Rattus norvegicus

0 known processes

C1r

complement component 1, r subcomponent

C1r biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
complement activation GO:0006956 11 0.916
response to molecule of bacterial origin GO:0002237 194 0.420
cell projection organization GO:0030030 302 0.387
rna metabolic process GO:0016070 406 0.337
immune response GO:0006955 104 0.332
response to cytokine GO:0034097 215 0.265
neuron death GO:0070997 127 0.257
response to nutrient levels GO:0031667 370 0.245
protein activation cascade GO:0072376 12 0.235
response to interferon alpha GO:0035455 1 0.227
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.226
regulation of body fluid levels GO:0050878 90 0.219
response to organophosphorus GO:0046683 102 0.197
regulation of rna biosynthetic process GO:2001141 381 0.197
response to other organism GO:0051707 220 0.178
aging GO:0007568 241 0.170
morphogenesis of a polarized epithelium GO:0001738 1 0.167
positive regulation of neuron projection development GO:0010976 99 0.163
negative regulation of innate immune response GO:0045824 4 0.159
negative regulation of cellular metabolic process GO:0031324 281 0.158
regulation of neurogenesis GO:0050767 247 0.154
regulation of signal transduction GO:0009966 318 0.149
regulation of neuron death GO:1901214 115 0.148
rna biosynthetic process GO:0032774 380 0.144
cellular response to organic cyclic compound GO:0071407 202 0.143
positive regulation of cell projection organization GO:0031346 111 0.140
regulation of molecular function GO:0065009 398 0.138
immune effector process GO:0002252 53 0.135
blood coagulation GO:0007596 26 0.133
negative regulation of gene expression GO:0010629 199 0.132
cellular response to cytokine stimulus GO:0071345 127 0.131
cell morphogenesis involved in differentiation GO:0000904 119 0.129
cellular response to hormone stimulus GO:0032870 247 0.122
response to cobalt ion GO:0032025 12 0.120
positive regulation of nervous system development GO:0051962 178 0.120
coagulation GO:0050817 28 0.118
organonitrogen compound biosynthetic process GO:1901566 167 0.117
neuron projection development GO:0031175 273 0.116
regulation of cellular protein metabolic process GO:0032268 267 0.116
regulation of establishment of planar polarity GO:0090175 2 0.116
regulation of phosphate metabolic process GO:0019220 349 0.114
cellular component morphogenesis GO:0032989 155 0.113
regulation of cell projection organization GO:0031344 175 0.111
response to camp GO:0051591 91 0.110
enzyme linked receptor protein signaling pathway GO:0007167 116 0.109
cell projection morphogenesis GO:0048858 123 0.109
regulation of catalytic activity GO:0050790 304 0.107
protein processing GO:0016485 68 0.105
positive regulation of blood coagulation GO:0030194 4 0.104
urogenital system development GO:0001655 78 0.100
response to estradiol GO:0032355 164 0.100
response to wounding GO:0009611 254 0.097
response to interleukin 1 GO:0070555 55 0.096
rhythmic process GO:0048511 156 0.095
regulation of neuron differentiation GO:0045664 208 0.092
negative regulation of cell death GO:0060548 229 0.090
cellular response to endogenous stimulus GO:0071495 377 0.090
response to nutrient GO:0007584 248 0.089
regulation of cellular component movement GO:0051270 150 0.089
locomotion GO:0040011 237 0.089
embryonic skeletal system development GO:0048706 3 0.089
intracellular signal transduction GO:0035556 314 0.088
positive regulation of neurogenesis GO:0050769 165 0.087
reproductive process GO:0022414 372 0.086
negative regulation of neuron death GO:1901215 69 0.086
regulation of multicellular organismal development GO:2000026 376 0.085
reproductive system development GO:0061458 128 0.085
response to external biotic stimulus GO:0043207 221 0.084
positive regulation of cellular component organization GO:0051130 200 0.084
positive regulation of developmental process GO:0051094 283 0.083
immune system process GO:0002376 204 0.083
response to bacterium GO:0009617 200 0.082
response to mechanical stimulus GO:0009612 134 0.082
negative regulation of macromolecule metabolic process GO:0010605 260 0.077
axonogenesis GO:0007409 71 0.076
behavior GO:0007610 205 0.076
positive regulation of response to stimulus GO:0048584 285 0.075
liver development GO:0001889 90 0.074
positive regulation of catalytic activity GO:0043085 184 0.073
response to metal ion GO:0010038 253 0.072
proteolysis GO:0006508 175 0.071
Human
neuron projection morphogenesis GO:0048812 122 0.069
regulation of rna metabolic process GO:0051252 391 0.068
response to lipopolysaccharide GO:0032496 191 0.068
cell part morphogenesis GO:0032990 123 0.067
camera type eye development GO:0043010 48 0.067
innate immune response GO:0045087 35 0.066
response to biotic stimulus GO:0009607 226 0.066
response to hexose GO:0009746 144 0.065
regulation of cellular component organization GO:0051128 368 0.065
response to inorganic substance GO:0010035 377 0.063
positive regulation of axon extension GO:0045773 14 0.062
positive regulation of phosphate metabolic process GO:0045937 262 0.062
cognition GO:0050890 92 0.061
response to extracellular stimulus GO:0009991 380 0.061
neuron development GO:0048666 286 0.060
response to glucose GO:0009749 136 0.060
positive regulation of gene expression GO:0010628 244 0.059
positive regulation of cell differentiation GO:0045597 217 0.059
positive regulation of phosphorus metabolic process GO:0010562 262 0.058
regulation of defense response GO:0031347 68 0.056
negative regulation of multicellular organismal process GO:0051241 203 0.056
protein maturation GO:0051604 68 0.056
response to estrogen GO:0043627 232 0.055
hemostasis GO:0007599 26 0.055
neuron differentiation GO:0030182 368 0.055
chemical homeostasis GO:0048878 292 0.055
negative regulation of humoral immune response GO:0002921 4 0.054
regulation of neuron projection development GO:0010975 161 0.053
positive regulation of signal transduction GO:0009967 175 0.052
transcription dna templated GO:0006351 377 0.052
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.052
renal system development GO:0072001 67 0.052
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.052
purine nucleotide biosynthetic process GO:0006164 83 0.052
positive regulation of neuron differentiation GO:0045666 126 0.051
organic acid metabolic process GO:0006082 292 0.050
positive regulation of molecular function GO:0044093 230 0.050
regulation of protein metabolic process GO:0051246 289 0.050
signal transduction by phosphorylation GO:0023014 144 0.048
regulation of locomotion GO:0040012 148 0.046
tissue development GO:0009888 252 0.046
developmental process involved in reproduction GO:0003006 159 0.045
cell migration GO:0016477 197 0.045
positive regulation of cellular protein metabolic process GO:0032270 167 0.045
axon development GO:0061564 96 0.045
kidney development GO:0001822 67 0.044
tube development GO:0035295 89 0.044
purine containing compound biosynthetic process GO:0072522 85 0.044
protein phosphorylation GO:0006468 345 0.044
peptidyl amino acid modification GO:0018193 126 0.044
regulation of hydrolase activity GO:0051336 143 0.043
positive regulation of cellular component movement GO:0051272 102 0.043
localization of cell GO:0051674 202 0.042
regulation of immune system process GO:0002682 123 0.042
positive regulation of intracellular signal transduction GO:1902533 138 0.042
multicellular organismal reproductive process GO:0048609 233 0.042
response to purine containing compound GO:0014074 126 0.042
ovulation cycle GO:0042698 67 0.042
respiratory system development GO:0060541 45 0.041
regulation of nucleic acid templated transcription GO:1903506 380 0.041
regulation of cell proliferation GO:0042127 359 0.041
regulation of programmed cell death GO:0043067 341 0.038
regulation of cell differentiation GO:0045595 320 0.038
positive regulation of hydrolase activity GO:0051345 86 0.038
cellular response to steroid hormone stimulus GO:0071383 93 0.038
cell motility GO:0048870 202 0.038
positive regulation of hemostasis GO:1900048 4 0.037
nucleic acid templated transcription GO:0097659 379 0.036
gland development GO:0048732 155 0.036
cellular component movement GO:0006928 248 0.036
ribonucleotide metabolic process GO:0009259 231 0.036
negative regulation of peptidase activity GO:0010466 38 0.035
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.035
organ morphogenesis GO:0009887 75 0.035
positive regulation of cell proliferation GO:0008284 249 0.034
response to glucocorticoid GO:0051384 223 0.034
neurological system process GO:0050877 219 0.033
nucleobase containing small molecule metabolic process GO:0055086 316 0.033
homeostatic process GO:0042592 331 0.033
gliogenesis GO:0042063 93 0.033
reactive oxygen species metabolic process GO:0072593 37 0.033
neuron apoptotic process GO:0051402 88 0.032
regulation of activation of janus kinase activity GO:0010533 1 0.032
negative regulation of defense response GO:0031348 19 0.031
negative regulation of apoptotic process GO:0043066 181 0.031
organonitrogen compound catabolic process GO:1901565 179 0.031
regulation of phosphorus metabolic process GO:0051174 349 0.031
regulation of nervous system development GO:0051960 264 0.030
multicellular organism reproduction GO:0032504 233 0.030
negative regulation of cellular protein metabolic process GO:0032269 106 0.030
cellular response to metal ion GO:0071248 55 0.030
hepaticobiliary system development GO:0061008 90 0.029
positive regulation of tyrosine phosphorylation of stat1 protein GO:0042511 1 0.029
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.029
ribose phosphate biosynthetic process GO:0046390 87 0.029
programmed cell death GO:0012501 392 0.029
cellular chemical homeostasis GO:0055082 247 0.029
negative regulation of cellular biosynthetic process GO:0031327 161 0.028
peptide cross linking GO:0018149 1 0.028
lens fiber cell differentiation GO:0070306 3 0.028
ras protein signal transduction GO:0007265 29 0.028
cellular amino acid metabolic process GO:0006520 107 0.028
cellular component assembly GO:0022607 360 0.028
positive regulation of immune system process GO:0002684 90 0.028
positive regulation of protein metabolic process GO:0051247 178 0.028
glycosyl compound metabolic process GO:1901657 182 0.027
cellular response to cobalt ion GO:0071279 3 0.026
wound healing GO:0042060 122 0.026
negative regulation of epithelial cell migration GO:0010633 4 0.026
negative regulation of cellular component organization GO:0051129 83 0.026
cellular response to interleukin 1 GO:0071347 37 0.026
organophosphate biosynthetic process GO:0090407 143 0.026
regulation of axonogenesis GO:0050770 37 0.026
reproductive structure development GO:0048608 128 0.026
positive regulation of cell development GO:0010720 176 0.026
embryonic pattern specification GO:0009880 1 0.026
regulation of protein modification process GO:0031399 194 0.025
transcription from rna polymerase ii promoter GO:0006366 252 0.025
viral gene expression GO:0019080 2 0.025
cellular response to oxygen containing compound GO:1901701 386 0.025
negative regulation of programmed cell death GO:0043069 183 0.025
tissue morphogenesis GO:0048729 22 0.025
inflammatory response GO:0006954 150 0.025
tissue remodeling GO:0048771 40 0.024
negative regulation of rna metabolic process GO:0051253 123 0.024
carbohydrate derivative biosynthetic process GO:1901137 124 0.024
regulation of phosphorylation GO:0042325 248 0.024
odontogenesis GO:0042476 32 0.024
immune system development GO:0002520 41 0.024
carbohydrate derivative metabolic process GO:1901135 346 0.024
regulation of proteolysis GO:0030162 66 0.024
positive regulation of phosphorylation GO:0042327 177 0.024
purine nucleotide metabolic process GO:0006163 229 0.024
mapk cascade GO:0000165 140 0.024
negative regulation of immune response GO:0050777 15 0.024
head development GO:0060322 247 0.023
anatomical structure morphogenesis GO:0009653 298 0.023
regulation of metanephros development GO:0072215 4 0.023
sensory organ development GO:0007423 74 0.023
regulation of transcription dna templated GO:0006355 374 0.023
single organism biosynthetic process GO:0044711 342 0.023
leukocyte mediated immunity GO:0002443 28 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.023
ribose phosphate metabolic process GO:0019693 235 0.022
jak stat cascade GO:0007259 26 0.022
establishment of planar polarity GO:0001736 1 0.022
regulation of viral entry into host cell GO:0046596 3 0.022
regulation of endopeptidase activity GO:0052548 51 0.022
epithelial cell differentiation GO:0030855 71 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.021
development of primary sexual characteristics GO:0045137 107 0.021
cellular amine metabolic process GO:0044106 38 0.021
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
negative regulation of response to stimulus GO:0048585 155 0.021
single organism reproductive process GO:0044702 297 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.021
intermediate filament bundle assembly GO:0045110 1 0.021
male gonad development GO:0008584 59 0.021
negative regulation of protein metabolic process GO:0051248 114 0.021
morphogenesis of an epithelium GO:0002009 20 0.021
sex differentiation GO:0007548 113 0.020
epithelium development GO:0060429 96 0.020
reproduction GO:0000003 245 0.020
positive regulation of cell communication GO:0010647 271 0.020
response to monosaccharide GO:0034284 159 0.020
regulation of innate immune response GO:0045088 15 0.020
purine ribonucleoside biosynthetic process GO:0046129 21 0.020
cellular response to inorganic substance GO:0071241 65 0.020
regulation of intracellular signal transduction GO:1902531 218 0.020
growth GO:0040007 165 0.020
regulation of nucleotide biosynthetic process GO:0030808 47 0.019
regulation of peptidase activity GO:0052547 55 0.019
negative regulation of endothelial cell migration GO:0010596 3 0.019
embryonic cranial skeleton morphogenesis GO:0048701 2 0.019
negative regulation of viral process GO:0048525 4 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.019
central nervous system development GO:0007417 311 0.019
cellular response to stress GO:0033554 269 0.019
regulation of neuron apoptotic process GO:0043523 83 0.019
negative regulation of protein processing GO:0010955 47 0.018
defense response GO:0006952 194 0.018
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.018
negative regulation of metabolic process GO:0009892 331 0.018
gastrulation GO:0007369 2 0.018
cellular response to acid chemical GO:0071229 75 0.018
response to decreased oxygen levels GO:0036293 237 0.018
response to starvation GO:0042594 59 0.018
gonad development GO:0008406 104 0.018
viral genome replication GO:0019079 2 0.017
response to ketone GO:1901654 182 0.017
positive regulation of signaling GO:0023056 270 0.017
negative regulation of viral entry into host cell GO:0046597 3 0.017
activation of immune response GO:0002253 26 0.017
regulation of hemostasis GO:1900046 9 0.017
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
negative regulation of catalytic activity GO:0043086 103 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.017
positive regulation of multicellular organismal process GO:0051240 387 0.017
cellular catabolic process GO:0044248 295 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.017
acute inflammatory response GO:0002526 58 0.016
cellular response to biotic stimulus GO:0071216 59 0.016
regulation of cell activation GO:0050865 50 0.016
glucose homeostasis GO:0042593 75 0.016
regulation of cell development GO:0060284 263 0.016
regulation of cell morphogenesis GO:0022604 77 0.016
regulation of nucleotide metabolic process GO:0006140 117 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.015
fibrinolysis GO:0042730 2 0.015
negative regulation of kidney development GO:0090185 2 0.015
metanephric renal vesicle morphogenesis GO:0072283 3 0.015
response to thyroid hormone GO:0097066 17 0.015
multi organism reproductive process GO:0044703 262 0.015
oxidation reduction process GO:0055114 304 0.015
establishment of tissue polarity GO:0007164 2 0.015
negative regulation of protein maturation GO:1903318 47 0.015
regulation of immune response GO:0050776 55 0.015
blood coagulation fibrin clot formation GO:0072378 1 0.015
positive regulation of non canonical wnt signaling pathway GO:2000052 1 0.015
cellular response to external stimulus GO:0071496 118 0.015
cell morphogenesis GO:0000902 142 0.015
catabolic process GO:0009056 351 0.015
regulation of cell motility GO:2000145 131 0.015
cardiovascular system development GO:0072358 134 0.015
purine ribonucleotide metabolic process GO:0009150 227 0.014
response to amino acid GO:0043200 75 0.014
organic substance catabolic process GO:1901575 316 0.014
nucleotide metabolic process GO:0009117 279 0.014
regulation of cellular amine metabolic process GO:0033238 8 0.014
regulation of receptor recycling GO:0001919 6 0.014
peptidyl tyrosine modification GO:0018212 72 0.014
amine metabolic process GO:0009308 38 0.014
formation of primary germ layer GO:0001704 1 0.014
metanephric nephron development GO:0072210 7 0.014
cellular response to hexose stimulus GO:0071331 65 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
embryonic skeletal system morphogenesis GO:0048704 3 0.014
regulation of reactive oxygen species metabolic process GO:2000377 26 0.014
negative regulation of immune system process GO:0002683 39 0.014
cellular response to carbohydrate stimulus GO:0071322 72 0.014
camera type eye morphogenesis GO:0048593 2 0.014
regulation of blood coagulation GO:0030193 9 0.014
regulation of cell migration GO:0030334 128 0.013
response to dexamethasone GO:0071548 49 0.013
positive regulation of cyclase activity GO:0031281 15 0.013
positive regulation of cell growth GO:0030307 44 0.013
regulation of apoptotic process GO:0042981 335 0.013
negative regulation of phosphorylation GO:0042326 57 0.013
nucleotide biosynthetic process GO:0009165 98 0.013
response to peptide GO:1901652 292 0.013
carbohydrate homeostasis GO:0033500 75 0.013
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.013
regulation of protein phosphorylation GO:0001932 183 0.013
response to growth factor GO:0070848 189 0.013
peptidyl tyrosine phosphorylation GO:0018108 72 0.013
positive regulation of cellular amine metabolic process GO:0033240 3 0.013
cellular response to interleukin 2 GO:0071352 1 0.013
response to retinoic acid GO:0032526 63 0.013
oxoacid metabolic process GO:0043436 290 0.013
regulation of response to stress GO:0080134 126 0.013
respiratory tube development GO:0030323 43 0.013
positive regulation of developmental growth GO:0048639 29 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
development of primary male sexual characteristics GO:0046546 59 0.012
glial cell differentiation GO:0010001 65 0.012
cellular response to vascular endothelial growth factor stimulus GO:0035924 6 0.012
negative regulation of cytokine production GO:0001818 16 0.012
regulation of protein processing GO:0070613 50 0.012
intermediate filament organization GO:0045109 1 0.012
purine containing compound metabolic process GO:0072521 253 0.012
cellular homeostasis GO:0019725 252 0.012
eye morphogenesis GO:0048592 4 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.012
nucleoside phosphate metabolic process GO:0006753 283 0.012
response to carbohydrate GO:0009743 183 0.012
positive regulation of camp metabolic process GO:0030816 31 0.012
eye development GO:0001654 50 0.011
heart development GO:0007507 72 0.011
anterior posterior pattern specification GO:0009952 1 0.011
negative regulation of hydrogen peroxide metabolic process GO:0010727 2 0.011
carboxylic acid metabolic process GO:0019752 289 0.011
digestive tract development GO:0048565 39 0.011
brain development GO:0007420 247 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.011
positive regulation of peptidase activity GO:0010952 17 0.011
regulation of growth GO:0040008 105 0.011
cellular response to glucose stimulus GO:0071333 65 0.011
cell type specific apoptotic process GO:0097285 134 0.011
camp metabolic process GO:0046058 63 0.011
cellular ketone metabolic process GO:0042180 51 0.011
organophosphate metabolic process GO:0019637 370 0.011
negative regulation of developmental process GO:0051093 125 0.011
odontogenesis of dentin containing tooth GO:0042475 18 0.011
cellular response to lipid GO:0071396 201 0.011
response to reactive oxygen species GO:0000302 120 0.011
cell growth GO:0016049 104 0.011
negative regulation of signaling GO:0023057 157 0.011
negative regulation of proteolysis GO:0045861 41 0.011
response to oxidative stress GO:0006979 186 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.010
smooth muscle cell proliferation GO:0048659 77 0.010
negative regulation of cell communication GO:0010648 158 0.010
regulation of smooth muscle cell proliferation GO:0048660 75 0.010
response to peptide hormone GO:0043434 278 0.010
apoptotic process GO:0006915 381 0.010
cytoplasmic transport GO:0016482 115 0.010
organelle organization GO:0006996 266 0.010

C1r disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
skin disease DOID:37 0 0.043
integumentary system disease DOID:16 0 0.043
immune system disease DOID:2914 0 0.010