Rattus norvegicus

19 known processes

Cflar

CASP8 and FADD-like apoptosis regulator

(Aliases: Flip,MGC108616)

Cflar biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein phosphorylation GO:0006468 345 0.065
positive regulation of response to stimulus GO:0048584 285 0.062
response to nutrient levels GO:0031667 370 0.060
carboxylic acid metabolic process GO:0019752 289 0.059
regulation of molecular function GO:0065009 398 0.058
carbohydrate derivative metabolic process GO:1901135 346 0.057
single organism biosynthetic process GO:0044711 342 0.056
regulation of signal transduction GO:0009966 318 0.056
cellular response to endogenous stimulus GO:0071495 377 0.053
response to decreased oxygen levels GO:0036293 237 0.048
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.047
response to extracellular stimulus GO:0009991 380 0.047
regulation of rna biosynthetic process GO:2001141 381 0.047
cellular amino acid metabolic process GO:0006520 107 0.046
purine containing compound metabolic process GO:0072521 253 0.045
regulation of phosphorus metabolic process GO:0051174 349 0.045
nucleobase containing small molecule metabolic process GO:0055086 316 0.044
response to biotic stimulus GO:0009607 226 0.043
negative regulation of metabolic process GO:0009892 331 0.042
organic acid metabolic process GO:0006082 292 0.042
intracellular signal transduction GO:0035556 314 0.041
regulation of protein metabolic process GO:0051246 289 0.040
nucleoside phosphate metabolic process GO:0006753 283 0.040
rna metabolic process GO:0016070 406 0.039
response to oxidative stress GO:0006979 186 0.039
cellular component assembly GO:0022607 360 0.038
positive regulation of signaling GO:0023056 270 0.038
organophosphate metabolic process GO:0019637 370 0.038
oxoacid metabolic process GO:0043436 290 0.037
regulation of cellular ketone metabolic process GO:0010565 27 0.037
amine metabolic process GO:0009308 38 0.037
response to hypoxia GO:0001666 231 0.037
nucleic acid templated transcription GO:0097659 379 0.037
regulation of cellular component organization GO:0051128 368 0.037
regulation of cellular protein metabolic process GO:0032268 267 0.037
positive regulation of transcription factor import into nucleus GO:0042993 4 0.036
regulation of rna metabolic process GO:0051252 391 0.036
cellular amine metabolic process GO:0044106 38 0.035
multi organism reproductive process GO:0044703 262 0.035
cellular response to cytokine stimulus GO:0071345 127 0.035
response to oxygen levels GO:0070482 265 0.034
amino acid transport GO:0006865 70 0.034
positive regulation of phosphate metabolic process GO:0045937 262 0.034
response to acid chemical GO:0001101 222 0.034
positive regulation of molecular function GO:0044093 230 0.034
ribonucleotide metabolic process GO:0009259 231 0.033
reproductive process GO:0022414 372 0.033
homeostatic process GO:0042592 331 0.033
response to peptide hormone GO:0043434 278 0.033
negative regulation of phosphorus metabolic process GO:0010563 80 0.033
regulation of cellular amino acid metabolic process GO:0006521 2 0.033
transcription dna templated GO:0006351 377 0.033
regulation of catalytic activity GO:0050790 304 0.031
regulation of intracellular signal transduction GO:1902531 218 0.031
purine ribonucleotide metabolic process GO:0009150 227 0.031
regulation of cellular amine metabolic process GO:0033238 8 0.031
negative regulation of innate immune response GO:0045824 4 0.030
response to peptide GO:1901652 292 0.030
organelle organization GO:0006996 266 0.030
negative regulation of cellular metabolic process GO:0031324 281 0.030
response to bacterium GO:0009617 200 0.029
response to camp GO:0051591 91 0.029
nucleotide metabolic process GO:0009117 279 0.029
regulation of protein phosphorylation GO:0001932 183 0.029
regulation of nervous system development GO:0051960 264 0.029
regulation of cell proliferation GO:0042127 359 0.029
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.029
negative regulation of macromolecule metabolic process GO:0010605 260 0.029
regulation of phosphorylation GO:0042325 248 0.029
response to glucocorticoid GO:0051384 223 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.028
catabolic process GO:0009056 351 0.028
positive regulation of multicellular organismal process GO:0051240 387 0.028
positive regulation of phosphorus metabolic process GO:0010562 262 0.028
cellular catabolic process GO:0044248 295 0.028
purine nucleotide metabolic process GO:0006163 229 0.028
positive regulation of cellular biosynthetic process GO:0031328 295 0.028
regulation of cell differentiation GO:0045595 320 0.028
purine ribonucleoside metabolic process GO:0046128 168 0.028
regulation of neurogenesis GO:0050767 247 0.028
protein complex assembly GO:0006461 263 0.027
response to external biotic stimulus GO:0043207 221 0.027
cellular response to stress GO:0033554 269 0.027
protein complex biogenesis GO:0070271 263 0.027
g protein coupled receptor signaling pathway GO:0007186 242 0.027
cellular response to nitrogen compound GO:1901699 210 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.027
response to other organism GO:0051707 220 0.027
macromolecular complex assembly GO:0065003 273 0.027
locomotion GO:0040011 237 0.026
cellular ketone metabolic process GO:0042180 51 0.026
negative regulation of cellular biosynthetic process GO:0031327 161 0.026
positive regulation of cell communication GO:0010647 271 0.026
regulation of phosphate metabolic process GO:0019220 349 0.026
multicellular organismal reproductive process GO:0048609 233 0.026
response to molecule of bacterial origin GO:0002237 194 0.026
response to carbohydrate GO:0009743 183 0.026
single organism reproductive process GO:0044702 297 0.026
negative regulation of response to stimulus GO:0048585 155 0.025
ribonucleoside metabolic process GO:0009119 174 0.025
positive regulation of cellular protein metabolic process GO:0032270 167 0.025
regulation of transcription dna templated GO:0006355 374 0.025
purine nucleoside metabolic process GO:0042278 169 0.025
chemical homeostasis GO:0048878 292 0.025
anion transport GO:0006820 178 0.024
organic substance catabolic process GO:1901575 316 0.024
cellular chemical homeostasis GO:0055082 247 0.024
regulation of hormone levels GO:0010817 187 0.024
regulation of protein modification process GO:0031399 194 0.024
rna biosynthetic process GO:0032774 380 0.024
positive regulation of biosynthetic process GO:0009891 319 0.024
regulation of multicellular organismal development GO:2000026 376 0.024
response to cytokine GO:0034097 215 0.024
central nervous system development GO:0007417 311 0.024
reproduction GO:0000003 245 0.024
nucleoside metabolic process GO:0009116 179 0.024
single organism catabolic process GO:0044712 283 0.023
cellular component biogenesis GO:0044085 368 0.023
alpha amino acid metabolic process GO:1901605 71 0.023
regulation of cellular localization GO:0060341 263 0.023
immune system process GO:0002376 204 0.023
positive regulation of developmental process GO:0051094 283 0.023
cellular component movement GO:0006928 248 0.022
regulation of immunoglobulin secretion GO:0051023 1 0.022
organic acid transport GO:0015849 116 0.022
peptidyl amino acid modification GO:0018193 126 0.022
response to radiation GO:0009314 137 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.022
response to lipopolysaccharide GO:0032496 191 0.022
neuron development GO:0048666 286 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.022
regulation of nucleotide metabolic process GO:0006140 117 0.022
cellular response to organonitrogen compound GO:0071417 197 0.022
negative regulation of biosynthetic process GO:0009890 168 0.022
organonitrogen compound catabolic process GO:1901565 179 0.022
cation transport GO:0006812 382 0.021
positive regulation of nervous system development GO:0051962 178 0.021
metal ion transport GO:0030001 289 0.021
positive regulation of protein metabolic process GO:0051247 178 0.021
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.021
cellular ion homeostasis GO:0006873 184 0.021
negative regulation of gene expression GO:0010629 199 0.021
response to mechanical stimulus GO:0009612 134 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
regulation of neuron death GO:1901214 115 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
neurological system process GO:0050877 219 0.021
positive regulation of cell death GO:0010942 184 0.020
ribose phosphate metabolic process GO:0019693 235 0.020
positive regulation of transport GO:0051050 245 0.020
response to purine containing compound GO:0014074 126 0.020
organonitrogen compound biosynthetic process GO:1901566 167 0.020
negative regulation of molecular function GO:0044092 133 0.020
response to organophosphorus GO:0046683 102 0.019
ribonucleotide catabolic process GO:0009261 136 0.019
regulation of apoptotic process GO:0042981 335 0.019
action potential GO:0001508 54 0.019
apoptotic process GO:0006915 381 0.019
cell projection organization GO:0030030 302 0.019
cytosolic calcium ion homeostasis GO:0051480 140 0.019
ion homeostasis GO:0050801 212 0.019
regulation of protein kinase activity GO:0045859 105 0.019
regulation of homeostatic process GO:0032844 101 0.019
macromolecule localization GO:0033036 252 0.019
organic anion transport GO:0015711 132 0.019
response to hydrogen peroxide GO:0042542 89 0.019
negative regulation of cell differentiation GO:0045596 99 0.019
programmed cell death GO:0012501 392 0.018
cell cell signaling GO:0007267 335 0.018
positive regulation of signal transduction GO:0009967 175 0.018
rhythmic process GO:0048511 156 0.018
regulation of nucleic acid templated transcription GO:1903506 380 0.018
ras protein signal transduction GO:0007265 29 0.018
intracellular transport GO:0046907 185 0.018
regulation of secretion by cell GO:1903530 208 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
growth GO:0040007 165 0.018
multicellular organism reproduction GO:0032504 233 0.018
transmembrane transport GO:0055085 412 0.018
regulation of catabolic process GO:0009894 113 0.018
cellular response to oxygen containing compound GO:1901701 386 0.018
synaptic transmission GO:0007268 235 0.018
response to insulin GO:0032868 133 0.018
negative regulation of multicellular organismal process GO:0051241 203 0.018
negative regulation of signaling GO:0023057 157 0.018
positive regulation of cellular component organization GO:0051130 200 0.018
regulation of purine nucleotide metabolic process GO:1900542 115 0.018
response to reactive oxygen species GO:0000302 120 0.018
positive regulation of cell proliferation GO:0008284 249 0.018
protein complex subunit organization GO:0071822 302 0.018
heterocycle catabolic process GO:0046700 167 0.018
response to ethanol GO:0045471 162 0.017
gland development GO:0048732 155 0.017
response to monosaccharide GO:0034284 159 0.017
cellular homeostasis GO:0019725 252 0.017
protein oligomerization GO:0051259 191 0.017
metal ion homeostasis GO:0055065 186 0.017
dephosphorylation GO:0016311 98 0.017
b cell mediated immunity GO:0019724 4 0.017
purine containing compound catabolic process GO:0072523 138 0.017
calcium ion transport GO:0006816 131 0.017
regulation of cell development GO:0060284 263 0.017
regulation of cellular catabolic process GO:0031329 101 0.017
regulation of ion transport GO:0043269 245 0.016
nucleotide catabolic process GO:0009166 139 0.016
reactive oxygen species metabolic process GO:0072593 37 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
brain development GO:0007420 247 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.016
nitrogen compound transport GO:0071705 229 0.016
reproductive system development GO:0061458 128 0.016
single organism organelle organization GO:1902589 180 0.016
cellular cation homeostasis GO:0030003 180 0.015
sexual reproduction GO:0019953 148 0.015
vesicle mediated transport GO:0016192 181 0.015
regulation of hydrolase activity GO:0051336 143 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
coenzyme metabolic process GO:0006732 86 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
sensory perception GO:0007600 101 0.015
nucleoside triphosphate metabolic process GO:0009141 144 0.015
regulation of programmed cell death GO:0043067 341 0.015
regulation of response to stress GO:0080134 126 0.015
ribonucleoside catabolic process GO:0042454 126 0.015
single organism intracellular transport GO:1902582 166 0.015
response to corticosteroid GO:0031960 235 0.015
cation homeostasis GO:0055080 195 0.015
purine ribonucleoside catabolic process GO:0046130 124 0.015
gastrulation GO:0007369 2 0.015
neuron differentiation GO:0030182 368 0.015
positive regulation of gene expression GO:0010628 244 0.015
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.015
cellular divalent inorganic cation homeostasis GO:0072503 162 0.015
neuron projection development GO:0031175 273 0.015
leukocyte differentiation GO:0002521 30 0.015
organophosphate catabolic process GO:0046434 148 0.014
response to starvation GO:0042594 59 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.014
amine transport GO:0015837 57 0.014
response to ketone GO:1901654 182 0.014
jak stat cascade GO:0007259 26 0.014
tumor necrosis factor mediated signaling pathway GO:0033209 4 0.014
response to glucose GO:0009749 136 0.014
negative regulation of cell communication GO:0010648 158 0.014
cellular protein localization GO:0034613 122 0.014
response to hexose GO:0009746 144 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.014
secretion GO:0046903 307 0.014
response to alkaloid GO:0043279 132 0.014
divalent inorganic cation transport GO:0072511 134 0.014
chromosome segregation GO:0007059 2 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.014
positive regulation of immune system process GO:0002684 90 0.014
salivary gland morphogenesis GO:0007435 1 0.014
circulatory system process GO:0003013 183 0.014
cell motility GO:0048870 202 0.014
peptidyl tyrosine modification GO:0018212 72 0.014
response to inorganic substance GO:0010035 377 0.014
circadian rhythm GO:0007623 88 0.014
protein localization GO:0008104 191 0.014
cell migration GO:0016477 197 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
cellular response to tumor necrosis factor GO:0071356 46 0.013
purine nucleotide catabolic process GO:0006195 136 0.013
negative regulation of cell death GO:0060548 229 0.013
positive regulation of cell development GO:0010720 176 0.013
positive regulation of protein modification process GO:0031401 142 0.013
guanosine containing compound catabolic process GO:1901069 71 0.013
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
regulation of organelle organization GO:0033043 80 0.013
calcium ion homeostasis GO:0055074 162 0.013
negative regulation of transport GO:0051051 136 0.013
carbohydrate derivative catabolic process GO:1901136 147 0.013
regulation of immune system process GO:0002682 123 0.013
nucleoside catabolic process GO:0009164 126 0.013
negative regulation of nucleic acid templated transcription GO:1903507 117 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
negative regulation of catalytic activity GO:0043086 103 0.013
purine nucleoside triphosphate metabolic process GO:0009144 141 0.013
proteolysis GO:0006508 175 0.013
peptidyl tyrosine phosphorylation GO:0018108 72 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
regeneration GO:0031099 163 0.013
carboxylic acid transport GO:0046942 115 0.013
reactive nitrogen species metabolic process GO:2001057 1 0.013
positive regulation of cell differentiation GO:0045597 217 0.013
salivary gland development GO:0007431 3 0.013
aromatic compound catabolic process GO:0019439 168 0.012
spindle organization GO:0007051 2 0.012
inflammatory response GO:0006954 150 0.012
nucleoside phosphate biosynthetic process GO:1901293 102 0.012
enzyme linked receptor protein signaling pathway GO:0007167 116 0.012
guanosine containing compound metabolic process GO:1901068 74 0.012
purine nucleoside catabolic process GO:0006152 124 0.012
cell activation GO:0001775 97 0.012
macromolecular complex subunit organization GO:0043933 339 0.012
gliogenesis GO:0042063 93 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
carbohydrate metabolic process GO:0005975 130 0.012
chemosensory behavior GO:0007635 2 0.012
axis specification GO:0009798 4 0.012
secretion by cell GO:0032940 248 0.012
cellular response to insulin stimulus GO:0032869 81 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
retinal metabolic process GO:0042574 3 0.012
response to nutrient GO:0007584 248 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
immune response GO:0006955 104 0.012
ion transmembrane transport GO:0034220 365 0.012
cellular response to hormone stimulus GO:0032870 247 0.012
small molecule biosynthetic process GO:0044283 124 0.012
negative regulation of phosphate metabolic process GO:0045936 80 0.012
negative regulation of cellular component organization GO:0051129 83 0.012
regulation of cell projection organization GO:0031344 175 0.012
response to estrogen GO:0043627 232 0.012
neuron death GO:0070997 127 0.012
gtp metabolic process GO:0046039 72 0.012
cell cycle checkpoint GO:0000075 2 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
regulation of interferon gamma production GO:0032649 3 0.012
cofactor metabolic process GO:0051186 95 0.012
monosaccharide metabolic process GO:0005996 61 0.011
response to activity GO:0014823 73 0.011
gamete generation GO:0007276 124 0.011
synaptic growth at neuromuscular junction GO:0051124 1 0.011
regulation of neuron projection development GO:0010975 161 0.011
establishment of protein localization GO:0045184 141 0.011
muscle system process GO:0003012 115 0.011
regulation of growth GO:0040008 105 0.011
regulation of proteasomal protein catabolic process GO:0061136 4 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
innate immune response GO:0045087 35 0.011
response to estradiol GO:0032355 164 0.011
cellular response to peptide GO:1901653 133 0.011
response to growth factor GO:0070848 189 0.011
macromolecule catabolic process GO:0009057 58 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
nucleotide biosynthetic process GO:0009165 98 0.011
lipid biosynthetic process GO:0008610 128 0.011
regulation of transferase activity GO:0051338 123 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
glial cell differentiation GO:0010001 65 0.011
multi multicellular organism process GO:0044706 138 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
circulatory system development GO:0072359 134 0.011
response to wounding GO:0009611 254 0.011
positive regulation of nf kappab import into nucleus GO:0042346 2 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.011
lymphocyte activation GO:0046649 43 0.011
behavior GO:0007610 205 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
regulation of gtpase activity GO:0043087 57 0.011
lipid metabolic process GO:0006629 283 0.011
sex differentiation GO:0007548 113 0.011
cellular macromolecule localization GO:0070727 122 0.011
alpha amino acid biosynthetic process GO:1901607 23 0.011
negative regulation of transcription dna templated GO:0045892 116 0.011
carboxylic acid biosynthetic process GO:0046394 83 0.011
single organism cellular localization GO:1902580 102 0.011
female pregnancy GO:0007565 122 0.011
regulation of peptide transport GO:0090087 87 0.011
response to amine GO:0014075 46 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
mapk cascade GO:0000165 140 0.011
organ regeneration GO:0031100 101 0.011
cell cycle GO:0007049 101 0.011
regulation of secretion GO:0051046 224 0.011
negative regulation of phosphorylation GO:0042326 57 0.011
regulation of synaptic transmission GO:0050804 141 0.011
olfactory behavior GO:0042048 2 0.011
intracellular protein transport GO:0006886 79 0.010
immunoglobulin secretion GO:0048305 1 0.010
activation of cysteine type endopeptidase activity GO:0097202 4 0.010
positive regulation of nucleotide metabolic process GO:0045981 91 0.010
leukocyte activation GO:0045321 76 0.010
peptide transport GO:0015833 97 0.010
cellular metal ion homeostasis GO:0006875 172 0.010
cyclic purine nucleotide metabolic process GO:0052652 62 0.010
purine ribonucleotide catabolic process GO:0009154 136 0.010
purine containing compound biosynthetic process GO:0072522 85 0.010
cytoplasmic transport GO:0016482 115 0.010
cell type specific apoptotic process GO:0097285 134 0.010
ribonucleoside triphosphate catabolic process GO:0009203 122 0.010
cellular response to abiotic stimulus GO:0071214 85 0.010
hexose metabolic process GO:0019318 58 0.010
regulation of nucleoside metabolic process GO:0009118 66 0.010
protein heterooligomerization GO:0051291 89 0.010
glycosyl compound catabolic process GO:1901658 126 0.010
gtp catabolic process GO:0006184 71 0.010
negative regulation of signal transduction GO:0009968 83 0.010
cellular response to external stimulus GO:0071496 118 0.010

Cflar disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.024
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
inherited metabolic disorder DOID:655 0 0.019
musculoskeletal system disease DOID:17 0 0.014
sensory system disease DOID:0050155 0 0.013
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011
central nervous system disease DOID:331 0 0.010