Rattus norvegicus

9 known processes

Obscn

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Obscn biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to oxygen levels GO:0070482 265 0.236
positive regulation of cell differentiation GO:0045597 217 0.180
cellular chemical homeostasis GO:0055082 247 0.158
positive regulation of developmental process GO:0051094 283 0.157
response to blue light GO:0009637 1 0.139
response to hypoxia GO:0001666 231 0.119
regulation of rna biosynthetic process GO:2001141 381 0.112
cellular response to oxygen containing compound GO:1901701 386 0.109
cellular response to mechanical stimulus GO:0071260 48 0.092
chemical homeostasis GO:0048878 292 0.091
response to nutrient levels GO:0031667 370 0.090
muscle structure development GO:0061061 87 0.079
cellular response to endogenous stimulus GO:0071495 377 0.075
muscle cell differentiation GO:0042692 52 0.075
homeostatic process GO:0042592 331 0.073
protein complex biogenesis GO:0070271 263 0.073
regulation of transcription dna templated GO:0006355 374 0.072
protein complex assembly GO:0006461 263 0.072
nucleic acid templated transcription GO:0097659 379 0.072
response to extracellular stimulus GO:0009991 380 0.072
positive regulation of multicellular organismal process GO:0051240 387 0.070
cellular component morphogenesis GO:0032989 155 0.070
cellular response to organonitrogen compound GO:0071417 197 0.069
muscle system process GO:0003012 115 0.069
response to purine containing compound GO:0014074 126 0.068
cation transmembrane transport GO:0098655 263 0.068
cellular response to abiotic stimulus GO:0071214 85 0.067
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.065
cardiac muscle cell contraction GO:0086003 10 0.064
protein complex subunit organization GO:0071822 302 0.062
regulation of neurogenesis GO:0050767 247 0.062
cytoskeleton organization GO:0007010 111 0.061
inorganic cation transmembrane transport GO:0098662 202 0.060
regulation of nucleic acid templated transcription GO:1903506 380 0.060
cell projection morphogenesis GO:0048858 123 0.060
cell projection organization GO:0030030 302 0.058
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.058
ion transmembrane transport GO:0034220 365 0.058
neuron death GO:0070997 127 0.057
neuron differentiation GO:0030182 368 0.057
cellular calcium ion homeostasis GO:0006874 160 0.057
potassium ion transport GO:0006813 97 0.055
positive regulation of nervous system development GO:0051962 178 0.055
actin filament based movement GO:0030048 16 0.054
cardiac muscle contraction GO:0060048 27 0.054
regulation of striated muscle contraction GO:0006942 21 0.052
nucleoside phosphate metabolic process GO:0006753 283 0.052
regulation of cell differentiation GO:0045595 320 0.051
response to cytokine GO:0034097 215 0.051
regulation of rna metabolic process GO:0051252 391 0.050
response to decreased oxygen levels GO:0036293 237 0.050
inorganic ion transmembrane transport GO:0098660 229 0.050
actin mediated cell contraction GO:0070252 12 0.049
regulation of neuron projection development GO:0010975 161 0.048
positive regulation of ion transport GO:0043270 94 0.048
carbohydrate derivative metabolic process GO:1901135 346 0.048
positive regulation of neurogenesis GO:0050769 165 0.048
response to electrical stimulus involved in regulation of muscle adaptation GO:0014878 4 0.048
brain development GO:0007420 247 0.048
intracellular transport GO:0046907 185 0.047
cellular homeostasis GO:0019725 252 0.047
response to corticosteroid GO:0031960 235 0.047
cellular component movement GO:0006928 248 0.046
blood circulation GO:0008015 183 0.046
l glutamate import GO:0051938 2 0.045
neuron projection morphogenesis GO:0048812 122 0.045
central nervous system development GO:0007417 311 0.045
anatomical structure morphogenesis GO:0009653 298 0.045
head development GO:0060322 247 0.043
positive regulation of biosynthetic process GO:0009891 319 0.042
rna biosynthetic process GO:0032774 380 0.042
regulation of system process GO:0044057 208 0.042
tissue development GO:0009888 252 0.041
circulatory system process GO:0003013 183 0.040
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 4 0.040
cellular cation homeostasis GO:0030003 180 0.040
cellular component biogenesis GO:0044085 368 0.040
cellular component assembly GO:0022607 360 0.039
cardiac muscle cell development GO:0055013 16 0.039
regulation of cellular localization GO:0060341 263 0.039
regulation of nervous system development GO:0051960 264 0.038
single organism biosynthetic process GO:0044711 342 0.038
organelle organization GO:0006996 266 0.037
regulation of dendrite development GO:0050773 59 0.037
muscle tissue development GO:0060537 58 0.036
potassium ion transmembrane transport GO:0071805 71 0.036
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.036
sequestering of calcium ion GO:0051208 8 0.035
regulation of cellular component movement GO:0051270 150 0.035
organic substance catabolic process GO:1901575 316 0.035
cellular response to nitrogen compound GO:1901699 210 0.034
cellular catabolic process GO:0044248 295 0.034
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.033
cell part morphogenesis GO:0032990 123 0.033
metal ion homeostasis GO:0055065 186 0.033
cellular potassium ion transport GO:0071804 72 0.033
response to glucocorticoid GO:0051384 223 0.033
rna metabolic process GO:0016070 406 0.033
circadian rhythm GO:0007623 88 0.033
metal ion transport GO:0030001 289 0.032
negative regulation of cell death GO:0060548 229 0.032
response to nutrient GO:0007584 248 0.032
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 4 0.032
regulation of cardiac muscle contraction GO:0055117 17 0.031
regulation of neuron death GO:1901214 115 0.031
heart contraction GO:0060047 57 0.031
cellular response to hormone stimulus GO:0032870 247 0.031
regulation of multicellular organismal development GO:2000026 376 0.031
single organism behavior GO:0044708 130 0.031
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.031
calcium ion homeostasis GO:0055074 162 0.031
membrane depolarization during action potential GO:0086010 1 0.030
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.030
cell morphogenesis involved in differentiation GO:0000904 119 0.030
cellular divalent inorganic cation homeostasis GO:0072503 162 0.030
response to organophosphorus GO:0046683 102 0.029
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.029
response to ketone GO:1901654 182 0.029
neuron apoptotic process GO:0051402 88 0.029
nucleotide metabolic process GO:0009117 279 0.029
regulation of cell projection organization GO:0031344 175 0.028
heart process GO:0003015 57 0.028
organophosphate metabolic process GO:0019637 370 0.028
regulation of cell development GO:0060284 263 0.028
transcription dna templated GO:0006351 377 0.027
regulation of cellular catabolic process GO:0031329 101 0.027
calcium ion transmembrane transport GO:0070588 70 0.027
macromolecular complex assembly GO:0065003 273 0.027
cellular metal ion homeostasis GO:0006875 172 0.027
regulation of ion transmembrane transporter activity GO:0032412 48 0.026
cytoplasmic transport GO:0016482 115 0.026
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.026
negative regulation of metabolic process GO:0009892 331 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.025
regulation of neuron differentiation GO:0045664 208 0.025
neuron development GO:0048666 286 0.025
nucleoside phosphate catabolic process GO:1901292 140 0.025
positive regulation of phosphorylation GO:0042327 177 0.025
response to peptide hormone GO:0043434 278 0.025
single organism intracellular transport GO:1902582 166 0.025
regulation of heart contraction GO:0008016 48 0.024
cardiac ventricle development GO:0003231 1 0.024
sequestering of metal ion GO:0051238 9 0.024
carbohydrate derivative catabolic process GO:1901136 147 0.024
actin filament based process GO:0030029 86 0.024
regulation of cell proliferation GO:0042127 359 0.023
regulation of membrane repolarization GO:0060306 1 0.023
transmembrane transport GO:0055085 412 0.023
transcription from rna polymerase ii promoter GO:0006366 252 0.023
sarcoplasmic reticulum calcium ion transport GO:0070296 8 0.023
cellular ion homeostasis GO:0006873 184 0.023
ribonucleoside metabolic process GO:0009119 174 0.023
programmed cell death GO:0012501 392 0.023
regulation of actin filament based movement GO:1903115 12 0.023
cellular response to stress GO:0033554 269 0.023
regulation of catabolic process GO:0009894 113 0.022
nucleoside catabolic process GO:0009164 126 0.022
regulation of programmed cell death GO:0043067 341 0.022
divalent inorganic cation transport GO:0072511 134 0.022
regulation of cellular component organization GO:0051128 368 0.022
response to estradiol GO:0032355 164 0.021
cation homeostasis GO:0055080 195 0.021
positive regulation of transcription dna templated GO:0045893 197 0.021
maintenance of location GO:0051235 17 0.021
heterocycle catabolic process GO:0046700 167 0.021
response to ethanol GO:0045471 162 0.021
regulation of establishment of planar polarity GO:0090175 2 0.021
striated muscle contraction GO:0006941 44 0.021
response to molecule of bacterial origin GO:0002237 194 0.021
ventricular cardiac muscle cell action potential GO:0086005 2 0.021
cellular response to external stimulus GO:0071496 118 0.021
rhythmic process GO:0048511 156 0.021
purine nucleoside triphosphate catabolic process GO:0009146 122 0.021
oxoacid metabolic process GO:0043436 290 0.020
positive regulation of molecular function GO:0044093 230 0.020
enzyme linked receptor protein signaling pathway GO:0007167 116 0.020
male sex differentiation GO:0046661 64 0.020
positive regulation of transport GO:0051050 245 0.020
striated muscle cell development GO:0055002 26 0.020
cytosolic calcium ion homeostasis GO:0051480 140 0.020
regulation of phosphorus metabolic process GO:0051174 349 0.020
positive regulation of cellular component organization GO:0051130 200 0.020
ion homeostasis GO:0050801 212 0.020
purine containing compound metabolic process GO:0072521 253 0.020
divalent inorganic cation homeostasis GO:0072507 165 0.019
female pregnancy GO:0007565 122 0.019
monovalent inorganic cation transport GO:0015672 172 0.019
actin cytoskeleton organization GO:0030036 73 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
purine containing compound catabolic process GO:0072523 138 0.019
organonitrogen compound biosynthetic process GO:1901566 167 0.019
negative regulation of cell differentiation GO:0045596 99 0.019
regulation of ion transport GO:0043269 245 0.019
regulation of molecular function GO:0065009 398 0.019
optic nerve development GO:0021554 3 0.019
regulation of stem cell differentiation GO:2000736 2 0.019
positive regulation of cellular biosynthetic process GO:0031328 295 0.019
developmental process involved in reproduction GO:0003006 159 0.019
regulation of intracellular signal transduction GO:1902531 218 0.019
cellular protein complex assembly GO:0043623 44 0.019
eye development GO:0001654 50 0.018
growth GO:0040007 165 0.018
multicellular organismal signaling GO:0035637 44 0.018
positive regulation of rna metabolic process GO:0051254 203 0.018
sensory organ development GO:0007423 74 0.018
catabolic process GO:0009056 351 0.018
aging GO:0007568 241 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.018
single organism organelle organization GO:1902589 180 0.018
response to biotic stimulus GO:0009607 226 0.017
positive regulation of signal transduction GO:0009967 175 0.017
regulation of neuron apoptotic process GO:0043523 83 0.017
protein phosphorylation GO:0006468 345 0.017
heart morphogenesis GO:0003007 3 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
protein tetramerization GO:0051262 38 0.017
dendrite development GO:0016358 72 0.017
positive regulation of neuron projection development GO:0010976 99 0.017
response to carbohydrate GO:0009743 183 0.017
protein heterooligomerization GO:0051291 89 0.017
skeletal muscle organ development GO:0060538 33 0.017
regulation of cardiac muscle cell contraction GO:0086004 11 0.016
ribonucleoside triphosphate metabolic process GO:0009199 141 0.016
regulation of growth GO:0040008 105 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
muscle organ development GO:0007517 50 0.016
positive regulation of rna biosynthetic process GO:1902680 197 0.016
regulation of muscle system process GO:0090257 79 0.016
calcium ion transport into cytosol GO:0060402 38 0.016
purine ribonucleotide metabolic process GO:0009150 227 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
cell morphogenesis GO:0000902 142 0.015
cellular macromolecular complex assembly GO:0034622 58 0.015
cytosolic calcium ion transport GO:0060401 39 0.015
bmp signaling pathway GO:0030509 4 0.015
intracellular signal transduction GO:0035556 314 0.015
cardiac chamber development GO:0003205 1 0.015
response to glucose GO:0009749 136 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
positive regulation of cell development GO:0010720 176 0.015
heart development GO:0007507 72 0.015
second messenger mediated signaling GO:0019932 51 0.015
positive regulation of response to stimulus GO:0048584 285 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
response to other organism GO:0051707 220 0.014
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.014
positive regulation of signaling GO:0023056 270 0.014
male gonad development GO:0008584 59 0.014
aromatic compound catabolic process GO:0019439 168 0.014
lipid metabolic process GO:0006629 283 0.014
protein polymerization GO:0051258 22 0.014
reproductive system development GO:0061458 128 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
nucleotide catabolic process GO:0009166 139 0.014
oxidation reduction process GO:0055114 304 0.014
cardiac conduction GO:0061337 2 0.014
sex differentiation GO:0007548 113 0.014
regulation of metal ion transport GO:0010959 118 0.014
nucleoside triphosphate catabolic process GO:0009143 123 0.014
regulation of secretion GO:0051046 224 0.014
organophosphate catabolic process GO:0046434 148 0.014
locomotion GO:0040011 237 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.013
action potential GO:0001508 54 0.013
cellular response to lipid GO:0071396 201 0.013
nucleobase containing small molecule metabolic process GO:0055086 316 0.013
response to mechanical stimulus GO:0009612 134 0.013
regulation of muscle contraction GO:0006937 53 0.013
regulation of catalytic activity GO:0050790 304 0.013
single organism catabolic process GO:0044712 283 0.013
regulation of transmembrane transporter activity GO:0022898 49 0.013
regulation of apoptotic process GO:0042981 335 0.013
cellular response to insulin stimulus GO:0032869 81 0.013
developmental growth GO:0048589 100 0.013
development of primary male sexual characteristics GO:0046546 59 0.012
ribose phosphate metabolic process GO:0019693 235 0.012
negative regulation of macromolecule metabolic process GO:0010605 260 0.012
positive regulation of phagocytosis engulfment GO:0060100 4 0.012
cellular amino acid metabolic process GO:0006520 107 0.012
protein homotetramerization GO:0051289 25 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
positive regulation of cellular catabolic process GO:0031331 71 0.012
motor neuron axon guidance GO:0008045 1 0.012
regulation of cellular protein metabolic process GO:0032268 267 0.012
cation transport GO:0006812 382 0.012
regulation of protein complex assembly GO:0043254 33 0.012
ribonucleotide metabolic process GO:0009259 231 0.012
gonad development GO:0008406 104 0.012
protein localization GO:0008104 191 0.012
membrane repolarization GO:0086009 1 0.012
positive regulation of potassium ion transmembrane transport GO:1901381 4 0.012
cellular response to organic cyclic compound GO:0071407 202 0.012
protein homooligomerization GO:0051260 91 0.012
negative regulation of calcium ion transport into cytosol GO:0010523 4 0.011
nucleoside metabolic process GO:0009116 179 0.011
positive regulation of cellular component biogenesis GO:0044089 55 0.011
negative regulation of arp2 3 complex mediated actin nucleation GO:0034316 1 0.011
response to toxic substance GO:0009636 133 0.011
neuron fate commitment GO:0048663 4 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
protein oligomerization GO:0051259 191 0.011
negative regulation of gene expression GO:0010629 199 0.011
response to hexose GO:0009746 144 0.011
muscle cell development GO:0055001 26 0.011
sarcomere organization GO:0045214 6 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
regulation of blood circulation GO:1903522 110 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
regulation of signal transduction GO:0009966 318 0.011
erythrocyte homeostasis GO:0034101 2 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
positive regulation of nucleic acid templated transcription GO:1903508 197 0.010
muscle contraction GO:0006936 88 0.010
cardiac muscle tissue morphogenesis GO:0055008 1 0.010
purine nucleotide catabolic process GO:0006195 136 0.010
regulation of homeostatic process GO:0032844 101 0.010
cellular ketone metabolic process GO:0042180 51 0.010
cellular response to growth factor stimulus GO:0071363 162 0.010
response to inorganic substance GO:0010035 377 0.010
positive regulation of cell communication GO:0010647 271 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
positive regulation of ion transmembrane transport GO:0034767 24 0.010
muscle organ morphogenesis GO:0048644 1 0.010
macromolecular complex subunit organization GO:0043933 339 0.010
ras protein signal transduction GO:0007265 29 0.010
neurological system process GO:0050877 219 0.010
regulation of intracellular transport GO:0032386 65 0.010

Obscn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
long qt syndrome DOID:2843 0 0.216
disease of anatomical entity DOID:7 0 0.164
cardiovascular system disease DOID:1287 0 0.164
musculoskeletal system disease DOID:17 0 0.121
myopathy DOID:423 0 0.041
muscular disease DOID:0080000 0 0.041
heart disease DOID:114 0 0.041
cardiomyopathy DOID:0050700 0 0.041
dilated cardiomyopathy DOID:12930 0 0.041
intrinsic cardiomyopathy DOID:0060036 0 0.041
muscle tissue disease DOID:66 0 0.041
disease of metabolism DOID:0014667 0 0.026
inherited metabolic disorder DOID:655 0 0.026
nervous system disease DOID:863 0 0.024