Rattus norvegicus

10 known processes

Grik4

glutamate receptor, ionotropic, kainate 4

(Aliases: KA1)

Grik4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic anion transport GO:0015711 132 0.148
protein complex assembly GO:0006461 263 0.140
macromolecular complex subunit organization GO:0043933 339 0.135
protein oligomerization GO:0051259 191 0.131
cellular response to endogenous stimulus GO:0071495 377 0.124
central nervous system development GO:0007417 311 0.119
cellular component assembly GO:0022607 360 0.117
multicellular organism reproduction GO:0032504 233 0.117
programmed cell death GO:0012501 392 0.111
Rat
neurological system process GO:0050877 219 0.107
organelle organization GO:0006996 266 0.105
cellular response to hormone stimulus GO:0032870 247 0.104
cell cell signaling GO:0007267 335 0.098
Rat
macromolecular complex assembly GO:0065003 273 0.098
g protein coupled receptor signaling pathway GO:0007186 242 0.097
regulation of signal transduction GO:0009966 318 0.097
regulation of cell differentiation GO:0045595 320 0.088
regulation of multicellular organismal development GO:2000026 376 0.087
carboxylic acid transport GO:0046942 115 0.084
single organism organelle organization GO:1902589 180 0.083
single organism behavior GO:0044708 130 0.079
nitrogen compound transport GO:0071705 229 0.076
regulation of nucleic acid templated transcription GO:1903506 380 0.075
synaptic transmission GO:0007268 235 0.073
Rat
regulation of neurogenesis GO:0050767 247 0.071
rna metabolic process GO:0016070 406 0.071
cellular component biogenesis GO:0044085 368 0.070
cation transmembrane transport GO:0098655 263 0.070
Rat
negative regulation of signaling GO:0023057 157 0.068
Rat
reproduction GO:0000003 245 0.066
regulation of anatomical structure morphogenesis GO:0022603 141 0.063
head development GO:0060322 247 0.063
cellular response to lipid GO:0071396 201 0.062
transcription dna templated GO:0006351 377 0.062
negative regulation of nervous system development GO:0051961 79 0.061
regulation of membrane potential GO:0042391 110 0.060
regulation of phosphate metabolic process GO:0019220 349 0.058
organic acid metabolic process GO:0006082 292 0.058
negative regulation of cell development GO:0010721 82 0.056
positive regulation of cell communication GO:0010647 271 0.056
Rat
regulation of neurotransmitter levels GO:0001505 42 0.054
rna biosynthetic process GO:0032774 380 0.054
response to growth factor GO:0070848 189 0.053
reproductive process GO:0022414 372 0.053
cellular response to acid chemical GO:0071229 75 0.053
brain development GO:0007420 247 0.052
secretion GO:0046903 307 0.052
negative regulation of multicellular organismal process GO:0051241 203 0.051
mapk cascade GO:0000165 140 0.051
negative regulation of cellular metabolic process GO:0031324 281 0.050
negative regulation of apoptotic process GO:0043066 181 0.050
dicarboxylic acid transport GO:0006835 34 0.050
single organism reproductive process GO:0044702 297 0.049
organophosphate metabolic process GO:0019637 370 0.047
negative regulation of cell communication GO:0010648 158 0.047
Rat
monovalent inorganic cation transport GO:0015672 172 0.046
cellular response to oxygen containing compound GO:1901701 386 0.046
Rat
oxoacid metabolic process GO:0043436 290 0.046
nucleoside phosphate metabolic process GO:0006753 283 0.046
protein autophosphorylation GO:0046777 66 0.046
nucleotide metabolic process GO:0009117 279 0.043
cellular response to nitrogen compound GO:1901699 210 0.043
cellular response to growth factor stimulus GO:0071363 162 0.043
cation transport GO:0006812 382 0.043
Rat
learning or memory GO:0007611 90 0.043
protein phosphorylation GO:0006468 345 0.042
multi organism reproductive process GO:0044703 262 0.042
ion transmembrane transport GO:0034220 365 0.042
Rat
regulation of phosphorylation GO:0042325 248 0.041
regulation of cellular component organization GO:0051128 368 0.041
cell projection organization GO:0030030 302 0.041
regulation of transcription dna templated GO:0006355 374 0.040
cellular response to peptide GO:1901653 133 0.040
nucleic acid templated transcription GO:0097659 379 0.039
cell type specific apoptotic process GO:0097285 134 0.039
Rat
action potential GO:0001508 54 0.038
negative regulation of transport GO:0051051 136 0.038
regulation of neuron differentiation GO:0045664 208 0.038
amino acid transport GO:0006865 70 0.038
regulation of cell development GO:0060284 263 0.038
regulation of programmed cell death GO:0043067 341 0.037
Rat
cellular calcium ion homeostasis GO:0006874 160 0.037
calcium ion homeostasis GO:0055074 162 0.037
regulation of secretion by cell GO:1903530 208 0.037
transmembrane transport GO:0055085 412 0.037
Rat
positive regulation of protein phosphorylation GO:0001934 135 0.037
protein complex subunit organization GO:0071822 302 0.036
homeostatic process GO:0042592 331 0.036
Rat
negative regulation of macromolecule metabolic process GO:0010605 260 0.036
regulation of nervous system development GO:0051960 264 0.036
regulation of rna biosynthetic process GO:2001141 381 0.035
negative regulation of metabolic process GO:0009892 331 0.035
multicellular organismal signaling GO:0035637 44 0.035
negative regulation of neurogenesis GO:0050768 78 0.035
positive regulation of signaling GO:0023056 270 0.035
Rat
neuron differentiation GO:0030182 368 0.034
negative regulation of neuron differentiation GO:0045665 62 0.034
protein localization GO:0008104 191 0.034
Rat
regulation of protein metabolic process GO:0051246 289 0.034
negative regulation of programmed cell death GO:0043069 183 0.033
negative regulation of cell differentiation GO:0045596 99 0.033
neurotransmitter transport GO:0006836 42 0.033
choline transport GO:0015871 4 0.033
purine containing compound metabolic process GO:0072521 253 0.033
positive regulation of phosphorus metabolic process GO:0010562 262 0.033
regulation of mapk cascade GO:0043408 116 0.032
transmission of nerve impulse GO:0019226 42 0.032
response to peptide GO:1901652 292 0.032
regulation of phosphorus metabolic process GO:0051174 349 0.031
sexual reproduction GO:0019953 148 0.031
metal ion transport GO:0030001 289 0.030
positive regulation of protein metabolic process GO:0051247 178 0.030
regulation of neuron projection development GO:0010975 161 0.030
positive regulation of rna biosynthetic process GO:1902680 197 0.030
developmental process involved in reproduction GO:0003006 159 0.030
regulation of cellular protein metabolic process GO:0032268 267 0.030
neuron development GO:0048666 286 0.029
cellular amine metabolic process GO:0044106 38 0.029
regulation of rna metabolic process GO:0051252 391 0.029
response to inorganic substance GO:0010035 377 0.029
catabolic process GO:0009056 351 0.029
cellular catabolic process GO:0044248 295 0.029
carbohydrate derivative metabolic process GO:1901135 346 0.029
cellular chemical homeostasis GO:0055082 247 0.029
Rat
cellular response to organonitrogen compound GO:0071417 197 0.028
response to glucocorticoid GO:0051384 223 0.028
inorganic ion transmembrane transport GO:0098660 229 0.028
response to decreased oxygen levels GO:0036293 237 0.028
positive regulation of neurogenesis GO:0050769 165 0.028
organic substance catabolic process GO:1901575 316 0.028
anion transport GO:0006820 178 0.028
regulation of amino acid transport GO:0051955 25 0.028
positive regulation of phosphorylation GO:0042327 177 0.028
response to oxygen levels GO:0070482 265 0.027
positive regulation of nervous system development GO:0051962 178 0.027
positive regulation of cell death GO:0010942 184 0.027
Rat
organophosphate catabolic process GO:0046434 148 0.027
negative regulation of cellular biosynthetic process GO:0031327 161 0.027
neurotransmitter secretion GO:0007269 33 0.026
regulation of cell projection organization GO:0031344 175 0.026
regulation of cell proliferation GO:0042127 359 0.026
protein complex biogenesis GO:0070271 263 0.026
ribonucleotide metabolic process GO:0009259 231 0.026
regulation of organic acid transport GO:0032890 35 0.025
regulation of molecular function GO:0065009 398 0.025
multicellular organismal reproductive process GO:0048609 233 0.025
amine metabolic process GO:0009308 38 0.025
cognition GO:0050890 92 0.025
organic acid transport GO:0015849 116 0.024
regulation of canonical wnt signaling pathway GO:0060828 4 0.024
regulation of protein phosphorylation GO:0001932 183 0.024
cellular amino acid metabolic process GO:0006520 107 0.024
positive regulation of cell development GO:0010720 176 0.024
negative regulation of biosynthetic process GO:0009890 168 0.024
proteolysis GO:0006508 175 0.024
gamete generation GO:0007276 124 0.024
transcription from rna polymerase ii promoter GO:0006366 252 0.023
negative regulation of cell death GO:0060548 229 0.023
acid secretion GO:0046717 48 0.023
behavior GO:0007610 205 0.023
activation of protein kinase activity GO:0032147 47 0.023
positive regulation of cellular protein metabolic process GO:0032270 167 0.023
positive regulation of gene expression GO:0010628 244 0.023
aging GO:0007568 241 0.023
learning GO:0007612 33 0.023
purine ribonucleotide metabolic process GO:0009150 227 0.023
chemical homeostasis GO:0048878 292 0.022
Rat
actin filament based process GO:0030029 86 0.022
response to hypoxia GO:0001666 231 0.022
signal transduction by phosphorylation GO:0023014 144 0.022
gliogenesis GO:0042063 93 0.022
negative regulation of signal transduction GO:0009968 83 0.022
cytoskeleton organization GO:0007010 111 0.022
regulation of anion transport GO:0044070 43 0.022
ribonucleotide catabolic process GO:0009261 136 0.022
adult locomotory behavior GO:0008344 4 0.021
apoptotic process GO:0006915 381 0.021
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.021
negative regulation of cellular component organization GO:0051129 83 0.021
regulation of protein kinase activity GO:0045859 105 0.021
cellular nitrogen compound catabolic process GO:0044270 163 0.021
response to extracellular stimulus GO:0009991 380 0.021
cellular divalent inorganic cation homeostasis GO:0072503 162 0.021
positive regulation of developmental process GO:0051094 283 0.021
single organism membrane organization GO:0044802 74 0.021
Rat
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
negative regulation of transcription dna templated GO:0045892 116 0.020
growth GO:0040007 165 0.020
cell cycle GO:0007049 101 0.020
purine nucleoside metabolic process GO:0042278 169 0.020
positive regulation of protein kinase activity GO:0045860 73 0.020
negative regulation of response to stimulus GO:0048585 155 0.020
positive regulation of nucleotide metabolic process GO:0045981 91 0.019
phototransduction visible light GO:0007603 2 0.019
muscle system process GO:0003012 115 0.019
memory GO:0007613 54 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
regulation of hydrolase activity GO:0051336 143 0.019
neural crest cell differentiation GO:0014033 2 0.019
protein heterooligomerization GO:0051291 89 0.019
nucleobase containing compound catabolic process GO:0034655 152 0.019
neuron projection development GO:0031175 273 0.018
anatomical structure morphogenesis GO:0009653 298 0.018
regulation of cellular localization GO:0060341 263 0.018
anion transmembrane transport GO:0098656 77 0.018
regulation of ion transport GO:0043269 245 0.018
Rat
synaptic growth at neuromuscular junction GO:0051124 1 0.018
positive regulation of signal transduction GO:0009967 175 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.018
endocytosis GO:0006897 84 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
cytosolic calcium ion homeostasis GO:0051480 140 0.018
positive regulation of cell proliferation GO:0008284 249 0.017
potassium ion transport GO:0006813 97 0.017
hair cycle process GO:0022405 2 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
secretion by cell GO:0032940 248 0.017
actin cytoskeleton organization GO:0030036 73 0.017
glycosyl compound metabolic process GO:1901657 182 0.017
regulation of intracellular signal transduction GO:1902531 218 0.017
amide transport GO:0042886 105 0.017
vesicle mediated transport GO:0016192 181 0.017
aromatic compound catabolic process GO:0019439 168 0.017
organ morphogenesis GO:0009887 75 0.017
response to acid chemical GO:0001101 222 0.016
eye morphogenesis GO:0048592 4 0.016
gtp catabolic process GO:0006184 71 0.016
positive regulation of rna metabolic process GO:0051254 203 0.016
glial cell differentiation GO:0010001 65 0.016
gonad development GO:0008406 104 0.016
divalent inorganic cation homeostasis GO:0072507 165 0.016
positive regulation of apoptotic process GO:0043065 154 0.016
Rat
organic hydroxy compound metabolic process GO:1901615 115 0.016
response to corticosteroid GO:0031960 235 0.016
cellular cation homeostasis GO:0030003 180 0.016
intracellular signal transduction GO:0035556 314 0.016
positive regulation of kinase activity GO:0033674 77 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
cell matrix adhesion GO:0007160 19 0.016
detection of visible light GO:0009584 3 0.016
regulation of apoptotic process GO:0042981 335 0.016
Rat
regulation of kinase activity GO:0043549 117 0.015
positive regulation of transcription dna templated GO:0045893 197 0.015
neuronal action potential GO:0019228 35 0.015
negative regulation of developmental process GO:0051093 125 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
regulation of g protein coupled receptor protein signaling pathway GO:0008277 28 0.015
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.015
single organism catabolic process GO:0044712 283 0.015
nucleoside phosphate catabolic process GO:1901292 140 0.015
positive regulation of neuron differentiation GO:0045666 126 0.015
response to estradiol GO:0032355 164 0.015
purine containing compound catabolic process GO:0072523 138 0.015
positive regulation of mapk cascade GO:0043410 92 0.015
positive regulation of biosynthetic process GO:0009891 319 0.015
multicellular organismal homeostasis GO:0048871 49 0.015
regulation of vesicle mediated transport GO:0060627 81 0.015
cellular response to organic cyclic compound GO:0071407 202 0.015
regulation of dendrite development GO:0050773 59 0.015
negative regulation of phosphate metabolic process GO:0045936 80 0.014
regulation of protein modification process GO:0031399 194 0.014
carbohydrate derivative catabolic process GO:1901136 147 0.014
negative regulation of phosphorus metabolic process GO:0010563 80 0.014
cellular homeostasis GO:0019725 252 0.014
Rat
cellular response to stress GO:0033554 269 0.014
positive regulation of molecular function GO:0044093 230 0.014
sex differentiation GO:0007548 113 0.014
regulation of synaptic transmission GO:0050804 141 0.014
Rat
signal release GO:0023061 145 0.014
carboxylic acid metabolic process GO:0019752 289 0.014
negative regulation of gene expression GO:0010629 199 0.014
nucleotide catabolic process GO:0009166 139 0.014
regulation of neural precursor cell proliferation GO:2000177 16 0.014
inner ear receptor cell differentiation GO:0060113 2 0.014
regulation of cellular ketone metabolic process GO:0010565 27 0.014
mechanoreceptor differentiation GO:0042490 2 0.013
protein modification by small protein conjugation or removal GO:0070647 35 0.013
neural crest cell development GO:0014032 2 0.013
positive regulation of protein modification process GO:0031401 142 0.013
neural crest cell migration GO:0001755 1 0.013
negative regulation of neuron apoptotic process GO:0043524 45 0.013
macromolecule localization GO:0033036 252 0.013
Rat
ion homeostasis GO:0050801 212 0.013
nucleoside metabolic process GO:0009116 179 0.013
hair follicle development GO:0001942 2 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
negative regulation of neuron projection development GO:0010977 46 0.013
sensory perception GO:0007600 101 0.013
heart morphogenesis GO:0003007 3 0.013
cellular ketone metabolic process GO:0042180 51 0.013
cell cell signaling involved in cell fate commitment GO:0045168 2 0.013
ossification GO:0001503 70 0.013
negative regulation of nucleic acid templated transcription GO:1903507 117 0.012
reproductive system development GO:0061458 128 0.012
positive regulation of ion transport GO:0043270 94 0.012
guanosine containing compound metabolic process GO:1901068 74 0.012
neurotransmitter uptake GO:0001504 3 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
alcohol metabolic process GO:0006066 77 0.012
hepaticobiliary system development GO:0061008 90 0.012
spermatogenesis GO:0007283 99 0.012
amino acid transmembrane transport GO:0003333 33 0.012
gastrulation GO:0007369 2 0.012
protein homooligomerization GO:0051260 91 0.012
axis specification GO:0009798 4 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
muscle contraction GO:0006936 88 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
development of primary sexual characteristics GO:0045137 107 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.011
fertilization GO:0009566 3 0.011
response to cgmp GO:0070305 3 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
regulation of cellular component biogenesis GO:0044087 86 0.011
positive regulation of programmed cell death GO:0043068 157 0.011
Rat
positive regulation of secretion GO:0051047 140 0.011
receptor mediated endocytosis GO:0006898 42 0.011
positive regulation of transferase activity GO:0051347 81 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
response to hexose GO:0009746 144 0.011
Rat
ribonucleoside metabolic process GO:0009119 174 0.011
axon ensheathment GO:0008366 40 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
male gamete generation GO:0048232 99 0.011
tissue development GO:0009888 252 0.011
negative regulation of secretion by cell GO:1903531 72 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
multicellular organism growth GO:0035264 1 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
ras protein signal transduction GO:0007265 29 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
regulation of anatomical structure size GO:0090066 135 0.011
cellular component morphogenesis GO:0032989 155 0.011
l glutamate import GO:0051938 2 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
female sex differentiation GO:0046660 59 0.010
peptide transport GO:0015833 97 0.010
hormone transport GO:0009914 121 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.010
male gonad development GO:0008584 59 0.010
positive regulation of amino acid transport GO:0051957 13 0.010
establishment of planar polarity GO:0001736 1 0.010
purine nucleotide metabolic process GO:0006163 229 0.010
organonitrogen compound catabolic process GO:1901565 179 0.010
ensheathment of neurons GO:0007272 40 0.010
negative regulation of secretion GO:0051048 82 0.010
divalent inorganic cation transport GO:0072511 134 0.010
purine nucleoside triphosphate metabolic process GO:0009144 141 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.010

Grik4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.085
nervous system disease DOID:863 0 0.085
sensory system disease DOID:0050155 0 0.037
retinal disease DOID:5679 0 0.022
eye and adnexa disease DOID:1492 0 0.022
eye disease DOID:5614 0 0.022
retinal degeneration DOID:8466 0 0.018
central nervous system disease DOID:331 0 0.015
disease of metabolism DOID:0014667 0 0.013
inherited metabolic disorder DOID:655 0 0.013
disease of cellular proliferation DOID:14566 0 0.010