Rattus norvegicus

0 known processes

Perp

PERP, TP53 apoptosis effector

Perp biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
reproductive process GO:0022414 372 0.125
cellular amino acid metabolic process GO:0006520 107 0.104
anatomical structure morphogenesis GO:0009653 298 0.101
organic acid metabolic process GO:0006082 292 0.098
carboxylic acid metabolic process GO:0019752 289 0.097
regulation of cell proliferation GO:0042127 359 0.094
tissue development GO:0009888 252 0.086
cellular component biogenesis GO:0044085 368 0.084
oxoacid metabolic process GO:0043436 290 0.076
response to wounding GO:0009611 254 0.075
cellular component assembly GO:0022607 360 0.073
single organism reproductive process GO:0044702 297 0.073
intracellular signal transduction GO:0035556 314 0.070
neuron development GO:0048666 286 0.070
cell projection organization GO:0030030 302 0.066
establishment of tissue polarity GO:0007164 2 0.065
response to inorganic substance GO:0010035 377 0.065
sulfur compound metabolic process GO:0006790 70 0.065
cellular response to endogenous stimulus GO:0071495 377 0.064
cell adhesion GO:0007155 110 0.062
regulation of apoptotic process GO:0042981 335 0.061
regulation of cellular component organization GO:0051128 368 0.057
regulation of programmed cell death GO:0043067 341 0.055
biological adhesion GO:0022610 110 0.054
neuron differentiation GO:0030182 368 0.053
apoptotic process GO:0006915 381 0.052
response to ketone GO:1901654 182 0.052
regulation of molecular function GO:0065009 398 0.051
reproductive system development GO:0061458 128 0.051
programmed cell death GO:0012501 392 0.051
locomotion GO:0040011 237 0.051
response to acid chemical GO:0001101 222 0.050
localization of cell GO:0051674 202 0.050
gland development GO:0048732 155 0.049
response to glucocorticoid GO:0051384 223 0.048
epithelium development GO:0060429 96 0.048
developmental process involved in reproduction GO:0003006 159 0.047
cellular modified amino acid metabolic process GO:0006575 61 0.047
cellular component movement GO:0006928 248 0.047
single organism biosynthetic process GO:0044711 342 0.046
regulation of signal transduction GO:0009966 318 0.046
brain development GO:0007420 247 0.045
cell morphogenesis GO:0000902 142 0.045
regulation of multicellular organismal development GO:2000026 376 0.044
positive regulation of phosphate metabolic process GO:0045937 262 0.044
multi organism reproductive process GO:0044703 262 0.044
response to corticosteroid GO:0031960 235 0.043
response to peptide hormone GO:0043434 278 0.043
cell migration GO:0016477 197 0.043
cellular component morphogenesis GO:0032989 155 0.043
positive regulation of response to stimulus GO:0048584 285 0.042
cell motility GO:0048870 202 0.042
protein phosphorylation GO:0006468 345 0.042
growth GO:0040007 165 0.042
protein complex subunit organization GO:0071822 302 0.042
cellular response to oxygen containing compound GO:1901701 386 0.042
macromolecular complex assembly GO:0065003 273 0.041
positive regulation of biosynthetic process GO:0009891 319 0.041
transmembrane transport GO:0055085 412 0.041
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.040
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.039
regulation of catalytic activity GO:0050790 304 0.039
response to peptide GO:1901652 292 0.038
neurological system process GO:0050877 219 0.038
organic substance catabolic process GO:1901575 316 0.038
response to toxic substance GO:0009636 133 0.038
alpha amino acid metabolic process GO:1901605 71 0.038
cellular response to lipid GO:0071396 201 0.038
actin filament based process GO:0030029 86 0.038
positive regulation of multicellular organismal process GO:0051240 387 0.037
cellular amine metabolic process GO:0044106 38 0.037
regulation of cellular amino acid metabolic process GO:0006521 2 0.037
regulation of protein phosphorylation GO:0001932 183 0.037
protein complex assembly GO:0006461 263 0.037
head development GO:0060322 247 0.036
amine metabolic process GO:0009308 38 0.035
regulation of cellular amine metabolic process GO:0033238 8 0.035
regulation of cell differentiation GO:0045595 320 0.035
regulation of cellular protein metabolic process GO:0032268 267 0.035
response to extracellular stimulus GO:0009991 380 0.035
response to metal ion GO:0010038 253 0.034
protein complex biogenesis GO:0070271 263 0.034
positive regulation of cell communication GO:0010647 271 0.034
regulation of membrane potential GO:0042391 110 0.034
neuron projection development GO:0031175 273 0.034
regulation of neurogenesis GO:0050767 247 0.034
response to nutrient levels GO:0031667 370 0.033
nucleic acid templated transcription GO:0097659 379 0.033
cellular lipid metabolic process GO:0044255 208 0.033
wound healing GO:0042060 122 0.033
macromolecular complex subunit organization GO:0043933 339 0.033
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
cell part morphogenesis GO:0032990 123 0.032
coenzyme metabolic process GO:0006732 86 0.032
anterior posterior pattern specification GO:0009952 1 0.032
regulation of rna biosynthetic process GO:2001141 381 0.032
regulation of phosphorylation GO:0042325 248 0.032
regulation of cellular ketone metabolic process GO:0010565 27 0.032
cellular ketone metabolic process GO:0042180 51 0.031
multicellular organism reproduction GO:0032504 233 0.031
cellular response to organic cyclic compound GO:0071407 202 0.031
response to growth factor GO:0070848 189 0.031
cation transmembrane transport GO:0098655 263 0.031
rna biosynthetic process GO:0032774 380 0.030
catabolic process GO:0009056 351 0.030
lipid metabolic process GO:0006629 283 0.030
positive regulation of cell proliferation GO:0008284 249 0.030
regulation of phosphorus metabolic process GO:0051174 349 0.030
metal ion transport GO:0030001 289 0.030
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.030
positive regulation of developmental process GO:0051094 283 0.030
response to nutrient GO:0007584 248 0.030
positive regulation of signal transduction GO:0009967 175 0.029
regulation of transcription dna templated GO:0006355 374 0.029
nucleobase containing small molecule metabolic process GO:0055086 316 0.029
regulation of protein metabolic process GO:0051246 289 0.029
cellular catabolic process GO:0044248 295 0.029
regulation of neuron differentiation GO:0045664 208 0.029
cofactor metabolic process GO:0051186 95 0.029
regulation of cell development GO:0060284 263 0.029
cellular response to growth factor stimulus GO:0071363 162 0.029
transcription dna templated GO:0006351 377 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.028
protein oligomerization GO:0051259 191 0.028
reproduction GO:0000003 245 0.028
single organism cell adhesion GO:0098602 46 0.028
secretion GO:0046903 307 0.028
action potential GO:0001508 54 0.028
regulation of nucleic acid templated transcription GO:1903506 380 0.028
positive regulation of phosphorylation GO:0042327 177 0.028
negative regulation of cell death GO:0060548 229 0.027
response to estrogen GO:0043627 232 0.027
response to estradiol GO:0032355 164 0.027
aging GO:0007568 241 0.027
central nervous system development GO:0007417 311 0.026
multicellular organismal reproductive process GO:0048609 233 0.026
positive regulation of signaling GO:0023056 270 0.026
rna metabolic process GO:0016070 406 0.026
regulation of nervous system development GO:0051960 264 0.026
positive regulation of molecular function GO:0044093 230 0.026
carbohydrate derivative metabolic process GO:1901135 346 0.026
single organism organelle organization GO:1902589 180 0.026
positive regulation of protein metabolic process GO:0051247 178 0.026
regulation of phosphate metabolic process GO:0019220 349 0.026
neuron projection morphogenesis GO:0048812 122 0.025
regulation of neuron projection development GO:0010975 161 0.025
multi multicellular organism process GO:0044706 138 0.025
cation transport GO:0006812 382 0.025
regulation of cell projection organization GO:0031344 175 0.025
cell cell signaling GO:0007267 335 0.025
response to oxygen levels GO:0070482 265 0.024
urogenital system development GO:0001655 78 0.024
response to oxidative stress GO:0006979 186 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.024
inorganic cation transmembrane transport GO:0098662 202 0.024
regulation of anatomical structure morphogenesis GO:0022603 141 0.024
regulation of cell motility GO:2000145 131 0.024
ion transmembrane transport GO:0034220 365 0.024
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
proteolysis GO:0006508 175 0.023
positive regulation of cellular amine metabolic process GO:0033240 3 0.023
single organism catabolic process GO:0044712 283 0.023
axon development GO:0061564 96 0.023
cellular response to hormone stimulus GO:0032870 247 0.023
cell morphogenesis involved in differentiation GO:0000904 119 0.023
organ morphogenesis GO:0009887 75 0.023
cell projection morphogenesis GO:0048858 123 0.023
axis specification GO:0009798 4 0.023
macromolecule localization GO:0033036 252 0.023
regulation of intracellular signal transduction GO:1902531 218 0.022
regulation of system process GO:0044057 208 0.022
negative regulation of cellular metabolic process GO:0031324 281 0.022
reproductive structure development GO:0048608 128 0.022
positive regulation of catalytic activity GO:0043085 184 0.022
organonitrogen compound biosynthetic process GO:1901566 167 0.022
regulation of cellular component movement GO:0051270 150 0.022
response to ethanol GO:0045471 162 0.022
single organismal cell cell adhesion GO:0016337 42 0.022
cell growth GO:0016049 104 0.022
homeostatic process GO:0042592 331 0.022
regulation of rna metabolic process GO:0051252 391 0.022
cellular chemical homeostasis GO:0055082 247 0.022
response to biotic stimulus GO:0009607 226 0.022
monovalent inorganic cation transport GO:0015672 172 0.021
female pregnancy GO:0007565 122 0.021
small gtpase mediated signal transduction GO:0007264 36 0.021
response to amino acid GO:0043200 75 0.021
positive regulation of rna metabolic process GO:0051254 203 0.021
negative regulation of cell communication GO:0010648 158 0.021
negative regulation of programmed cell death GO:0043069 183 0.021
chemical homeostasis GO:0048878 292 0.021
organophosphate metabolic process GO:0019637 370 0.021
regulation of protein modification process GO:0031399 194 0.021
cellular response to stress GO:0033554 269 0.020
oxidation reduction process GO:0055114 304 0.020
negative regulation of response to stimulus GO:0048585 155 0.020
cellular response to organonitrogen compound GO:0071417 197 0.020
hepaticobiliary system development GO:0061008 90 0.020
regulation of cell adhesion GO:0030155 52 0.020
sexual reproduction GO:0019953 148 0.020
regulation of hormone levels GO:0010817 187 0.020
negative regulation of apoptotic process GO:0043066 181 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.020
developmental growth GO:0048589 100 0.020
cytoskeleton organization GO:0007010 111 0.020
transmission of nerve impulse GO:0019226 42 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
response to hypoxia GO:0001666 231 0.020
cellular amide metabolic process GO:0043603 44 0.020
nitrogen compound transport GO:0071705 229 0.020
protein homooligomerization GO:0051260 91 0.020
regeneration GO:0031099 163 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.019
carboxylic acid biosynthetic process GO:0046394 83 0.019
ras protein signal transduction GO:0007265 29 0.019
neuronal action potential GO:0019228 35 0.019
ion homeostasis GO:0050801 212 0.019
negative regulation of cell proliferation GO:0008285 119 0.019
negative regulation of metabolic process GO:0009892 331 0.019
nucleotide metabolic process GO:0009117 279 0.019
positive regulation of nervous system development GO:0051962 178 0.019
signal transduction by phosphorylation GO:0023014 144 0.019
purine containing compound metabolic process GO:0072521 253 0.019
response to decreased oxygen levels GO:0036293 237 0.018
glycosyl compound metabolic process GO:1901657 182 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
cellular homeostasis GO:0019725 252 0.018
response to vitamin GO:0033273 131 0.018
positive regulation of intracellular signal transduction GO:1902533 138 0.018
organic cyclic compound catabolic process GO:1901361 175 0.018
male sex differentiation GO:0046661 64 0.018
protein localization GO:0008104 191 0.018
organic acid biosynthetic process GO:0016053 83 0.018
lipid biosynthetic process GO:0008610 128 0.018
rhythmic process GO:0048511 156 0.018
nucleoside metabolic process GO:0009116 179 0.017
positive regulation of protein modification process GO:0031401 142 0.017
positive regulation of apoptotic process GO:0043065 154 0.017
embryonic pattern specification GO:0009880 1 0.017
regulation of synaptic transmission GO:0050804 141 0.017
regulation of growth GO:0040008 105 0.017
purine ribonucleotide metabolic process GO:0009150 227 0.017
response to reactive oxygen species GO:0000302 120 0.017
mapk cascade GO:0000165 140 0.017
liver development GO:0001889 90 0.017
dendrite development GO:0016358 72 0.017
tube development GO:0035295 89 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.017
negative regulation of signaling GO:0023057 157 0.017
cation homeostasis GO:0055080 195 0.017
cardiac conduction GO:0061337 2 0.017
inorganic ion transmembrane transport GO:0098660 229 0.017
response to temperature stimulus GO:0009266 94 0.017
regulation of establishment of planar polarity GO:0090175 2 0.017
positive regulation of programmed cell death GO:0043068 157 0.017
response to cytokine GO:0034097 215 0.016
regulation of canonical wnt signaling pathway GO:0060828 4 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
multicellular organismal signaling GO:0035637 44 0.016
circulatory system process GO:0003013 183 0.016
cellular cation homeostasis GO:0030003 180 0.016
renal system development GO:0072001 67 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
positive regulation of cell motility GO:2000147 97 0.016
regulation of blood circulation GO:1903522 110 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.016
forebrain development GO:0030900 98 0.016
purine ribonucleoside metabolic process GO:0046128 168 0.016
gamete generation GO:0007276 124 0.016
response to other organism GO:0051707 220 0.016
organelle organization GO:0006996 266 0.016
synaptic growth at neuromuscular junction GO:0051124 1 0.015
metal ion homeostasis GO:0055065 186 0.015
establishment of protein localization GO:0045184 141 0.015
sex differentiation GO:0007548 113 0.015
cellular ion homeostasis GO:0006873 184 0.015
kidney development GO:0001822 67 0.015
regulation of hydrolase activity GO:0051336 143 0.015
synaptic transmission GO:0007268 235 0.015
response to molecule of bacterial origin GO:0002237 194 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
positive regulation of nucleic acid templated transcription GO:1903508 197 0.015
response to monosaccharide GO:0034284 159 0.015
response to carbohydrate GO:0009743 183 0.015
behavior GO:0007610 205 0.015
regulation of protein kinase activity GO:0045859 105 0.015
regulation of transferase activity GO:0051338 123 0.015
positive regulation of protein phosphorylation GO:0001934 135 0.015
negative regulation of molecular function GO:0044092 133 0.015
regulation of ion transport GO:0043269 245 0.015
regulation of secretion by cell GO:1903530 208 0.015
cellular response to oxidative stress GO:0034599 76 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
hormone metabolic process GO:0042445 69 0.015
cell communication involved in cardiac conduction GO:0086065 2 0.015
cell type specific apoptotic process GO:0097285 134 0.014
response to hydrogen peroxide GO:0042542 89 0.014
positive regulation of cell development GO:0010720 176 0.014
heterocycle catabolic process GO:0046700 167 0.014
positive regulation of mapk cascade GO:0043410 92 0.014
cell junction organization GO:0034330 21 0.014
response to glucose GO:0009749 136 0.014
potassium ion transport GO:0006813 97 0.014
positive regulation of cell migration GO:0030335 96 0.014
positive regulation of cell death GO:0010942 184 0.014
blood circulation GO:0008015 183 0.014
defense response GO:0006952 194 0.014
anatomical structure formation involved in morphogenesis GO:0048646 83 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
morphogenesis of a polarized epithelium GO:0001738 1 0.014
development of primary sexual characteristics GO:0045137 107 0.014
ribonucleoside catabolic process GO:0042454 126 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
response to external biotic stimulus GO:0043207 221 0.014
response to hexose GO:0009746 144 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
epithelial cell differentiation GO:0030855 71 0.014
positive regulation of gene expression GO:0010628 244 0.014
organ regeneration GO:0031100 101 0.014
response to insulin GO:0032868 133 0.013
regulation of kinase activity GO:0043549 117 0.013
regulation of catabolic process GO:0009894 113 0.013
cellular nitrogen compound catabolic process GO:0044270 163 0.013
response to radiation GO:0009314 137 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.013
thioester metabolic process GO:0035383 28 0.013
purine ribonucleoside catabolic process GO:0046130 124 0.013
response to retinoic acid GO:0032526 63 0.013
negative regulation of cellular biosynthetic process GO:0031327 161 0.013
response to alkaloid GO:0043279 132 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
aromatic compound catabolic process GO:0019439 168 0.013
response to bacterium GO:0009617 200 0.013
negative regulation of cell differentiation GO:0045596 99 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.013
protein transport GO:0015031 132 0.013
response to transition metal nanoparticle GO:1990267 122 0.013
regulation of cell migration GO:0030334 128 0.013
carbohydrate metabolic process GO:0005975 130 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
positive regulation of transcription dna templated GO:0045893 197 0.013
small molecule biosynthetic process GO:0044283 124 0.013
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.012
gastrulation GO:0007369 2 0.012
dephosphorylation GO:0016311 98 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
axonogenesis GO:0007409 71 0.012
embryonic axis specification GO:0000578 1 0.012
regulation of secretion GO:0051046 224 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
regulation of neuron death GO:1901214 115 0.012
intracellular transport GO:0046907 185 0.012
muscle structure development GO:0061061 87 0.012
cellular macromolecule localization GO:0070727 122 0.012
embryo development GO:0009790 49 0.012
immune system process GO:0002376 204 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
cardiovascular system development GO:0072358 134 0.012
spermatogenesis GO:0007283 99 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
amide transport GO:0042886 105 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.012
cellular protein localization GO:0034613 122 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
dna metabolic process GO:0006259 96 0.012
vesicle mediated transport GO:0016192 181 0.012
negative regulation of cellular protein metabolic process GO:0032269 106 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
regulation of locomotion GO:0040012 148 0.012
cellular response to reactive oxygen species GO:0034614 55 0.012
regulation of neuron apoptotic process GO:0043523 83 0.012
peptidyl amino acid modification GO:0018193 126 0.011
establishment of planar polarity GO:0001736 1 0.011
sulfur amino acid metabolic process GO:0000096 9 0.011
actin cytoskeleton organization GO:0030036 73 0.011
negative regulation of gene expression GO:0010629 199 0.011
transcription from rna polymerase ii promoter GO:0006366 252 0.011
cardiac chamber development GO:0003205 1 0.011
positive regulation of transport GO:0051050 245 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
sensory organ development GO:0007423 74 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
organic anion transport GO:0015711 132 0.011
nucleoside catabolic process GO:0009164 126 0.011
membrane organization GO:0061024 94 0.011
inner ear morphogenesis GO:0042472 1 0.011
inflammatory response GO:0006954 150 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
peptide metabolic process GO:0006518 32 0.011
bmp signaling pathway GO:0030509 4 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
cellular response to peptide hormone stimulus GO:0071375 120 0.011
cellular response to steroid hormone stimulus GO:0071383 93 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
male gamete generation GO:0048232 99 0.011
cell cycle checkpoint GO:0000075 2 0.011
chemosensory behavior GO:0007635 2 0.011
regulation of proteasomal protein catabolic process GO:0061136 4 0.011
nucleotide catabolic process GO:0009166 139 0.011
positive regulation of transferase activity GO:0051347 81 0.011
negative regulation of transcription dna templated GO:0045892 116 0.011
cellular response to glucocorticoid stimulus GO:0071385 68 0.011
rho protein signal transduction GO:0007266 11 0.011
positive regulation of locomotion GO:0040017 102 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
response to axon injury GO:0048678 59 0.011
myelination GO:0042552 39 0.011
vascular process in circulatory system GO:0003018 96 0.011
regulation of cellular localization GO:0060341 263 0.010
single organism cellular localization GO:1902580 102 0.010
peptidyl tyrosine modification GO:0018212 72 0.010
cellular response to peptide GO:1901653 133 0.010
calcium ion transport GO:0006816 131 0.010
regulation of anatomical structure size GO:0090066 135 0.010
regulation of cell growth GO:0001558 85 0.010
morphogenesis of embryonic epithelium GO:0016331 3 0.010
negative regulation of developmental process GO:0051093 125 0.010
negative regulation of biosynthetic process GO:0009890 168 0.010
negative regulation of neurogenesis GO:0050768 78 0.010
response to progesterone GO:0032570 48 0.010
response to testosterone GO:0033574 55 0.010
negative regulation of transport GO:0051051 136 0.010
gtp catabolic process GO:0006184 71 0.010

Perp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
cardiovascular system disease DOID:1287 0 0.016
central nervous system disease DOID:331 0 0.014
myopathy DOID:423 0 0.013
muscular disease DOID:0080000 0 0.013
musculoskeletal system disease DOID:17 0 0.013
muscle tissue disease DOID:66 0 0.013