Rattus norvegicus

121 known processes

Nf1

neurofibromin 1

Nf1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of phosphate metabolic process GO:0019220 349 0.268
macromolecular complex subunit organization GO:0043933 339 0.239
Mouse
rna metabolic process GO:0016070 406 0.193
positive regulation of cell communication GO:0010647 271 0.154
Mouse
regulation of intracellular signal transduction GO:1902531 218 0.143
regulation of cellular protein metabolic process GO:0032268 267 0.142
Mouse
cation transport GO:0006812 382 0.138
intracellular signal transduction GO:0035556 314 0.126
Human Zebrafish Mouse
reproductive process GO:0022414 372 0.119
cellular protein localization GO:0034613 122 0.109
Mouse
regulation of phosphorus metabolic process GO:0051174 349 0.107
positive regulation of molecular function GO:0044093 230 0.094
Human Mouse
negative regulation of metabolic process GO:0009892 331 0.088
Human Zebrafish Mouse
programmed cell death GO:0012501 392 0.087
Mouse
negative regulation of signaling GO:0023057 157 0.086
Human Zebrafish Mouse
single organism biosynthetic process GO:0044711 342 0.082
Mouse
sarcoplasmic reticulum calcium ion transport GO:0070296 8 0.080
homeostatic process GO:0042592 331 0.078
Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.074
negative regulation of macromolecule metabolic process GO:0010605 260 0.073
Mouse
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.068
macromolecular complex assembly GO:0065003 273 0.065
cell type specific apoptotic process GO:0097285 134 0.064
Mouse
single organism intracellular transport GO:1902582 166 0.064
Mouse
calcium ion import GO:0070509 22 0.063
protein phosphorylation GO:0006468 345 0.059
Mouse
rna biosynthetic process GO:0032774 380 0.059
positive regulation of signaling GO:0023056 270 0.058
Mouse
cellular divalent inorganic cation homeostasis GO:0072503 162 0.058
regulation of phosphorylation GO:0042325 248 0.058
Human Zebrafish Mouse
regulation of nucleic acid templated transcription GO:1903506 380 0.057
purine ribonucleotide metabolic process GO:0009150 227 0.056
purine ribonucleotide biosynthetic process GO:0009152 81 0.054
Mouse
locomotory exploration behavior GO:0035641 1 0.054
protein localization GO:0008104 191 0.054
Mouse
regulation of muscle contraction GO:0006937 53 0.054
cognition GO:0050890 92 0.054
Human Mouse
organic substance catabolic process GO:1901575 316 0.053
positive regulation of phosphorus metabolic process GO:0010562 262 0.052
Human Mouse
circadian rhythm GO:0007623 88 0.052
positive regulation of biosynthetic process GO:0009891 319 0.052
Mouse
metal ion homeostasis GO:0055065 186 0.050
cellular component assembly GO:0022607 360 0.050
protein complex subunit organization GO:0071822 302 0.049
Mouse
cation homeostasis GO:0055080 195 0.048
regulation of signal transduction GO:0009966 318 0.048
central nervous system development GO:0007417 311 0.047
Mouse
negative regulation of cellular metabolic process GO:0031324 281 0.046
Human Zebrafish Mouse
maintenance of location GO:0051235 17 0.045
protein complex assembly GO:0006461 263 0.045
cellular response to external stimulus GO:0071496 118 0.045
multi organism reproductive process GO:0044703 262 0.042
regulation of peptide secretion GO:0002791 82 0.042
rhythmic process GO:0048511 156 0.041
neurological system process GO:0050877 219 0.041
Human Mouse
transcription dna templated GO:0006351 377 0.041
purine containing compound metabolic process GO:0072521 253 0.041
regulation of transmembrane transport GO:0034762 122 0.040
purine nucleotide metabolic process GO:0006163 229 0.040
cellular metal ion homeostasis GO:0006875 172 0.040
regulation of purine nucleotide metabolic process GO:1900542 115 0.040
blood circulation GO:0008015 183 0.039
regulation of ion transmembrane transport GO:0034765 121 0.038
inorganic cation transmembrane transport GO:0098662 202 0.038
small gtpase mediated signal transduction GO:0007264 36 0.037
Mouse
single organism reproductive process GO:0044702 297 0.037
regulation of catalytic activity GO:0050790 304 0.035
protein oligomerization GO:0051259 191 0.035
regulation of molecular function GO:0065009 398 0.035
ras protein signal transduction GO:0007265 29 0.035
Mouse
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 3 0.034
organophosphate metabolic process GO:0019637 370 0.034
regulation of programmed cell death GO:0043067 341 0.034
Mouse
calcium ion transport GO:0006816 131 0.034
sequestering of metal ion GO:0051238 9 0.034
ossification GO:0001503 70 0.033
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.033
nucleoside phosphate biosynthetic process GO:1901293 102 0.033
Mouse
secretion GO:0046903 307 0.033
Mouse
insulin like growth factor receptor signaling pathway GO:0048009 3 0.031
positive regulation of mapk cascade GO:0043410 92 0.031
negative regulation of cell death GO:0060548 229 0.031
positive regulation of cell proliferation GO:0008284 249 0.031
Mouse
sex differentiation GO:0007548 113 0.030
regulation of small gtpase mediated signal transduction GO:0051056 48 0.030
positive regulation of intracellular signal transduction GO:1902533 138 0.030
cellular catabolic process GO:0044248 295 0.029
nucleoside phosphate metabolic process GO:0006753 283 0.029
oxidation reduction process GO:0055114 304 0.029
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.029
Human Mouse
cellular ketone metabolic process GO:0042180 51 0.029
ribose phosphate metabolic process GO:0019693 235 0.029
defecation GO:0030421 1 0.029
negative regulation of multicellular organismal process GO:0051241 203 0.028
Mouse
single organism cellular localization GO:1902580 102 0.028
Mouse
single organism behavior GO:0044708 130 0.028
Mouse
regulation of secretion GO:0051046 224 0.027
Mouse
protein transport GO:0015031 132 0.027
Mouse
regulation of cardiac muscle contraction GO:0055117 17 0.027
divalent inorganic cation transport GO:0072511 134 0.027
regulation of transcription dna templated GO:0006355 374 0.026
positive regulation of behavior GO:0048520 38 0.026
cellular response to lipid GO:0071396 201 0.026
circulatory system development GO:0072359 134 0.026
Human Zebrafish Mouse
apoptotic process GO:0006915 381 0.026
Mouse
cellular component biogenesis GO:0044085 368 0.025
cellular amine metabolic process GO:0044106 38 0.025
epinephrine secretion GO:0048242 6 0.025
negative regulation of signal transduction GO:0009968 83 0.025
Human Zebrafish Mouse
cellular response to endogenous stimulus GO:0071495 377 0.025
response to hypoxia GO:0001666 231 0.025
Mouse
carbohydrate derivative biosynthetic process GO:1901137 124 0.025
Mouse
ribonucleotide metabolic process GO:0009259 231 0.025
ion transmembrane transport GO:0034220 365 0.024
nucleobase containing small molecule metabolic process GO:0055086 316 0.024
cytosolic calcium ion homeostasis GO:0051480 140 0.024
striated muscle tissue development GO:0014706 58 0.024
Mouse
regulation of peptide transport GO:0090087 87 0.024
regulation of tube size GO:0035150 89 0.024
cellular ion homeostasis GO:0006873 184 0.024
circulatory system process GO:0003013 183 0.023
neuron differentiation GO:0030182 368 0.023
positive regulation of protein metabolic process GO:0051247 178 0.023
negative regulation of innate immune response GO:0045824 4 0.022
aromatic compound catabolic process GO:0019439 168 0.022
cellular calcium ion homeostasis GO:0006874 160 0.022
response to mechanical stimulus GO:0009612 134 0.022
multi multicellular organism process GO:0044706 138 0.022
carbohydrate derivative metabolic process GO:1901135 346 0.022
divalent metal ion transport GO:0070838 132 0.022
regulation of anatomical structure size GO:0090066 135 0.022
ion homeostasis GO:0050801 212 0.022
brain development GO:0007420 247 0.022
Mouse
cytosolic calcium ion transport GO:0060401 39 0.021
calcium ion homeostasis GO:0055074 162 0.021
motor neuron axon guidance GO:0008045 1 0.021
protein complex biogenesis GO:0070271 263 0.021
negative regulation of ion transport GO:0043271 51 0.021
protein heterooligomerization GO:0051291 89 0.021
regulation of protein metabolic process GO:0051246 289 0.021
Mouse
positive regulation of phosphorylation GO:0042327 177 0.020
metal ion transport GO:0030001 289 0.020
divalent inorganic cation homeostasis GO:0072507 165 0.020
urinary bladder smooth muscle contraction GO:0014832 4 0.020
catabolic process GO:0009056 351 0.020
peptidyl amino acid modification GO:0018193 126 0.020
ribonucleotide biosynthetic process GO:0009260 85 0.020
Mouse
development of primary sexual characteristics GO:0045137 107 0.020
nucleoside phosphate catabolic process GO:1901292 140 0.020
regulation of protein phosphorylation GO:0001932 183 0.020
Mouse
regulation of rna biosynthetic process GO:2001141 381 0.020
peptide secretion GO:0002790 86 0.020
intracellular transport GO:0046907 185 0.019
Mouse
cellular cation homeostasis GO:0030003 180 0.019
regulation of hydrolase activity GO:0051336 143 0.019
regulation of organ formation GO:0003156 2 0.019
negative regulation of gene expression GO:0010629 199 0.019
establishment of protein localization GO:0045184 141 0.019
Mouse
response to estrogen GO:0043627 232 0.019
cardiovascular system development GO:0072358 134 0.019
Human Zebrafish Mouse
aging GO:0007568 241 0.019
response to metal ion GO:0010038 253 0.019
muscle cell proliferation GO:0033002 84 0.019
nitrogen compound transport GO:0071705 229 0.019
regulation of intracellular transport GO:0032386 65 0.019
Mouse
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 4 0.019
cytoplasmic transport GO:0016482 115 0.019
Mouse
calcium ion transport into cytosol GO:0060402 38 0.019
regulation of blood circulation GO:1903522 110 0.019
regulation of blood vessel size GO:0050880 89 0.019
asymmetric stem cell division GO:0098722 2 0.019
gonad development GO:0008406 104 0.018
positive regulation of phosphate metabolic process GO:0045937 262 0.018
Human Mouse
negative regulation of transport GO:0051051 136 0.018
Mouse
behavior GO:0007610 205 0.018
Mouse
glycogen metabolic process GO:0005977 23 0.018
second messenger mediated signaling GO:0019932 51 0.018
male germ line stem cell asymmetric division GO:0048133 1 0.018
response to reactive oxygen species GO:0000302 120 0.018
regulation of synaptic transmission GO:0050804 141 0.017
Mouse
vasoconstriction GO:0042310 54 0.017
response to inorganic substance GO:0010035 377 0.017
regulation of cellular localization GO:0060341 263 0.017
Mouse
transmembrane transport GO:0055085 412 0.017
dna metabolic process GO:0006259 96 0.017
regulation of exocytosis GO:0017157 37 0.017
head development GO:0060322 247 0.017
Mouse
cellular response to magnesium ion GO:0071286 4 0.017
glycogen biosynthetic process GO:0005978 15 0.017
positive regulation of locomotion GO:0040017 102 0.017
negative regulation of smooth muscle cell proliferation GO:0048662 21 0.016
purine ribonucleotide catabolic process GO:0009154 136 0.016
germline stem cell asymmetric division GO:0098728 1 0.016
positive regulation of serotonin secretion GO:0014064 1 0.016
regulation of feeding behavior GO:0060259 14 0.016
response to glucocorticoid GO:0051384 223 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
sleep GO:0030431 30 0.016
neuromuscular synaptic transmission GO:0007274 2 0.016
vascular process in circulatory system GO:0003018 96 0.016
multicellular organism reproduction GO:0032504 233 0.016
nucleotide metabolic process GO:0009117 279 0.016
cellular component movement GO:0006928 248 0.016
Human Mouse
cardiac muscle cell contraction GO:0086003 10 0.016
dopamine metabolic process GO:0042417 12 0.016
regulation of rna metabolic process GO:0051252 391 0.016
regulation of nervous system development GO:0051960 264 0.016
macromolecule localization GO:0033036 252 0.015
Mouse
cell motility GO:0048870 202 0.015
Human Mouse
negative regulation of neuron death GO:1901215 69 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
transcription from rna polymerase ii promoter GO:0006366 252 0.015
regulation of nucleotide metabolic process GO:0006140 117 0.015
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.015
amine metabolic process GO:0009308 38 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
Human Mouse
negative regulation of protein metabolic process GO:0051248 114 0.015
Mouse
positive regulation of nucleic acid templated transcription GO:1903508 197 0.015
salivary gland development GO:0007431 3 0.015
regulation of cell proliferation GO:0042127 359 0.015
Human Zebrafish Mouse
feeding behavior GO:0007631 53 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
sequestering of calcium ion GO:0051208 8 0.015
defense response to gram negative bacterium GO:0050829 3 0.015
reproduction GO:0000003 245 0.015
response to decreased oxygen levels GO:0036293 237 0.015
Mouse
purine ribonucleoside metabolic process GO:0046128 168 0.014
regulation of actin filament based process GO:0032970 42 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
endoplasmic reticulum to cytosol transport GO:1903513 4 0.014
positive regulation of nucleotide metabolic process GO:0045981 91 0.014
Human Mouse
response to carbohydrate GO:0009743 183 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
Mouse
regulation of protein modification process GO:0031399 194 0.014
Mouse
regulation of ras protein signal transduction GO:0046578 45 0.014
muscle structure development GO:0061061 87 0.014
Mouse
action potential GO:0001508 54 0.014
Mouse
nucleic acid templated transcription GO:0097659 379 0.014
response to anoxia GO:0034059 4 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.014
Human Mouse
negative regulation of cell proliferation GO:0008285 119 0.014
Human Mouse
epithelium development GO:0060429 96 0.014
Mouse
response to oxygen levels GO:0070482 265 0.014
Mouse
biological adhesion GO:0022610 110 0.014
Mouse
cellular response to hormone stimulus GO:0032870 247 0.014
negative regulation of biosynthetic process GO:0009890 168 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
Human Zebrafish Mouse
regulation of transferase activity GO:0051338 123 0.013
Mouse
chemical homeostasis GO:0048878 292 0.013
circadian sleep wake cycle GO:0042745 23 0.013
cyclic purine nucleotide metabolic process GO:0052652 62 0.013
Mouse
single organism catabolic process GO:0044712 283 0.013
sensory perception of pain GO:0019233 73 0.013
lipid metabolic process GO:0006629 283 0.013
cellular macromolecule localization GO:0070727 122 0.013
Mouse
negative regulation of secretion by cell GO:1903531 72 0.013
Mouse
protein autophosphorylation GO:0046777 66 0.013
nucleobase containing compound catabolic process GO:0034655 152 0.013
heart contraction GO:0060047 57 0.013
glycerolipid metabolic process GO:0046486 67 0.013
positive regulation of blood circulation GO:1903524 65 0.013
adult locomotory behavior GO:0008344 4 0.013
memory GO:0007613 54 0.013
negative regulation of ion transmembrane transport GO:0034766 16 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
positive regulation of cyclase activity GO:0031281 15 0.013
Mouse
negative regulation of apoptotic process GO:0043066 181 0.013
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 4 0.013
regulation of neuron differentiation GO:0045664 208 0.013
regulation of apoptotic process GO:0042981 335 0.013
Mouse
negative regulation of transporter activity GO:0032410 13 0.012
regulation of cellular amino acid metabolic process GO:0006521 2 0.012
t cell tolerance induction GO:0002517 3 0.012
positive regulation of cell activation GO:0050867 34 0.012
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.012
Mouse
rho protein signal transduction GO:0007266 11 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
Mouse
cell migration GO:0016477 197 0.012
Human Mouse
glucan metabolic process GO:0044042 23 0.012
regulation of system process GO:0044057 208 0.012
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.012
regulation of vesicle mediated transport GO:0060627 81 0.012
glucan biosynthetic process GO:0009250 15 0.012
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.012
heart morphogenesis GO:0003007 3 0.012
regulation of homeostatic process GO:0032844 101 0.012
Mouse
regulation of cellular ketone metabolic process GO:0010565 27 0.012
actin filament based process GO:0030029 86 0.012
Mouse
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.012
Mouse
nucleoside metabolic process GO:0009116 179 0.012
multicellular organism growth GO:0035264 1 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.012
regulation of neuron death GO:1901214 115 0.012
Mouse
monoamine transport GO:0015844 43 0.012
cellular polysaccharide metabolic process GO:0044264 23 0.012
response to peptide GO:1901652 292 0.012
organophosphate catabolic process GO:0046434 148 0.012
smooth muscle cell proliferation GO:0048659 77 0.012
cyclic nucleotide biosynthetic process GO:0009190 63 0.012
Mouse
positive regulation of cell development GO:0010720 176 0.011
regulation of smooth muscle cell proliferation GO:0048660 75 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
circadian sleep wake cycle process GO:0022410 21 0.011
regulation of cell differentiation GO:0045595 320 0.011
neuron projection development GO:0031175 273 0.011
organ formation GO:0048645 3 0.011
calcium ion export GO:1901660 6 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
response to external biotic stimulus GO:0043207 221 0.011
negative regulation of calcium ion import GO:0090281 2 0.011
enzyme linked receptor protein signaling pathway GO:0007167 116 0.011
peptidyl tyrosine phosphorylation GO:0018108 72 0.011
cellular chemical homeostasis GO:0055082 247 0.011
exploration behavior GO:0035640 1 0.011
cellular response to oxygen containing compound GO:1901701 386 0.011
axis specification GO:0009798 4 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
response to interleukin 15 GO:0070672 4 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
regulation of cell migration GO:0030334 128 0.011
Human Mouse
macromolecule catabolic process GO:0009057 58 0.011
response to ammonium ion GO:0060359 71 0.011
regulation of cell development GO:0060284 263 0.011
cell morphogenesis GO:0000902 142 0.011
ribonucleoside metabolic process GO:0009119 174 0.010
response to ethanol GO:0045471 162 0.010
inorganic ion transmembrane transport GO:0098660 229 0.010
cellular homeostasis GO:0019725 252 0.010
adult behavior GO:0030534 16 0.010
regulation of catabolic process GO:0009894 113 0.010
potassium ion transport GO:0006813 97 0.010
negative regulation of cellular biosynthetic process GO:0031327 161 0.010
cellular response to steroid hormone stimulus GO:0071383 93 0.010
regulation of canonical wnt signaling pathway GO:0060828 4 0.010
regulation of calcium ion transport GO:0051924 77 0.010
regulation of norepinephrine secretion GO:0014061 15 0.010
coronary vasculature morphogenesis GO:0060977 3 0.010
peptide hormone secretion GO:0030072 84 0.010
regulation of anatomical structure morphogenesis GO:0022603 141 0.010
Human Mouse
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.010

Nf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
substance dependence DOID:9973 0 0.034
substance related disorder DOID:303 0 0.034
disease of mental health DOID:150 0 0.034
central nervous system disease DOID:331 0 0.021
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.021