neurogenesis GO:0050767 247 0.026
negative regulation of cellular metabolic process GO:0031324 281 0.026
gland development GO:0048732 155 0.025
cellular metal ion homeostasis GO:0006875 172 0.025
regulation of muscle system process GO:0090257 79 0.025
programmed cell death GO:0012501 392 0.025
negative regulation of rna metabolic process GO:0051253 123 0.025
lipid metabolic process GO:0006629 283 0.025
regulation of multicellular organismal development GO:2000026 376 0.025
neuron projection development GO:0031175 273 0.025
negative regulation of metabolic process GO:0009892 331 0.024
protein complex subunit organization GO:0071822 302 0.024
positive regulation of biosynthetic process GO:0009891 319 0.024
anatomical structure formation involved in morphogenesis GO:0048646 83 0.024
cellular response to stress GO:0033554 269 0.024
response to biotic stimulus GO:0009607 226 0.024
regulation of phosphate metabolic process GO:0019220 349 0.024
cellular calcium ion homeostasis GO:0006874 160 0.024
regulation of response to stress GO:0080134 126 0.024
multicellular organismal reproductive process GO:0048609 233 0.023
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.023
oxidation reduction process GO:0055114 304 0.023
response to lipopolysaccharide GO:0032496 191 0.023
positive regulation of cellular biosynthetic process GO:0031328 295 0.023
reproductive system development GO:0061458 128 0.023
central nervous system development GO:0007417 311 0.023
response to carbohydrate GO:0009743 183 0.023
organophosphate metabolic process GO:0019637 370 0.023
response to heat GO:0009408 60 0.023
regulation of ion transport GO:0043269 245 0.022
regulation of stem cell differentiation GO:2000736 2 0.022
response to insulin GO:0032868 133 0.022
cellular component biogenesis GO:0044085 368 0.022
limb morphogenesis GO:0035108 4 0.022
positive regulation of transcription dna templated GO:0045893 197 0.022
multi multicellular organism process GO:0044706 138 0.022
positive regulation of locomotion GO:0040017 102 0.022
regulation of cell growth GO:0001558 85 0.022
blood vessel morphogenesis GO:0048514 58 0.022
nitrogen compound transport GO:0071705 229 0.022
vesicle mediated transport GO:0016192 181 0.022
negative regulation of biosynthetic process GO:0009890 168 0.022
cellular amino acid metabolic process GO:0006520 107 0.022
regulation of rna biosynthetic process GO:2001141 381 0.022
axis specification GO:0009798 4 0.022
blood vessel development GO:0001568 69 0.022
response to peptide GO:1901652 292 0.021
response to monosaccharide GO:0034284 159 0.021
developmental growth GO:0048589 100 0.021
positive regulation of defense response GO:0031349 37 0.021
regulation of membrane potential GO:0042391 110 0.021
regulation of cell development GO:0060284 263 0.021
reproduction GO:0000003 245 0.021
negative regulation of molecular function GO:0044092 133 0.021
positive regulation of cellular component organization GO:0051130 200 0.021
negative regulation of rna biosynthetic process GO:1902679 118 0.021
macromolecular complex subunit organization GO:0043933 339 0.021
bmp signaling pathway GO:0030509 4 0.021
negative regulation of transcription dna templated GO:0045892 116 0.021
sensory perception GO:0007600 101 0.021
regulation of catalytic activity GO:0050790 304 0.020
divalent inorganic cation transport GO:0072511 134 0.020
regulation of cell adhesion GO:0030155 52 0.020
single organism biosynthetic process GO:0044711 342 0.020
reproductive structure development GO:0048608 128 0.020
regulation of protein modification process GO:0031399 194 0.020
regulation of blood vessel size GO:0050880 89 0.020
positive regulation of neurogenesis GO:0050769 165 0.020
response to growth factor GO:0070848 189 0.020
positive regulation of nervous system development GO:0051962 178 0.020
cellular component assembly GO:0022607 360 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
macromolecule localization GO:0033036 252 0.020
cellular response to peptide hormone stimulus GO:0071375 120 0.020
regulation of molecular function GO:0065009 398 0.020
positive regulation of gene expression GO:0010628 244 0.020
response to temperature stimulus GO:0009266 94 0.020
cellular divalent inorganic cation homeostasis GO:0072503 162 0.020
appendage morphogenesis GO:0035107 4 0.019
response to cytokine GO:0034097 215 0.019
positive regulation of molecular function GO:0044093 230 0.019
negative regulation of multicellular organismal process GO:0051241 203 0.019
Rat
response to peptide hormone GO:0043434 278 0.019
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.019
protein phosphorylation GO:0006468 345 0.019
renal system development GO:0072001 67 0.019
calcium ion transport GO:0006816 131 0.019
epithelial cell proliferation GO:0050673 54 0.019
female pregnancy GO:0007565 122 0.018
kidney development GO:0001822 67 0.018
regulation of transmembrane transport GO:0034762 122 0.018
positive regulation of phosphate metabolic process GO:0045937 262 0.018
regulation of cell projection organization GO:0031344 175 0.018
positive regulation of apoptotic process GO:0043065 154 0.018
regulation of homeostatic process GO:0032844 101 0.018
positive regulation of cell death GO:0010942 184 0.018
anterior posterior pattern specification GO:0009952 1 0.018
cellular response to alcohol GO:0097306 87 0.018
cellular response to peptide GO:1901653 133 0.018
cation transport GO:0006812 382 0.018
response to corticosteroid GO:0031960 235 0.018
actin filament based process GO:0030029 86 0.018
growth GO:0040007 165 0.018
cardiac chamber development GO:0003205 1 0.018
positive regulation of secretion GO:0051047 140 0.018
behavior GO:0007610 205 0.018
regulation of peptide transport GO:0090087 87 0.018
cell morphogenesis GO:0000902 142 0.018
negative regulation of cellular biosynthetic process GO:0031327 161 0.018
ion transmembrane transport GO:0034220 365 0.017
calcium ion homeostasis GO:0055074 162 0.017
development of primary sexual characteristics GO:0045137 107 0.017
sex differentiation GO:0007548 113 0.017
single organism catabolic process GO:0044712 283 0.017
regulation of calcium ion transport GO:0051924 77 0.017
regulation of epithelial cell proliferation GO:0050678 49 0.017
embryonic appendage morphogenesis GO:0035113 4 0.017
positive regulation of intracellular signal transduction GO:1902533 138 0.017
cellular lipid metabolic process GO:0044255 208 0.017
nucleotide metabolic process GO:0009117 279 0.017
regulation of bmp signaling pathway GO:0030510 2 0.017
regulation of canonical wnt signaling pathway GO:0060828 4 0.017
Human
regulation of phosphorus metabolic process GO:0051174 349 0.017
neurological system process GO:0050877 219 0.017
antigen receptor mediated signaling pathway GO:0050851 1 0.017
cytokine production GO:0001816 61 0.017
regulation of nervous system development GO:0051960 264 0.017
muscle system process GO:0003012 115 0.017
skeletal system development GO:0001501 41 0.016
lipid biosynthetic process GO:0008610 128 0.016
biological adhesion GO:0022610 110 0.016
hormone secretion GO:0046879 115 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
regulation of anatomical structure size GO:0090066 135 0.016
regulation of blood circulation GO:1903522 110 0.016
carbohydrate homeostasis GO:0033500 75 0.016
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.016
Human
purine containing compound metabolic process GO:0072521 253 0.016
response to vitamin GO:0033273 131 0.016
response to estradiol GO:0032355 164 0.016
regulation of anatomical structure morphogenesis GO:0022603 141 0.016
organic substance catabolic process GO:1901575 316 0.016
divalent inorganic cation homeostasis GO:0072507 165 0.016
response to acid chemical GO:0001101 222 0.016
organ formation GO:0048645 3 0.016
cellular response to steroid hormone stimulus GO:0071383 93 0.016
positive regulation of catalytic activity GO:0043085 184 0.016
regulation of response to external stimulus GO:0032101 106 0.016
cellular response to glucocorticoid stimulus GO:0071385 68 0.016
regulation of intracellular signal transduction GO:1902531 218 0.016
regulation of phosphorylation GO:0042325 248 0.016
response to ketone GO:1901654 182 0.015
synaptic transmission GO:0007268 235 0.015
positive regulation of cell motility GO:2000147 97 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.015
regulation of growth GO:0040008 105 0.015
heart development GO:0007507 72 0.015
regulation of metal ion transport GO:0010959 118 0.015
sexual reproduction GO:0019953 148 0.015
muscle cell proliferation GO:0033002 84 0.015
sensory perception of pain GO:0019233 73 0.015
regulation of body fluid levels GO:0050878 90 0.015
cellular component morphogenesis GO:0032989 155 0.015
cellular response to lipopolysaccharide GO:0071222 55 0.015
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.014
chemotaxis GO:0006935 66 0.014
action potential GO:0001508 54 0.014
cell growth GO:0016049 104 0.014
nucleobase containing small molecule metabolic process GO:0055086 316 0.014
response to hexose GO:0009746 144 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
transmission of nerve impulse GO:0019226 42 0.014
hormone metabolic process GO:0042445 69 0.014
anion transport GO:0006820 178 0.014
negative regulation of cell death GO:0060548 229 0.014
regulation of ion transmembrane transport GO:0034765 121 0.014
epithelium development GO:0060429 96 0.013
negative regulation of transport GO:0051051 136 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
response to glucose GO:0009749 136 0.013
cellular response to ketone GO:1901655 51 0.013
response to glucocorticoid GO:0051384 223 0.013
alcohol metabolic process GO:0006066 77 0.013
gastrulation GO:0007369 2 0.013
cellular response to cytokine stimulus GO:0071345 127 0.013
vascular process in circulatory system GO:0003018 96 0.013
regulation of cell motility GO:2000145 131 0.013
muscle contraction GO:0006936 88 0.013
ras protein signal transduction GO:0007265 29 0.013
organelle organization GO:0006996 266 0.013
muscle tissue development GO:0060537 58 0.013
regulation of synaptic transmission GO:0050804 141 0.013
positive regulation of secretion by cell GO:1903532 128 0.013
male gamete generation GO:0048232 99 0.013
mesoderm development GO:0007498 2 0.013
regulation of muscle contraction GO:0006937 53 0.013
cellular response to biotic stimulus GO:0071216 59 0.013
t cell receptor signaling pathway GO:0050852 1 0.013
actin cytoskeleton organization GO:0030036 73 0.013
macromolecular complex assembly GO:0065003 273 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
proteolysis GO:0006508 175 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
metal ion transport GO:0030001 289 0.013
cellular response to corticosteroid stimulus GO:0071384 69 0.013
response to oxidative stress GO:0006979 186 0.013
positive regulation of protein modification process GO:0031401 142 0.013
apoptotic process GO:0006915 381 0.012
regulation of blood pressure GO:0008217 83 0.012
positive regulation of cell migration GO:0030335 96 0.012
single organism carbohydrate metabolic process GO:0044723 118 0.012
chromosome segregation GO:0007059 2 0.012
insulin like growth factor receptor signaling pathway GO:0048009 3 0.012
metal ion homeostasis GO:0055065 186 0.012
regulation of cellular catabolic process GO:0031329 101 0.012
embryonic limb morphogenesis GO:0030326 4 0.012
cell projection morphogenesis GO:0048858 123 0.012
neuromuscular process GO:0050905 2 0.012
regulation of neuron projection development GO:0010975 161 0.012
negative regulation of programmed cell death GO:0043069 183 0.012
glucose homeostasis GO:0042593 75 0.012
spermatogenesis GO:0007283 99 0.012
monosaccharide metabolic process GO:0005996 61 0.012
positive regulation of cellular component movement GO:0051272 102 0.012
peptide hormone secretion GO:0030072 84 0.012
cell junction organization GO:0034330 21 0.012
response to reactive oxygen species GO:0000302 120 0.012
response to camp GO:0051591 91 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
regulation of tube size GO:0035150 89 0.012
heterocycle catabolic process GO:0046700 167 0.012
cellular response to insulin stimulus GO:0032869 81 0.012
regulation of defense response GO:0031347 68 0.012
regulation of hormone secretion GO:0046883 106 0.012
gamete generation GO:0007276 124 0.012
single organism organelle organization GO:1902589 180 0.012
neuron projection morphogenesis GO:0048812 122 0.012
regulation of cell migration GO:0030334 128 0.012
lipid transport GO:0006869 61 0.012
cardiac muscle contraction GO:0060048 27 0.012
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.012
protein maturation GO:0051604 68 0.012
salivary gland development GO:0007431 3 0.012
organic hydroxy compound metabolic process GO:1901615 115 0.012
cellular carbohydrate metabolic process GO:0044262 72 0.011
liver development GO:0001889 90 0.011
muscle structure development GO:0061061 87 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
protein complex biogenesis GO:0070271 263 0.011
dna metabolic process GO:0006259 96 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
regulation of fat cell differentiation GO:0045598 3 0.011
regulation of smooth muscle cell proliferation GO:0048660 75 0.011
ossification GO:0001503 70 0.011
Rat
inorganic ion transmembrane transport GO:0098660 229 0.011
cell fate determination GO:0001709 2 0.011
cardiac muscle cell contraction GO:0086003 10 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
motor neuron axon guidance GO:0008045 1 0.011
regulation of neuron differentiation GO:0045664 208 0.011
steroid metabolic process GO:0008202 73 0.011
cellular hormone metabolic process GO:0034754 49 0.011
meiotic cell cycle process GO:1903046 3 0.011
multicellular organism growth GO:0035264 1 0.011
positive regulation of catabolic process GO:0009896 78 0.011
signal release GO:0023061 145 0.011
non canonical wnt signaling pathway GO:0035567 3 0.011
protein localization GO:0008104 191 0.011
cell adhesion GO:0007155 110 0.011
monocarboxylic acid metabolic process GO:0032787 152 0.011
embryonic skeletal system development GO:0048706 3 0.010
heart contraction GO:0060047 57 0.010
peptidyl amino acid modification GO:0018193 126 0.010
immune response activating signal transduction GO:0002757 15 0.010
salivary gland morphogenesis GO:0007435 1 0.010
male sex differentiation GO:0046661 64 0.010
negative regulation of apoptotic process GO:0043066 181 0.010
hemostasis GO:0007599 26 0.010
hepatocyte proliferation GO:0072574 3 0.010
cellular response to abiotic stimulus GO:0071214 85 0.010
hormone transport GO:0009914 121 0.010
response to dexamethasone GO:0071548 49 0.010
protein oligomerization GO:0051259 191 0.010
regulation of mapk cascade GO:0043408 116 0.010
ribose phosphate metabolic process GO:0019693 235 0.010
coagulation GO:0050817 28 0.010
negative regulation of protein metabolic process GO:0051248 114 0.010
activation of cysteine type endopeptidase activity GO:0097202 4 0.010
smooth muscle cell proliferation GO:0048659 77 0.010
maintenance of location GO:0051235 17 0.010

Dkk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.018
nervous system disease DOID:863 0 0.018
urinary system disease DOID:18 0 0.016
cardiovascular system disease DOID:1287 0 0.015
musculoskeletal system disease DOID:17 0 0.011