Rattus norvegicus

16 known processes

Irx4

iroquois homeobox 4

Irx4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
tissue development GO:0009888 252 0.518
regulation of cellular component movement GO:0051270 150 0.241
enzyme linked receptor protein signaling pathway GO:0007167 116 0.239
response to corticosteroid GO:0031960 235 0.182
anatomical structure morphogenesis GO:0009653 298 0.174
regulation of transporter activity GO:0032409 50 0.155
regulation of rna metabolic process GO:0051252 391 0.151
response to glucocorticoid GO:0051384 223 0.147
organ morphogenesis GO:0009887 75 0.120
cell migration GO:0016477 197 0.113
positive regulation of response to stimulus GO:0048584 285 0.110
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.100
ion transmembrane transport GO:0034220 365 0.100
apoptotic process GO:0006915 381 0.098
cell motility GO:0048870 202 0.097
cellular response to lipid GO:0071396 201 0.090
cellular response to alkaloid GO:0071312 25 0.090
regulation of cell migration GO:0030334 128 0.084
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.082
cellular component movement GO:0006928 248 0.082
sodium ion transport GO:0006814 82 0.082
positive regulation of cell proliferation GO:0008284 249 0.080
transcription from rna polymerase ii promoter GO:0006366 252 0.077
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.076
localization of cell GO:0051674 202 0.076
regulation of signal transduction GO:0009966 318 0.074
regulation of cell proliferation GO:0042127 359 0.073
cell projection organization GO:0030030 302 0.070
reproductive system development GO:0061458 128 0.068
epithelium development GO:0060429 96 0.067
regulation of transmembrane transport GO:0034762 122 0.065
l glutamate import GO:0051938 2 0.064
neuron development GO:0048666 286 0.064
tissue morphogenesis GO:0048729 22 0.064
homeostatic process GO:0042592 331 0.063
regulation of intracellular signal transduction GO:1902531 218 0.061
regulation of apoptotic process GO:0042981 335 0.061
regulation of cell differentiation GO:0045595 320 0.060
cellular metal ion homeostasis GO:0006875 172 0.060
regulation of molecular function GO:0065009 398 0.060
cellular response to organic cyclic compound GO:0071407 202 0.059
regulation of cell motility GO:2000145 131 0.059
neuron death GO:0070997 127 0.058
development of primary sexual characteristics GO:0045137 107 0.058
regulation of transmembrane transporter activity GO:0022898 49 0.057
cellular response to endogenous stimulus GO:0071495 377 0.056
locomotion GO:0040011 237 0.054
neuron differentiation GO:0030182 368 0.054
positive regulation of intracellular signal transduction GO:1902533 138 0.054
regulation of programmed cell death GO:0043067 341 0.053
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.051
regulation of multicellular organismal development GO:2000026 376 0.051
regulation of rna biosynthetic process GO:2001141 381 0.051
central nervous system development GO:0007417 311 0.051
regulation of phosphate metabolic process GO:0019220 349 0.051
positive regulation of locomotion GO:0040017 102 0.048
cellular response to steroid hormone stimulus GO:0071383 93 0.048
positive regulation of nucleic acid templated transcription GO:1903508 197 0.047
chemical homeostasis GO:0048878 292 0.047
response to extracellular stimulus GO:0009991 380 0.047
nucleic acid templated transcription GO:0097659 379 0.047
carbohydrate derivative catabolic process GO:1901136 147 0.046
regulation of establishment of planar polarity GO:0090175 2 0.046
response to bacterium GO:0009617 200 0.046
urogenital system development GO:0001655 78 0.046
response to hyperoxia GO:0055093 45 0.046
response to nutrient levels GO:0031667 370 0.046
negative regulation of apoptotic process GO:0043066 181 0.045
tube development GO:0035295 89 0.045
response to peptide GO:1901652 292 0.045
ossification GO:0001503 70 0.045
response to cytokine GO:0034097 215 0.044
regulation of transcription dna templated GO:0006355 374 0.044
regulation of ion transport GO:0043269 245 0.044
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.043
positive regulation of transcription dna templated GO:0045893 197 0.042
transmembrane transport GO:0055085 412 0.041
regulation of nucleic acid templated transcription GO:1903506 380 0.041
cellular response to growth factor stimulus GO:0071363 162 0.041
positive regulation of molecular function GO:0044093 230 0.041
respiratory system development GO:0060541 45 0.040
gland development GO:0048732 155 0.040
cardiac muscle cell contraction GO:0086003 10 0.040
positive regulation of programmed cell death GO:0043068 157 0.040
positive regulation of cellular component movement GO:0051272 102 0.040
cellular lipid metabolic process GO:0044255 208 0.039
actin filament based process GO:0030029 86 0.039
negative regulation of multicellular organismal process GO:0051241 203 0.039
reproductive structure development GO:0048608 128 0.039
response to insulin GO:0032868 133 0.039
negative regulation of cell communication GO:0010648 158 0.038
cellular chemical homeostasis GO:0055082 247 0.038
response to estrogen GO:0043627 232 0.038
response to monosaccharide GO:0034284 159 0.038
behavior GO:0007610 205 0.037
negative regulation of cellular biosynthetic process GO:0031327 161 0.037
response to acid chemical GO:0001101 222 0.037
negative regulation of signal transduction GO:0009968 83 0.037
negative regulation of transport GO:0051051 136 0.037
response to external biotic stimulus GO:0043207 221 0.037
positive regulation of developmental process GO:0051094 283 0.037
organophosphate metabolic process GO:0019637 370 0.036
positive regulation of cell migration GO:0030335 96 0.036
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.036
immune system process GO:0002376 204 0.036
response to oxygen levels GO:0070482 265 0.036
head development GO:0060322 247 0.035
inorganic ion transmembrane transport GO:0098660 229 0.035
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.035
neurological system process GO:0050877 219 0.035
oxoacid metabolic process GO:0043436 290 0.034
inorganic cation transmembrane transport GO:0098662 202 0.034
response to wounding GO:0009611 254 0.034
negative regulation of cell death GO:0060548 229 0.034
response to ketone GO:1901654 182 0.034
positive regulation of biosynthetic process GO:0009891 319 0.033
regulation of homeostatic process GO:0032844 101 0.033
rna biosynthetic process GO:0032774 380 0.033
positive regulation of gene expression GO:0010628 244 0.033
lipid metabolic process GO:0006629 283 0.033
transcription dna templated GO:0006351 377 0.032
positive regulation of rna biosynthetic process GO:1902680 197 0.032
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
positive regulation of signal transduction GO:0009967 175 0.032
cell part morphogenesis GO:0032990 123 0.032
cellular amino acid metabolic process GO:0006520 107 0.032
developmental process involved in reproduction GO:0003006 159 0.032
regulation of cellular component organization GO:0051128 368 0.032
cation transmembrane transport GO:0098655 263 0.032
development of primary female sexual characteristics GO:0046545 56 0.031
kidney development GO:0001822 67 0.031
response to peptide hormone GO:0043434 278 0.031
negative regulation of signaling GO:0023057 157 0.031
axis specification GO:0009798 4 0.031
neuron projection development GO:0031175 273 0.031
regulation of ion transmembrane transporter activity GO:0032412 48 0.031
immune response GO:0006955 104 0.030
purine containing compound catabolic process GO:0072523 138 0.030
multicellular organismal homeostasis GO:0048871 49 0.030
multicellular organism reproduction GO:0032504 233 0.030
organ formation GO:0048645 3 0.030
single organism reproductive process GO:0044702 297 0.030
female sex differentiation GO:0046660 59 0.030
anatomical structure formation involved in morphogenesis GO:0048646 83 0.030
regulation of secretion GO:0051046 224 0.029
rna metabolic process GO:0016070 406 0.029
regulation of protein phosphorylation GO:0001932 183 0.029
circulatory system development GO:0072359 134 0.029
positive regulation of signaling GO:0023056 270 0.029
regulation of ion transmembrane transport GO:0034765 121 0.029
organic acid metabolic process GO:0006082 292 0.029
positive regulation of cellular biosynthetic process GO:0031328 295 0.029
chemosensory behavior GO:0007635 2 0.028
regulation of secretion by cell GO:1903530 208 0.028
cellular response to nitrogen compound GO:1901699 210 0.028
regulation of catalytic activity GO:0050790 304 0.028
response to vitamin GO:0033273 131 0.028
reproduction GO:0000003 245 0.028
positive regulation of rna metabolic process GO:0051254 203 0.028
intracellular signal transduction GO:0035556 314 0.028
programmed cell death GO:0012501 392 0.028
alcohol metabolic process GO:0006066 77 0.028
regulation of phosphorylation GO:0042325 248 0.027
regulation of protein modification process GO:0031399 194 0.027
cellular component morphogenesis GO:0032989 155 0.027
positive regulation of cell motility GO:2000147 97 0.027
cellular response to reactive oxygen species GO:0034614 55 0.027
organic substance catabolic process GO:1901575 316 0.026
cellular response to oxygen containing compound GO:1901701 386 0.026
morphogenesis of an epithelium GO:0002009 20 0.026
cytosolic calcium ion homeostasis GO:0051480 140 0.026
response to hexose GO:0009746 144 0.026
regulation of metal ion transport GO:0010959 118 0.026
negative regulation of biosynthetic process GO:0009890 168 0.026
negative regulation of molecular function GO:0044092 133 0.026
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.025
positive regulation of ion transmembrane transporter activity GO:0032414 13 0.025
single organism catabolic process GO:0044712 283 0.025
regulation of locomotion GO:0040012 148 0.025
response to estradiol GO:0032355 164 0.025
eye morphogenesis GO:0048592 4 0.025
regulation of protein metabolic process GO:0051246 289 0.025
amine metabolic process GO:0009308 38 0.025
response to growth factor GO:0070848 189 0.025
biological adhesion GO:0022610 110 0.025
regulation of hormone levels GO:0010817 187 0.024
positive regulation of phosphorylation GO:0042327 177 0.024
negative regulation of metabolic process GO:0009892 331 0.024
negative regulation of rna biosynthetic process GO:1902679 118 0.024
gonad development GO:0008406 104 0.024
negative regulation of ion transport GO:0043271 51 0.024
establishment of tissue polarity GO:0007164 2 0.024
cellular component biogenesis GO:0044085 368 0.023
carbohydrate derivative metabolic process GO:1901135 346 0.023
regulation of cation channel activity GO:2001257 23 0.023
positive regulation of cell differentiation GO:0045597 217 0.023
metal ion transport GO:0030001 289 0.023
regeneration GO:0031099 163 0.023
cellular homeostasis GO:0019725 252 0.023
regulation of cell development GO:0060284 263 0.022
monovalent inorganic cation transport GO:0015672 172 0.022
catabolic process GO:0009056 351 0.022
cellular amine metabolic process GO:0044106 38 0.022
positive regulation of cellular component organization GO:0051130 200 0.022
response to retinoic acid GO:0032526 63 0.022
negative regulation of programmed cell death GO:0043069 183 0.022
positive regulation of cell communication GO:0010647 271 0.022
negative regulation of gene expression GO:0010629 199 0.022
ion homeostasis GO:0050801 212 0.021
bone development GO:0060348 25 0.021
positive regulation of apoptotic process GO:0043065 154 0.021
cell morphogenesis GO:0000902 142 0.021
response to molecule of bacterial origin GO:0002237 194 0.021
reproductive process GO:0022414 372 0.021
positive regulation of transport GO:0051050 245 0.021
cellular amide metabolic process GO:0043603 44 0.021
hormone secretion GO:0046879 115 0.021
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.020
heart morphogenesis GO:0003007 3 0.020
aging GO:0007568 241 0.020
organic hydroxy compound metabolic process GO:1901615 115 0.020
cellular response to hormone stimulus GO:0032870 247 0.020
macromolecule localization GO:0033036 252 0.020
response to oxidative stress GO:0006979 186 0.020
cellular catabolic process GO:0044248 295 0.020
hematopoietic progenitor cell differentiation GO:0002244 2 0.020
cellular response to stress GO:0033554 269 0.020
angiogenesis GO:0001525 53 0.020
epithelial cell differentiation GO:0030855 71 0.020
purine containing compound metabolic process GO:0072521 253 0.020
forebrain development GO:0030900 98 0.020
secretion GO:0046903 307 0.020
cellular calcium ion homeostasis GO:0006874 160 0.020
ribose phosphate metabolic process GO:0019693 235 0.020
cellular ion homeostasis GO:0006873 184 0.019
lung development GO:0030324 43 0.019
protein complex subunit organization GO:0071822 302 0.019
coronary vasculature morphogenesis GO:0060977 3 0.019
glycosyl compound metabolic process GO:1901657 182 0.019
regulation of system process GO:0044057 208 0.019
single organismal cell cell adhesion GO:0016337 42 0.019
ribonucleotide catabolic process GO:0009261 136 0.019
metal ion homeostasis GO:0055065 186 0.019
adult locomotory behavior GO:0008344 4 0.019
sensory perception GO:0007600 101 0.018
sensory organ development GO:0007423 74 0.018
cellular response to nicotine GO:0071316 7 0.018
macromolecular complex subunit organization GO:0043933 339 0.018
cation transport GO:0006812 382 0.018
regulation of ion homeostasis GO:2000021 63 0.018
regulation of cellular protein metabolic process GO:0032268 267 0.018
divalent inorganic cation homeostasis GO:0072507 165 0.018
calcium ion homeostasis GO:0055074 162 0.018
renal system development GO:0072001 67 0.018
protein localization GO:0008104 191 0.018
male gonad development GO:0008584 59 0.018
palate development GO:0060021 2 0.018
regulation of fat cell differentiation GO:0045598 3 0.018
secretion by cell GO:0032940 248 0.018
multicellular organismal reproductive process GO:0048609 233 0.018
response to other organism GO:0051707 220 0.018
development of primary male sexual characteristics GO:0046546 59 0.017
ribonucleotide metabolic process GO:0009259 231 0.017
cellular response to oxidative stress GO:0034599 76 0.017
olfactory behavior GO:0042048 2 0.017
regulation of cell projection organization GO:0031344 175 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
regulation of smooth muscle cell proliferation GO:0048660 75 0.017
regulation of epithelial cell proliferation GO:0050678 49 0.017
membrane depolarization during cardiac muscle cell action potential GO:0086012 1 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.017
vasculature development GO:0001944 70 0.017
negative regulation of macromolecule metabolic process GO:0010605 260 0.017
response to tumor necrosis factor GO:0034612 56 0.017
regulation of phosphorus metabolic process GO:0051174 349 0.017
s shaped body morphogenesis GO:0072050 2 0.017
female gonad development GO:0008585 53 0.017
cardiovascular system development GO:0072358 134 0.017
retina morphogenesis in camera type eye GO:0060042 1 0.017
positive regulation of phosphate metabolic process GO:0045937 262 0.016
single organism biosynthetic process GO:0044711 342 0.016
muscle tissue development GO:0060537 58 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.016
cellular cation homeostasis GO:0030003 180 0.016
brain development GO:0007420 247 0.016
cellular response to mechanical stimulus GO:0071260 48 0.016
response to reactive oxygen species GO:0000302 120 0.016
organophosphate catabolic process GO:0046434 148 0.016
positive regulation of kinase activity GO:0033674 77 0.016
salivary gland development GO:0007431 3 0.015
organelle organization GO:0006996 266 0.015
response to purine containing compound GO:0014074 126 0.015
negative regulation of rna metabolic process GO:0051253 123 0.015
purine nucleotide catabolic process GO:0006195 136 0.015
regulation of neuron apoptotic process GO:0043523 83 0.015
cellular response to cytokine stimulus GO:0071345 127 0.015
morphogenesis of a polarized epithelium GO:0001738 1 0.015
skeletal system development GO:0001501 41 0.015
regulation of protein transport GO:0051223 68 0.015
positive regulation of protein modification process GO:0031401 142 0.015
positive regulation of multicellular organismal process GO:0051240 387 0.015
developmental growth GO:0048589 100 0.015
protein complex biogenesis GO:0070271 263 0.015
response to increased oxygen levels GO:0036296 45 0.015
endocrine system development GO:0035270 30 0.015
response to glucose GO:0009749 136 0.015
regulation of hydrolase activity GO:0051336 143 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
purine nucleoside metabolic process GO:0042278 169 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
cellular ketone metabolic process GO:0042180 51 0.015
negative regulation of transcription dna templated GO:0045892 116 0.015
regulation of cellular localization GO:0060341 263 0.015
cytoskeleton organization GO:0007010 111 0.015
rhythmic process GO:0048511 156 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.015
negative regulation of cellular metabolic process GO:0031324 281 0.014
sodium ion transmembrane transport GO:0035725 67 0.014
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.014
regulation of transferase activity GO:0051338 123 0.014
embryonic pattern specification GO:0009880 1 0.014
cellular response to external stimulus GO:0071496 118 0.014
regulation of neurogenesis GO:0050767 247 0.014
intracellular transport GO:0046907 185 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
cellular nitrogen compound catabolic process GO:0044270 163 0.014
leukocyte migration GO:0050900 38 0.014
anion transport GO:0006820 178 0.014
angiogenesis involved in coronary vascular morphogenesis GO:0060978 3 0.014
hematopoietic or lymphoid organ development GO:0048534 36 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
divalent metal ion transport GO:0070838 132 0.014
cellular divalent inorganic cation homeostasis GO:0072503 162 0.014
immune system development GO:0002520 41 0.014
response to lipopolysaccharide GO:0032496 191 0.013
cardiac muscle contraction GO:0060048 27 0.013
respiratory tube development GO:0030323 43 0.013
regulation of sodium ion transport GO:0002028 21 0.013
nucleoside metabolic process GO:0009116 179 0.013
growth GO:0040007 165 0.013
nerve development GO:0021675 11 0.013
entrainment of circadian clock GO:0009649 3 0.013
carbohydrate metabolic process GO:0005975 130 0.013
bmp signaling pathway GO:0030509 4 0.013
protein transport GO:0015031 132 0.013
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.013
single organism organelle organization GO:1902589 180 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
establishment of planar polarity GO:0001736 1 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.013
sensory perception of light stimulus GO:0050953 3 0.013
negative regulation of developmental process GO:0051093 125 0.013
cell cell signaling involved in cell fate commitment GO:0045168 2 0.013
positive regulation of potassium ion transport GO:0043268 13 0.013
cellular response to organonitrogen compound GO:0071417 197 0.012
response to decreased oxygen levels GO:0036293 237 0.012
organ induction GO:0001759 1 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
muscle system process GO:0003012 115 0.012
cellular component assembly GO:0022607 360 0.012
taxis GO:0042330 67 0.012
lens fiber cell differentiation GO:0070306 3 0.012
cellular response to peptide GO:1901653 133 0.012
response to fibroblast growth factor GO:0071774 29 0.012
cell differentiation involved in kidney development GO:0061005 4 0.012
carboxylic acid transport GO:0046942 115 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.012
response to hydrogen peroxide GO:0042542 89 0.012
regulation of kinase activity GO:0043549 117 0.012
response to testosterone GO:0033574 55 0.012
oxidation reduction process GO:0055114 304 0.012
regulation of cellular ketone metabolic process GO:0010565 27 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.012
cell projection morphogenesis GO:0048858 123 0.012
single organism cellular localization GO:1902580 102 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
metestrus GO:0060210 1 0.011
gamete generation GO:0007276 124 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
muscle structure development GO:0061061 87 0.011
response to biotic stimulus GO:0009607 226 0.011
maintenance of location GO:0051235 17 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
camera type eye development GO:0043010 48 0.011
camera type eye morphogenesis GO:0048593 2 0.011
metanephric s shaped body morphogenesis GO:0072284 2 0.011
striated muscle tissue development GO:0014706 58 0.011
insulin secretion GO:0030073 69 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
response to blue light GO:0009637 1 0.011
positive regulation of growth GO:0045927 55 0.011
muscle contraction GO:0006936 88 0.011
cell growth GO:0016049 104 0.011
anterior posterior pattern specification GO:0009952 1 0.010
lipid storage GO:0019915 1 0.010
cell activation GO:0001775 97 0.010
specification of organ identity GO:0010092 2 0.010
regulation of peptide hormone secretion GO:0090276 80 0.010
cation homeostasis GO:0055080 195 0.010
cell cycle checkpoint GO:0000075 2 0.010
muscle cell proliferation GO:0033002 84 0.010
wound healing GO:0042060 122 0.010
circadian rhythm GO:0007623 88 0.010
positive regulation of cell development GO:0010720 176 0.010
sex differentiation GO:0007548 113 0.010
cytoplasmic transport GO:0016482 115 0.010
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.010
regulation of intracellular transport GO:0032386 65 0.010
phospholipid metabolic process GO:0006644 61 0.010

Irx4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 0 0.083
retinal degeneration DOID:8466 0 0.083
sensory system disease DOID:0050155 0 0.083
disease of anatomical entity DOID:7 0 0.083
retinitis pigmentosa DOID:10584 0 0.083
eye and adnexa disease DOID:1492 0 0.083
nervous system disease DOID:863 0 0.083
eye disease DOID:5614 0 0.083
musculoskeletal system disease DOID:17 0 0.032
connective tissue disease DOID:65 0 0.018
heart disease DOID:114 0 0.018
cardiovascular system disease DOID:1287 0 0.018
bone disease DOID:0080001 0 0.015
muscular disease DOID:0080000 0 0.013
muscle tissue disease DOID:66 0 0.013
myopathy DOID:423 0 0.013
bone development disease DOID:0080006 0 0.012