Rattus norvegicus

0 known processes

Geft

RhoA/RAC/CDC42 exchange factor

(Aliases: MGC72605,Arhgef25)

Geft biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell projection organization GO:0030030 302 0.134
Rat
anatomical structure morphogenesis GO:0009653 298 0.128
Rat
macromolecular complex subunit organization GO:0043933 339 0.119
regulation of phosphorus metabolic process GO:0051174 349 0.106
intracellular signal transduction GO:0035556 314 0.088
Rat
macromolecular complex assembly GO:0065003 273 0.086
protein complex assembly GO:0006461 263 0.086
cellular component assembly GO:0022607 360 0.084
protein complex subunit organization GO:0071822 302 0.082
organelle organization GO:0006996 266 0.077
single organism reproductive process GO:0044702 297 0.074
organophosphate metabolic process GO:0019637 370 0.068
regulation of cellular component organization GO:0051128 368 0.068
Rat
rna biosynthetic process GO:0032774 380 0.066
neuron differentiation GO:0030182 368 0.066
Rat
nucleic acid templated transcription GO:0097659 379 0.064
regulation of multicellular organismal development GO:2000026 376 0.063
Rat
nucleobase containing small molecule metabolic process GO:0055086 316 0.062
positive regulation of phosphorus metabolic process GO:0010562 262 0.062
rna metabolic process GO:0016070 406 0.061
cellular component biogenesis GO:0044085 368 0.060
positive regulation of phosphate metabolic process GO:0045937 262 0.060
regulation of rna biosynthetic process GO:2001141 381 0.058
positive regulation of rna metabolic process GO:0051254 203 0.056
positive regulation of cellular biosynthetic process GO:0031328 295 0.055
positive regulation of biosynthetic process GO:0009891 319 0.054
reproductive process GO:0022414 372 0.053
protein complex biogenesis GO:0070271 263 0.052
transcription dna templated GO:0006351 377 0.052
ribonucleotide metabolic process GO:0009259 231 0.051
regulation of catalytic activity GO:0050790 304 0.051
single organism organelle organization GO:1902589 180 0.050
regulation of rna metabolic process GO:0051252 391 0.049
apoptotic process GO:0006915 381 0.047
positive regulation of cell proliferation GO:0008284 249 0.046
single organism biosynthetic process GO:0044711 342 0.045
nucleotide metabolic process GO:0009117 279 0.045
endocytosis GO:0006897 84 0.044
purine ribonucleotide metabolic process GO:0009150 227 0.044
regulation of signal transduction GO:0009966 318 0.044
programmed cell death GO:0012501 392 0.044
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.044
ribose phosphate metabolic process GO:0019693 235 0.042
multi organism reproductive process GO:0044703 262 0.042
organic acid metabolic process GO:0006082 292 0.041
single organism behavior GO:0044708 130 0.041
cytosolic calcium ion homeostasis GO:0051480 140 0.041
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.041
neuron projection development GO:0031175 273 0.041
Rat
negative regulation of metabolic process GO:0009892 331 0.039
circulatory system development GO:0072359 134 0.039
developmental process involved in reproduction GO:0003006 159 0.039
protein phosphorylation GO:0006468 345 0.038
nucleoside phosphate metabolic process GO:0006753 283 0.037
purine containing compound metabolic process GO:0072521 253 0.037
purine nucleotide metabolic process GO:0006163 229 0.037
response to acid chemical GO:0001101 222 0.037
positive regulation of gene expression GO:0010628 244 0.037
response to extracellular stimulus GO:0009991 380 0.037
regulation of cellular protein metabolic process GO:0032268 267 0.037
organic substance catabolic process GO:1901575 316 0.036
transmembrane transport GO:0055085 412 0.036
vesicle mediated transport GO:0016192 181 0.036
cellular component movement GO:0006928 248 0.036
response to nutrient levels GO:0031667 370 0.036
response to metal ion GO:0010038 253 0.035
regulation of nervous system development GO:0051960 264 0.035
Rat
oxoacid metabolic process GO:0043436 290 0.035
response to growth factor GO:0070848 189 0.035
reproduction GO:0000003 245 0.035
brain development GO:0007420 247 0.034
protein oligomerization GO:0051259 191 0.034
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.034
regulation of cell differentiation GO:0045595 320 0.034
Rat
single organism catabolic process GO:0044712 283 0.033
regulation of cell development GO:0060284 263 0.033
Rat
response to inorganic substance GO:0010035 377 0.033
cytoskeleton organization GO:0007010 111 0.033
protein dna complex disassembly GO:0032986 1 0.033
positive regulation of cell communication GO:0010647 271 0.033
positive regulation of transcription dna templated GO:0045893 197 0.033
transcription from rna polymerase ii promoter GO:0006366 252 0.032
neuron development GO:0048666 286 0.032
Rat
cellular response to endogenous stimulus GO:0071495 377 0.031
positive regulation of multicellular organismal process GO:0051240 387 0.031
negative regulation of cell communication GO:0010648 158 0.031
regulation of transcription dna templated GO:0006355 374 0.031
chemical homeostasis GO:0048878 292 0.030
head development GO:0060322 247 0.030
neuron projection morphogenesis GO:0048812 122 0.030
Rat
cellular response to oxygen containing compound GO:1901701 386 0.030
regulation of cellular localization GO:0060341 263 0.030
cell projection morphogenesis GO:0048858 123 0.029
Rat
cellular component morphogenesis GO:0032989 155 0.028
Rat
regulation of cell projection organization GO:0031344 175 0.028
Rat
negative regulation of macromolecule metabolic process GO:0010605 260 0.028
carbohydrate derivative metabolic process GO:1901135 346 0.028
regulation of neurogenesis GO:0050767 247 0.028
Rat
regulation of molecular function GO:0065009 398 0.028
positive regulation of catalytic activity GO:0043085 184 0.028
homeostatic process GO:0042592 331 0.027
central nervous system development GO:0007417 311 0.027
intracellular transport GO:0046907 185 0.027
cardiac chamber development GO:0003205 1 0.027
positive regulation of transport GO:0051050 245 0.027
regulation of anatomical structure morphogenesis GO:0022603 141 0.026
receptor mediated endocytosis GO:0006898 42 0.026
multicellular organism reproduction GO:0032504 233 0.026
positive regulation of rna biosynthetic process GO:1902680 197 0.026
positive regulation of developmental process GO:0051094 283 0.026
chromatin assembly or disassembly GO:0006333 1 0.026
regulation of apoptotic process GO:0042981 335 0.025
regulation of nucleic acid templated transcription GO:1903506 380 0.025
cell morphogenesis involved in differentiation GO:0000904 119 0.025
Rat
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.025
regulation of nucleotide metabolic process GO:0006140 117 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.025
regulation of protein modification process GO:0031399 194 0.025
negative regulation of cellular metabolic process GO:0031324 281 0.024
cell morphogenesis GO:0000902 142 0.024
Rat
organophosphate biosynthetic process GO:0090407 143 0.024
multicellular organismal reproductive process GO:0048609 233 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.024
locomotion GO:0040011 237 0.024
carbohydrate metabolic process GO:0005975 130 0.024
membrane organization GO:0061024 94 0.023
cardiovascular system development GO:0072358 134 0.023
tissue development GO:0009888 252 0.023
nucleosome organization GO:0034728 1 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
cell migration GO:0016477 197 0.023
positive regulation of nucleic acid templated transcription GO:1903508 197 0.023
cellular response to stress GO:0033554 269 0.023
negative regulation of gene expression GO:0010629 199 0.023
negative regulation of cellular biosynthetic process GO:0031327 161 0.023
response to corticosteroid GO:0031960 235 0.023
cellular chemical homeostasis GO:0055082 247 0.023
purine ribonucleoside metabolic process GO:0046128 168 0.023
regulation of programmed cell death GO:0043067 341 0.022
anatomical structure formation involved in morphogenesis GO:0048646 83 0.022
ribonucleoside triphosphate catabolic process GO:0009203 122 0.022
nucleoside metabolic process GO:0009116 179 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.022
response to oxygen levels GO:0070482 265 0.022
single organism carbohydrate metabolic process GO:0044723 118 0.022
positive regulation of cellular component organization GO:0051130 200 0.022
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.022
cellular metal ion homeostasis GO:0006875 172 0.022
carboxylic acid metabolic process GO:0019752 289 0.022
response to reactive oxygen species GO:0000302 120 0.022
spindle organization GO:0007051 2 0.022
negative regulation of cell death GO:0060548 229 0.022
positive regulation of cell differentiation GO:0045597 217 0.022
cellular ketone metabolic process GO:0042180 51 0.022
catabolic process GO:0009056 351 0.022
negative regulation of apoptotic process GO:0043066 181 0.022
localization of cell GO:0051674 202 0.021
behavior GO:0007610 205 0.021
g protein coupled receptor signaling pathway GO:0007186 242 0.021
development of primary sexual characteristics GO:0045137 107 0.021
regulation of neuron projection development GO:0010975 161 0.021
Rat
cellular homeostasis GO:0019725 252 0.021
sensory perception GO:0007600 101 0.021
protein localization GO:0008104 191 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.021
cellular catabolic process GO:0044248 295 0.021
divalent inorganic cation homeostasis GO:0072507 165 0.020
purine containing compound catabolic process GO:0072523 138 0.020
response to biotic stimulus GO:0009607 226 0.020
cell motility GO:0048870 202 0.020
calcium ion homeostasis GO:0055074 162 0.020
cellular calcium ion homeostasis GO:0006874 160 0.020
amine metabolic process GO:0009308 38 0.020
positive regulation of signaling GO:0023056 270 0.020
cellular amino acid metabolic process GO:0006520 107 0.020
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.020
cell part morphogenesis GO:0032990 123 0.020
Rat
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.019
purine ribonucleotide catabolic process GO:0009154 136 0.019
organic cyclic compound catabolic process GO:1901361 175 0.019
regulation of protein metabolic process GO:0051246 289 0.019
growth GO:0040007 165 0.019
eye morphogenesis GO:0048592 4 0.019
positive regulation of cell development GO:0010720 176 0.019
cellular amine metabolic process GO:0044106 38 0.019
regulation of intracellular signal transduction GO:1902531 218 0.019
calcium ion transport GO:0006816 131 0.019
organ formation GO:0048645 3 0.019
actin filament organization GO:0007015 42 0.019
rhythmic process GO:0048511 156 0.019
positive regulation of protein phosphorylation GO:0001934 135 0.019
response to carbohydrate GO:0009743 183 0.018
cellular response to growth factor stimulus GO:0071363 162 0.018
regulation of phosphorylation GO:0042325 248 0.018
response to cytokine GO:0034097 215 0.018
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.018
regulation of proteasomal protein catabolic process GO:0061136 4 0.018
ion transmembrane transport GO:0034220 365 0.018
reproductive structure development GO:0048608 128 0.018
response to estradiol GO:0032355 164 0.018
organonitrogen compound biosynthetic process GO:1901566 167 0.018
metal ion homeostasis GO:0055065 186 0.018
regulation of anatomical structure size GO:0090066 135 0.018
aromatic compound catabolic process GO:0019439 168 0.018
forebrain development GO:0030900 98 0.018
negative regulation of signaling GO:0023057 157 0.018
ribonucleotide biosynthetic process GO:0009260 85 0.018
cellular response to acid chemical GO:0071229 75 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.018
actin filament based process GO:0030029 86 0.018
positive regulation of molecular function GO:0044093 230 0.017
negative regulation of molecular function GO:0044092 133 0.017
cellular nitrogen compound catabolic process GO:0044270 163 0.017
nucleoside triphosphate metabolic process GO:0009141 144 0.017
organophosphate catabolic process GO:0046434 148 0.017
sex differentiation GO:0007548 113 0.017
cellular response to lipid GO:0071396 201 0.017
nucleotide catabolic process GO:0009166 139 0.017
regulation of cellular component biogenesis GO:0044087 86 0.017
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
negative regulation of response to stimulus GO:0048585 155 0.017
ion homeostasis GO:0050801 212 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
chromatin disassembly GO:0031498 1 0.017
response to glucocorticoid GO:0051384 223 0.017
regulation of hydrolase activity GO:0051336 143 0.017
positive regulation of signal transduction GO:0009967 175 0.017
response to monosaccharide GO:0034284 159 0.016
nucleoside phosphate biosynthetic process GO:1901293 102 0.016
regulation of cellular amine metabolic process GO:0033238 8 0.016
response to purine containing compound GO:0014074 126 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
purine nucleotide biosynthetic process GO:0006164 83 0.016
regulation of purine nucleotide metabolic process GO:1900542 115 0.016
metal ion transport GO:0030001 289 0.016
response to ketone GO:1901654 182 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
reproductive system development GO:0061458 128 0.016
synaptic transmission GO:0007268 235 0.016
regulation of secretion by cell GO:1903530 208 0.016
nucleosome disassembly GO:0006337 1 0.016
purine ribonucleotide biosynthetic process GO:0009152 81 0.016
neurological system process GO:0050877 219 0.015
macromolecule localization GO:0033036 252 0.015
carbohydrate derivative catabolic process GO:1901136 147 0.015
cell cell signaling GO:0007267 335 0.015
cellular cation homeostasis GO:0030003 180 0.015
maintenance of location GO:0051235 17 0.015
positive regulation of response to stimulus GO:0048584 285 0.015
dephosphorylation GO:0016311 98 0.015
peptidyl amino acid modification GO:0018193 126 0.015
regulation of locomotion GO:0040012 148 0.015
regulation of cell proliferation GO:0042127 359 0.015
secretion GO:0046903 307 0.015
cell cycle GO:0007049 101 0.015
sequestering of metal ion GO:0051238 9 0.015
heterocycle catabolic process GO:0046700 167 0.015
negative regulation of biosynthetic process GO:0009890 168 0.015
negative regulation of rna biosynthetic process GO:1902679 118 0.015
regulation of ion transport GO:0043269 245 0.015
negative regulation of rna metabolic process GO:0051253 123 0.015
cellular ion homeostasis GO:0006873 184 0.015
regulation of response to external stimulus GO:0032101 106 0.015
single organism intracellular transport GO:1902582 166 0.014
regulation of kinase activity GO:0043549 117 0.014
nucleotide biosynthetic process GO:0009165 98 0.014
response to fatty acid GO:0070542 65 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
nucleoside triphosphate catabolic process GO:0009143 123 0.014
response to hydrogen peroxide GO:0042542 89 0.014
regulation of g2 m transition of mitotic cell cycle GO:0010389 4 0.014
response to nutrient GO:0007584 248 0.014
regulation of actin cytoskeleton organization GO:0032956 30 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
response to hexose GO:0009746 144 0.014
organic hydroxy compound metabolic process GO:1901615 115 0.014
gland development GO:0048732 155 0.014
ras protein signal transduction GO:0007265 29 0.013
immune system process GO:0002376 204 0.013
cellular protein localization GO:0034613 122 0.013
purine nucleoside triphosphate catabolic process GO:0009146 122 0.013
response to hypoxia GO:0001666 231 0.013
response to organophosphorus GO:0046683 102 0.013
gamete generation GO:0007276 124 0.013
ribonucleoside metabolic process GO:0009119 174 0.013
negative regulation of transport GO:0051051 136 0.013
muscle cell differentiation GO:0042692 52 0.013
response to estrogen GO:0043627 232 0.013
cytoskeleton dependent cytokinesis GO:0061640 2 0.013
positive regulation of neurogenesis GO:0050769 165 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
blood vessel morphogenesis GO:0048514 58 0.013
cell growth GO:0016049 104 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
gtp catabolic process GO:0006184 71 0.013
ribose phosphate biosynthetic process GO:0046390 87 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
cardiac ventricle development GO:0003231 1 0.013
positive regulation of protein modification process GO:0031401 142 0.013
small molecule biosynthetic process GO:0044283 124 0.013
receptor metabolic process GO:0043112 18 0.013
negative regulation of transcription dna templated GO:0045892 116 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
positive regulation of cellular amine metabolic process GO:0033240 3 0.013
nucleoside phosphate catabolic process GO:1901292 140 0.013
regulation of cellular catabolic process GO:0031329 101 0.013
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
mitotic cell cycle process GO:1903047 35 0.012
circadian rhythm GO:0007623 88 0.012
synaptic vesicle endocytosis GO:0048488 4 0.012
cyclic nucleotide biosynthetic process GO:0009190 63 0.012
artery development GO:0060840 3 0.012
single organism membrane organization GO:0044802 74 0.012
cellular macromolecular complex assembly GO:0034622 58 0.012
response to decreased oxygen levels GO:0036293 237 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.012
regulation of gtpase activity GO:0043087 57 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.012
Rat
negative regulation of cellular protein metabolic process GO:0032269 106 0.012
glucose metabolic process GO:0006006 52 0.012
purine containing compound biosynthetic process GO:0072522 85 0.012
regulation of cell adhesion GO:0030155 52 0.012
regulation of vesicle mediated transport GO:0060627 81 0.012
actin cytoskeleton organization GO:0030036 73 0.012
monocarboxylic acid metabolic process GO:0032787 152 0.012
lipid metabolic process GO:0006629 283 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
ribonucleoside catabolic process GO:0042454 126 0.012
response to molecule of bacterial origin GO:0002237 194 0.012
response to ethanol GO:0045471 162 0.012
regulation of cellular component size GO:0032535 51 0.011
regulation of stem cell differentiation GO:2000736 2 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
purine ribonucleoside catabolic process GO:0046130 124 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
regulation of cell motility GO:2000145 131 0.011
regulation of cell cycle g2 m phase transition GO:1902749 4 0.011
sexual reproduction GO:0019953 148 0.011
synaptic growth at neuromuscular junction GO:0051124 1 0.011
gastrulation GO:0007369 2 0.011
regulation of homeostatic process GO:0032844 101 0.011
cell type specific apoptotic process GO:0097285 134 0.011
regulation of organelle organization GO:0033043 80 0.011
divalent metal ion transport GO:0070838 132 0.011
positive regulation of nervous system development GO:0051962 178 0.011
regulation of cytoskeleton organization GO:0051493 49 0.011
oxidation reduction process GO:0055114 304 0.011
heart development GO:0007507 72 0.011
alcohol metabolic process GO:0006066 77 0.011
cytoplasmic transport GO:0016482 115 0.011
salivary gland development GO:0007431 3 0.011
regulation of dendrite development GO:0050773 59 0.011
Rat
glycosyl compound catabolic process GO:1901658 126 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
gonad development GO:0008406 104 0.011
cation transport GO:0006812 382 0.011
cellular response to hormone stimulus GO:0032870 247 0.011
regulation of cell cycle GO:0051726 73 0.011
axonogenesis GO:0007409 71 0.011
Rat
cellular macromolecule localization GO:0070727 122 0.011
blood vessel development GO:0001568 69 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
memory GO:0007613 54 0.011
ovulation cycle GO:0042698 67 0.011
cellular response to cytokine stimulus GO:0071345 127 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
regulation of transmembrane transport GO:0034762 122 0.011
regulation of system process GO:0044057 208 0.011
regulation of catabolic process GO:0009894 113 0.011
regulation of membrane potential GO:0042391 110 0.010
divalent inorganic cation transport GO:0072511 134 0.010
cell cycle process GO:0022402 57 0.010
regulation of protein complex assembly GO:0043254 33 0.010
regeneration GO:0031099 163 0.010
ribonucleotide catabolic process GO:0009261 136 0.010
response to glucose GO:0009749 136 0.010
positive regulation of cellular protein metabolic process GO:0032270 167 0.010
secretion by cell GO:0032940 248 0.010
t cell receptor signaling pathway GO:0050852 1 0.010
cyclic nucleotide metabolic process GO:0009187 80 0.010

Geft disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014
central nervous system disease DOID:331 0 0.012