Rattus norvegicus

0 known processes

Evc2

Ellis van Creveld syndrome 2 homolog (human)

Evc2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.047
cellular response to oxygen containing compound GO:1901701 386 0.047
rna metabolic process GO:0016070 406 0.045
regulation of phosphorus metabolic process GO:0051174 349 0.041
nucleic acid templated transcription GO:0097659 379 0.039
transcription dna templated GO:0006351 377 0.039
cellular response to endogenous stimulus GO:0071495 377 0.038
response to extracellular stimulus GO:0009991 380 0.038
rna biosynthetic process GO:0032774 380 0.037
response to nutrient levels GO:0031667 370 0.037
regulation of cell proliferation GO:0042127 359 0.037
reproductive process GO:0022414 372 0.037
regulation of rna biosynthetic process GO:2001141 381 0.036
response to inorganic substance GO:0010035 377 0.036
intracellular signal transduction GO:0035556 314 0.036
regulation of programmed cell death GO:0043067 341 0.036
regulation of rna metabolic process GO:0051252 391 0.035
positive regulation of multicellular organismal process GO:0051240 387 0.035
cellular response to stress GO:0033554 269 0.035
cellular amino acid metabolic process GO:0006520 107 0.035
cation transport GO:0006812 382 0.034
response to oxygen levels GO:0070482 265 0.034
regulation of cellular component organization GO:0051128 368 0.034
homeostatic process GO:0042592 331 0.033
protein phosphorylation GO:0006468 345 0.033
response to peptide GO:1901652 292 0.033
response to estrogen GO:0043627 232 0.033
regulation of multicellular organismal development GO:2000026 376 0.033
regulation of phosphate metabolic process GO:0019220 349 0.033
negative regulation of metabolic process GO:0009892 331 0.033
regulation of molecular function GO:0065009 398 0.032
regulation of transcription dna templated GO:0006355 374 0.032
carboxylic acid metabolic process GO:0019752 289 0.032
single organism reproductive process GO:0044702 297 0.031
organelle organization GO:0006996 266 0.031
regulation of nucleic acid templated transcription GO:1903506 380 0.031
organic acid metabolic process GO:0006082 292 0.031
regulation of protein metabolic process GO:0051246 289 0.031
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.031
positive regulation of biosynthetic process GO:0009891 319 0.031
oxoacid metabolic process GO:0043436 290 0.031
regulation of cell differentiation GO:0045595 320 0.031
positive regulation of cellular biosynthetic process GO:0031328 295 0.031
programmed cell death GO:0012501 392 0.030
neuron differentiation GO:0030182 368 0.030
regulation of cellular amino acid metabolic process GO:0006521 2 0.030
cellular amine metabolic process GO:0044106 38 0.029
chemical homeostasis GO:0048878 292 0.029
regulation of apoptotic process GO:0042981 335 0.029
regulation of cellular amine metabolic process GO:0033238 8 0.029
secretion GO:0046903 307 0.029
organophosphate metabolic process GO:0019637 370 0.029
central nervous system development GO:0007417 311 0.029
cellular chemical homeostasis GO:0055082 247 0.029
amine metabolic process GO:0009308 38 0.029
cell cell signaling GO:0007267 335 0.029
regulation of cellular protein metabolic process GO:0032268 267 0.029
negative regulation of macromolecule metabolic process GO:0010605 260 0.028
multi organism reproductive process GO:0044703 262 0.028
cellular response to nitrogen compound GO:1901699 210 0.028
regulation of catalytic activity GO:0050790 304 0.028
carbohydrate derivative metabolic process GO:1901135 346 0.028
positive regulation of phosphate metabolic process GO:0045937 262 0.028
apoptotic process GO:0006915 381 0.028
transmembrane transport GO:0055085 412 0.028
response to hypoxia GO:0001666 231 0.028
cellular ketone metabolic process GO:0042180 51 0.028
ion homeostasis GO:0050801 212 0.028
positive regulation of cell proliferation GO:0008284 249 0.027
regulation of cellular ketone metabolic process GO:0010565 27 0.027
regulation of phosphorylation GO:0042325 248 0.027
cellular component biogenesis GO:0044085 368 0.027
positive regulation of response to stimulus GO:0048584 285 0.027
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
anatomical structure morphogenesis GO:0009653 298 0.027
metal ion transport GO:0030001 289 0.027
single organism biosynthetic process GO:0044711 342 0.026
response to peptide hormone GO:0043434 278 0.026
response to nutrient GO:0007584 248 0.026
positive regulation of signaling GO:0023056 270 0.026
positive regulation of phosphorus metabolic process GO:0010562 262 0.025
reproduction GO:0000003 245 0.025
nucleotide metabolic process GO:0009117 279 0.025
multicellular organism reproduction GO:0032504 233 0.025
neurological system process GO:0050877 219 0.025
cellular response to hormone stimulus GO:0032870 247 0.025
positive regulation of gene expression GO:0010628 244 0.025
circulatory system process GO:0003013 183 0.025
purine containing compound metabolic process GO:0072521 253 0.025
head development GO:0060322 247 0.025
multicellular organismal reproductive process GO:0048609 233 0.025
response to decreased oxygen levels GO:0036293 237 0.025
cellular component assembly GO:0022607 360 0.025
metal ion homeostasis GO:0055065 186 0.025
positive regulation of transport GO:0051050 245 0.025
macromolecular complex subunit organization GO:0043933 339 0.024
regulation of system process GO:0044057 208 0.024
ion transmembrane transport GO:0034220 365 0.024
negative regulation of cellular metabolic process GO:0031324 281 0.024
catabolic process GO:0009056 351 0.024
cell projection organization GO:0030030 302 0.024
regulation of cell development GO:0060284 263 0.024
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.024
response to acid chemical GO:0001101 222 0.024
regulation of signal transduction GO:0009966 318 0.024
cellular response to organonitrogen compound GO:0071417 197 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.024
response to corticosteroid GO:0031960 235 0.023
cellular component movement GO:0006928 248 0.023
positive regulation of cell communication GO:0010647 271 0.023
cation homeostasis GO:0055080 195 0.023
brain development GO:0007420 247 0.023
neuron projection development GO:0031175 273 0.023
tissue development GO:0009888 252 0.023
regulation of protein modification process GO:0031399 194 0.023
nucleoside phosphate metabolic process GO:0006753 283 0.023
g protein coupled receptor signaling pathway GO:0007186 242 0.023
cellular response to lipid GO:0071396 201 0.023
organic substance catabolic process GO:1901575 316 0.023
cellular catabolic process GO:0044248 295 0.023
protein complex subunit organization GO:0071822 302 0.023
regulation of nervous system development GO:0051960 264 0.023
cellular homeostasis GO:0019725 252 0.022
negative regulation of cell death GO:0060548 229 0.022
ribose phosphate metabolic process GO:0019693 235 0.022
positive regulation of molecular function GO:0044093 230 0.022
blood circulation GO:0008015 183 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.022
calcium ion homeostasis GO:0055074 162 0.022
regulation of cellular localization GO:0060341 263 0.022
cellular response to organic cyclic compound GO:0071407 202 0.022
purine ribonucleotide metabolic process GO:0009150 227 0.022
locomotion GO:0040011 237 0.022
secretion by cell GO:0032940 248 0.022
positive regulation of cell differentiation GO:0045597 217 0.022
single organism organelle organization GO:1902589 180 0.021
macromolecular complex assembly GO:0065003 273 0.021
cellular ion homeostasis GO:0006873 184 0.021
neuron development GO:0048666 286 0.021
response to wounding GO:0009611 254 0.021
purine nucleotide metabolic process GO:0006163 229 0.021
regulation of intracellular signal transduction GO:1902531 218 0.021
cellular cation homeostasis GO:0030003 180 0.021
cellular calcium ion homeostasis GO:0006874 160 0.021
regulation of ion transport GO:0043269 245 0.021
regulation of neurogenesis GO:0050767 247 0.021
response to metal ion GO:0010038 253 0.021
regulation of protein phosphorylation GO:0001932 183 0.021
protein complex biogenesis GO:0070271 263 0.021
muscle system process GO:0003012 115 0.021
regulation of secretion GO:0051046 224 0.020
ribonucleotide metabolic process GO:0009259 231 0.020
positive regulation of developmental process GO:0051094 283 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
positive regulation of protein metabolic process GO:0051247 178 0.020
response to growth factor GO:0070848 189 0.020
positive regulation of transcription dna templated GO:0045893 197 0.020
cellular metal ion homeostasis GO:0006875 172 0.020
negative regulation of multicellular organismal process GO:0051241 203 0.020
response to lipopolysaccharide GO:0032496 191 0.020
cellular response to growth factor stimulus GO:0071363 162 0.020
negative regulation of gene expression GO:0010629 199 0.020
divalent inorganic cation homeostasis GO:0072507 165 0.020
macromolecule localization GO:0033036 252 0.020
positive regulation of rna biosynthetic process GO:1902680 197 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.019
positive regulation of catalytic activity GO:0043085 184 0.019
aging GO:0007568 241 0.019
growth GO:0040007 165 0.019
response to biotic stimulus GO:0009607 226 0.019
response to cytokine GO:0034097 215 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
response to external biotic stimulus GO:0043207 221 0.019
divalent metal ion transport GO:0070838 132 0.019
response to other organism GO:0051707 220 0.019
cellular divalent inorganic cation homeostasis GO:0072503 162 0.019
cellular response to peptide GO:1901653 133 0.019
negative regulation of biosynthetic process GO:0009890 168 0.019
response to glucocorticoid GO:0051384 223 0.019
defense response GO:0006952 194 0.019
negative regulation of programmed cell death GO:0043069 183 0.018
gland development GO:0048732 155 0.018
single organism catabolic process GO:0044712 283 0.018
localization of cell GO:0051674 202 0.018
synaptic transmission GO:0007268 235 0.018
regulation of secretion by cell GO:1903530 208 0.018
developmental process involved in reproduction GO:0003006 159 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
response to bacterium GO:0009617 200 0.018
protein complex assembly GO:0006461 263 0.018
cell motility GO:0048870 202 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
organonitrogen compound biosynthetic process GO:1901566 167 0.018
reproductive system development GO:0061458 128 0.018
cell migration GO:0016477 197 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
cytosolic calcium ion homeostasis GO:0051480 140 0.017
positive regulation of cellular component organization GO:0051130 200 0.017
negative regulation of cellular biosynthetic process GO:0031327 161 0.017
nitrogen compound transport GO:0071705 229 0.017
positive regulation of nervous system development GO:0051962 178 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
positive regulation of cell death GO:0010942 184 0.017
response to carbohydrate GO:0009743 183 0.017
response to estradiol GO:0032355 164 0.017
positive regulation of secretion GO:0051047 140 0.017
regeneration GO:0031099 163 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.017
response to molecule of bacterial origin GO:0002237 194 0.016
calcium ion transport GO:0006816 131 0.016
positive regulation of cell development GO:0010720 176 0.016
axis specification GO:0009798 4 0.016
response to monosaccharide GO:0034284 159 0.016
response to vitamin GO:0033273 131 0.016
lipid metabolic process GO:0006629 283 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
sexual reproduction GO:0019953 148 0.016
reproductive structure development GO:0048608 128 0.016
positive regulation of signal transduction GO:0009967 175 0.015
proteolysis GO:0006508 175 0.015
regulation of hormone levels GO:0010817 187 0.015
inflammatory response GO:0006954 150 0.015
regulation of anatomical structure size GO:0090066 135 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.015
muscle contraction GO:0006936 88 0.015
regulation of cell projection organization GO:0031344 175 0.015
anterior posterior pattern specification GO:0009952 1 0.015
organophosphate biosynthetic process GO:0090407 143 0.015
response to oxidative stress GO:0006979 186 0.015
signal transduction by phosphorylation GO:0023014 144 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
intracellular transport GO:0046907 185 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.015
regulation of neuron differentiation GO:0045664 208 0.015
response to glucose GO:0009749 136 0.015
divalent inorganic cation transport GO:0072511 134 0.015
anion transport GO:0006820 178 0.015
cell growth GO:0016049 104 0.015
cellular component morphogenesis GO:0032989 155 0.015
inorganic cation transmembrane transport GO:0098662 202 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
multi multicellular organism process GO:0044706 138 0.015
immune system process GO:0002376 204 0.015
regulation of synaptic transmission GO:0050804 141 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
inorganic ion transmembrane transport GO:0098660 229 0.015
positive regulation of intracellular signal transduction GO:1902533 138 0.015
signal release GO:0023061 145 0.014
behavior GO:0007610 205 0.014
female pregnancy GO:0007565 122 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
gamete generation GO:0007276 124 0.014
response to ketone GO:1901654 182 0.014
limb morphogenesis GO:0035108 4 0.014
positive regulation of neurogenesis GO:0050769 165 0.014
ras protein signal transduction GO:0007265 29 0.014
cellular nitrogen compound catabolic process GO:0044270 163 0.014
carbohydrate metabolic process GO:0005975 130 0.014
positive regulation of ion transport GO:0043270 94 0.014
single organism carbohydrate metabolic process GO:0044723 118 0.014
mapk cascade GO:0000165 140 0.014
regulation of membrane potential GO:0042391 110 0.014
gastrulation GO:0007369 2 0.014
reactive oxygen species metabolic process GO:0072593 37 0.014
heart morphogenesis GO:0003007 3 0.014
positive regulation of secretion by cell GO:1903532 128 0.014
response to alkaloid GO:0043279 132 0.014
response to radiation GO:0009314 137 0.014
negative regulation of molecular function GO:0044092 133 0.014
regulation of blood circulation GO:1903522 110 0.014
negative regulation of nucleic acid templated transcription GO:1903507 117 0.014
regulation of metal ion transport GO:0010959 118 0.014
rhythmic process GO:0048511 156 0.014
nucleoside metabolic process GO:0009116 179 0.014
regulation of mapk cascade GO:0043408 116 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
sensory perception GO:0007600 101 0.014
positive regulation of protein phosphorylation GO:0001934 135 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
nucleoside phosphate biosynthetic process GO:1901293 102 0.014
response to transition metal nanoparticle GO:1990267 122 0.013
positive regulation of protein modification process GO:0031401 142 0.013
regulation of transferase activity GO:0051338 123 0.013
negative regulation of transcription dna templated GO:0045892 116 0.013
regulation of cellular component movement GO:0051270 150 0.013
regulation of hydrolase activity GO:0051336 143 0.013
protein localization GO:0008104 191 0.013
response to ethanol GO:0045471 162 0.013
ribonucleoside metabolic process GO:0009119 174 0.013
hormone secretion GO:0046879 115 0.013
organic acid transport GO:0015849 116 0.013
heterocycle catabolic process GO:0046700 167 0.013
cellular response to external stimulus GO:0071496 118 0.013
single organism intracellular transport GO:1902582 166 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
negative regulation of transport GO:0051051 136 0.013
vesicle mediated transport GO:0016192 181 0.013
regulation of anatomical structure morphogenesis GO:0022603 141 0.013
vascular process in circulatory system GO:0003018 96 0.013
hormone transport GO:0009914 121 0.013
cation transmembrane transport GO:0098655 263 0.013
regulation of response to external stimulus GO:0032101 106 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
regulation of cell motility GO:2000145 131 0.013
regulation of neuron projection development GO:0010975 161 0.013
response to hexose GO:0009746 144 0.013
aromatic compound catabolic process GO:0019439 168 0.013
monovalent inorganic cation transport GO:0015672 172 0.013
embryonic pattern specification GO:0009880 1 0.013
cellular response to cytokine stimulus GO:0071345 127 0.012
response to purine containing compound GO:0014074 126 0.012
nucleotide biosynthetic process GO:0009165 98 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
negative regulation of cell communication GO:0010648 158 0.012
peptidyl amino acid modification GO:0018193 126 0.012
regulation of cell migration GO:0030334 128 0.012
negative regulation of developmental process GO:0051093 125 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
regulation of tube size GO:0035150 89 0.012
response to toxic substance GO:0009636 133 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
cell part morphogenesis GO:0032990 123 0.012
cellular response to peptide hormone stimulus GO:0071375 120 0.012
cytoplasmic transport GO:0016482 115 0.012
regulation of blood vessel size GO:0050880 89 0.012
sex differentiation GO:0007548 113 0.012
negative regulation of cellular protein metabolic process GO:0032269 106 0.012
regulation of body fluid levels GO:0050878 90 0.012
cardiovascular system development GO:0072358 134 0.012
response to insulin GO:0032868 133 0.012
wound healing GO:0042060 122 0.012
forebrain development GO:0030900 98 0.012
oxidation reduction process GO:0055114 304 0.012
spermatogenesis GO:0007283 99 0.012
negative regulation of rna metabolic process GO:0051253 123 0.012
non canonical wnt signaling pathway GO:0035567 3 0.012
establishment of tissue polarity GO:0007164 2 0.012
regulation of locomotion GO:0040012 148 0.012
response to reactive oxygen species GO:0000302 120 0.012
response to mechanical stimulus GO:0009612 134 0.012
carboxylic acid transport GO:0046942 115 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.012
regulation of kinase activity GO:0043549 117 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
regulation of transmembrane transport GO:0034762 122 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
regulation of neuron death GO:1901214 115 0.012
actin filament based process GO:0030029 86 0.012
cell projection morphogenesis GO:0048858 123 0.011
cytoskeleton organization GO:0007010 111 0.011
cellular lipid metabolic process GO:0044255 208 0.011
purine nucleotide biosynthetic process GO:0006164 83 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
action potential GO:0001508 54 0.011
developmental growth GO:0048589 100 0.011
regulation of homeostatic process GO:0032844 101 0.011
regulation of response to stress GO:0080134 126 0.011
transmission of nerve impulse GO:0019226 42 0.011
neuron death GO:0070997 127 0.011
ossification GO:0001503 70 0.011
negative regulation of phosphate metabolic process GO:0045936 80 0.011
axon development GO:0061564 96 0.011
regulation of calcium ion transport GO:0051924 77 0.011
development of primary sexual characteristics GO:0045137 107 0.011
male gamete generation GO:0048232 99 0.011
multicellular organismal signaling GO:0035637 44 0.011
regulation of growth GO:0040008 105 0.011
sequestering of metal ion GO:0051238 9 0.011
gonad development GO:0008406 104 0.011
small molecule biosynthetic process GO:0044283 124 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
ribonucleotide biosynthetic process GO:0009260 85 0.011
salivary gland development GO:0007431 3 0.011
establishment of protein localization GO:0045184 141 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
response to organophosphorus GO:0046683 102 0.011
regulation of muscle system process GO:0090257 79 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
embryonic appendage morphogenesis GO:0035113 4 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
regulation of hormone secretion GO:0046883 106 0.011
appendage morphogenesis GO:0035107 4 0.011
organophosphate catabolic process GO:0046434 148 0.011
amide transport GO:0042886 105 0.011
circulatory system development GO:0072359 134 0.011
sequestering of calcium ion GO:0051208 8 0.011
dna metabolic process GO:0006259 96 0.011
cell type specific apoptotic process GO:0097285 134 0.011
neuron projection morphogenesis GO:0048812 122 0.011
protein oligomerization GO:0051259 191 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
positive regulation of cellular component movement GO:0051272 102 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
hematopoietic progenitor cell differentiation GO:0002244 2 0.011
negative regulation of phosphorus metabolic process GO:0010563 80 0.011
cell activation GO:0001775 97 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
organ regeneration GO:0031100 101 0.011
muscle cell proliferation GO:0033002 84 0.011
cellular response to steroid hormone stimulus GO:0071383 93 0.011
tube development GO:0035295 89 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
muscle structure development GO:0061061 87 0.011
regulation of protein kinase activity GO:0045859 105 0.010
nucleotide catabolic process GO:0009166 139 0.010
cyclic nucleotide metabolic process GO:0009187 80 0.010
chromosome segregation GO:0007059 2 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
lipid storage GO:0019915 1 0.010
purine nucleotide catabolic process GO:0006195 136 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.010
cellular response to alcohol GO:0097306 87 0.010
ribose phosphate biosynthetic process GO:0046390 87 0.010
purine containing compound catabolic process GO:0072523 138 0.010
protein transport GO:0015031 132 0.010
meiotic cell cycle process GO:1903046 3 0.010
formation of primary germ layer GO:0001704 1 0.010
nucleoside phosphate catabolic process GO:1901292 140 0.010
maintenance of location GO:0051235 17 0.010
negative regulation of cell cycle phase transition GO:1901988 4 0.010
cell cycle checkpoint GO:0000075 2 0.010
regulation of catabolic process GO:0009894 113 0.010
negative regulation of cell differentiation GO:0045596 99 0.010
rho protein signal transduction GO:0007266 11 0.010
neuronal action potential GO:0019228 35 0.010
regulation of ion transmembrane transport GO:0034765 121 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.010

Evc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.030
nervous system disease DOID:863 0 0.030
sensory system disease DOID:0050155 0 0.017
musculoskeletal system disease DOID:17 0 0.016
disease of metabolism DOID:0014667 0 0.016
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012
retinal disease DOID:5679 0 0.011
cardiovascular system disease DOID:1287 0 0.010