Rattus norvegicus

28 known processes

C1s

complement component 1, s subcomponent

(Aliases: r-gsp)

C1s biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
complement activation GO:0006956 11 0.995
response to inorganic substance GO:0010035 377 0.795
protein activation cascade GO:0072376 12 0.770
response to cytokine GO:0034097 215 0.742
response to lipopolysaccharide GO:0032496 191 0.714
coagulation GO:0050817 28 0.663
fibrinolysis GO:0042730 2 0.623
response to molecule of bacterial origin GO:0002237 194 0.570
negative regulation of innate immune response GO:0045824 4 0.524
positive regulation of blood coagulation GO:0030194 4 0.521
tissue development GO:0009888 252 0.491
response to nutrient levels GO:0031667 370 0.461
blood coagulation GO:0007596 26 0.453
negative regulation of fibrinolysis GO:0051918 2 0.447
response to cobalt ion GO:0032025 12 0.390
regulation of response to stress GO:0080134 126 0.363
response to wounding GO:0009611 254 0.318
regulation of blood coagulation GO:0030193 9 0.313
kidney development GO:0001822 67 0.310
tissue remodeling GO:0048771 40 0.299
response to metal ion GO:0010038 253 0.295
defense response GO:0006952 194 0.293
regulation of coagulation GO:0050818 11 0.266
protein processing GO:0016485 68 0.255
response to other organism GO:0051707 220 0.239
positive regulation of hemostasis GO:1900048 4 0.236
hemostasis GO:0007599 26 0.212
positive regulation of neuron projection development GO:0010976 99 0.210
regulation of wound healing GO:0061041 14 0.209
response to external biotic stimulus GO:0043207 221 0.201
protein maturation GO:0051604 68 0.199
regulation of hydrolase activity GO:0051336 143 0.198
cellular response to vascular endothelial growth factor stimulus GO:0035924 6 0.188
cellular response to cytokine stimulus GO:0071345 127 0.187
innate immune response GO:0045087 35 0.181
wound healing GO:0042060 122 0.174
activation of immune response GO:0002253 26 0.168
regulation of locomotion GO:0040012 148 0.164
positive regulation of wound healing GO:0090303 6 0.160
regulation of neuron death GO:1901214 115 0.157
regulation of catalytic activity GO:0050790 304 0.150
negative regulation of humoral immune response GO:0002921 4 0.147
regulation of acute inflammatory response GO:0002673 23 0.140
programmed cell death GO:0012501 392 0.136
cellular response to organic cyclic compound GO:0071407 202 0.134
renal system development GO:0072001 67 0.127
negative regulation of multicellular organismal process GO:0051241 203 0.127
regulation of transcription dna templated GO:0006355 374 0.126
negative regulation of macromolecule metabolic process GO:0010605 260 0.119
regulation of immune system process GO:0002682 123 0.116
cell projection morphogenesis GO:0048858 123 0.116
neuron death GO:0070997 127 0.112
immune response GO:0006955 104 0.108
neurological system process GO:0050877 219 0.107
reproductive structure development GO:0048608 128 0.105
negative regulation of metabolic process GO:0009892 331 0.104
immune system process GO:0002376 204 0.102
rna metabolic process GO:0016070 406 0.102
response to retinoic acid GO:0032526 63 0.101
immune effector process GO:0002252 53 0.101
positive regulation of response to stimulus GO:0048584 285 0.101
cellular response to oxygen containing compound GO:1901701 386 0.100
acute inflammatory response GO:0002526 58 0.098
response to glucose GO:0009749 136 0.098
hepaticobiliary system development GO:0061008 90 0.097
response to estradiol GO:0032355 164 0.093
response to interferon gamma GO:0034341 20 0.093
respiratory system development GO:0060541 45 0.092
intracellular signal transduction GO:0035556 314 0.092
regulation of protein maturation GO:1903317 50 0.091
negative regulation of hemostasis GO:1900047 6 0.090
response to monosaccharide GO:0034284 159 0.087
response to biotic stimulus GO:0009607 226 0.087
response to dexamethasone GO:0071548 49 0.085
homeostatic process GO:0042592 331 0.083
positive regulation of cellular protein metabolic process GO:0032270 167 0.079
regulation of body fluid levels GO:0050878 90 0.079
response to glucocorticoid GO:0051384 223 0.078
rna biosynthetic process GO:0032774 380 0.078
inflammatory response GO:0006954 150 0.075
urogenital system development GO:0001655 78 0.072
regulation of multicellular organismal development GO:2000026 376 0.072
cellular response to steroid hormone stimulus GO:0071383 93 0.071
response to vitamin k GO:0032571 4 0.071
regulation of cellular component movement GO:0051270 150 0.069
response to bacterium GO:0009617 200 0.069
positive regulation of immune system process GO:0002684 90 0.068
regulation of cellular protein metabolic process GO:0032268 267 0.066
reproductive process GO:0022414 372 0.066
response to carbohydrate GO:0009743 183 0.064
sensory organ development GO:0007423 74 0.061
regulation of proteolysis GO:0030162 66 0.061
negative regulation of response to wounding GO:1903035 23 0.061
regulation of rna metabolic process GO:0051252 391 0.060
glycosyl compound catabolic process GO:1901658 126 0.060
liver development GO:0001889 90 0.060
response to extracellular stimulus GO:0009991 380 0.058
neuron projection development GO:0031175 273 0.057
positive regulation of phosphorus metabolic process GO:0010562 262 0.057
single organism reproductive process GO:0044702 297 0.056
protein phosphorylation GO:0006468 345 0.056
eye morphogenesis GO:0048592 4 0.055
positive regulation of cell projection organization GO:0031346 111 0.055
response to nutrient GO:0007584 248 0.054
cellular response to corticosteroid stimulus GO:0071384 69 0.053
organic substance catabolic process GO:1901575 316 0.053
cellular catabolic process GO:0044248 295 0.052
cellular response to biotic stimulus GO:0071216 59 0.052
response to hexose GO:0009746 144 0.052
negative regulation of response to external stimulus GO:0032102 37 0.052
neuron development GO:0048666 286 0.051
locomotion GO:0040011 237 0.051
multicellular organism reproduction GO:0032504 233 0.050
peptidyl amino acid modification GO:0018193 126 0.050
regulation of phosphate metabolic process GO:0019220 349 0.050
negative regulation of wound healing GO:0061045 8 0.049
regulation of axonogenesis GO:0050770 37 0.048
positive regulation of gene expression GO:0010628 244 0.047
enzyme linked receptor protein signaling pathway GO:0007167 116 0.047
cellular response to lipid GO:0071396 201 0.046
chemical homeostasis GO:0048878 292 0.046
anatomical structure morphogenesis GO:0009653 298 0.046
regulation of phosphorylation GO:0042325 248 0.046
positive regulation of phosphate metabolic process GO:0045937 262 0.045
response to interferon beta GO:0035456 1 0.044
regulation of protein metabolic process GO:0051246 289 0.043
reproduction GO:0000003 245 0.043
regulation of response to external stimulus GO:0032101 106 0.042
metal ion homeostasis GO:0055065 186 0.042
regulation of rna biosynthetic process GO:2001141 381 0.042
regulation of viral entry into host cell GO:0046596 3 0.042
carbohydrate derivative metabolic process GO:1901135 346 0.042
regulation of immune response GO:0050776 55 0.042
regulation of cell projection organization GO:0031344 175 0.041
multicellular organismal reproductive process GO:0048609 233 0.041
regulation of molecular function GO:0065009 398 0.041
viral gene expression GO:0019080 2 0.041
positive regulation of phosphorylation GO:0042327 177 0.041
positive regulation of nervous system development GO:0051962 178 0.038
negative regulation of endothelial cell migration GO:0010596 3 0.037
cellular response to growth factor stimulus GO:0071363 162 0.037
humoral immune response GO:0006959 12 0.037
cell projection organization GO:0030030 302 0.036
response to estrogen GO:0043627 232 0.036
regulation of nucleic acid templated transcription GO:1903506 380 0.036
cellular chemical homeostasis GO:0055082 247 0.036
viral genome replication GO:0019079 2 0.036
regulation of cell differentiation GO:0045595 320 0.035
negative regulation of apoptotic process GO:0043066 181 0.035
regulation of hemostasis GO:1900046 9 0.035
organ regeneration GO:0031100 101 0.034
cellular response to dexamethasone stimulus GO:0071549 36 0.034
regulation of phosphorus metabolic process GO:0051174 349 0.034
transcription dna templated GO:0006351 377 0.034
behavior GO:0007610 205 0.034
rhythmic process GO:0048511 156 0.033
organ morphogenesis GO:0009887 75 0.033
regulation of cellular component organization GO:0051128 368 0.033
transmembrane transport GO:0055085 412 0.032
negative regulation of peptidase activity GO:0010466 38 0.032
positive regulation of neuron differentiation GO:0045666 126 0.032
negative regulation of response to stimulus GO:0048585 155 0.032
regulation of nervous system development GO:0051960 264 0.032
negative regulation of cell death GO:0060548 229 0.032
positive regulation of cellular biosynthetic process GO:0031328 295 0.031
cellular response to endogenous stimulus GO:0071495 377 0.031
morphogenesis of a polarized epithelium GO:0001738 1 0.031
cellular response to alcohol GO:0097306 87 0.031
regulation of erk1 and erk2 cascade GO:0070372 41 0.031
cellular component movement GO:0006928 248 0.031
localization of cell GO:0051674 202 0.031
aging GO:0007568 241 0.030
negative regulation of endopeptidase activity GO:0010951 36 0.030
cellular response to hexose stimulus GO:0071331 65 0.030
carbohydrate homeostasis GO:0033500 75 0.030
signal transduction by phosphorylation GO:0023014 144 0.029
cellular response to molecule of bacterial origin GO:0071219 56 0.029
cellular homeostasis GO:0019725 252 0.029
negative regulation of gene expression GO:0010629 199 0.029
reactive oxygen species metabolic process GO:0072593 37 0.029
regulation of immune effector process GO:0002697 32 0.029
developmental process involved in reproduction GO:0003006 159 0.029
lipid metabolic process GO:0006629 283 0.028
brain renin angiotensin system GO:0002035 3 0.028
response to corticosteroid GO:0031960 235 0.027
reproductive system development GO:0061458 128 0.027
aromatic compound catabolic process GO:0019439 168 0.027
organonitrogen compound catabolic process GO:1901565 179 0.026
regulation of protein activation cascade GO:2000257 6 0.026
glycosyl compound metabolic process GO:1901657 182 0.026
regulation of neurogenesis GO:0050767 247 0.026
regulation of neuron projection development GO:0010975 161 0.026
negative regulation of protein processing GO:0010955 47 0.025
negative regulation of programmed cell death GO:0043069 183 0.025
regulation of cell proliferation GO:0042127 359 0.025
catabolic process GO:0009056 351 0.025
negative regulation of viral process GO:0048525 4 0.025
heterocycle catabolic process GO:0046700 167 0.024
response to interferon alpha GO:0035455 1 0.024
regulation of protein processing GO:0070613 50 0.024
sex differentiation GO:0007548 113 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.024
cellular amine metabolic process GO:0044106 38 0.023
single organism biosynthetic process GO:0044711 342 0.023
cellular response to cobalt ion GO:0071279 3 0.023
positive regulation of biosynthetic process GO:0009891 319 0.023
multi multicellular organism process GO:0044706 138 0.023
positive regulation of hydrolase activity GO:0051345 86 0.023
epithelium development GO:0060429 96 0.022
cellular response to hormone stimulus GO:0032870 247 0.022
cellular response to retinoic acid GO:0071300 27 0.022
response to interleukin 1 GO:0070555 55 0.022
axonogenesis GO:0007409 71 0.021
regulation of cell activation GO:0050865 50 0.021
negative regulation of developmental process GO:0051093 125 0.021
negative regulation of proteolysis GO:0045861 41 0.021
organic cyclic compound catabolic process GO:1901361 175 0.021
proteolysis GO:0006508 175 0.021
Human Rat
organic acid metabolic process GO:0006082 292 0.020
response to mechanical stimulus GO:0009612 134 0.020
cellular response to stress GO:0033554 269 0.020
positive regulation of protein metabolic process GO:0051247 178 0.020
positive regulation of cellular component organization GO:0051130 200 0.020
positive regulation of multicellular organismal process GO:0051240 387 0.020
phosphatidylethanolamine metabolic process GO:0046337 1 0.020
regulation of neuron differentiation GO:0045664 208 0.020
negative regulation of epithelial cell migration GO:0010633 4 0.020
tissue morphogenesis GO:0048729 22 0.020
cardiovascular system development GO:0072358 134 0.020
anterior posterior pattern specification GO:0009952 1 0.019
response to peptide GO:1901652 292 0.019
regulation of protein modification process GO:0031399 194 0.019
negative regulation of immune system process GO:0002683 39 0.019
response to camp GO:0051591 91 0.019
regulation of proteasomal protein catabolic process GO:0061136 4 0.019
negative regulation of cellular protein metabolic process GO:0032269 106 0.019
development of primary male sexual characteristics GO:0046546 59 0.019
regulation of apoptotic process GO:0042981 335 0.019
regulation of innate immune response GO:0045088 15 0.019
negative regulation of molecular function GO:0044092 133 0.018
negative regulation of locomotion GO:0040013 41 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
regulation of cellular ketone metabolic process GO:0010565 27 0.018
response to tumor necrosis factor GO:0034612 56 0.018
cognition GO:0050890 92 0.018
metanephric glomerulus morphogenesis GO:0072275 1 0.018
regulation of defense response GO:0031347 68 0.018
negative regulation of rna metabolic process GO:0051253 123 0.018
response to aluminum ion GO:0010044 10 0.018
nucleobase containing small molecule metabolic process GO:0055086 316 0.018
regeneration GO:0031099 163 0.018
p38mapk cascade GO:0038066 1 0.017
regulation of heart morphogenesis GO:2000826 2 0.017
response to ketone GO:1901654 182 0.017
single organism carbohydrate catabolic process GO:0044724 40 0.017
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.017
transcription from rna polymerase ii promoter GO:0006366 252 0.017
cellular response to external stimulus GO:0071496 118 0.017
inflammatory cell apoptotic process GO:0006925 5 0.017
regulation of reactive oxygen species metabolic process GO:2000377 26 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.016
cell motility GO:0048870 202 0.016
positive regulation of cell development GO:0010720 176 0.016
brain development GO:0007420 247 0.016
regulation of endopeptidase activity GO:0052548 51 0.016
single organism catabolic process GO:0044712 283 0.016
cell migration GO:0016477 197 0.016
blood coagulation fibrin clot formation GO:0072378 1 0.016
ovulation cycle GO:0042698 67 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
macromolecule localization GO:0033036 252 0.016
regulation of complement activation GO:0030449 6 0.015
vasculature development GO:0001944 70 0.015
response to transition metal nanoparticle GO:1990267 122 0.015
cellular response to mechanical stimulus GO:0071260 48 0.015
response to amino acid GO:0043200 75 0.015
negative regulation of protein maturation GO:1903318 47 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
nucleoside metabolic process GO:0009116 179 0.015
response to ethanol GO:0045471 162 0.015
single organism behavior GO:0044708 130 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
organophosphate metabolic process GO:0019637 370 0.015
positive regulation of molecular function GO:0044093 230 0.014
endocytosis GO:0006897 84 0.014
gland development GO:0048732 155 0.014
circulatory system development GO:0072359 134 0.014
leukocyte mediated immunity GO:0002443 28 0.014
vascular endothelial growth factor signaling pathway GO:0038084 4 0.014
amine metabolic process GO:0009308 38 0.014
head development GO:0060322 247 0.014
negative regulation of immune response GO:0050777 15 0.014
cellular response to extracellular stimulus GO:0031668 73 0.014
response to acetate GO:0010034 3 0.014
cellular response to reactive oxygen species GO:0034614 55 0.014
maternal process involved in female pregnancy GO:0060135 38 0.014
negative regulation of cellular metabolic process GO:0031324 281 0.014
regulation of programmed cell death GO:0043067 341 0.014
multi organism reproductive process GO:0044703 262 0.014
response to decreased oxygen levels GO:0036293 237 0.013
purine nucleoside triphosphate metabolic process GO:0009144 141 0.013
multicellular organismal signaling GO:0035637 44 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
response to growth factor GO:0070848 189 0.013
peptidyl tyrosine modification GO:0018212 72 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
positive regulation of transport GO:0051050 245 0.013
mapk cascade GO:0000165 140 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
cellular response to inorganic substance GO:0071241 65 0.013
positive regulation of immune response GO:0050778 42 0.013
growth GO:0040007 165 0.013
proteoglycan metabolic process GO:0006029 3 0.012
response to hypoxia GO:0001666 231 0.012
nuclear transport GO:0051169 49 0.012
negative regulation of coagulation GO:0050819 7 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
cellular glucose homeostasis GO:0001678 66 0.012
regulation of p38mapk cascade GO:1900744 1 0.012
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.012
respiratory tube development GO:0030323 43 0.012
vesicle mediated transport GO:0016192 181 0.012
viral transcription GO:0019083 2 0.012
renin secretion into blood stream GO:0002001 1 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.012
oxoacid metabolic process GO:0043436 290 0.012
positive regulation of developmental process GO:0051094 283 0.012
lung development GO:0030324 43 0.012
negative regulation of signaling GO:0023057 157 0.012
cell morphogenesis involved in differentiation GO:0000904 119 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
cation homeostasis GO:0055080 195 0.011
regulation of anatomical structure morphogenesis GO:0022603 141 0.011
regulation of peptidase activity GO:0052547 55 0.011
cell part morphogenesis GO:0032990 123 0.011
purine containing compound metabolic process GO:0072521 253 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
intramembranous ossification GO:0001957 1 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
neuron apoptotic process GO:0051402 88 0.011
ras protein signal transduction GO:0007265 29 0.011
striated muscle tissue development GO:0014706 58 0.011
ossification GO:0001503 70 0.011
skeletal system development GO:0001501 41 0.011
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 4 0.011
metal ion transport GO:0030001 289 0.011
rho protein signal transduction GO:0007266 11 0.011
tissue homeostasis GO:0001894 28 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.010
positive regulation of transcription dna templated GO:0045893 197 0.010
embryonic skeletal system development GO:0048706 3 0.010
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.010
response to vitamin d GO:0033280 34 0.010
gonad development GO:0008406 104 0.010
negative regulation of cell differentiation GO:0045596 99 0.010
reactive nitrogen species metabolic process GO:2001057 1 0.010
muscle tissue development GO:0060537 58 0.010
neuron differentiation GO:0030182 368 0.010
sensory perception GO:0007600 101 0.010

C1s disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.106
integumentary system disease DOID:16 0 0.106
sensory system disease DOID:0050155 0 0.045
eye and adnexa disease DOID:1492 0 0.045
nervous system disease DOID:863 0 0.045
eye disease DOID:5614 0 0.045
hemolytic anemia DOID:583 0 0.041
immune system disease DOID:2914 0 0.041
normocytic anemia DOID:720 0 0.041
anemia DOID:2355 0 0.041
hematopoietic system disease DOID:74 0 0.041
retinal disease DOID:5679 0 0.035
retinal degeneration DOID:8466 0 0.035
degeneration of macula and posterior pole DOID:2007 0 0.018
macular degeneration DOID:4448 0 0.018
age related macular degeneration DOID:10871 0 0.018
skin disease DOID:37 0 0.018
musculoskeletal system disease DOID:17 0 0.014
connective tissue disease DOID:65 0 0.014