Rattus norvegicus

59 known processes

Nr1i2

nuclear receptor subfamily 1, group I, member 2

(Aliases: MGC108643,PXR)

Nr1i2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to biotic stimulus GO:0009607 226 0.468
Rat
response to external biotic stimulus GO:0043207 221 0.316
Rat
response to other organism GO:0051707 220 0.297
Rat
regulation of telomerase activity GO:0051972 2 0.240
Rat
carboxylic acid metabolic process GO:0019752 289 0.180
Rat
organic acid metabolic process GO:0006082 292 0.158
Rat
vitamin d receptor signaling pathway GO:0070561 1 0.148
Rat
oxoacid metabolic process GO:0043436 290 0.147
Rat
chemical homeostasis GO:0048878 292 0.134
Fly
response to lipopolysaccharide GO:0032496 191 0.114
Rat
gonad development GO:0008406 104 0.112
regulation of nervous system development GO:0051960 264 0.106
Rat
single organism biosynthetic process GO:0044711 342 0.100
Rat
oxidation reduction process GO:0055114 304 0.100
Rat Fly
coenzyme metabolic process GO:0006732 86 0.097
regulation of locomotion GO:0040012 148 0.094
Rat
locomotion GO:0040011 237 0.092
Rat
reproduction GO:0000003 245 0.090
Rat
response to nutrient levels GO:0031667 370 0.089
Rat Fly
cellular response to oxygen containing compound GO:1901701 386 0.088
Rat
monocarboxylic acid metabolic process GO:0032787 152 0.081
Rat
cellular response to hormone stimulus GO:0032870 247 0.081
Zebrafish Rat
cellular amino acid metabolic process GO:0006520 107 0.081
response to oxygen levels GO:0070482 265 0.078
Rat
regulation of cell development GO:0060284 263 0.078
Rat
cellular chemical homeostasis GO:0055082 247 0.077
organ regeneration GO:0031100 101 0.075
Rat
single organism carbohydrate catabolic process GO:0044724 40 0.074
thioester metabolic process GO:0035383 28 0.074
insulin secretion GO:0030073 69 0.072
Rat
negative regulation of pancreatic stellate cell proliferation GO:2000230 1 0.072
Rat
single organism reproductive process GO:0044702 297 0.070
Rat
response to extracellular stimulus GO:0009991 380 0.069
Rat Fly
multicellular organism reproduction GO:0032504 233 0.069
Rat
fatty acid oxidation GO:0019395 29 0.068
Rat
lipid oxidation GO:0034440 30 0.066
Rat
positive regulation of phagocytosis engulfment GO:0060100 4 0.066
Rat
organic hydroxy compound metabolic process GO:1901615 115 0.063
Rat
neuron differentiation GO:0030182 368 0.061
acyl coa metabolic process GO:0006637 28 0.060
response to purine containing compound GO:0014074 126 0.059
Rat
positive regulation of cellular component movement GO:0051272 102 0.059
regulation of apoptotic process GO:0042981 335 0.057
Rat
negative regulation of cell death GO:0060548 229 0.057
Rat
monosaccharide metabolic process GO:0005996 61 0.056
Fly
vitamin a metabolic process GO:0006776 2 0.055
Rat
cofactor metabolic process GO:0051186 95 0.054
regulation of peptide hormone secretion GO:0090276 80 0.053
Rat
lipid metabolic process GO:0006629 283 0.052
Rat
response to bacterium GO:0009617 200 0.051
Rat
response to cytokine GO:0034097 215 0.050
apoptotic process GO:0006915 381 0.050
Rat
carbohydrate catabolic process GO:0016052 40 0.050
positive regulation of nervous system development GO:0051962 178 0.049
Rat
peptide hormone secretion GO:0030072 84 0.048
Rat
transcription from rna polymerase ii promoter GO:0006366 252 0.048
regulation of neurogenesis GO:0050767 247 0.048
Rat
anatomical structure morphogenesis GO:0009653 298 0.048
alpha amino acid metabolic process GO:1901605 71 0.048
neuron development GO:0048666 286 0.047
organic substance catabolic process GO:1901575 316 0.046
response to carbohydrate GO:0009743 183 0.046
Rat
response to organophosphorus GO:0046683 102 0.042
response to monosaccharide GO:0034284 159 0.041
Rat
catabolic process GO:0009056 351 0.041
Human
regulation of transcription dna templated GO:0006355 374 0.041
reproductive process GO:0022414 372 0.041
Rat
negative regulation of response to external stimulus GO:0032102 37 0.040
Rat
cell motility GO:0048870 202 0.040
Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.040
regulation of response to external stimulus GO:0032101 106 0.039
Rat
regulation of multicellular organismal development GO:2000026 376 0.039
Rat
tube development GO:0035295 89 0.039
Rat
regulation of cellular amino acid metabolic process GO:0006521 2 0.038
cellular response to stress GO:0033554 269 0.038
Rat
regulation of insulin secretion GO:0050796 65 0.038
Rat
mrna transcription GO:0009299 2 0.037
Rat
cell morphogenesis involved in differentiation GO:0000904 119 0.037
negative regulation of acute inflammatory response GO:0002674 4 0.037
Rat
establishment or maintenance of transmembrane electrochemical gradient GO:0010248 1 0.037
hormone secretion GO:0046879 115 0.037
Rat
rhythmic process GO:0048511 156 0.037
response to glucose GO:0009749 136 0.037
Rat
regulation of neuron death GO:1901214 115 0.036
Rat
glutamine family amino acid metabolic process GO:0009064 15 0.036
regulation of peptide transport GO:0090087 87 0.036
Rat
peptidyl amino acid modification GO:0018193 126 0.036
cellular component movement GO:0006928 248 0.035
Rat
regulation of molecular function GO:0065009 398 0.035
Rat
sterol homeostasis GO:0055092 3 0.035
Fly
negative regulation of tyrosine phosphorylation of stat5 protein GO:0042524 1 0.034
regulation of cellular ketone metabolic process GO:0010565 27 0.034
Rat
amine metabolic process GO:0009308 38 0.034
antibiotic transport GO:0042891 2 0.034
transcription dna templated GO:0006351 377 0.034
anion transmembrane transport GO:0098656 77 0.033
peptide transport GO:0015833 97 0.033
Rat
peptide secretion GO:0002790 86 0.033
Rat
nitrogen cycle metabolic process GO:0071941 5 0.033
organophosphate metabolic process GO:0019637 370 0.032
Rat
cellular carbohydrate metabolic process GO:0044262 72 0.032
Fly
response to peptide GO:1901652 292 0.032
Rat
amide transport GO:0042886 105 0.032
Rat
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.031
Rat
negative regulation of cell differentiation GO:0045596 99 0.031
negative regulation of cell proliferation GO:0008285 119 0.031
Rat
carboxylic acid catabolic process GO:0046395 49 0.031
small molecule biosynthetic process GO:0044283 124 0.031
regulation of neuron projection development GO:0010975 161 0.030
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
Human Rat
metal ion transport GO:0030001 289 0.030
Rat
positive regulation of gene expression GO:0010628 244 0.030
Human Mouse Rat
cholesterol homeostasis GO:0042632 3 0.030
Fly
response to decreased oxygen levels GO:0036293 237 0.030
Rat
growth GO:0040007 165 0.029
Rat
signal release GO:0023061 145 0.029
Rat
secretion by cell GO:0032940 248 0.029
Rat
sensory organ development GO:0007423 74 0.028
glutathione transport GO:0034635 2 0.028
regulation of peptide secretion GO:0002791 82 0.028
Rat
cellular response to endogenous stimulus GO:0071495 377 0.027
Zebrafish Rat
cellular response to lipid GO:0071396 201 0.027
Zebrafish Rat
negative regulation of neurogenesis GO:0050768 78 0.027
ion transmembrane transport GO:0034220 365 0.027
regulation of rna metabolic process GO:0051252 391 0.027
gland development GO:0048732 155 0.026
cellular amine metabolic process GO:0044106 38 0.026
cation transport GO:0006812 382 0.026
Rat
multicellular organismal reproductive process GO:0048609 233 0.025
Rat
positive regulation of cell communication GO:0010647 271 0.025
Rat
fatty acid metabolic process GO:0006631 99 0.025
Rat
epithelium development GO:0060429 96 0.025
Rat
regulation of anatomical structure size GO:0090066 135 0.025
Rat
cellular component assembly GO:0022607 360 0.025
reproductive structure development GO:0048608 128 0.025
Rat
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.025
salivary gland development GO:0007431 3 0.025
embryo implantation GO:0007566 15 0.025
Rat
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.025
Human Rat
organic cyclic compound catabolic process GO:1901361 175 0.025
oligopeptide transport GO:0006857 4 0.025
neuron projection development GO:0031175 273 0.024
programmed cell death GO:0012501 392 0.024
Rat
lipid biosynthetic process GO:0008610 128 0.024
Rat
cellular calcium ion homeostasis GO:0006874 160 0.024
sulfur compound metabolic process GO:0006790 70 0.024
cellular metal ion homeostasis GO:0006875 172 0.024
negative regulation of programmed cell death GO:0043069 183 0.024
Rat
response to estrogen GO:0043627 232 0.024
Rat
positive regulation of locomotion GO:0040017 102 0.023
homeostatic process GO:0042592 331 0.023
Fly
rna biosynthetic process GO:0032774 380 0.023
cellular homeostasis GO:0019725 252 0.023
regulation of cell migration GO:0030334 128 0.023
Rat
sodium ion transmembrane transport GO:0035725 67 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.023
Human Rat
ion homeostasis GO:0050801 212 0.023
single organism behavior GO:0044708 130 0.022
Rat
response to vitamin GO:0033273 131 0.022
Rat
hexose metabolic process GO:0019318 58 0.022
Fly
regulation of cell growth GO:0001558 85 0.022
Rat
regulation of phagocytosis engulfment GO:0060099 4 0.022
Rat
circadian regulation of gene expression GO:0032922 3 0.021
cell cycle GO:0007049 101 0.021
cellular cation homeostasis GO:0030003 180 0.021
positive regulation of multicellular organismal process GO:0051240 387 0.021
Rat
negative regulation of rna biosynthetic process GO:1902679 118 0.021
Human Rat
regulation of dendrite development GO:0050773 59 0.021
calcium ion transport GO:0006816 131 0.021
Rat
neuron death GO:0070997 127 0.021
Rat
nitrogen compound transport GO:0071705 229 0.021
Rat
regulation of fat cell differentiation GO:0045598 3 0.021
Rat
negative regulation of response to stimulus GO:0048585 155 0.020
Rat
response to nutrient GO:0007584 248 0.020
Rat
secretion GO:0046903 307 0.020
Rat
localization of cell GO:0051674 202 0.020
Rat
regulation of hormone levels GO:0010817 187 0.020
Rat
positive regulation of transcription dna templated GO:0045893 197 0.020
Human Rat
regulation of inflammatory response GO:0050727 48 0.020
Rat
positive regulation of response to external stimulus GO:0032103 51 0.020
positive regulation of biosynthetic process GO:0009891 319 0.020
Human Rat
regulation of programmed cell death GO:0043067 341 0.020
Rat
pyruvate metabolic process GO:0006090 27 0.020
sodium independent organic anion transport GO:0043252 2 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.020
cellular response to alcohol GO:0097306 87 0.020
Rat
small molecule catabolic process GO:0044282 59 0.019
cell migration GO:0016477 197 0.019
Rat
regulation of pancreatic stellate cell proliferation GO:2000229 2 0.019
Rat
developmental process involved in reproduction GO:0003006 159 0.019
Rat
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.019
smooth muscle cell proliferation GO:0048659 77 0.019
Rat
defense response GO:0006952 194 0.019
Rat
regulation of cellular component movement GO:0051270 150 0.019
Rat
regulation of system process GO:0044057 208 0.019
Rat
regulation of calcium ion transport GO:0051924 77 0.019
Rat
cell projection organization GO:0030030 302 0.019
transmembrane transport GO:0055085 412 0.019
negative regulation of signaling GO:0023057 157 0.018
regulation of protein phosphorylation GO:0001932 183 0.018
response to oxidative stress GO:0006979 186 0.018
cell part morphogenesis GO:0032990 123 0.018
organic cation transport GO:0015695 11 0.018
behavior GO:0007610 205 0.018
Rat
negative regulation of developmental process GO:0051093 125 0.017
cellular lipid metabolic process GO:0044255 208 0.017
Rat
multi organism reproductive process GO:0044703 262 0.017
Rat
response to wounding GO:0009611 254 0.017
Rat
regulation of cell morphogenesis GO:0022604 77 0.017
divalent metal ion transport GO:0070838 132 0.017
Rat
response to estradiol GO:0032355 164 0.017
Rat
hormone transport GO:0009914 121 0.017
Rat
male sex differentiation GO:0046661 64 0.017
positive regulation of molecular function GO:0044093 230 0.017
kidney development GO:0001822 67 0.017
response to metformin GO:1901558 1 0.017
Rat
cellular divalent inorganic cation homeostasis GO:0072503 162 0.017
glycolytic process GO:0006096 17 0.017
regulation of hormone secretion GO:0046883 106 0.016
Rat
regulation of cell proliferation GO:0042127 359 0.016
Rat
steroid hormone mediated signaling pathway GO:0043401 8 0.016
Zebrafish Rat
glucose metabolic process GO:0006006 52 0.016
Fly
divalent inorganic cation homeostasis GO:0072507 165 0.016
positive regulation of hormone secretion GO:0046887 65 0.016
Rat
maintenance of location GO:0051235 17 0.016
carbohydrate biosynthetic process GO:0016051 42 0.016
response to insulin GO:0032868 133 0.016
Rat
negative regulation of cellular metabolic process GO:0031324 281 0.016
Human Rat
carbohydrate metabolic process GO:0005975 130 0.015
Rat Fly
adult behavior GO:0030534 16 0.015
Rat
regulation of microvillus organization GO:0032530 1 0.015
activation of jak2 kinase activity GO:0042977 2 0.015
cellular amino acid biosynthetic process GO:0008652 32 0.015
response to inorganic substance GO:0010035 377 0.015
Rat
placenta development GO:0001890 22 0.015
Rat
response to growth factor GO:0070848 189 0.015
regeneration GO:0031099 163 0.015
Rat
cation homeostasis GO:0055080 195 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
Human Rat
negative regulation of activation of jak2 kinase activity GO:1902569 1 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
Human Rat
regulation of response to wounding GO:1903034 69 0.015
Rat
cytosolic calcium ion homeostasis GO:0051480 140 0.015
cellular response to vitamin e GO:0071306 3 0.015
Rat
dopamine transport GO:0015872 18 0.015
lipid storage GO:0019915 1 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.015
Human Rat
response to hexose GO:0009746 144 0.015
Rat
cellular response to oxygen levels GO:0071453 60 0.014
Rat
negative regulation of transcription dna templated GO:0045892 116 0.014
Human Rat
organic acid catabolic process GO:0016054 49 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
Human Rat
negative regulation of nucleic acid templated transcription GO:1903507 117 0.014
Human Rat
ribonucleoside metabolic process GO:0009119 174 0.014
positive regulation of cell development GO:0010720 176 0.014
Rat
acute inflammatory response GO:0002526 58 0.014
Rat
cell projection morphogenesis GO:0048858 123 0.014
calcium ion homeostasis GO:0055074 162 0.014
regulation of dendrite morphogenesis GO:0048814 33 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
Rat
mechanoreceptor differentiation GO:0042490 2 0.014
lipid modification GO:0030258 52 0.014
Rat
response to alkaloid GO:0043279 132 0.014
Rat
sex differentiation GO:0007548 113 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
Human Rat
cellular response to organic cyclic compound GO:0071407 202 0.014
Zebrafish Rat
positive regulation of signal transduction GO:0009967 175 0.014
cardiovascular system development GO:0072358 134 0.014
Rat
single organism carbohydrate metabolic process GO:0044723 118 0.014
Fly
single organism catabolic process GO:0044712 283 0.014
regulation of cellular protein metabolic process GO:0032268 267 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
Rat
dendrite development GO:0016358 72 0.013
response to starvation GO:0042594 59 0.013
Rat Fly
hepaticobiliary system development GO:0061008 90 0.013
positive regulation of neurogenesis GO:0050769 165 0.013
Rat
regulation of protein metabolic process GO:0051246 289 0.013
cell morphogenesis GO:0000902 142 0.013
cellular modified amino acid metabolic process GO:0006575 61 0.013
liver development GO:0001889 90 0.013
cellular component morphogenesis GO:0032989 155 0.013
carnitine transport GO:0015879 1 0.013
cellular ketone metabolic process GO:0042180 51 0.013
Rat
negative regulation of molecular function GO:0044092 133 0.013
Rat
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
positive regulation of cell projection organization GO:0031346 111 0.013
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.013
regulation of transcription regulatory region dna binding GO:2000677 4 0.013
Rat
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.013
rna metabolic process GO:0016070 406 0.013
positive regulation of peptide hormone secretion GO:0090277 50 0.013
Rat
regulation of activation of jak2 kinase activity GO:0010534 1 0.013
cellular glucan metabolic process GO:0006073 23 0.013
Fly
positive regulation of neuron projection development GO:0010976 99 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
Human Rat
synaptic transmission gabaergic GO:0051932 22 0.013
amino acid transmembrane transport GO:0003333 33 0.013
action potential GO:0001508 54 0.012
regulation of acute inflammatory response GO:0002673 23 0.012
Rat
regulation of cell projection organization GO:0031344 175 0.012
blood circulation GO:0008015 183 0.012
Rat
regulation of cell motility GO:2000145 131 0.012
Rat
response to vitamin e GO:0033197 24 0.012
Rat
negative regulation of apoptotic process GO:0043066 181 0.012
Rat
response to transition metal nanoparticle GO:1990267 122 0.012
glucose homeostasis GO:0042593 75 0.012
positive regulation of rna biosynthetic process GO:1902680 197 0.012
Human Rat
inflammatory response GO:0006954 150 0.012
Rat
negative regulation of protein metabolic process GO:0051248 114 0.012
mesoderm development GO:0007498 2 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.012
Human Rat
carboxylic acid biosynthetic process GO:0046394 83 0.012
cell growth GO:0016049 104 0.012
Rat
positive regulation of cell proliferation GO:0008284 249 0.012
behavioral response to nicotine GO:0035095 2 0.012
Rat
positive regulation of neuron differentiation GO:0045666 126 0.012
organelle organization GO:0006996 266 0.012
metal ion homeostasis GO:0055065 186 0.012
defense response to gram negative bacterium GO:0050829 3 0.012
muscle cell apoptotic process GO:0010657 30 0.011
cellular catabolic process GO:0044248 295 0.011
Human
epithelial cell differentiation GO:0030855 71 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
positive regulation of cell migration GO:0030335 96 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
negative regulation of neuron death GO:1901215 69 0.011
Rat
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
regulation of secretion by cell GO:1903530 208 0.011
Rat
inorganic ion transmembrane transport GO:0098660 229 0.011
male gamete generation GO:0048232 99 0.011
terpenoid metabolic process GO:0006721 37 0.011
Rat
sexual reproduction GO:0019953 148 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
Rat
positive regulation of developmental process GO:0051094 283 0.011
Rat
negative regulation of catalytic activity GO:0043086 103 0.011
Rat
cellular ion homeostasis GO:0006873 184 0.011
establishment of tissue polarity GO:0007164 2 0.011
peptidyl tyrosine modification GO:0018212 72 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
Rat
regulation of catalytic activity GO:0050790 304 0.011
Rat
enzyme linked receptor protein signaling pathway GO:0007167 116 0.011
monosaccharide biosynthetic process GO:0046364 16 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
Rat
spermatogenesis GO:0007283 99 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
Rat
regulation of lipid biosynthetic process GO:0046890 38 0.011
maternal process involved in female pregnancy GO:0060135 38 0.011
Rat
nucleoside metabolic process GO:0009116 179 0.010
gliogenesis GO:0042063 93 0.010
Rat
positive regulation of catalytic activity GO:0043085 184 0.010
macromolecular complex assembly GO:0065003 273 0.010
regulation of growth GO:0040008 105 0.010
Rat
regulation of cellular component size GO:0032535 51 0.010
regulation of hydrolase activity GO:0051336 143 0.010
circadian rhythm GO:0007623 88 0.010
regulation of gluconeogenesis GO:0006111 4 0.010
positive regulation of response to stimulus GO:0048584 285 0.010
axon development GO:0061564 96 0.010
camera type eye development GO:0043010 48 0.010
glycosyl compound metabolic process GO:1901657 182 0.010
muscle cell proliferation GO:0033002 84 0.010
Rat
protein complex assembly GO:0006461 263 0.010
regulation of cellular catabolic process GO:0031329 101 0.010

Nr1i2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.044
nervous system disease DOID:863 0 0.044
disease of metabolism DOID:0014667 0 0.019
cardiovascular system disease DOID:1287 0 0.017
sensory system disease DOID:0050155 0 0.014
artery disease DOID:0050828 0 0.011
vascular disease DOID:178 0 0.011
inherited metabolic disorder DOID:655 0 0.011