Rattus norvegicus

139 known processes

Akr1b1

aldo-keto reductase family 1, member B1 (aldose reductase)

(Aliases: ALR-P-I,RATALDRED,Aldr1,Akr1b3,ALDRED,Alr,Akr1b4)

Akr1b1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to oxidative stress GO:0006979 186 0.136
regulation of apoptotic process GO:0042981 335 0.084
carboxylic acid metabolic process GO:0019752 289 0.079
cellular amino acid metabolic process GO:0006520 107 0.075
intracellular signal transduction GO:0035556 314 0.071
programmed cell death GO:0012501 392 0.066
catabolic process GO:0009056 351 0.058
regulation of cell proliferation GO:0042127 359 0.058
cellular lipid metabolic process GO:0044255 208 0.057
Rat
cellular response to endogenous stimulus GO:0071495 377 0.055
cellular response to stress GO:0033554 269 0.055
organic substance catabolic process GO:1901575 316 0.054
apoptotic process GO:0006915 381 0.053
response to inorganic substance GO:0010035 377 0.053
regulation of programmed cell death GO:0043067 341 0.052
oxoacid metabolic process GO:0043436 290 0.051
negative regulation of metabolic process GO:0009892 331 0.049
regulation of intracellular signal transduction GO:1902531 218 0.048
macromolecular complex subunit organization GO:0043933 339 0.047
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.046
reproduction GO:0000003 245 0.045
response to carbohydrate GO:0009743 183 0.043
organophosphate metabolic process GO:0019637 370 0.042
response to estrogen GO:0043627 232 0.042
Rat
organic acid metabolic process GO:0006082 292 0.038
response to ketone GO:1901654 182 0.037
negative regulation of response to stimulus GO:0048585 155 0.037
cell projection organization GO:0030030 302 0.036
aging GO:0007568 241 0.036
regulation of rna metabolic process GO:0051252 391 0.036
neuron projection development GO:0031175 273 0.036
single organism biosynthetic process GO:0044711 342 0.035
regulation of rna biosynthetic process GO:2001141 381 0.035
response to reactive oxygen species GO:0000302 120 0.035
protein complex assembly GO:0006461 263 0.034
cellular amide metabolic process GO:0043603 44 0.034
regulation of nucleic acid templated transcription GO:1903506 380 0.034
response to external biotic stimulus GO:0043207 221 0.034
regulation of molecular function GO:0065009 398 0.034
transcription dna templated GO:0006351 377 0.033
multi organism reproductive process GO:0044703 262 0.033
single organism carbohydrate metabolic process GO:0044723 118 0.032
cellular ketone metabolic process GO:0042180 51 0.032
Human
secretion GO:0046903 307 0.032
cellular response to oxidative stress GO:0034599 76 0.032
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.031
response to nutrient levels GO:0031667 370 0.031
protein complex subunit organization GO:0071822 302 0.030
negative regulation of transport GO:0051051 136 0.030
cellular response to reactive oxygen species GO:0034614 55 0.030
macromolecular complex assembly GO:0065003 273 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.030
negative regulation of cell death GO:0060548 229 0.029
single organism reproductive process GO:0044702 297 0.027
cellular catabolic process GO:0044248 295 0.027
regulation of phosphate metabolic process GO:0019220 349 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
regulation of transcription dna templated GO:0006355 374 0.026
rna metabolic process GO:0016070 406 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
regulation of catalytic activity GO:0050790 304 0.025
cellular response to organonitrogen compound GO:0071417 197 0.025
cellular response to organic cyclic compound GO:0071407 202 0.025
reproductive process GO:0022414 372 0.025
proteolysis GO:0006508 175 0.025
cellular response to oxygen containing compound GO:1901701 386 0.025
regeneration GO:0031099 163 0.025
negative regulation of programmed cell death GO:0043069 183 0.024
response to peptide GO:1901652 292 0.024
response to estradiol GO:0032355 164 0.023
regulation of signal transduction GO:0009966 318 0.023
negative regulation of apoptotic process GO:0043066 181 0.023
nucleobase containing small molecule metabolic process GO:0055086 316 0.023
positive regulation of apoptotic process GO:0043065 154 0.023
neuron development GO:0048666 286 0.023
negative regulation of cell communication GO:0010648 158 0.023
response to hydrogen peroxide GO:0042542 89 0.023
chemical homeostasis GO:0048878 292 0.023
cellular amine metabolic process GO:0044106 38 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
lipid metabolic process GO:0006629 283 0.022
Rat
defense response GO:0006952 194 0.022
secretion by cell GO:0032940 248 0.022
amine metabolic process GO:0009308 38 0.022
nucleoside phosphate metabolic process GO:0006753 283 0.022
small molecule biosynthetic process GO:0044283 124 0.022
positive regulation of rna metabolic process GO:0051254 203 0.022
central nervous system development GO:0007417 311 0.022
Rat Fly
response to glucocorticoid GO:0051384 223 0.022
neuron differentiation GO:0030182 368 0.022
response to acid chemical GO:0001101 222 0.022
negative regulation of multicellular organismal process GO:0051241 203 0.021
positive regulation of nucleic acid templated transcription GO:1903508 197 0.021
response to metal ion GO:0010038 253 0.021
protein phosphorylation GO:0006468 345 0.021
response to radiation GO:0009314 137 0.021
regulation of phosphorus metabolic process GO:0051174 349 0.021
rhythmic process GO:0048511 156 0.021
positive regulation of cell communication GO:0010647 271 0.021
regulation of cellular amine metabolic process GO:0033238 8 0.020
meiotic cell cycle process GO:1903046 3 0.020
chromosome segregation GO:0007059 2 0.020
positive regulation of biosynthetic process GO:0009891 319 0.020
regulation of neurogenesis GO:0050767 247 0.020
cellular response to hormone stimulus GO:0032870 247 0.020
response to amino acid GO:0043200 75 0.020
nucleic acid templated transcription GO:0097659 379 0.020
cellular component biogenesis GO:0044085 368 0.020
negative regulation of biosynthetic process GO:0009890 168 0.020
response to peptide hormone GO:0043434 278 0.020
response to monosaccharide GO:0034284 159 0.020
cellular response to nitrogen compound GO:1901699 210 0.020
transmembrane transport GO:0055085 412 0.019
response to biotic stimulus GO:0009607 226 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
negative regulation of molecular function GO:0044092 133 0.019
negative regulation of macromolecule metabolic process GO:0010605 260 0.019
cation transport GO:0006812 382 0.019
positive regulation of cell death GO:0010942 184 0.019
response to decreased oxygen levels GO:0036293 237 0.019
single organism catabolic process GO:0044712 283 0.018
positive regulation of gene expression GO:0010628 244 0.018
ion homeostasis GO:0050801 212 0.018
immune system process GO:0002376 204 0.018
organic hydroxy compound metabolic process GO:1901615 115 0.018
regulation of response to stress GO:0080134 126 0.018
female pregnancy GO:0007565 122 0.018
ion transmembrane transport GO:0034220 365 0.018
anion transport GO:0006820 178 0.018
regulation of phosphorylation GO:0042325 248 0.018
carbohydrate metabolic process GO:0005975 130 0.018
response to transition metal nanoparticle GO:1990267 122 0.017
positive regulation of transcription dna templated GO:0045893 197 0.017
cellular protein complex assembly GO:0043623 44 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
response to vitamin GO:0033273 131 0.017
response to extracellular stimulus GO:0009991 380 0.017
negative regulation of cellular metabolic process GO:0031324 281 0.017
transcription from rna polymerase ii promoter GO:0006366 252 0.017
regulation of cellular localization GO:0060341 263 0.017
homeostatic process GO:0042592 331 0.017
regulation of protein modification process GO:0031399 194 0.017
response to alkaloid GO:0043279 132 0.017
protein oligomerization GO:0051259 191 0.017
negative regulation of signal transduction GO:0009968 83 0.017
reproductive structure development GO:0048608 128 0.017
protein complex biogenesis GO:0070271 263 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
rna biosynthetic process GO:0032774 380 0.016
negative regulation of neuron differentiation GO:0045665 62 0.016
brain development GO:0007420 247 0.016
Rat Fly
mitotic cell cycle GO:0000278 49 0.016
response to bacterium GO:0009617 200 0.016
axis specification GO:0009798 4 0.016
cellular homeostasis GO:0019725 252 0.016
response to wounding GO:0009611 254 0.016
response to hypoxia GO:0001666 231 0.016
multicellular organism reproduction GO:0032504 233 0.016
response to molecule of bacterial origin GO:0002237 194 0.016
sexual reproduction GO:0019953 148 0.016
oxidation reduction process GO:0055114 304 0.016
negative regulation of cellular protein metabolic process GO:0032269 106 0.016
locomotion GO:0040011 237 0.016
negative regulation of protein metabolic process GO:0051248 114 0.015
inorganic ion transmembrane transport GO:0098660 229 0.015
response to ethanol GO:0045471 162 0.015
regulation of protein metabolic process GO:0051246 289 0.015
organic acid biosynthetic process GO:0016053 83 0.015
cell type specific apoptotic process GO:0097285 134 0.015
metal ion transport GO:0030001 289 0.015
organonitrogen compound biosynthetic process GO:1901566 167 0.015
monosaccharide metabolic process GO:0005996 61 0.015
response to toxic substance GO:0009636 133 0.015
cellular response to glucocorticoid stimulus GO:0071385 68 0.015
cellular modified amino acid metabolic process GO:0006575 61 0.015
nucleotide metabolic process GO:0009117 279 0.015
regulation of cellular protein metabolic process GO:0032268 267 0.015
cellular component assembly GO:0022607 360 0.015
response to glucose GO:0009749 136 0.015
negative regulation of signaling GO:0023057 157 0.015
regulation of hormone levels GO:0010817 187 0.015
Rat
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
purine containing compound metabolic process GO:0072521 253 0.014
regulation of multicellular organismal development GO:2000026 376 0.014
anterior posterior pattern specification GO:0009952 1 0.014
cell cycle GO:0007049 101 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
carbohydrate derivative metabolic process GO:1901135 346 0.014
Human
positive regulation of developmental process GO:0051094 283 0.014
negative regulation of gene expression GO:0010629 199 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
establishment of protein localization GO:0045184 141 0.014
positive regulation of multicellular organismal process GO:0051240 387 0.014
single organism behavior GO:0044708 130 0.014
response to cytokine GO:0034097 215 0.014
response to growth factor GO:0070848 189 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
response to nutrient GO:0007584 248 0.014
ras protein signal transduction GO:0007265 29 0.014
positive regulation of phosphate metabolic process GO:0045937 262 0.014
response to corticosteroid GO:0031960 235 0.014
response to lipopolysaccharide GO:0032496 191 0.014
cellular response to abiotic stimulus GO:0071214 85 0.014
cellular response to corticosteroid stimulus GO:0071384 69 0.014
response to herbicide GO:0009635 16 0.014
developmental process involved in reproduction GO:0003006 159 0.013
regulation of neuron projection development GO:0010975 161 0.013
telencephalon development GO:0021537 62 0.013
Rat
positive regulation of programmed cell death GO:0043068 157 0.013
regulation of anatomical structure size GO:0090066 135 0.013
intracellular transport GO:0046907 185 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
regulation of neuron apoptotic process GO:0043523 83 0.013
regulation of membrane potential GO:0042391 110 0.013
cation transmembrane transport GO:0098655 263 0.013
peptide metabolic process GO:0006518 32 0.013
response to other organism GO:0051707 220 0.013
gamete generation GO:0007276 124 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.013
cellular response to peptide GO:1901653 133 0.013
metal ion homeostasis GO:0055065 186 0.013
regulation of secretion GO:0051046 224 0.012
spindle organization GO:0007051 2 0.012
positive regulation of signaling GO:0023056 270 0.012
gonad development GO:0008406 104 0.012
regulation of ion transport GO:0043269 245 0.012
positive regulation of molecular function GO:0044093 230 0.012
cellular response to lipid GO:0071396 201 0.012
positive regulation of phosphorus metabolic process GO:0010562 262 0.012
regulation of secretion by cell GO:1903530 208 0.012
vascular process in circulatory system GO:0003018 96 0.012
response to oxygen levels GO:0070482 265 0.012
mitotic spindle organization GO:0007052 2 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
gliogenesis GO:0042063 93 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.012
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
reproductive system development GO:0061458 128 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
circulatory system process GO:0003013 183 0.012
cellular response to steroid hormone stimulus GO:0071383 93 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
positive regulation of protein modification process GO:0031401 142 0.012
spermatogenesis GO:0007283 99 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
behavior GO:0007610 205 0.011
sulfur compound metabolic process GO:0006790 70 0.011
organelle organization GO:0006996 266 0.011
synaptic growth at neuromuscular junction GO:0051124 1 0.011
vesicle mediated transport GO:0016192 181 0.011
response to hexose GO:0009746 144 0.011
cation homeostasis GO:0055080 195 0.011
cellular response to external stimulus GO:0071496 118 0.011
blood circulation GO:0008015 183 0.011
hexose metabolic process GO:0019318 58 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
neuron apoptotic process GO:0051402 88 0.011
ribonucleotide metabolic process GO:0009259 231 0.011
regulation of protein kinase activity GO:0045859 105 0.011
regulation of nervous system development GO:0051960 264 0.011
divalent inorganic cation homeostasis GO:0072507 165 0.011
regulation of hydrolase activity GO:0051336 143 0.011
monocarboxylic acid metabolic process GO:0032787 152 0.011
cellular component movement GO:0006928 248 0.011
regulation of neuron differentiation GO:0045664 208 0.011
response to light stimulus GO:0009416 52 0.011
apoptotic signaling pathway GO:0097190 27 0.011
regulation of cell development GO:0060284 263 0.011
cellular chemical homeostasis GO:0055082 247 0.011
positive regulation of signal transduction GO:0009967 175 0.011
regulation of cell differentiation GO:0045595 320 0.011
immune response GO:0006955 104 0.010
organophosphate biosynthetic process GO:0090407 143 0.010
protein transport GO:0015031 132 0.010
positive regulation of catalytic activity GO:0043085 184 0.010
alcohol metabolic process GO:0006066 77 0.010
organic anion transport GO:0015711 132 0.010
negative regulation of protein modification process GO:0031400 52 0.010
regulation of catabolic process GO:0009894 113 0.010
single organism cellular localization GO:1902580 102 0.010
macromolecule localization GO:0033036 252 0.010
wound healing GO:0042060 122 0.010
regulation of cell migration GO:0030334 128 0.010
single organism carbohydrate catabolic process GO:0044724 40 0.010
regulation of kinase activity GO:0043549 117 0.010

Akr1b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
musculoskeletal system disease DOID:17 0 0.020
nervous system disease DOID:863 0 0.013
cardiovascular system disease DOID:1287 0 0.012
central nervous system disease DOID:331 0 0.010