Rattus norvegicus

102 known processes

Pkp2

plakophilin 2

Pkp2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
catabolic process GO:0009056 351 0.072
organic acid metabolic process GO:0006082 292 0.069
anatomical structure morphogenesis GO:0009653 298 0.057
Human
cellular amino acid metabolic process GO:0006520 107 0.056
blood circulation GO:0008015 183 0.056
Human
carboxylic acid metabolic process GO:0019752 289 0.055
organophosphate metabolic process GO:0019637 370 0.054
response to inorganic substance GO:0010035 377 0.052
regulation of molecular function GO:0065009 398 0.050
oxoacid metabolic process GO:0043436 290 0.049
transcription dna templated GO:0006351 377 0.047
positive regulation of developmental process GO:0051094 283 0.047
negative regulation of metabolic process GO:0009892 331 0.046
positive regulation of multicellular organismal process GO:0051240 387 0.045
neuron development GO:0048666 286 0.044
nucleic acid templated transcription GO:0097659 379 0.043
organelle organization GO:0006996 266 0.042
Human
regulation of system process GO:0044057 208 0.041
single organism catabolic process GO:0044712 283 0.040
single organism biosynthetic process GO:0044711 342 0.039
regulation of transcription dna templated GO:0006355 374 0.039
organonitrogen compound biosynthetic process GO:1901566 167 0.039
nucleobase containing small molecule metabolic process GO:0055086 316 0.038
neuron projection development GO:0031175 273 0.038
neuron differentiation GO:0030182 368 0.038
carbohydrate derivative metabolic process GO:1901135 346 0.037
regulation of rna metabolic process GO:0051252 391 0.037
regulation of catalytic activity GO:0050790 304 0.037
rna metabolic process GO:0016070 406 0.036
intracellular signal transduction GO:0035556 314 0.036
rna biosynthetic process GO:0032774 380 0.036
response to metal ion GO:0010038 253 0.036
cell projection organization GO:0030030 302 0.035
regulation of membrane potential GO:0042391 110 0.034
response to peptide hormone GO:0043434 278 0.034
programmed cell death GO:0012501 392 0.034
regulation of ion transport GO:0043269 245 0.034
organic substance catabolic process GO:1901575 316 0.034
cellular amine metabolic process GO:0044106 38 0.034
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.033
positive regulation of cellular biosynthetic process GO:0031328 295 0.033
cellular component assembly GO:0022607 360 0.033
response to nutrient GO:0007584 248 0.032
cellular response to oxygen containing compound GO:1901701 386 0.032
positive regulation of biosynthetic process GO:0009891 319 0.032
regulation of cell proliferation GO:0042127 359 0.032
response to nutrient levels GO:0031667 370 0.032
negative regulation of macromolecule metabolic process GO:0010605 260 0.032
protein complex subunit organization GO:0071822 302 0.032
Human
lipid biosynthetic process GO:0008610 128 0.032
cell morphogenesis GO:0000902 142 0.032
regulation of nucleic acid templated transcription GO:1903506 380 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
cellular homeostasis GO:0019725 252 0.031
regulation of cellular amino acid metabolic process GO:0006521 2 0.030
negative regulation of cellular metabolic process GO:0031324 281 0.030
regulation of rna biosynthetic process GO:2001141 381 0.030
regulation of neurogenesis GO:0050767 247 0.030
cell part morphogenesis GO:0032990 123 0.030
cellular response to endogenous stimulus GO:0071495 377 0.030
nucleoside phosphate metabolic process GO:0006753 283 0.030
central nervous system development GO:0007417 311 0.029
Rat
ion homeostasis GO:0050801 212 0.029
protein complex assembly GO:0006461 263 0.029
tissue development GO:0009888 252 0.029
Human
cellular ketone metabolic process GO:0042180 51 0.029
transmembrane transport GO:0055085 412 0.029
positive regulation of gene expression GO:0010628 244 0.029
cellular component biogenesis GO:0044085 368 0.029
ribonucleoside metabolic process GO:0009119 174 0.029
nucleotide metabolic process GO:0009117 279 0.029
regulation of cellular amine metabolic process GO:0033238 8 0.028
heart morphogenesis GO:0003007 3 0.028
Human
regulation of phosphate metabolic process GO:0019220 349 0.028
response to oxygen levels GO:0070482 265 0.028
cellular cation homeostasis GO:0030003 180 0.028
positive regulation of molecular function GO:0044093 230 0.028
response to corticosteroid GO:0031960 235 0.028
secretion GO:0046903 307 0.028
cellular response to peptide hormone stimulus GO:0071375 120 0.028
regulation of cell differentiation GO:0045595 320 0.028
Human
homeostatic process GO:0042592 331 0.028
positive regulation of cell proliferation GO:0008284 249 0.028
response to glucocorticoid GO:0051384 223 0.027
cellular catabolic process GO:0044248 295 0.027
cell projection morphogenesis GO:0048858 123 0.027
regulation of multicellular organismal development GO:2000026 376 0.027
amine metabolic process GO:0009308 38 0.027
organonitrogen compound catabolic process GO:1901565 179 0.027
regulation of programmed cell death GO:0043067 341 0.027
response to hypoxia GO:0001666 231 0.027
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.027
ion transmembrane transport GO:0034220 365 0.026
regulation of catabolic process GO:0009894 113 0.026
oxidation reduction process GO:0055114 304 0.026
cation transport GO:0006812 382 0.026
ribose phosphate metabolic process GO:0019693 235 0.026
transcription from rna polymerase ii promoter GO:0006366 252 0.026
muscle contraction GO:0006936 88 0.026
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.026
response to peptide GO:1901652 292 0.026
coenzyme metabolic process GO:0006732 86 0.026
negative regulation of gene expression GO:0010629 199 0.025
positive regulation of response to stimulus GO:0048584 285 0.025
response to extracellular stimulus GO:0009991 380 0.025
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.024
response to oxidative stress GO:0006979 186 0.024
cardiac muscle contraction GO:0060048 27 0.024
response to wounding GO:0009611 254 0.024
negative regulation of response to stimulus GO:0048585 155 0.024
cation homeostasis GO:0055080 195 0.024
response to estrogen GO:0043627 232 0.024
regulation of cellular localization GO:0060341 263 0.024
positive regulation of cell differentiation GO:0045597 217 0.024
regulation of cellular component organization GO:0051128 368 0.023
regulation of phosphorus metabolic process GO:0051174 349 0.023
nucleobase containing compound catabolic process GO:0034655 152 0.023
regulation of signal transduction GO:0009966 318 0.023
muscle system process GO:0003012 115 0.023
nucleoside metabolic process GO:0009116 179 0.023
immune system process GO:0002376 204 0.023
cellular response to hormone stimulus GO:0032870 247 0.023
positive regulation of cellular amine metabolic process GO:0033240 3 0.023
response to acid chemical GO:0001101 222 0.023
purine containing compound metabolic process GO:0072521 253 0.022
regulation of nervous system development GO:0051960 264 0.022
regulation of cell development GO:0060284 263 0.022
purine nucleoside metabolic process GO:0042278 169 0.022
nucleoside catabolic process GO:0009164 126 0.022
negative regulation of biosynthetic process GO:0009890 168 0.022
negative regulation of cellular biosynthetic process GO:0031327 161 0.022
positive regulation of catalytic activity GO:0043085 184 0.022
cell cell signaling GO:0007267 335 0.022
Human
regulation of intracellular signal transduction GO:1902531 218 0.022
response to ethanol GO:0045471 162 0.022
neuron projection morphogenesis GO:0048812 122 0.022
purine ribonucleotide metabolic process GO:0009150 227 0.021
circulatory system process GO:0003013 183 0.021
Human
response to decreased oxygen levels GO:0036293 237 0.021
chemical homeostasis GO:0048878 292 0.021
cellular component morphogenesis GO:0032989 155 0.021
ribonucleoside triphosphate metabolic process GO:0009199 141 0.021
intracellular transport GO:0046907 185 0.021
gland development GO:0048732 155 0.021
purine ribonucleoside metabolic process GO:0046128 168 0.021
negative regulation of cell communication GO:0010648 158 0.021
purine nucleotide metabolic process GO:0006163 229 0.021
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.020
cellular component movement GO:0006928 248 0.020
regulation of apoptotic process GO:0042981 335 0.020
lipid metabolic process GO:0006629 283 0.020
protein complex biogenesis GO:0070271 263 0.020
positive regulation of cell development GO:0010720 176 0.020
regulation of protein metabolic process GO:0051246 289 0.020
negative regulation of multicellular organismal process GO:0051241 203 0.020
heterocycle catabolic process GO:0046700 167 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.020
positive regulation of cell communication GO:0010647 271 0.020
reproductive process GO:0022414 372 0.020
regulation of hydrolase activity GO:0051336 143 0.020
organic cyclic compound catabolic process GO:1901361 175 0.020
response to ketone GO:1901654 182 0.019
response to monosaccharide GO:0034284 159 0.019
cation transmembrane transport GO:0098655 263 0.019
response to glucose GO:0009749 136 0.019
protein phosphorylation GO:0006468 345 0.019
regulation of anatomical structure size GO:0090066 135 0.019
cellular nitrogen compound catabolic process GO:0044270 163 0.019
protein oligomerization GO:0051259 191 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
cellular chemical homeostasis GO:0055082 247 0.019
monovalent inorganic cation transport GO:0015672 172 0.019
single organism intracellular transport GO:1902582 166 0.019
glycosyl compound catabolic process GO:1901658 126 0.019
regulation of cellular catabolic process GO:0031329 101 0.019
positive regulation of cellular component organization GO:0051130 200 0.019
positive regulation of phosphorus metabolic process GO:0010562 262 0.019
secretion by cell GO:0032940 248 0.019
cofactor metabolic process GO:0051186 95 0.019
heart process GO:0003015 57 0.019
Human
carbohydrate derivative catabolic process GO:1901136 147 0.019
actin filament based process GO:0030029 86 0.018
synaptic transmission GO:0007268 235 0.018
macromolecular complex assembly GO:0065003 273 0.018
single organism organelle organization GO:1902589 180 0.018
Human
cellular response to stress GO:0033554 269 0.018
ventricular cardiac muscle cell action potential GO:0086005 2 0.018
Human
glycosyl compound metabolic process GO:1901657 182 0.018
aromatic compound catabolic process GO:0019439 168 0.018
positive regulation of transcription dna templated GO:0045893 197 0.018
negative regulation of signaling GO:0023057 157 0.018
regulation of anatomical structure morphogenesis GO:0022603 141 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.018
regulation of secretion GO:0051046 224 0.018
nucleoside triphosphate metabolic process GO:0009141 144 0.018
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
ras protein signal transduction GO:0007265 29 0.018
macromolecular complex subunit organization GO:0043933 339 0.018
Human
small gtpase mediated signal transduction GO:0007264 36 0.018
response to carbohydrate GO:0009743 183 0.018
positive regulation of transport GO:0051050 245 0.018
metal ion homeostasis GO:0055065 186 0.018
regulation of blood circulation GO:1903522 110 0.018
cellular ion homeostasis GO:0006873 184 0.017
purine nucleoside triphosphate catabolic process GO:0009146 122 0.017
cell morphogenesis involved in differentiation GO:0000904 119 0.017
neurological system process GO:0050877 219 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
regulation of hormone levels GO:0010817 187 0.017
regulation of secretion by cell GO:1903530 208 0.017
divalent inorganic cation homeostasis GO:0072507 165 0.017
single organism reproductive process GO:0044702 297 0.017
positive regulation of signaling GO:0023056 270 0.017
dna metabolic process GO:0006259 96 0.017
purine ribonucleotide catabolic process GO:0009154 136 0.017
axon development GO:0061564 96 0.017
circulatory system development GO:0072359 134 0.017
Human
aging GO:0007568 241 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.017
purine nucleoside triphosphate metabolic process GO:0009144 141 0.017
response to vitamin GO:0033273 131 0.017
regulation of cell projection organization GO:0031344 175 0.017
cellular response to organic cyclic compound GO:0071407 202 0.017
inorganic ion transmembrane transport GO:0098660 229 0.016
negative regulation of cell proliferation GO:0008285 119 0.016
regulation of phosphorylation GO:0042325 248 0.016
purine containing compound catabolic process GO:0072523 138 0.016
purine ribonucleoside catabolic process GO:0046130 124 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.016
cellular metal ion homeostasis GO:0006875 172 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
response to insulin GO:0032868 133 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
positive regulation of rna metabolic process GO:0051254 203 0.016
negative regulation of phosphate metabolic process GO:0045936 80 0.016
response to reactive oxygen species GO:0000302 120 0.016
heart contraction GO:0060047 57 0.016
Human
ribonucleoside catabolic process GO:0042454 126 0.016
organic acid biosynthetic process GO:0016053 83 0.016
axis specification GO:0009798 4 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
action potential GO:0001508 54 0.016
cellular divalent inorganic cation homeostasis GO:0072503 162 0.016
regulation of purine nucleotide metabolic process GO:1900542 115 0.016
regulation of neuron projection development GO:0010975 161 0.016
positive regulation of nervous system development GO:0051962 178 0.016
regulation of metal ion transport GO:0010959 118 0.016
wound healing GO:0042060 122 0.015
regulation of homeostatic process GO:0032844 101 0.015
negative regulation of molecular function GO:0044092 133 0.015
gastrulation GO:0007369 2 0.015
organophosphate biosynthetic process GO:0090407 143 0.015
organ morphogenesis GO:0009887 75 0.015
Human
response to hexose GO:0009746 144 0.015
cellular lipid metabolic process GO:0044255 208 0.015
actin cytoskeleton organization GO:0030036 73 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
positive regulation of cell projection organization GO:0031346 111 0.015
negative regulation of cell death GO:0060548 229 0.015
multicellular organismal signaling GO:0035637 44 0.015
monocarboxylic acid metabolic process GO:0032787 152 0.015
negative regulation of rna biosynthetic process GO:1902679 118 0.015
anion transport GO:0006820 178 0.015
regulation of protein modification process GO:0031399 194 0.015
dephosphorylation GO:0016311 98 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
nucleoside phosphate catabolic process GO:1901292 140 0.015
sex differentiation GO:0007548 113 0.014
mesoderm development GO:0007498 2 0.014
regulation of transmembrane transport GO:0034762 122 0.014
cellular macromolecule localization GO:0070727 122 0.014
divalent metal ion transport GO:0070838 132 0.014
regulation of response to external stimulus GO:0032101 106 0.014
protein transport GO:0015031 132 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
nucleotide catabolic process GO:0009166 139 0.014
negative regulation of signal transduction GO:0009968 83 0.014
regulation of neuron differentiation GO:0045664 208 0.014
metal ion transport GO:0030001 289 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
negative regulation of rna metabolic process GO:0051253 123 0.014
ribonucleoside triphosphate catabolic process GO:0009203 122 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
developmental process involved in reproduction GO:0003006 159 0.014
multi multicellular organism process GO:0044706 138 0.014
apoptotic process GO:0006915 381 0.014
signal transduction by phosphorylation GO:0023014 144 0.014
cellular response to nitrogen compound GO:1901699 210 0.014
defense response GO:0006952 194 0.014
salivary gland development GO:0007431 3 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
head development GO:0060322 247 0.014
Rat
multi organism reproductive process GO:0044703 262 0.014
positive regulation of catabolic process GO:0009896 78 0.013
chromosome segregation GO:0007059 2 0.013
protein localization GO:0008104 191 0.013
negative regulation of phosphorus metabolic process GO:0010563 80 0.013
purine nucleotide catabolic process GO:0006195 136 0.013
cardiac conduction GO:0061337 2 0.013
developmental growth GO:0048589 100 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
regulation of mapk cascade GO:0043408 116 0.013
muscle structure development GO:0061061 87 0.013
Human
purine nucleoside catabolic process GO:0006152 124 0.013
macromolecule localization GO:0033036 252 0.013
regulation of response to stress GO:0080134 126 0.013
carbohydrate metabolic process GO:0005975 130 0.013
cellular response to lipid GO:0071396 201 0.013
regeneration GO:0031099 163 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
growth GO:0040007 165 0.013
regulation of muscle system process GO:0090257 79 0.013
Human
carboxylic acid biosynthetic process GO:0046394 83 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
divalent inorganic cation transport GO:0072511 134 0.013
reproduction GO:0000003 245 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
multicellular organism reproduction GO:0032504 233 0.013
brain development GO:0007420 247 0.013
Rat
positive regulation of neurogenesis GO:0050769 165 0.013
calcium ion homeostasis GO:0055074 162 0.013
negative regulation of cardiac muscle tissue development GO:0055026 3 0.013
anterior posterior pattern specification GO:0009952 1 0.013
regulation of protein phosphorylation GO:0001932 183 0.012
hepaticobiliary system development GO:0061008 90 0.012
positive regulation of phosphate metabolic process GO:0045937 262 0.012
positive regulation of mapk cascade GO:0043410 92 0.012
response to biotic stimulus GO:0009607 226 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
response to bacterium GO:0009617 200 0.012
cardiac muscle cell contraction GO:0086003 10 0.012
regulation of neuron death GO:1901214 115 0.012
camera type eye development GO:0043010 48 0.012
regulation of ion transmembrane transport GO:0034765 121 0.012
cell type specific apoptotic process GO:0097285 134 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
locomotion GO:0040011 237 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
axonogenesis GO:0007409 71 0.012
cellular response to oxidative stress GO:0034599 76 0.012
response to estradiol GO:0032355 164 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
regulation of synaptic transmission GO:0050804 141 0.012
regulation of kinase activity GO:0043549 117 0.012
signal release GO:0023061 145 0.012
regulation of body fluid levels GO:0050878 90 0.012
organophosphate catabolic process GO:0046434 148 0.012
tube development GO:0035295 89 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
regulation of gtpase activity GO:0043087 57 0.011
positive regulation of secretion by cell GO:1903532 128 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
response to cytokine GO:0034097 215 0.011
inorganic cation transmembrane transport GO:0098662 202 0.011
chemosensory behavior GO:0007635 2 0.011
cellular response to organonitrogen compound GO:0071417 197 0.011
negative regulation of transport GO:0051051 136 0.011
cell migration GO:0016477 197 0.011
embryonic pattern specification GO:0009880 1 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
gonad development GO:0008406 104 0.011
eye morphogenesis GO:0048592 4 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
striated muscle tissue development GO:0014706 58 0.011
Human
organic anion transport GO:0015711 132 0.011
appendage morphogenesis GO:0035107 4 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
liver development GO:0001889 90 0.011
positive regulation of blood circulation GO:1903524 65 0.011
cell motility GO:0048870 202 0.011
amide transport GO:0042886 105 0.011
positive regulation of signal transduction GO:0009967 175 0.011
regulation of canonical wnt signaling pathway GO:0060828 4 0.011
cardiovascular system development GO:0072358 134 0.011
Human
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
negative regulation of organ growth GO:0046621 3 0.011
response to growth factor GO:0070848 189 0.011
localization of cell GO:0051674 202 0.011
gliogenesis GO:0042063 93 0.011
regulation of tube size GO:0035150 89 0.011
enzyme linked receptor protein signaling pathway GO:0007167 116 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.010
cellular response to fluid shear stress GO:0071498 4 0.010
reproductive structure development GO:0048608 128 0.010
response to toxic substance GO:0009636 133 0.010
positive regulation of hydrolase activity GO:0051345 86 0.010
actin filament based movement GO:0030048 16 0.010
negative regulation of catalytic activity GO:0043086 103 0.010
muscle organ development GO:0007517 50 0.010
Human
glomerular epithelial cell differentiation GO:0072311 2 0.010
cellular response to external stimulus GO:0071496 118 0.010
male gamete generation GO:0048232 99 0.010
nucleoside phosphate biosynthetic process GO:1901293 102 0.010
anatomical structure formation involved in morphogenesis GO:0048646 83 0.010
sexual reproduction GO:0019953 148 0.010
response to mineralocorticoid GO:0051385 49 0.010
ribonucleotide catabolic process GO:0009261 136 0.010
negative regulation of heart growth GO:0061117 3 0.010
positive regulation of protein modification process GO:0031401 142 0.010
mapk cascade GO:0000165 140 0.010
lipid storage GO:0019915 1 0.010
regulation of cellular component biogenesis GO:0044087 86 0.010
proteolysis GO:0006508 175 0.010
vesicle mediated transport GO:0016192 181 0.010

Pkp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.024
disease of anatomical entity DOID:7 0 0.024
Human
musculoskeletal system disease DOID:17 0 0.023
Human
muscular disease DOID:0080000 0 0.023
Human
heart disease DOID:114 0 0.017
Human
cardiovascular system disease DOID:1287 0 0.017
Human
intrinsic cardiomyopathy DOID:0060036 0 0.013
Human
cardiomyopathy DOID:0050700 0 0.013
Human
myopathy DOID:423 0 0.013
Human
muscle tissue disease DOID:66 0 0.013
Human
sensory system disease DOID:0050155 0 0.012
disease of metabolism DOID:0014667 0 0.011