Rattus norvegicus

0 known processes

Irx2

iroquois homeobox 2

(Aliases: Irx5)

Irx2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
nucleic acid templated transcription GO:0097659 379 0.154
transcription dna templated GO:0006351 377 0.131
regulation of transcription dna templated GO:0006355 374 0.129
rna biosynthetic process GO:0032774 380 0.125
rna metabolic process GO:0016070 406 0.120
regulation of multicellular organismal development GO:2000026 376 0.112
regulation of nucleic acid templated transcription GO:1903506 380 0.104
regulation of rna metabolic process GO:0051252 391 0.096
transcription from rna polymerase ii promoter GO:0006366 252 0.086
negative regulation of transcription dna templated GO:0045892 116 0.072
regulation of signal transduction GO:0009966 318 0.072
positive regulation of biosynthetic process GO:0009891 319 0.067
negative regulation of rna metabolic process GO:0051253 123 0.066
positive regulation of developmental process GO:0051094 283 0.064
positive regulation of cellular biosynthetic process GO:0031328 295 0.064
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.063
regulation of rna biosynthetic process GO:2001141 381 0.063
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.062
negative regulation of cellular biosynthetic process GO:0031327 161 0.059
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.058
response to metal ion GO:0010038 253 0.058
regulation of cell proliferation GO:0042127 359 0.056
neuron differentiation GO:0030182 368 0.056
anatomical structure morphogenesis GO:0009653 298 0.055
Rat
intracellular signal transduction GO:0035556 314 0.055
regulation of protein metabolic process GO:0051246 289 0.052
cellular response to hormone stimulus GO:0032870 247 0.052
apoptotic process GO:0006915 381 0.049
positive regulation of gene expression GO:0010628 244 0.047
organelle organization GO:0006996 266 0.047
positive regulation of rna metabolic process GO:0051254 203 0.047
negative regulation of metabolic process GO:0009892 331 0.046
positive regulation of cell differentiation GO:0045597 217 0.045
regulation of cell differentiation GO:0045595 320 0.045
protein phosphorylation GO:0006468 345 0.044
response to inorganic substance GO:0010035 377 0.043
immune system process GO:0002376 204 0.043
negative regulation of cellular metabolic process GO:0031324 281 0.042
negative regulation of macromolecule metabolic process GO:0010605 260 0.042
regulation of phosphorus metabolic process GO:0051174 349 0.042
positive regulation of multicellular organismal process GO:0051240 387 0.041
positive regulation of rna biosynthetic process GO:1902680 197 0.041
response to extracellular stimulus GO:0009991 380 0.041
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.040
positive regulation of transcription dna templated GO:0045893 197 0.040
regulation of cellular protein metabolic process GO:0032268 267 0.039
response to nutrient levels GO:0031667 370 0.039
cellular response to oxygen containing compound GO:1901701 386 0.039
programmed cell death GO:0012501 392 0.039
regulation of phosphate metabolic process GO:0019220 349 0.038
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.037
regulation of programmed cell death GO:0043067 341 0.037
reproductive process GO:0022414 372 0.037
regulation of phosphorylation GO:0042325 248 0.036
tissue development GO:0009888 252 0.035
organic acid metabolic process GO:0006082 292 0.035
positive regulation of response to stimulus GO:0048584 285 0.035
biological adhesion GO:0022610 110 0.034
negative regulation of rna biosynthetic process GO:1902679 118 0.034
cellular response to stress GO:0033554 269 0.034
oxoacid metabolic process GO:0043436 290 0.034
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.034
cell adhesion GO:0007155 110 0.034
brain development GO:0007420 247 0.033
cellular response to endogenous stimulus GO:0071495 377 0.033
positive regulation of cell proliferation GO:0008284 249 0.033
negative regulation of gene expression GO:0010629 199 0.032
cellular response to lipid GO:0071396 201 0.032
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.031
negative regulation of nucleic acid templated transcription GO:1903507 117 0.031
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.031
head development GO:0060322 247 0.030
regulation of catalytic activity GO:0050790 304 0.030
regulation of intracellular signal transduction GO:1902531 218 0.030
carbohydrate derivative metabolic process GO:1901135 346 0.030
response to other organism GO:0051707 220 0.029
macromolecular complex subunit organization GO:0043933 339 0.029
negative regulation of biosynthetic process GO:0009890 168 0.029
localization of cell GO:0051674 202 0.028
central nervous system development GO:0007417 311 0.028
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.028
response to wounding GO:0009611 254 0.027
cellular component movement GO:0006928 248 0.027
positive regulation of nucleic acid templated transcription GO:1903508 197 0.026
regulation of cellular component movement GO:0051270 150 0.026
cellular component assembly GO:0022607 360 0.026
establishment of organ orientation GO:0048561 1 0.026
Rat
cellular response to nitrogen compound GO:1901699 210 0.026
positive regulation of protein phosphorylation GO:0001934 135 0.026
response to external biotic stimulus GO:0043207 221 0.025
cellular response to organonitrogen compound GO:0071417 197 0.025
regulation of apoptotic process GO:0042981 335 0.025
homeostatic process GO:0042592 331 0.025
circulatory system development GO:0072359 134 0.025
positive regulation of phosphorus metabolic process GO:0010562 262 0.024
cellular response to organic cyclic compound GO:0071407 202 0.024
renal system development GO:0072001 67 0.024
regulation of cellular component organization GO:0051128 368 0.024
response to estrogen GO:0043627 232 0.024
positive regulation of phosphate metabolic process GO:0045937 262 0.024
regulation of protein modification process GO:0031399 194 0.024
carbohydrate metabolic process GO:0005975 130 0.024
carboxylic acid metabolic process GO:0019752 289 0.024
cellular component biogenesis GO:0044085 368 0.024
chemical homeostasis GO:0048878 292 0.023
regulation of cellular amino acid metabolic process GO:0006521 2 0.023
locomotion GO:0040011 237 0.023
cellular amino acid metabolic process GO:0006520 107 0.023
cellular chemical homeostasis GO:0055082 247 0.023
positive regulation of protein metabolic process GO:0051247 178 0.023
cellular amine metabolic process GO:0044106 38 0.023
macromolecule localization GO:0033036 252 0.023
cell part morphogenesis GO:0032990 123 0.022
nucleotide metabolic process GO:0009117 279 0.022
regulation of neuron differentiation GO:0045664 208 0.022
signal transduction by phosphorylation GO:0023014 144 0.022
regeneration GO:0031099 163 0.022
regulation of immune system process GO:0002682 123 0.022
positive regulation of cellular component organization GO:0051130 200 0.022
cell projection organization GO:0030030 302 0.022
response to ketone GO:1901654 182 0.022
response to acid chemical GO:0001101 222 0.021
response to transition metal nanoparticle GO:1990267 122 0.021
positive regulation of molecular function GO:0044093 230 0.021
cellular ion homeostasis GO:0006873 184 0.021
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.021
response to oxygen levels GO:0070482 265 0.021
negative regulation of apoptotic process GO:0043066 181 0.020
organonitrogen compound biosynthetic process GO:1901566 167 0.020
regulation of molecular function GO:0065009 398 0.020
cell migration GO:0016477 197 0.020
enzyme linked receptor protein signaling pathway GO:0007167 116 0.020
regulation of establishment of planar polarity GO:0090175 2 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
neuron development GO:0048666 286 0.019
kidney development GO:0001822 67 0.019
organ morphogenesis GO:0009887 75 0.019
Rat
regulation of protein phosphorylation GO:0001932 183 0.019
aging GO:0007568 241 0.019
regulation of neurogenesis GO:0050767 247 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
response to hypoxia GO:0001666 231 0.019
neurological system process GO:0050877 219 0.019
axis specification GO:0009798 4 0.019
Rat
cellular ketone metabolic process GO:0042180 51 0.018
growth GO:0040007 165 0.018
positive regulation of protein modification process GO:0031401 142 0.018
positive regulation of cellular protein metabolic process GO:0032270 167 0.018
organic substance catabolic process GO:1901575 316 0.018
organ regeneration GO:0031100 101 0.018
neuron projection development GO:0031175 273 0.018
single organism cell adhesion GO:0098602 46 0.018
single organism organelle organization GO:1902589 180 0.018
establishment of protein localization GO:0045184 141 0.018
regulation of cell development GO:0060284 263 0.018
regulation of cell projection organization GO:0031344 175 0.018
response to estradiol GO:0032355 164 0.017
amine metabolic process GO:0009308 38 0.017
negative regulation of multicellular organismal process GO:0051241 203 0.017
regulation of canonical wnt signaling pathway GO:0060828 4 0.017
establishment of tissue polarity GO:0007164 2 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
positive regulation of catalytic activity GO:0043085 184 0.017
single organismal cell cell adhesion GO:0016337 42 0.017
multi organism reproductive process GO:0044703 262 0.017
positive regulation of phosphorylation GO:0042327 177 0.017
regulation of mapk cascade GO:0043408 116 0.017
positive regulation of signal transduction GO:0009967 175 0.016
response to bacterium GO:0009617 200 0.016
response to testosterone GO:0033574 55 0.016
cellular component morphogenesis GO:0032989 155 0.016
tube formation GO:0035148 3 0.016
mapk cascade GO:0000165 140 0.016
positive regulation of immune system process GO:0002684 90 0.016
regulation of nervous system development GO:0051960 264 0.016
protein localization GO:0008104 191 0.016
regulation of cellular amine metabolic process GO:0033238 8 0.016
single organism biosynthetic process GO:0044711 342 0.016
single organism intracellular transport GO:1902582 166 0.016
cell morphogenesis GO:0000902 142 0.016
ribonucleotide metabolic process GO:0009259 231 0.015
negative regulation of cell proliferation GO:0008285 119 0.015
inorganic ion transmembrane transport GO:0098660 229 0.015
response to decreased oxygen levels GO:0036293 237 0.015
cellular catabolic process GO:0044248 295 0.015
urogenital system development GO:0001655 78 0.015
catabolic process GO:0009056 351 0.015
response to molecule of bacterial origin GO:0002237 194 0.015
single organism carbohydrate metabolic process GO:0044723 118 0.015
circulatory system process GO:0003013 183 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.015
single organism catabolic process GO:0044712 283 0.015
cell type specific apoptotic process GO:0097285 134 0.015
protein complex subunit organization GO:0071822 302 0.015
cellular homeostasis GO:0019725 252 0.015
metestrus GO:0060210 1 0.015
response to growth factor GO:0070848 189 0.014
negative regulation of signaling GO:0023057 157 0.014
b cell differentiation GO:0030183 2 0.014
intracellular transport GO:0046907 185 0.014
ossification GO:0001503 70 0.014
cell motility GO:0048870 202 0.014
negative regulation of developmental process GO:0051093 125 0.014
cell projection morphogenesis GO:0048858 123 0.014
cellular response to peptide GO:1901653 133 0.014
response to nutrient GO:0007584 248 0.014
hematopoietic progenitor cell differentiation GO:0002244 2 0.014
positive regulation of cell death GO:0010942 184 0.014
regulation of protein kinase activity GO:0045859 105 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
protein complex assembly GO:0006461 263 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.014
positive regulation of cellular component movement GO:0051272 102 0.014
regulation of cell motility GO:2000145 131 0.014
positive regulation of programmed cell death GO:0043068 157 0.014
anatomical structure formation involved in morphogenesis GO:0048646 83 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
single organism reproductive process GO:0044702 297 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
regulation of cellular ketone metabolic process GO:0010565 27 0.013
response to glucocorticoid GO:0051384 223 0.013
response to reactive oxygen species GO:0000302 120 0.013
heart morphogenesis GO:0003007 3 0.013
positive regulation of transport GO:0051050 245 0.013
cation homeostasis GO:0055080 195 0.013
cell cell signaling GO:0007267 335 0.013
negative regulation of cell communication GO:0010648 158 0.013
regulation of neuron projection development GO:0010975 161 0.013
positive regulation of signaling GO:0023056 270 0.013
cellular response to reactive oxygen species GO:0034614 55 0.013
positive regulation of locomotion GO:0040017 102 0.013
gland development GO:0048732 155 0.013
response to toxic substance GO:0009636 133 0.013
positive regulation of nervous system development GO:0051962 178 0.013
proteolysis GO:0006508 175 0.013
multicellular organism reproduction GO:0032504 233 0.012
retina morphogenesis in camera type eye GO:0060042 1 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
multicellular organismal signaling GO:0035637 44 0.012
non canonical wnt signaling pathway GO:0035567 3 0.012
cytokine production GO:0001816 61 0.012
ras protein signal transduction GO:0007265 29 0.012
secretion GO:0046903 307 0.012
regulation of secretion GO:0051046 224 0.012
organophosphate metabolic process GO:0019637 370 0.012
transmembrane transport GO:0055085 412 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
vesicle mediated transport GO:0016192 181 0.012
anterior posterior pattern specification GO:0009952 1 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
regulation of transferase activity GO:0051338 123 0.012
cytoskeleton organization GO:0007010 111 0.012
cellular response to fluid shear stress GO:0071498 4 0.012
response to oxidative stress GO:0006979 186 0.012
embryonic pattern specification GO:0009880 1 0.012
carboxylic acid transport GO:0046942 115 0.012
female pregnancy GO:0007565 122 0.012
response to biotic stimulus GO:0009607 226 0.011
sensory organ development GO:0007423 74 0.011
developmental process involved in reproduction GO:0003006 159 0.011
hematopoietic or lymphoid organ development GO:0048534 36 0.011
gliogenesis GO:0042063 93 0.011
muscle system process GO:0003012 115 0.011
positive regulation of protein kinase activity GO:0045860 73 0.011
actin filament based process GO:0030029 86 0.011
positive regulation of apoptotic process GO:0043065 154 0.011
cellular response to steroid hormone stimulus GO:0071383 93 0.011
single organism cellular localization GO:1902580 102 0.011
bmp signaling pathway GO:0030509 4 0.011
protein transport GO:0015031 132 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
neuron projection morphogenesis GO:0048812 122 0.011
morphogenesis of a polarized epithelium GO:0001738 1 0.011
epithelium development GO:0060429 96 0.011
cellular protein localization GO:0034613 122 0.011
regulation of system process GO:0044057 208 0.011
regulation of bmp signaling pathway GO:0030510 2 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
positive regulation of cell communication GO:0010647 271 0.011
chemosensory behavior GO:0007635 2 0.011
immune system development GO:0002520 41 0.011
purine containing compound metabolic process GO:0072521 253 0.011
developmental growth GO:0048589 100 0.011
cellular macromolecule localization GO:0070727 122 0.011
anion transport GO:0006820 178 0.011
nitrogen compound transport GO:0071705 229 0.011
regulation of leukocyte differentiation GO:1902105 20 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
regulation of kinase activity GO:0043549 117 0.011
response to lipopolysaccharide GO:0032496 191 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.011
positive regulation of cell development GO:0010720 176 0.011
cellular response to growth factor stimulus GO:0071363 162 0.010
metal ion homeostasis GO:0055065 186 0.010
peptidyl amino acid modification GO:0018193 126 0.010
inner ear morphogenesis GO:0042472 1 0.010
oxidation reduction process GO:0055114 304 0.010
negative regulation of transport GO:0051051 136 0.010
muscle structure development GO:0061061 87 0.010
morphogenesis of embryonic epithelium GO:0016331 3 0.010
transmission of nerve impulse GO:0019226 42 0.010
cardiac chamber development GO:0003205 1 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010
epithelial cell differentiation GO:0030855 71 0.010
regulation of proteasomal protein catabolic process GO:0061136 4 0.010
reproductive structure development GO:0048608 128 0.010
response to carbohydrate GO:0009743 183 0.010

Irx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014
musculoskeletal system disease DOID:17 0 0.011