Rattus norvegicus

18 known processes

Nf2

neurofibromin 2 (merlin)

(Aliases: merlin)

Nf2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of transcription dna templated GO:0006355 374 0.266
rna biosynthetic process GO:0032774 380 0.189
apoptotic process GO:0006915 381 0.135
Fly
transcription dna templated GO:0006351 377 0.132
regulation of nucleic acid templated transcription GO:1903506 380 0.121
organelle organization GO:0006996 266 0.093
Human Rat Fly
regulation of rna biosynthetic process GO:2001141 381 0.091
positive regulation of developmental process GO:0051094 283 0.091
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.089
synaptic transmission GO:0007268 235 0.088
rna metabolic process GO:0016070 406 0.080
response to growth factor GO:0070848 189 0.079
Rat
ribonucleotide metabolic process GO:0009259 231 0.076
transcription from rna polymerase ii promoter GO:0006366 252 0.073
negative regulation of metabolic process GO:0009892 331 0.073
Human Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.068
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.068
regulation of cell development GO:0060284 263 0.067
Fly
response to monosaccharide GO:0034284 159 0.062
regulation of cell differentiation GO:0045595 320 0.061
Mouse Fly
nucleic acid templated transcription GO:0097659 379 0.061
neuron differentiation GO:0030182 368 0.060
Fly
regulation of rna metabolic process GO:0051252 391 0.060
purine ribonucleotide biosynthetic process GO:0009152 81 0.059
cellular response to growth factor stimulus GO:0071363 162 0.057
Rat
regulation of neuron projection development GO:0010975 161 0.055
nucleotide metabolic process GO:0009117 279 0.054
neuron development GO:0048666 286 0.054
positive regulation of neurogenesis GO:0050769 165 0.054
positive regulation of transport GO:0051050 245 0.053
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 24 0.051
negative regulation of nervous system development GO:0051961 79 0.050
Fly
nucleoside phosphate metabolic process GO:0006753 283 0.049
nucleoside phosphate biosynthetic process GO:1901293 102 0.049
regulation of neuron differentiation GO:0045664 208 0.049
positive regulation of cellular biosynthetic process GO:0031328 295 0.048
purine nucleotide metabolic process GO:0006163 229 0.048
cyclic purine nucleotide metabolic process GO:0052652 62 0.048
purine nucleotide biosynthetic process GO:0006164 83 0.047
programmed cell death GO:0012501 392 0.046
Fly
purine containing compound metabolic process GO:0072521 253 0.046
carbohydrate derivative metabolic process GO:1901135 346 0.046
regulation of phosphorus metabolic process GO:0051174 349 0.046
Human Mouse Fly
positive regulation of camp metabolic process GO:0030816 31 0.045
regulation of apoptotic process GO:0042981 335 0.045
Fly
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.044
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.042
protein complex subunit organization GO:0071822 302 0.042
Human Rat
regulation of nervous system development GO:0051960 264 0.042
Fly
organophosphate metabolic process GO:0019637 370 0.041
cell cell signaling GO:0007267 335 0.041
Fly
ribonucleotide biosynthetic process GO:0009260 85 0.041
positive regulation of cell differentiation GO:0045597 217 0.040
Mouse
response to extracellular stimulus GO:0009991 380 0.039
cellular response to endogenous stimulus GO:0071495 377 0.036
Rat
negative regulation of transcription dna templated GO:0045892 116 0.036
nucleobase containing small molecule metabolic process GO:0055086 316 0.036
enzyme linked receptor protein signaling pathway GO:0007167 116 0.036
Fly
response to cytokine GO:0034097 215 0.036
negative regulation of macromolecule metabolic process GO:0010605 260 0.036
Human Mouse
cellular component morphogenesis GO:0032989 155 0.035
carboxylic acid metabolic process GO:0019752 289 0.035
positive regulation of neuron projection development GO:0010976 99 0.035
negative regulation of signaling GO:0023057 157 0.035
Human Mouse
regulation of camp metabolic process GO:0030814 43 0.034
positive regulation of neuron differentiation GO:0045666 126 0.034
positive regulation of response to stimulus GO:0048584 285 0.034
nucleotide biosynthetic process GO:0009165 98 0.034
positive regulation of phosphate metabolic process GO:0045937 262 0.034
Fly
cell growth GO:0016049 104 0.034
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.034
Human
regulation of cell projection organization GO:0031344 175 0.034
positive regulation of rna biosynthetic process GO:1902680 197 0.033
cellular component biogenesis GO:0044085 368 0.033
Human Rat Fly
protein complex biogenesis GO:0070271 263 0.033
Rat
single organism catabolic process GO:0044712 283 0.032
positive regulation of multicellular organismal process GO:0051240 387 0.032
reproductive process GO:0022414 372 0.032
Fly
multi organism reproductive process GO:0044703 262 0.032
Fly
organophosphate biosynthetic process GO:0090407 143 0.032
regulation of phosphate metabolic process GO:0019220 349 0.032
Human Mouse Fly
secretion by cell GO:0032940 248 0.031
cardiovascular system development GO:0072358 134 0.030
head development GO:0060322 247 0.030
Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.030
negative regulation of gene expression GO:0010629 199 0.030
positive regulation of nervous system development GO:0051962 178 0.030
single organism organelle organization GO:1902589 180 0.030
Human Rat
positive regulation of cell development GO:0010720 176 0.029
purine containing compound biosynthetic process GO:0072522 85 0.029
regulation of secretion GO:0051046 224 0.029
cellular chemical homeostasis GO:0055082 247 0.028
anatomical structure morphogenesis GO:0009653 298 0.028
Mouse Fly
organonitrogen compound biosynthetic process GO:1901566 167 0.028
response to hypoxia GO:0001666 231 0.028
protein localization GO:0008104 191 0.028
Mouse Rat Fly
regulation of neurogenesis GO:0050767 247 0.028
Fly
catabolic process GO:0009056 351 0.028
purine ribonucleotide metabolic process GO:0009150 227 0.028
circulatory system development GO:0072359 134 0.028
homeostatic process GO:0042592 331 0.027
ribose phosphate metabolic process GO:0019693 235 0.027
intracellular signal transduction GO:0035556 314 0.027
Human Mouse Fly
positive regulation of gene expression GO:0010628 244 0.027
ribose phosphate biosynthetic process GO:0046390 87 0.027
central nervous system development GO:0007417 311 0.027
Mouse
response to transforming growth factor beta GO:0071559 46 0.027
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.027
second messenger mediated signaling GO:0019932 51 0.027
tissue development GO:0009888 252 0.027
Mouse Rat
regulation of multicellular organismal development GO:2000026 376 0.027
Fly
regulation of cellular amine metabolic process GO:0033238 8 0.027
regulation of anatomical structure morphogenesis GO:0022603 141 0.026
Fly
regulation of cellular localization GO:0060341 263 0.026
Mouse
organic substance catabolic process GO:1901575 316 0.026
cellular homeostasis GO:0019725 252 0.026
negative regulation of rna metabolic process GO:0051253 123 0.026
regulation of programmed cell death GO:0043067 341 0.026
Fly
cell projection organization GO:0030030 302 0.026
Rat
regulation of cellular ketone metabolic process GO:0010565 27 0.025
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.025
development of primary sexual characteristics GO:0045137 107 0.025
cellular response to oxygen containing compound GO:1901701 386 0.025
negative regulation of programmed cell death GO:0043069 183 0.025
positive regulation of rna metabolic process GO:0051254 203 0.024
neurological system process GO:0050877 219 0.024
secretion GO:0046903 307 0.024
regulation of homeostatic process GO:0032844 101 0.024
negative regulation of cellular metabolic process GO:0031324 281 0.024
Human Mouse
cyclic nucleotide metabolic process GO:0009187 80 0.024
negative regulation of cell communication GO:0010648 158 0.023
Human Mouse
cellular calcium ion homeostasis GO:0006874 160 0.023
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.023
Human
vasculature development GO:0001944 70 0.023
single organism reproductive process GO:0044702 297 0.023
Fly
motor neuron axon guidance GO:0008045 1 0.023
carbohydrate derivative biosynthetic process GO:1901137 124 0.023
cellular amino acid metabolic process GO:0006520 107 0.023
regulation of nucleotide biosynthetic process GO:0030808 47 0.023
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.023
Human
regulation of molecular function GO:0065009 398 0.023
Mouse
actin filament based process GO:0030029 86 0.022
Human Rat
cell projection morphogenesis GO:0048858 123 0.022
cyclic nucleotide biosynthetic process GO:0009190 63 0.022
cellular divalent inorganic cation homeostasis GO:0072503 162 0.022
negative regulation of phosphorus metabolic process GO:0010563 80 0.022
Human Mouse
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.022
bmp signaling pathway GO:0030509 4 0.022
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.022
nucleoside metabolic process GO:0009116 179 0.022
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.022
regulation of cell proliferation GO:0042127 359 0.022
Human Mouse Fly
organophosphate catabolic process GO:0046434 148 0.022
cellular component assembly GO:0022607 360 0.022
Human Rat Fly
regulation of phosphorylation GO:0042325 248 0.021
Human Mouse Fly
negative regulation of apoptotic process GO:0043066 181 0.021
response to hexose GO:0009746 144 0.021
brain development GO:0007420 247 0.021
Mouse
g protein coupled receptor signaling pathway GO:0007186 242 0.021
positive regulation of cell death GO:0010942 184 0.021
macromolecular complex assembly GO:0065003 273 0.021
Rat
cellular catabolic process GO:0044248 295 0.021
positive regulation of biosynthetic process GO:0009891 319 0.021
regulation of nucleotide metabolic process GO:0006140 117 0.020
regulation of cellular component organization GO:0051128 368 0.020
divalent inorganic cation homeostasis GO:0072507 165 0.020
positive regulation of secretion GO:0051047 140 0.020
ion homeostasis GO:0050801 212 0.020
cellular ketone metabolic process GO:0042180 51 0.020
sulfur amino acid metabolic process GO:0000096 9 0.019
response to decreased oxygen levels GO:0036293 237 0.019
multicellular organismal signaling GO:0035637 44 0.019
lipid metabolic process GO:0006629 283 0.019
cellular response to stress GO:0033554 269 0.019
negative regulation of rna biosynthetic process GO:1902679 118 0.019
cellular amine metabolic process GO:0044106 38 0.019
macromolecule localization GO:0033036 252 0.019
Mouse Rat Fly
cellular component movement GO:0006928 248 0.019
positive regulation of transcription dna templated GO:0045893 197 0.019
regulation of synaptic plasticity GO:0048167 70 0.019
sexual reproduction GO:0019953 148 0.018
Fly
neuron projection development GO:0031175 273 0.018
regulation of purine nucleotide metabolic process GO:1900542 115 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
Fly
negative regulation of cellular component organization GO:0051129 83 0.018
Rat
circulatory system process GO:0003013 183 0.018
regulation of secretion by cell GO:1903530 208 0.018
organic acid metabolic process GO:0006082 292 0.018
positive regulation of signaling GO:0023056 270 0.018
negative regulation of multicellular organismal process GO:0051241 203 0.018
Fly
negative regulation of cell death GO:0060548 229 0.018
chromosome segregation GO:0007059 2 0.018
Fly
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
cell type specific apoptotic process GO:0097285 134 0.017
multicellular organism reproduction GO:0032504 233 0.017
Fly
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.017
nucleoside phosphate catabolic process GO:1901292 140 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.017
cellular response to cytokine stimulus GO:0071345 127 0.017
cytoskeleton organization GO:0007010 111 0.017
Human Rat
behavior GO:0007610 205 0.017
Fly
response to nutrient levels GO:0031667 370 0.017
purine nucleoside catabolic process GO:0006152 124 0.017
positive regulation of camp biosynthetic process GO:0030819 28 0.017
regulation of ion transport GO:0043269 245 0.017
response to carbohydrate GO:0009743 183 0.017
amine metabolic process GO:0009308 38 0.017
cellular metal ion homeostasis GO:0006875 172 0.017
cardiac ventricle development GO:0003231 1 0.017
respiratory gaseous exchange GO:0007585 4 0.017
cardiac muscle tissue morphogenesis GO:0055008 1 0.017
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.016
response to glucose GO:0009749 136 0.016
regulation of neuron death GO:1901214 115 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
regulation of blood pressure GO:0008217 83 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
camp metabolic process GO:0046058 63 0.016
protein phosphorylation GO:0006468 345 0.016
Human Mouse Fly
regulation of cellular amino acid metabolic process GO:0006521 2 0.016
defense response GO:0006952 194 0.016
tube development GO:0035295 89 0.016
Mouse
single organism biosynthetic process GO:0044711 342 0.016
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.016
response to oxygen levels GO:0070482 265 0.016
metal ion transport GO:0030001 289 0.016
anatomical structure formation involved in morphogenesis GO:0048646 83 0.016
Mouse Fly
skeletal system development GO:0001501 41 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
cytosolic calcium ion homeostasis GO:0051480 140 0.016
divalent inorganic cation transport GO:0072511 134 0.016
cell morphogenesis GO:0000902 142 0.016
establishment of protein localization GO:0045184 141 0.015
cellular response to organonitrogen compound GO:0071417 197 0.015
negative regulation of cellular biosynthetic process GO:0031327 161 0.015
Human
protein transport GO:0015031 132 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
regulation of signal transduction GO:0009966 318 0.015
Human Mouse Fly
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.015
Human
multicellular organismal reproductive process GO:0048609 233 0.015
Fly
regulation of anatomical structure size GO:0090066 135 0.015
Rat
purine ribonucleoside metabolic process GO:0046128 168 0.015
signal release GO:0023061 145 0.015
female pregnancy GO:0007565 122 0.014
cellular lipid metabolic process GO:0044255 208 0.014
macromolecular complex subunit organization GO:0043933 339 0.014
Human Rat
positive regulation of nucleotide metabolic process GO:0045981 91 0.014
membrane repolarization GO:0086009 1 0.014
negative regulation of biosynthetic process GO:0009890 168 0.014
Human
positive regulation of cell projection organization GO:0031346 111 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
cellular protein localization GO:0034613 122 0.014
Mouse Fly
oxoacid metabolic process GO:0043436 290 0.014
male sex differentiation GO:0046661 64 0.014
regulation of cellular protein metabolic process GO:0032268 267 0.014
Human Mouse Fly
protein complex assembly GO:0006461 263 0.014
Rat
positive regulation of ion transport GO:0043270 94 0.014
cognition GO:0050890 92 0.014
positive regulation of secretion by cell GO:1903532 128 0.014
cellular response to nitrogen compound GO:1901699 210 0.014
myeloid leukocyte activation GO:0002274 36 0.014
positive regulation of cellular component organization GO:0051130 200 0.014
Human
ras protein signal transduction GO:0007265 29 0.014
muscle tissue morphogenesis GO:0060415 1 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
Human Mouse
metal ion homeostasis GO:0055065 186 0.014
negative regulation of nucleic acid templated transcription GO:1903507 117 0.014
sex differentiation GO:0007548 113 0.014
muscle structure development GO:0061061 87 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
cytokine mediated signaling pathway GO:0019221 43 0.014
heart morphogenesis GO:0003007 3 0.014
heterocycle catabolic process GO:0046700 167 0.013
negative regulation of cell development GO:0010721 82 0.013
Fly
ribonucleoside metabolic process GO:0009119 174 0.013
cation homeostasis GO:0055080 195 0.013
exocytosis GO:0006887 60 0.013
regulation of dendrite development GO:0050773 59 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.013
appendage morphogenesis GO:0035107 4 0.013
Fly
regulation of lyase activity GO:0051339 22 0.013
single organism intracellular transport GO:1902582 166 0.013
Fly
purine nucleoside monophosphate metabolic process GO:0009126 84 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
regulation of protein modification process GO:0031399 194 0.013
Human Mouse Fly
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.013
nucleoside triphosphate metabolic process GO:0009141 144 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
regulation of synaptic transmission GO:0050804 141 0.013
sensory perception GO:0007600 101 0.013
response to bacterium GO:0009617 200 0.013
response to interleukin 1 GO:0070555 55 0.013
reproduction GO:0000003 245 0.013
Fly
inorganic cation transmembrane transport GO:0098662 202 0.013
chemical homeostasis GO:0048878 292 0.012
reproductive system development GO:0061458 128 0.012
calcium ion homeostasis GO:0055074 162 0.012
ribonucleotide catabolic process GO:0009261 136 0.012
alpha amino acid metabolic process GO:1901605 71 0.012
mechanoreceptor differentiation GO:0042490 2 0.012
ribonucleoside monophosphate metabolic process GO:0009161 88 0.012
adult locomotory behavior GO:0008344 4 0.012
neuron projection morphogenesis GO:0048812 122 0.012
ion transmembrane transport GO:0034220 365 0.012
regulation of hydrolase activity GO:0051336 143 0.012
response to organophosphorus GO:0046683 102 0.012
negative regulation of neuron differentiation GO:0045665 62 0.012
cytokine production GO:0001816 61 0.012
response to cocaine GO:0042220 39 0.012
response to nutrient GO:0007584 248 0.012
activation of cysteine type endopeptidase activity GO:0097202 4 0.012
regulation of catalytic activity GO:0050790 304 0.012
Mouse
intracellular transport GO:0046907 185 0.012
Fly
response to inorganic substance GO:0010035 377 0.012
negative regulation of developmental process GO:0051093 125 0.012
Fly
negative regulation of transport GO:0051051 136 0.012
oxidation reduction process GO:0055114 304 0.012
cell part morphogenesis GO:0032990 123 0.012
regulation of calcium ion transport GO:0051924 77 0.012
axon development GO:0061564 96 0.011
regulation of cell morphogenesis GO:0022604 77 0.011
peptide transport GO:0015833 97 0.011
organ formation GO:0048645 3 0.011
regulation of catecholamine secretion GO:0050433 32 0.011
localization of cell GO:0051674 202 0.011
hormone secretion GO:0046879 115 0.011
regulation of camp biosynthetic process GO:0030817 38 0.011
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.011
regulation of blood circulation GO:1903522 110 0.011
rhythmic process GO:0048511 156 0.011
regulation of cyclase activity GO:0031279 21 0.011
multicellular organism growth GO:0035264 1 0.011
striated muscle contraction GO:0006941 44 0.011
negative regulation of neurogenesis GO:0050768 78 0.011
Fly
negative regulation of molecular function GO:0044092 133 0.011
Mouse
purine containing compound catabolic process GO:0072523 138 0.011
aging GO:0007568 241 0.011
positive regulation of molecular function GO:0044093 230 0.011
gamete generation GO:0007276 124 0.011
Fly
response to ethanol GO:0045471 162 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.011
ribonucleoside catabolic process GO:0042454 126 0.010
proteolysis GO:0006508 175 0.010
vascular process in circulatory system GO:0003018 96 0.010
angiogenesis GO:0001525 53 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
positive regulation of cell communication GO:0010647 271 0.010
regulation of membrane potential GO:0042391 110 0.010
cation transport GO:0006812 382 0.010
amide transport GO:0042886 105 0.010
purine nucleotide catabolic process GO:0006195 136 0.010
negative regulation of secretion GO:0051048 82 0.010
cell fate determination GO:0001709 2 0.010
protein oligomerization GO:0051259 191 0.010
regulation of sodium ion transport GO:0002028 21 0.010
anterior posterior pattern specification GO:0009952 1 0.010
Fly

Nf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
cardiovascular system disease DOID:1287 0 0.025
muscular disease DOID:0080000 0 0.019
musculoskeletal system disease DOID:17 0 0.019
muscle tissue disease DOID:66 0 0.019
myopathy DOID:423 0 0.017
nervous system disease DOID:863 0 0.016
central nervous system disease DOID:331 0 0.014