Rattus norvegicus

23 known processes

Pcsk2

proprotein convertase subtilisin/kexin type 2

Pcsk2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transmembrane transport GO:0055085 412 0.411
neuron development GO:0048666 286 0.356
cell projection morphogenesis GO:0048858 123 0.303
cellular component assembly GO:0022607 360 0.272
cation transport GO:0006812 382 0.255
secretion GO:0046903 307 0.243
Rat
intracellular signal transduction GO:0035556 314 0.234
regulation of rna metabolic process GO:0051252 391 0.232
neurological system process GO:0050877 219 0.230
protein complex subunit organization GO:0071822 302 0.201
regulation of cellular component organization GO:0051128 368 0.198
cell projection organization GO:0030030 302 0.192
protein complex biogenesis GO:0070271 263 0.190
neuron differentiation GO:0030182 368 0.189
regulation of ion transport GO:0043269 245 0.178
cell part morphogenesis GO:0032990 123 0.162
vesicle mediated transport GO:0016192 181 0.158
macromolecular complex subunit organization GO:0043933 339 0.141
regulation of phosphate metabolic process GO:0019220 349 0.138
ion transmembrane transport GO:0034220 365 0.130
cell morphogenesis involved in differentiation GO:0000904 119 0.130
catabolic process GO:0009056 351 0.116
neuron projection development GO:0031175 273 0.112
cellular component morphogenesis GO:0032989 155 0.112
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.109
macromolecular complex assembly GO:0065003 273 0.104
rna biosynthetic process GO:0032774 380 0.102
cellular ion homeostasis GO:0006873 184 0.098
regulation of intracellular signal transduction GO:1902531 218 0.098
secretion by cell GO:0032940 248 0.096
Rat
synapse organization GO:0050808 46 0.095
protein oligomerization GO:0051259 191 0.095
regulation of neuron differentiation GO:0045664 208 0.094
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.093
regulation of nucleic acid templated transcription GO:1903506 380 0.092
cell cell signaling GO:0007267 335 0.092
organophosphate metabolic process GO:0019637 370 0.088
cellular divalent inorganic cation homeostasis GO:0072503 162 0.088
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.084
regulation of neuron projection development GO:0010975 161 0.082
regulation of molecular function GO:0065009 398 0.082
synaptic transmission GO:0007268 235 0.080
protein homooligomerization GO:0051260 91 0.080
protein complex assembly GO:0006461 263 0.080
behavior GO:0007610 205 0.080
anatomical structure morphogenesis GO:0009653 298 0.079
sensory perception GO:0007600 101 0.079
regulation of cell projection organization GO:0031344 175 0.077
cellular response to stress GO:0033554 269 0.076
cellular component biogenesis GO:0044085 368 0.073
monovalent inorganic cation transport GO:0015672 172 0.072
neurotransmitter transport GO:0006836 42 0.072
regulation of multicellular organismal development GO:2000026 376 0.071
g protein coupled receptor signaling pathway GO:0007186 242 0.069
cellular cation homeostasis GO:0030003 180 0.068
neurotransmitter secretion GO:0007269 33 0.067
cation transmembrane transport GO:0098655 263 0.067
organic substance catabolic process GO:1901575 316 0.067
regulation of metal ion transport GO:0010959 118 0.067
regulation of cell development GO:0060284 263 0.065
positive regulation of gene expression GO:0010628 244 0.065
single organism behavior GO:0044708 130 0.065
negative regulation of cellular metabolic process GO:0031324 281 0.065
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.065
apoptotic process GO:0006915 381 0.064
positive regulation of cellular component organization GO:0051130 200 0.063
negative regulation of macromolecule metabolic process GO:0010605 260 0.062
positive regulation of signal transduction GO:0009967 175 0.062
Rat
regulation of membrane potential GO:0042391 110 0.062
rhythmic synaptic transmission GO:0060024 1 0.061
macromolecule localization GO:0033036 252 0.060
Rat
inorganic cation transmembrane transport GO:0098662 202 0.060
nucleobase containing small molecule metabolic process GO:0055086 316 0.060
positive regulation of synaptic transmission GO:0050806 62 0.059
neuron projection morphogenesis GO:0048812 122 0.059
positive regulation of transport GO:0051050 245 0.059
Rat
metal ion transport GO:0030001 289 0.058
regulation of apoptotic process GO:0042981 335 0.058
negative regulation of metabolic process GO:0009892 331 0.058
exocytosis GO:0006887 60 0.057
regulation of secretion by cell GO:1903530 208 0.056
Rat
positive regulation of molecular function GO:0044093 230 0.055
divalent inorganic cation transport GO:0072511 134 0.055
anion transport GO:0006820 178 0.055
regulation of transmembrane transport GO:0034762 122 0.055
nucleic acid templated transcription GO:0097659 379 0.055
positive regulation of cell projection organization GO:0031346 111 0.054
regulation of programmed cell death GO:0043067 341 0.053
response to inorganic substance GO:0010035 377 0.052
Rat
cellular response to organonitrogen compound GO:0071417 197 0.051
cellular chemical homeostasis GO:0055082 247 0.051
cellular homeostasis GO:0019725 252 0.051
fatty acid metabolic process GO:0006631 99 0.049
ribonucleoside catabolic process GO:0042454 126 0.049
positive regulation of rna metabolic process GO:0051254 203 0.049
protein transport GO:0015031 132 0.047
Rat
response to bacterium GO:0009617 200 0.047
Rat
calcium ion transport GO:0006816 131 0.046
positive regulation of phosphorus metabolic process GO:0010562 262 0.046
regulation of phosphorus metabolic process GO:0051174 349 0.045
potassium ion transport GO:0006813 97 0.045
programmed cell death GO:0012501 392 0.045
regulation of nervous system development GO:0051960 264 0.044
divalent inorganic cation homeostasis GO:0072507 165 0.044
positive regulation of transcription dna templated GO:0045893 197 0.044
chemical homeostasis GO:0048878 292 0.044
calcium ion homeostasis GO:0055074 162 0.044
cellular calcium ion homeostasis GO:0006874 160 0.044
positive regulation of neuron projection development GO:0010976 99 0.043
cellular response to endogenous stimulus GO:0071495 377 0.043
Rat
cell morphogenesis GO:0000902 142 0.042
nucleotide metabolic process GO:0009117 279 0.042
oxoacid metabolic process GO:0043436 290 0.042
mechanoreceptor differentiation GO:0042490 2 0.041
regulation of mapk cascade GO:0043408 116 0.041
regulation of synaptic plasticity GO:0048167 70 0.041
response to metal ion GO:0010038 253 0.041
Rat
response to histamine GO:0034776 3 0.041
positive regulation of catalytic activity GO:0043085 184 0.041
protein heterooligomerization GO:0051291 89 0.040
regulation of protein metabolic process GO:0051246 289 0.040
negative regulation of biosynthetic process GO:0009890 168 0.040
cellular response to oxygen containing compound GO:1901701 386 0.039
negative regulation of molecular function GO:0044092 133 0.039
purine containing compound metabolic process GO:0072521 253 0.038
positive regulation of response to stimulus GO:0048584 285 0.038
Rat
negative regulation of cellular biosynthetic process GO:0031327 161 0.038
regulation of catalytic activity GO:0050790 304 0.038
carboxylic acid transport GO:0046942 115 0.038
small gtpase mediated signal transduction GO:0007264 36 0.037
negative regulation of transcription dna templated GO:0045892 116 0.037
regulation of neurotransmitter levels GO:0001505 42 0.037
cellular lipid metabolic process GO:0044255 208 0.037
hormone secretion GO:0046879 115 0.037
negative regulation of rna biosynthetic process GO:1902679 118 0.037
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.037
embryonic axis specification GO:0000578 1 0.037
divalent metal ion transport GO:0070838 132 0.036
synaptic growth at neuromuscular junction GO:0051124 1 0.036
positive regulation of cellular biosynthetic process GO:0031328 295 0.036
cellular amine metabolic process GO:0044106 38 0.036
rna metabolic process GO:0016070 406 0.036
central nervous system development GO:0007417 311 0.036
Rat
synaptic vesicle exocytosis GO:0016079 15 0.036
single organism organelle organization GO:1902589 180 0.035
regulation of cellular protein metabolic process GO:0032268 267 0.035
regulation of signal transduction GO:0009966 318 0.035
Rat
regulation of cell differentiation GO:0045595 320 0.035
head development GO:0060322 247 0.034
Rat
lipid metabolic process GO:0006629 283 0.034
ion homeostasis GO:0050801 212 0.034
retina morphogenesis in camera type eye GO:0060042 1 0.034
regulation of neurogenesis GO:0050767 247 0.033
inorganic ion transmembrane transport GO:0098660 229 0.033
establishment of organelle localization GO:0051656 37 0.033
response to estrogen GO:0043627 232 0.033
axonogenesis GO:0007409 71 0.032
establishment of protein localization GO:0045184 141 0.032
Rat
positive regulation of programmed cell death GO:0043068 157 0.032
locomotor rhythm GO:0045475 1 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.032
regulation of transcription dna templated GO:0006355 374 0.031
cellular response to nitrogen compound GO:1901699 210 0.031
nucleoside metabolic process GO:0009116 179 0.031
regulation of hydrolase activity GO:0051336 143 0.031
single organism reproductive process GO:0044702 297 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
nitrogen compound transport GO:0071705 229 0.030
negative regulation of rna metabolic process GO:0051253 123 0.030
heart morphogenesis GO:0003007 3 0.030
atp metabolic process GO:0046034 72 0.030
aging GO:0007568 241 0.030
Rat
positive regulation of nervous system development GO:0051962 178 0.030
negative regulation of vesicle fusion GO:0031339 2 0.029
transcription from rna polymerase ii promoter GO:0006366 252 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.029
cellular response to lipid GO:0071396 201 0.029
dendrite development GO:0016358 72 0.029
intracellular transport GO:0046907 185 0.029
adult locomotory behavior GO:0008344 4 0.028
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.028
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.028
membrane organization GO:0061024 94 0.028
glycosyl compound metabolic process GO:1901657 182 0.028
regulation of secretion GO:0051046 224 0.028
Rat
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.027
nucleoside triphosphate metabolic process GO:0009141 144 0.027
positive regulation of signaling GO:0023056 270 0.027
Rat
blood circulation GO:0008015 183 0.027
regulation of protein phosphorylation GO:0001932 183 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.027
regulation of neuron death GO:1901214 115 0.027
response to nutrient levels GO:0031667 370 0.026
Rat
positive regulation of nucleic acid templated transcription GO:1903508 197 0.026
cellular ketone metabolic process GO:0042180 51 0.026
carboxylic acid metabolic process GO:0019752 289 0.026
ribonucleoside triphosphate metabolic process GO:0009199 141 0.026
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.026
positive regulation of protein metabolic process GO:0051247 178 0.026
regulation of locomotion GO:0040012 148 0.026
Rat
nucleoside phosphate metabolic process GO:0006753 283 0.026
positive regulation of biosynthetic process GO:0009891 319 0.025
brain development GO:0007420 247 0.025
Rat
cellular metal ion homeostasis GO:0006875 172 0.025
cellular response to hormone stimulus GO:0032870 247 0.025
response to decreased oxygen levels GO:0036293 237 0.025
reproductive process GO:0022414 372 0.025
reproduction GO:0000003 245 0.024
phosphatidylinositol dephosphorylation GO:0046856 4 0.024
male mating behavior GO:0060179 3 0.024
positive regulation of ion transport GO:0043270 94 0.024
cellular catabolic process GO:0044248 295 0.024
regulation of catabolic process GO:0009894 113 0.024
homeostatic process GO:0042592 331 0.024
nucleoside phosphate catabolic process GO:1901292 140 0.024
nucleoside monophosphate metabolic process GO:0009123 93 0.024
axis specification GO:0009798 4 0.024
cellular amino acid metabolic process GO:0006520 107 0.023
multicellular organism growth GO:0035264 1 0.023
ribonucleotide metabolic process GO:0009259 231 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.023
response to mechanical stimulus GO:0009612 134 0.023
positive regulation of phosphate metabolic process GO:0045937 262 0.023
negative regulation of nucleic acid templated transcription GO:1903507 117 0.023
transcription dna templated GO:0006351 377 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
regulation of cell migration GO:0030334 128 0.023
Rat
locomotion GO:0040011 237 0.023
Rat
purine ribonucleotide metabolic process GO:0009150 227 0.023
transmission of nerve impulse GO:0019226 42 0.023
amine metabolic process GO:0009308 38 0.023
regulation of protein modification process GO:0031399 194 0.023
organelle organization GO:0006996 266 0.023
cellular response to organic cyclic compound GO:0071407 202 0.023
positive regulation of neuron differentiation GO:0045666 126 0.022
ras protein signal transduction GO:0007265 29 0.022
metal ion homeostasis GO:0055065 186 0.022
response to oxygen levels GO:0070482 265 0.022
positive regulation of cell development GO:0010720 176 0.022
inner ear receptor cell differentiation GO:0060113 2 0.022
cation homeostasis GO:0055080 195 0.022
glutamate receptor signaling pathway GO:0007215 43 0.022
monocarboxylic acid transport GO:0015718 52 0.022
cognition GO:0050890 92 0.022
regulation of neuron apoptotic process GO:0043523 83 0.022
organic acid metabolic process GO:0006082 292 0.022
regulation of calcium ion transport GO:0051924 77 0.022
response to peptide hormone GO:0043434 278 0.021
Rat
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.021
purine ribonucleoside metabolic process GO:0046128 168 0.021
regulation of cellular amino acid metabolic process GO:0006521 2 0.021
positive regulation of protein phosphorylation GO:0001934 135 0.021
negative regulation of receptor internalization GO:0002091 2 0.021
glycerolipid metabolic process GO:0046486 67 0.021
cell adhesion GO:0007155 110 0.021
single organism membrane organization GO:0044802 74 0.021
embryonic pattern specification GO:0009880 1 0.021
protein phosphorylation GO:0006468 345 0.021
hair cell differentiation GO:0035315 2 0.021
carbohydrate derivative catabolic process GO:1901136 147 0.021
negative regulation of transport GO:0051051 136 0.021
synaptic transmission glycinergic GO:0060012 2 0.020
response to camp GO:0051591 91 0.020
cellular response to abiotic stimulus GO:0071214 85 0.020
organic anion transport GO:0015711 132 0.020
positive regulation of cell death GO:0010942 184 0.020
response to ammonium ion GO:0060359 71 0.020
Rat
regulation of cell motility GO:2000145 131 0.020
Rat
purine containing compound catabolic process GO:0072523 138 0.020
negative regulation of cell death GO:0060548 229 0.020
response to organophosphorus GO:0046683 102 0.020
organonitrogen compound biosynthetic process GO:1901566 167 0.020
calcium ion dependent exocytosis of neurotransmitter GO:0048791 2 0.020
neuronal ion channel clustering GO:0045161 3 0.019
purine nucleoside metabolic process GO:0042278 169 0.019
eye morphogenesis GO:0048592 4 0.019
gamete generation GO:0007276 124 0.019
neuronal action potential GO:0019228 35 0.019
response to wounding GO:0009611 254 0.019
Rat
auditory receptor cell differentiation GO:0042491 2 0.019
cellular component movement GO:0006928 248 0.019
Rat
regulation of cellular component biogenesis GO:0044087 86 0.019
developmental process involved in reproduction GO:0003006 159 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
cellular response to histamine GO:0071420 3 0.019
phospholipid metabolic process GO:0006644 61 0.019
organ morphogenesis GO:0009887 75 0.019
ribonucleotide catabolic process GO:0009261 136 0.019
regulation of cell proliferation GO:0042127 359 0.019
purine nucleotide catabolic process GO:0006195 136 0.019
multi organism reproductive process GO:0044703 262 0.019
negative regulation of developmental process GO:0051093 125 0.018
response to radiation GO:0009314 137 0.018
purine nucleoside monophosphate metabolic process GO:0009126 84 0.018
vesicle organization GO:0016050 29 0.018
negative regulation of cell communication GO:0010648 158 0.018
response to mineralocorticoid GO:0051385 49 0.018
cerebellar purkinje cell layer development GO:0021680 2 0.018
cytosolic calcium ion homeostasis GO:0051480 140 0.018
carbohydrate derivative metabolic process GO:1901135 346 0.018
regulation of neuronal synaptic plasticity GO:0048168 31 0.018
negative regulation of signaling GO:0023057 157 0.018
nucleoside triphosphate catabolic process GO:0009143 123 0.018
atp catabolic process GO:0006200 54 0.018
regulation of anatomical structure size GO:0090066 135 0.018
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.018
indole containing compound metabolic process GO:0042430 11 0.017
glucose homeostasis GO:0042593 75 0.017
taxis GO:0042330 67 0.017
purine nucleoside triphosphate catabolic process GO:0009146 122 0.017
response to monosaccharide GO:0034284 159 0.017
Rat
response to extracellular stimulus GO:0009991 380 0.017
Rat
cellular response to growth factor stimulus GO:0071363 162 0.017
Rat
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
positive regulation of locomotion GO:0040017 102 0.017
Rat
cellular nitrogen compound catabolic process GO:0044270 163 0.017
regulation of ion transmembrane transport GO:0034765 121 0.017
regulation of organelle organization GO:0033043 80 0.017
nucleotide catabolic process GO:0009166 139 0.017
organonitrogen compound catabolic process GO:1901565 179 0.017
response to alkaloid GO:0043279 132 0.017
Rat
immune system process GO:0002376 204 0.017
cellular protein localization GO:0034613 122 0.017
regulation of synaptic transmission GO:0050804 141 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
detection of calcium ion GO:0005513 1 0.016
multicellular organism reproduction GO:0032504 233 0.016
aromatic compound catabolic process GO:0019439 168 0.016
response to fibroblast growth factor GO:0071774 29 0.016
regulation of synaptic vesicle exocytosis GO:2000300 6 0.016
negative regulation of catalytic activity GO:0043086 103 0.016
protein localization GO:0008104 191 0.016
Rat
fat cell proliferation GO:0070341 2 0.016
response to amine GO:0014075 46 0.016
reactive nitrogen species metabolic process GO:2001057 1 0.016
neuron death GO:0070997 127 0.016
response to growth factor GO:0070848 189 0.016
Rat
positive regulation of rna biosynthetic process GO:1902680 197 0.016
negative regulation of gene expression GO:0010629 199 0.016
detection of stimulus GO:0051606 24 0.016
localization of cell GO:0051674 202 0.016
Rat
negative regulation of programmed cell death GO:0043069 183 0.016
reproductive structure development GO:0048608 128 0.016
chemosensory behavior GO:0007635 2 0.016
sensory organ development GO:0007423 74 0.015
stress activated mapk cascade GO:0051403 35 0.015
intracellular protein transport GO:0006886 79 0.015
biological adhesion GO:0022610 110 0.015
establishment of vesicle localization GO:0051650 31 0.015
response to corticosteroid GO:0031960 235 0.015
Rat
cell cell junction organization GO:0045216 20 0.015
potassium ion transmembrane transport GO:0071805 71 0.015
guanosine containing compound metabolic process GO:1901068 74 0.015
female gonad development GO:0008585 53 0.015
positive regulation of catabolic process GO:0009896 78 0.015
growth GO:0040007 165 0.015
regulation of vesicle mediated transport GO:0060627 81 0.015
regulation of peptide hormone secretion GO:0090276 80 0.015
purine nucleoside catabolic process GO:0006152 124 0.015
morphogenesis of embryonic epithelium GO:0016331 3 0.015
cellular macromolecule localization GO:0070727 122 0.015
insulin secretion GO:0030073 69 0.015
endocytosis GO:0006897 84 0.015
regulation of cellular catabolic process GO:0031329 101 0.015
cell migration GO:0016477 197 0.015
Rat
cellular response to oxidative stress GO:0034599 76 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.015
synaptic vesicle docking involved in exocytosis GO:0016081 2 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
negative regulation of secretion GO:0051048 82 0.015
single organism biosynthetic process GO:0044711 342 0.015
positive regulation of cell migration GO:0030335 96 0.015
Rat
negative regulation of secretion by cell GO:1903531 72 0.014
single organism intracellular transport GO:1902582 166 0.014
olfactory behavior GO:0042048 2 0.014
response to purine containing compound GO:0014074 126 0.014
regulation of embryonic development GO:0045995 2 0.014
inner ear morphogenesis GO:0042472 1 0.014
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
heterocycle catabolic process GO:0046700 167 0.014
amino acid transport GO:0006865 70 0.014
negative regulation of cellular component organization GO:0051129 83 0.014
regulation of insulin secretion GO:0050796 65 0.014
single fertilization GO:0007338 3 0.014
developmental maturation GO:0021700 25 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.014
regeneration GO:0031099 163 0.014
ribonucleoside monophosphate metabolic process GO:0009161 88 0.014
response to carbohydrate GO:0009743 183 0.014
Rat
response to vitamin GO:0033273 131 0.014
tissue development GO:0009888 252 0.014
response to external biotic stimulus GO:0043207 221 0.014
Rat
organic hydroxy compound metabolic process GO:1901615 115 0.014
developmental growth GO:0048589 100 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
monocarboxylic acid metabolic process GO:0032787 152 0.014
regulation of potassium ion transport GO:0043266 29 0.014
positive regulation of synaptic vesicle exocytosis GO:2000302 3 0.013
regulation of peptide secretion GO:0002791 82 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.013
calcium ion dependent exocytosis GO:0017156 16 0.013
cellular response to alcohol GO:0097306 87 0.013
single organism cellular localization GO:1902580 102 0.013
purine nucleoside triphosphate metabolic process GO:0009144 141 0.013
regulation of phosphatidylinositol dephosphorylation GO:0060304 1 0.013
single organism catabolic process GO:0044712 283 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
positive regulation of mapk cascade GO:0043410 92 0.013
rna localization GO:0006403 4 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
regulation of establishment of protein localization GO:0070201 69 0.013
Rat
regulation of neurotransmitter secretion GO:0046928 19 0.013
vesicle localization GO:0051648 33 0.013
learning or memory GO:0007611 90 0.013
detection of chemical stimulus GO:0009593 10 0.012
neuromuscular process GO:0050905 2 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
sexual reproduction GO:0019953 148 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
wound healing GO:0042060 122 0.012
positive regulation of protein modification process GO:0031401 142 0.012
olfactory learning GO:0008355 1 0.012
cellular response to interleukin 1 GO:0071347 37 0.012
synaptic vesicle endocytosis GO:0048488 4 0.012
calcium ion transmembrane transport GO:0070588 70 0.012
axon development GO:0061564 96 0.012
nucleoside monophosphate catabolic process GO:0009125 56 0.012
positive regulation of cell differentiation GO:0045597 217 0.012
positive regulation of cell communication GO:0010647 271 0.012
Rat
negative regulation of cell proliferation GO:0008285 119 0.012
proteolysis GO:0006508 175 0.012
reproductive system development GO:0061458 128 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
development of primary sexual characteristics GO:0045137 107 0.012
negative regulation of cell differentiation GO:0045596 99 0.012
positive regulation of organelle organization GO:0010638 48 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
regulation of axonogenesis GO:0050770 37 0.012
receptor mediated endocytosis GO:0006898 42 0.012
negative regulation of apoptotic process GO:0043066 181 0.012
ovulation cycle GO:0042698 67 0.012
axon guidance GO:0007411 24 0.012
response to hexose GO:0009746 144 0.012
Rat
cell motility GO:0048870 202 0.012
Rat
nucleoside catabolic process GO:0009164 126 0.011
gonad development GO:0008406 104 0.011
negative regulation of calcium ion dependent exocytosis GO:0045955 5 0.011
positive regulation of nucleoside metabolic process GO:0045979 55 0.011
jnk cascade GO:0007254 28 0.011
phototransduction visible light GO:0007603 2 0.011
cellular potassium ion transport GO:0071804 72 0.011
peptide secretion GO:0002790 86 0.011
regulation of cellular localization GO:0060341 263 0.011
Rat
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.011
regulation of cell cycle GO:0051726 73 0.011
organophosphate catabolic process GO:0046434 148 0.011
response to toxic substance GO:0009636 133 0.011
cellular response to fibroblast growth factor stimulus GO:0044344 24 0.011
inorganic anion transport GO:0015698 41 0.011
purine ribonucleotide catabolic process GO:0009154 136 0.011
fertilization GO:0009566 3 0.011
central nervous system neuron differentiation GO:0021953 17 0.011
cellular response to external stimulus GO:0071496 118 0.011
dendrite morphogenesis GO:0048813 43 0.011
fatty acid transport GO:0015908 25 0.011
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.011
response to glucose GO:0009749 136 0.011
Rat
purine nucleoside monophosphate catabolic process GO:0009128 55 0.011
hormone transport GO:0009914 121 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
positive regulation of dna metabolic process GO:0051054 39 0.011
ear development GO:0043583 21 0.011
rho protein signal transduction GO:0007266 11 0.011
regulation of cell maturation GO:1903429 3 0.011
anterior posterior pattern specification GO:0009952 1 0.011
regulation of canonical wnt signaling pathway GO:0060828 4 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
icosanoid metabolic process GO:0006690 38 0.011
negative regulation of neuron death GO:1901215 69 0.011
regulation of small gtpase mediated signal transduction GO:0051056 48 0.011
protein maturation GO:0051604 68 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.010
negative regulation of intracellular signal transduction GO:1902532 38 0.010
multicellular organismal signaling GO:0035637 44 0.010
activation of phospholipase d activity GO:0031584 2 0.010
regulation of system process GO:0044057 208 0.010
sex differentiation GO:0007548 113 0.010
positive regulation of neurogenesis GO:0050769 165 0.010
epithelium development GO:0060429 96 0.010
regulation of dna metabolic process GO:0051052 60 0.010

Pcsk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.049
nervous system disease DOID:863 0 0.049
central nervous system disease DOID:331 0 0.032
disease of cellular proliferation DOID:14566 0 0.015
cancer DOID:162 0 0.010