Rattus norvegicus

0 known processes

Foxo3

forkhead box O3

(Aliases: Fkhrl1,Foxo3a)

Foxo3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleic acid templated transcription GO:0097659 379 0.420
Human
regulation of nucleic acid templated transcription GO:1903506 380 0.406
Human
transcription dna templated GO:0006351 377 0.303
Human
regulation of rna metabolic process GO:0051252 391 0.275
Human
rna biosynthetic process GO:0032774 380 0.269
Human
regulation of rna biosynthetic process GO:2001141 381 0.263
Human
cellular response to oxygen containing compound GO:1901701 386 0.218
aging GO:0007568 241 0.213
response to other organism GO:0051707 220 0.205
positive regulation of biosynthetic process GO:0009891 319 0.192
Human
cellular response to acid chemical GO:0071229 75 0.184
response to retinoic acid GO:0032526 63 0.166
cellular response to lipid GO:0071396 201 0.163
transcription from rna polymerase ii promoter GO:0006366 252 0.151
Human
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.150
Human
metal ion homeostasis GO:0055065 186 0.149
regulation of transcription dna templated GO:0006355 374 0.147
Human
carbohydrate derivative metabolic process GO:1901135 346 0.146
organophosphate metabolic process GO:0019637 370 0.145
cellular response to hormone stimulus GO:0032870 247 0.139
ion transmembrane transport GO:0034220 365 0.130
rna metabolic process GO:0016070 406 0.127
Human
cation homeostasis GO:0055080 195 0.126
cation transmembrane transport GO:0098655 263 0.116
response to decreased oxygen levels GO:0036293 237 0.108
response to acid chemical GO:0001101 222 0.104
intracellular signal transduction GO:0035556 314 0.102
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.101
Human
macromolecular complex subunit organization GO:0043933 339 0.098
positive regulation of cellular biosynthetic process GO:0031328 295 0.095
Human
positive regulation of rna biosynthetic process GO:1902680 197 0.091
Human
inorganic cation transmembrane transport GO:0098662 202 0.090
regulation of apoptotic process GO:0042981 335 0.089
Human
negative regulation of apoptotic process GO:0043066 181 0.086
response to molecule of bacterial origin GO:0002237 194 0.086
response to cytokine GO:0034097 215 0.084
regulation of programmed cell death GO:0043067 341 0.084
Human
rhythmic process GO:0048511 156 0.083
cellular response to organic cyclic compound GO:0071407 202 0.083
response to hypoxia GO:0001666 231 0.082
organic acid transport GO:0015849 116 0.080
organophosphate biosynthetic process GO:0090407 143 0.079
ribonucleotide metabolic process GO:0009259 231 0.075
multicellular organism reproduction GO:0032504 233 0.073
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.072
Human
positive regulation of rna metabolic process GO:0051254 203 0.072
Human
response to bacterium GO:0009617 200 0.071
cyclic nucleotide metabolic process GO:0009187 80 0.070
brain development GO:0007420 247 0.070
carbohydrate derivative biosynthetic process GO:1901137 124 0.070
cell migration GO:0016477 197 0.069
positive regulation of nucleic acid templated transcription GO:1903508 197 0.068
Human
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.065
Human
cellular response to stress GO:0033554 269 0.064
response to purine containing compound GO:0014074 126 0.063
negative regulation of macromolecule metabolic process GO:0010605 260 0.063
Human
multi multicellular organism process GO:0044706 138 0.063
action potential GO:0001508 54 0.062
inorganic ion transmembrane transport GO:0098660 229 0.061
carboxylic acid transport GO:0046942 115 0.060
single organism reproductive process GO:0044702 297 0.060
nucleoside phosphate metabolic process GO:0006753 283 0.060
cellular cation homeostasis GO:0030003 180 0.058
response to extracellular stimulus GO:0009991 380 0.058
cation transport GO:0006812 382 0.058
chemical homeostasis GO:0048878 292 0.057
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.056
Human
cellular response to endogenous stimulus GO:0071495 377 0.056
organonitrogen compound biosynthetic process GO:1901566 167 0.055
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.055
Human
circadian rhythm GO:0007623 88 0.055
negative regulation of rna metabolic process GO:0051253 123 0.054
Human
cardiovascular system development GO:0072358 134 0.053
regulation of ion transport GO:0043269 245 0.051
regulation of phosphorus metabolic process GO:0051174 349 0.051
negative regulation of cell proliferation GO:0008285 119 0.050
cellular chemical homeostasis GO:0055082 247 0.050
reproductive process GO:0022414 372 0.050
neurological system process GO:0050877 219 0.049
response to external biotic stimulus GO:0043207 221 0.049
purine nucleotide metabolic process GO:0006163 229 0.049
single organism biosynthetic process GO:0044711 342 0.049
response to peptide hormone GO:0043434 278 0.048
multi organism reproductive process GO:0044703 262 0.048
calcium ion import GO:0070509 22 0.046
smooth muscle cell proliferation GO:0048659 77 0.046
regulation of smooth muscle cell proliferation GO:0048660 75 0.045
response to oxygen levels GO:0070482 265 0.045
nucleobase containing small molecule metabolic process GO:0055086 316 0.045
amino acid transport GO:0006865 70 0.045
cellular metal ion homeostasis GO:0006875 172 0.045
cellular response to retinoic acid GO:0071300 27 0.045
positive regulation of developmental process GO:0051094 283 0.044
Human
programmed cell death GO:0012501 392 0.044
Human
regulation of intracellular signal transduction GO:1902531 218 0.044
regulation of multicellular organismal development GO:2000026 376 0.044
Human
neuron death GO:0070997 127 0.044
Human
response to light stimulus GO:0009416 52 0.043
regulation of cell proliferation GO:0042127 359 0.043
response to estradiol GO:0032355 164 0.043
cellular ion homeostasis GO:0006873 184 0.042
circulatory system development GO:0072359 134 0.042
cell growth GO:0016049 104 0.042
apoptotic process GO:0006915 381 0.041
Human
muscle cell proliferation GO:0033002 84 0.040
positive regulation of phosphate metabolic process GO:0045937 262 0.039
ribose phosphate biosynthetic process GO:0046390 87 0.039
positive regulation of transcription dna templated GO:0045893 197 0.039
Human
ion homeostasis GO:0050801 212 0.039
positive regulation of catalytic activity GO:0043085 184 0.039
cyclic nucleotide biosynthetic process GO:0009190 63 0.039
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.038
Human
response to nutrient levels GO:0031667 370 0.038
homeostatic process GO:0042592 331 0.038
Human
negative regulation of biosynthetic process GO:0009890 168 0.038
Human
cellular calcium ion homeostasis GO:0006874 160 0.037
mapk cascade GO:0000165 140 0.037
negative regulation of multicellular organismal process GO:0051241 203 0.037
negative regulation of cell death GO:0060548 229 0.036
catabolic process GO:0009056 351 0.036
positive regulation of phosphorus metabolic process GO:0010562 262 0.036
locomotion GO:0040011 237 0.036
cellular homeostasis GO:0019725 252 0.035
regulation of phosphate metabolic process GO:0019220 349 0.035
female mating behavior GO:0060180 6 0.035
regulation of signal transduction GO:0009966 318 0.034
response to alkaloid GO:0043279 132 0.034
positive regulation of gene expression GO:0010628 244 0.034
Human
response to radiation GO:0009314 137 0.034
secretion GO:0046903 307 0.034
organ regeneration GO:0031100 101 0.034
protein phosphorylation GO:0006468 345 0.034
multicellular organismal signaling GO:0035637 44 0.033
regulation of cellular ketone metabolic process GO:0010565 27 0.032
regulation of growth GO:0040008 105 0.032
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.032
Human
response to temperature stimulus GO:0009266 94 0.032
cellular divalent inorganic cation homeostasis GO:0072503 162 0.032
central nervous system development GO:0007417 311 0.032
ribonucleotide biosynthetic process GO:0009260 85 0.032
negative regulation of gene expression GO:0010629 199 0.032
Human
blood circulation GO:0008015 183 0.032
cellular ketone metabolic process GO:0042180 51 0.031
response to food GO:0032094 27 0.031
purine containing compound metabolic process GO:0072521 253 0.031
organic anion transport GO:0015711 132 0.030
heart development GO:0007507 72 0.030
monocarboxylic acid metabolic process GO:0032787 152 0.030
response to organophosphorus GO:0046683 102 0.030
regulation of catalytic activity GO:0050790 304 0.030
protein complex assembly GO:0006461 263 0.029
regulation of blood pressure GO:0008217 83 0.029
regulation of cell growth GO:0001558 85 0.029
response to toxic substance GO:0009636 133 0.029
cell motility GO:0048870 202 0.029
nucleoside phosphate biosynthetic process GO:1901293 102 0.028
calcium ion homeostasis GO:0055074 162 0.028
regulation of lipid metabolic process GO:0019216 68 0.028
localization of cell GO:0051674 202 0.028
response to nutrient GO:0007584 248 0.028
neuron development GO:0048666 286 0.028
interleukin 18 production GO:0032621 1 0.028
response to glucocorticoid GO:0051384 223 0.027
cellular response to organonitrogen compound GO:0071417 197 0.027
response to lipopolysaccharide GO:0032496 191 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.027
Human
negative regulation of phosphate metabolic process GO:0045936 80 0.027
response to carbohydrate GO:0009743 183 0.027
regulation of nervous system development GO:0051960 264 0.027
divalent inorganic cation homeostasis GO:0072507 165 0.027
transmission of nerve impulse GO:0019226 42 0.026
negative regulation of metabolic process GO:0009892 331 0.026
Human
nitrogen compound transport GO:0071705 229 0.026
g protein coupled receptor signaling pathway GO:0007186 242 0.026
cytosolic calcium ion homeostasis GO:0051480 140 0.026
negative regulation of cellular biosynthetic process GO:0031327 161 0.026
Human
protein oligomerization GO:0051259 191 0.026
regulation of cell motility GO:2000145 131 0.026
anion transport GO:0006820 178 0.025
positive regulation of intracellular signal transduction GO:1902533 138 0.025
nucleotide biosynthetic process GO:0009165 98 0.025
macromolecular complex assembly GO:0065003 273 0.025
response to hexose GO:0009746 144 0.025
response to metal ion GO:0010038 253 0.024
regulation of purine nucleotide metabolic process GO:1900542 115 0.024
organ formation GO:0048645 3 0.024
cellular response to growth factor stimulus GO:0071363 162 0.024
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.024
cellular response to glucocorticoid stimulus GO:0071385 68 0.024
regulation of cellular localization GO:0060341 263 0.024
organic hydroxy compound metabolic process GO:1901615 115 0.024
ribose phosphate metabolic process GO:0019693 235 0.024
response to fungicide GO:0060992 20 0.023
heart morphogenesis GO:0003007 3 0.023
regulation of cell migration GO:0030334 128 0.023
tolerance induction dependent upon immune response GO:0002461 2 0.023
cellular carbohydrate metabolic process GO:0044262 72 0.023
positive regulation of interleukin 18 production GO:0032741 1 0.023
cellular response to extracellular stimulus GO:0031668 73 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.023
Human
protein complex biogenesis GO:0070271 263 0.023
developmental process involved in reproduction GO:0003006 159 0.023
response to reactive oxygen species GO:0000302 120 0.022
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.022
purine ribonucleotide biosynthetic process GO:0009152 81 0.022
regulation of cellular carbohydrate metabolic process GO:0010675 39 0.022
positive regulation of cell proliferation GO:0008284 249 0.022
response to inorganic substance GO:0010035 377 0.022
reproduction GO:0000003 245 0.022
regulation of cellular component organization GO:0051128 368 0.022
regulation of metal ion transport GO:0010959 118 0.022
regulation of blood vessel size GO:0050880 89 0.021
negative regulation of transport GO:0051051 136 0.021
female pregnancy GO:0007565 122 0.021
response to glucose GO:0009749 136 0.021
response to growth factor GO:0070848 189 0.021
regulation of system process GO:0044057 208 0.021
sensory organ development GO:0007423 74 0.021
regulation of membrane potential GO:0042391 110 0.021
response to corticosteroid GO:0031960 235 0.021
regulation of molecular function GO:0065009 398 0.020
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.020
signal transduction by phosphorylation GO:0023014 144 0.020
regulation of carbohydrate metabolic process GO:0006109 41 0.020
substrate dependent cell migration GO:0006929 1 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
regulation of cellular component movement GO:0051270 150 0.020
metal ion transport GO:0030001 289 0.020
response to estrogen GO:0043627 232 0.020
salivary gland development GO:0007431 3 0.020
negative regulation of cell communication GO:0010648 158 0.020
cellular response to cytokine stimulus GO:0071345 127 0.020
head development GO:0060322 247 0.020
eye morphogenesis GO:0048592 4 0.019
response to camp GO:0051591 91 0.019
nucleotide metabolic process GO:0009117 279 0.019
growth GO:0040007 165 0.019
regulation of secretion GO:0051046 224 0.019
negative regulation of developmental process GO:0051093 125 0.019
sex differentiation GO:0007548 113 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.019
Human
axis specification GO:0009798 4 0.019
phenol containing compound metabolic process GO:0018958 30 0.019
cellular response to steroid hormone stimulus GO:0071383 93 0.018
cell type specific apoptotic process GO:0097285 134 0.018
Human
single organism intracellular transport GO:1902582 166 0.018
response to hydrogen peroxide GO:0042542 89 0.018
negative regulation of cell development GO:0010721 82 0.018
proteolysis GO:0006508 175 0.018
purine containing compound biosynthetic process GO:0072522 85 0.018
enzyme linked receptor protein signaling pathway GO:0007167 116 0.018
modified amino acid transport GO:0072337 12 0.017
negative regulation of transcription dna templated GO:0045892 116 0.017
Human
purine ribonucleotide metabolic process GO:0009150 227 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.017
regulation of protein metabolic process GO:0051246 289 0.017
Human
vascular process in circulatory system GO:0003018 96 0.017
protein complex subunit organization GO:0071822 302 0.017
regeneration GO:0031099 163 0.017
positive regulation of hydrolase activity GO:0051345 86 0.017
multicellular organism growth GO:0035264 1 0.017
myeloid cell differentiation GO:0030099 22 0.017
Human
response to oxidative stress GO:0006979 186 0.017
regulation of locomotion GO:0040012 148 0.017
response to biotic stimulus GO:0009607 226 0.016
regulation of neurogenesis GO:0050767 247 0.016
divalent inorganic cation transport GO:0072511 134 0.016
positive regulation of secretion by cell GO:1903532 128 0.016
response to monosaccharide GO:0034284 159 0.016
negative regulation of pancreatic stellate cell proliferation GO:2000230 1 0.016
positive regulation of programmed cell death GO:0043068 157 0.016
Human
response to peptide GO:1901652 292 0.016
regulation of mapk cascade GO:0043408 116 0.016
steroid metabolic process GO:0008202 73 0.016
tissue development GO:0009888 252 0.016
regulation of nucleotide biosynthetic process GO:0030808 47 0.016
response to ionizing radiation GO:0010212 59 0.016
organelle organization GO:0006996 266 0.016
positive regulation of molecular function GO:0044093 230 0.016
positive regulation of signal transduction GO:0009967 175 0.016
neuronal action potential GO:0019228 35 0.016
cytoskeleton organization GO:0007010 111 0.016
regulation of tube size GO:0035150 89 0.016
cellular response to corticosteroid stimulus GO:0071384 69 0.015
t cell tolerance induction GO:0002517 3 0.015
lipid biosynthetic process GO:0008610 128 0.015
vesicle mediated transport GO:0016192 181 0.015
response to transition metal nanoparticle GO:1990267 122 0.015
cellular component assembly GO:0022607 360 0.015
reproductive system development GO:0061458 128 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
multicellular organismal response to stress GO:0033555 25 0.015
cellular response to nitrogen compound GO:1901699 210 0.014
cellular catabolic process GO:0044248 295 0.014
cellular response to molecule of bacterial origin GO:0071219 56 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
Human
organic hydroxy compound transport GO:0015850 77 0.014
learning or memory GO:0007611 90 0.014
regulation of hormone levels GO:0010817 187 0.014
calcium ion transport GO:0006816 131 0.014
camera type eye morphogenesis GO:0048593 2 0.014
cerebral cortex cell migration GO:0021795 4 0.014
response to activity GO:0014823 73 0.014
cellular potassium ion transport GO:0071804 72 0.014
amine metabolic process GO:0009308 38 0.014
protein homooligomerization GO:0051260 91 0.014
embryonic appendage morphogenesis GO:0035113 4 0.014
cerebral cortex tangential migration GO:0021800 1 0.014
organic hydroxy compound biosynthetic process GO:1901617 51 0.014
negative regulation of programmed cell death GO:0043069 183 0.014
forebrain development GO:0030900 98 0.014
cellular component movement GO:0006928 248 0.014
hexose metabolic process GO:0019318 58 0.014
regulation of protein kinase activity GO:0045859 105 0.014
cellular amine metabolic process GO:0044106 38 0.013
regulation of epithelial cell proliferation GO:0050678 49 0.013
positive regulation of growth GO:0045927 55 0.013
response to insulin GO:0032868 133 0.013
positive regulation of cellular component organization GO:0051130 200 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.013
Human
regulation of cell projection organization GO:0031344 175 0.013
appendage morphogenesis GO:0035107 4 0.013
gliogenesis GO:0042063 93 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.013
palate development GO:0060021 2 0.013
response to starvation GO:0042594 59 0.013
glutamate receptor signaling pathway GO:0007215 43 0.013
regulation of cell development GO:0060284 263 0.013
negative regulation of signaling GO:0023057 157 0.013
camp metabolic process GO:0046058 63 0.013
secretion by cell GO:0032940 248 0.013
oxoacid metabolic process GO:0043436 290 0.013
regulation of secretion by cell GO:1903530 208 0.013
negative regulation of cell differentiation GO:0045596 99 0.012
glucose metabolic process GO:0006006 52 0.012
acid secretion GO:0046717 48 0.012
synaptic transmission GO:0007268 235 0.012
bmp signaling pathway GO:0030509 4 0.012
norepinephrine transport GO:0015874 18 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.012
response to ammonium ion GO:0060359 71 0.012
catecholamine transport GO:0051937 37 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
anatomical structure morphogenesis GO:0009653 298 0.012
jak stat cascade GO:0007259 26 0.012
vasculature development GO:0001944 70 0.012
norepinephrine secretion GO:0048243 16 0.012
neuron projection development GO:0031175 273 0.012
negative regulation of phosphorus metabolic process GO:0010563 80 0.012
inflammatory response GO:0006954 150 0.012
ras protein signal transduction GO:0007265 29 0.012
development of primary sexual characteristics GO:0045137 107 0.012
fibroblast proliferation GO:0048144 22 0.012
transmembrane transport GO:0055085 412 0.012
positive regulation of developmental growth GO:0048639 29 0.012
organic substance catabolic process GO:1901575 316 0.012
response to calcium ion GO:0051592 59 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
circulatory system process GO:0003013 183 0.011
eye development GO:0001654 50 0.011
regulation of anatomical structure size GO:0090066 135 0.011
sexual reproduction GO:0019953 148 0.011
positive regulation of secretion GO:0051047 140 0.011
mrna transcription GO:0009299 2 0.011
keratinocyte migration GO:0051546 2 0.011
potassium ion transmembrane transport GO:0071805 71 0.011
renal sodium excretion GO:0035812 20 0.011
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.011
regulation of blood circulation GO:1903522 110 0.011
positive regulation of phosphorylation GO:0042327 177 0.011
tube development GO:0035295 89 0.011
positive regulation of cell death GO:0010942 184 0.011
Human
organic cyclic compound catabolic process GO:1901361 175 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
Human
transformation of host cell by virus GO:0019087 4 0.011
positive regulation of multicellular organismal process GO:0051240 387 0.011
Human
hormone biosynthetic process GO:0042446 25 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
embryonic pattern specification GO:0009880 1 0.011
negative regulation of lyase activity GO:0051350 8 0.011
regulation of insulin secretion GO:0050796 65 0.011
immune response GO:0006955 104 0.011
carbohydrate homeostasis GO:0033500 75 0.011
response to metformin GO:1901558 1 0.010
sensory perception GO:0007600 101 0.010
neuron differentiation GO:0030182 368 0.010
carbohydrate biosynthetic process GO:0016051 42 0.010
response to nicotine GO:0035094 51 0.010
detection of visible light GO:0009584 3 0.010
urogenital system development GO:0001655 78 0.010
digestive tract development GO:0048565 39 0.010
somatostatin receptor signaling pathway GO:0038169 4 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.010
positive regulation of apoptotic process GO:0043065 154 0.010
Human
cellular component biogenesis GO:0044085 368 0.010
neuromuscular process GO:0050905 2 0.010
myeloid leukocyte differentiation GO:0002573 20 0.010
regulation of pancreatic stellate cell proliferation GO:2000229 2 0.010
positive regulation of transport GO:0051050 245 0.010
response to mechanical stimulus GO:0009612 134 0.010
response to atp GO:0033198 13 0.010
negative regulation of neurogenesis GO:0050768 78 0.010

Foxo3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
bone disease DOID:0080001 0 0.018
musculoskeletal system disease DOID:17 0 0.018
connective tissue disease DOID:65 0 0.018
sensory system disease DOID:0050155 0 0.010