Rattus norvegicus

36 known processes

Crem

cAMP responsive element modulator

(Aliases: Icer)

Crem biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carbohydrate derivative metabolic process GO:1901135 346 0.176
Mouse
response to temperature stimulus GO:0009266 94 0.170
response to extracellular stimulus GO:0009991 380 0.155
cellular amino acid metabolic process GO:0006520 107 0.118
carboxylic acid metabolic process GO:0019752 289 0.118
response to peptide GO:1901652 292 0.105
oxoacid metabolic process GO:0043436 290 0.088
purine containing compound metabolic process GO:0072521 253 0.087
organophosphate metabolic process GO:0019637 370 0.080
organic substance catabolic process GO:1901575 316 0.079
single organism catabolic process GO:0044712 283 0.075
response to molecule of bacterial origin GO:0002237 194 0.074
secretion GO:0046903 307 0.072
response to nutrient GO:0007584 248 0.071
catabolic process GO:0009056 351 0.070
nucleobase containing small molecule metabolic process GO:0055086 316 0.066
cellular response to oxygen containing compound GO:1901701 386 0.065
blood circulation GO:0008015 183 0.061
response to peptide hormone GO:0043434 278 0.059
single organism biosynthetic process GO:0044711 342 0.059
regulation of molecular function GO:0065009 398 0.056
negative regulation of programmed cell death GO:0043069 183 0.055
positive regulation of cellular component movement GO:0051272 102 0.054
ribonucleotide metabolic process GO:0009259 231 0.054
response to cytokine GO:0034097 215 0.052
cellular response to endogenous stimulus GO:0071495 377 0.050
Rat
purine nucleotide metabolic process GO:0006163 229 0.049
regulation of programmed cell death GO:0043067 341 0.049
Rat
response to estrogen GO:0043627 232 0.049
secretion by cell GO:0032940 248 0.048
regulation of cellular component organization GO:0051128 368 0.048
Rat
response to nutrient levels GO:0031667 370 0.047
chemical homeostasis GO:0048878 292 0.047
cellular lipid metabolic process GO:0044255 208 0.047
response to estradiol GO:0032355 164 0.046
hormone secretion GO:0046879 115 0.046
positive regulation of catalytic activity GO:0043085 184 0.046
signal release GO:0023061 145 0.046
regulation of secretion by cell GO:1903530 208 0.046
cellular amine metabolic process GO:0044106 38 0.044
positive regulation of phosphorus metabolic process GO:0010562 262 0.044
response to glucocorticoid GO:0051384 223 0.044
cellular catabolic process GO:0044248 295 0.044
nucleoside phosphate metabolic process GO:0006753 283 0.044
homeostatic process GO:0042592 331 0.043
ribose phosphate metabolic process GO:0019693 235 0.043
organic acid metabolic process GO:0006082 292 0.043
nucleotide metabolic process GO:0009117 279 0.043
regulation of hormone secretion GO:0046883 106 0.042
cellular modified amino acid metabolic process GO:0006575 61 0.042
cellular response to stress GO:0033554 269 0.042
g protein coupled receptor signaling pathway GO:0007186 242 0.042
purine ribonucleotide metabolic process GO:0009150 227 0.041
regulation of catalytic activity GO:0050790 304 0.041
response to corticosteroid GO:0031960 235 0.040
response to organophosphorus GO:0046683 102 0.040
Mouse
cellular chemical homeostasis GO:0055082 247 0.040
cellular ion homeostasis GO:0006873 184 0.039
alpha amino acid metabolic process GO:1901605 71 0.039
amine metabolic process GO:0009308 38 0.039
response to inorganic substance GO:0010035 377 0.039
Rat
programmed cell death GO:0012501 392 0.039
Rat
nucleoside metabolic process GO:0009116 179 0.038
regeneration GO:0031099 163 0.038
regulation of apoptotic process GO:0042981 335 0.038
Rat
regulation of secretion GO:0051046 224 0.037
regulation of phosphorus metabolic process GO:0051174 349 0.037
cell cell signaling GO:0007267 335 0.037
lipid metabolic process GO:0006629 283 0.036
regulation of nucleic acid templated transcription GO:1903506 380 0.035
Human Mouse Rat
positive regulation of multicellular organismal process GO:0051240 387 0.035
Rat
regulation of rna metabolic process GO:0051252 391 0.035
Human Mouse Rat
negative regulation of cellular metabolic process GO:0031324 281 0.034
Mouse
regulation of nucleotide metabolic process GO:0006140 117 0.034
single organism reproductive process GO:0044702 297 0.033
Mouse
nucleic acid templated transcription GO:0097659 379 0.033
Human Mouse Rat
cellular homeostasis GO:0019725 252 0.033
reproductive process GO:0022414 372 0.033
Mouse
nucleotide catabolic process GO:0009166 139 0.033
glycerolipid metabolic process GO:0046486 67 0.032
circulatory system process GO:0003013 183 0.032
aging GO:0007568 241 0.032
neuron development GO:0048666 286 0.031
Rat
negative regulation of cell death GO:0060548 229 0.031
cellular ketone metabolic process GO:0042180 51 0.031
multicellular organism reproduction GO:0032504 233 0.031
Mouse
regulation of cellular catabolic process GO:0031329 101 0.030
regulation of phosphate metabolic process GO:0019220 349 0.030
neurological system process GO:0050877 219 0.030
response to ketone GO:1901654 182 0.030
retina morphogenesis in camera type eye GO:0060042 1 0.030
response to heat GO:0009408 60 0.030
positive regulation of developmental process GO:0051094 283 0.030
Rat
organ regeneration GO:0031100 101 0.030
response to metal ion GO:0010038 253 0.030
Rat
regulation of intracellular signal transduction GO:1902531 218 0.029
regulation of rna biosynthetic process GO:2001141 381 0.029
Human Mouse Rat
nucleobase containing compound catabolic process GO:0034655 152 0.029
hormone transport GO:0009914 121 0.029
carbohydrate metabolic process GO:0005975 130 0.029
sulfur compound metabolic process GO:0006790 70 0.029
response to lipopolysaccharide GO:0032496 191 0.028
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.028
response to oxygen levels GO:0070482 265 0.028
signal transduction by phosphorylation GO:0023014 144 0.028
apoptotic process GO:0006915 381 0.028
Rat
organonitrogen compound biosynthetic process GO:1901566 167 0.027
regulation of catabolic process GO:0009894 113 0.027
cellular metal ion homeostasis GO:0006875 172 0.027
peptide secretion GO:0002790 86 0.027
transcription from rna polymerase ii promoter GO:0006366 252 0.027
Mouse Rat
purine ribonucleotide catabolic process GO:0009154 136 0.027
neuron death GO:0070997 127 0.026
glycosyl compound metabolic process GO:1901657 182 0.026
purine nucleoside metabolic process GO:0042278 169 0.026
negative regulation of macromolecule metabolic process GO:0010605 260 0.026
Mouse
intracellular signal transduction GO:0035556 314 0.026
negative regulation of signaling GO:0023057 157 0.026
carbohydrate derivative catabolic process GO:1901136 147 0.026
monocarboxylic acid metabolic process GO:0032787 152 0.026
regulation of nervous system development GO:0051960 264 0.026
Rat
peptide hormone secretion GO:0030072 84 0.026
female pregnancy GO:0007565 122 0.026
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.025
Mouse Rat
response to wounding GO:0009611 254 0.025
regulation of kinase activity GO:0043549 117 0.025
regulation of phosphorylation GO:0042325 248 0.025
positive regulation of cellular component organization GO:0051130 200 0.025
Rat
negative regulation of apoptotic process GO:0043066 181 0.024
monosaccharide metabolic process GO:0005996 61 0.024
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.024
response to radiation GO:0009314 137 0.023
heterocycle catabolic process GO:0046700 167 0.023
regulation of protein metabolic process GO:0051246 289 0.023
regulation of signal transduction GO:0009966 318 0.023
response to insulin GO:0032868 133 0.023
nitrogen compound transport GO:0071705 229 0.023
purine ribonucleoside metabolic process GO:0046128 168 0.023
behavior GO:0007610 205 0.023
response to cold GO:0009409 29 0.023
multicellular organism growth GO:0035264 1 0.022
cell migration GO:0016477 197 0.022
response to vitamin GO:0033273 131 0.022
negative regulation of metabolic process GO:0009892 331 0.022
Mouse
regulation of cellular amino acid metabolic process GO:0006521 2 0.022
regulation of system process GO:0044057 208 0.022
response to oxidative stress GO:0006979 186 0.022
coenzyme metabolic process GO:0006732 86 0.022
organonitrogen compound catabolic process GO:1901565 179 0.022
organic hydroxy compound metabolic process GO:1901615 115 0.022
regulation of cell differentiation GO:0045595 320 0.022
Rat
purine nucleotide catabolic process GO:0006195 136 0.022
regulation of peptide hormone secretion GO:0090276 80 0.022
regulation of peptide secretion GO:0002791 82 0.022
nucleoside phosphate catabolic process GO:1901292 140 0.021
multi organism reproductive process GO:0044703 262 0.021
Mouse
organophosphate catabolic process GO:0046434 148 0.021
regulation of anatomical structure size GO:0090066 135 0.021
protein complex biogenesis GO:0070271 263 0.021
Rat
regulation of cellular ketone metabolic process GO:0010565 27 0.021
regulation of insulin secretion GO:0050796 65 0.021
lipid biosynthetic process GO:0008610 128 0.021
cellular component biogenesis GO:0044085 368 0.021
Rat
eye morphogenesis GO:0048592 4 0.021
cellular component assembly GO:0022607 360 0.020
Rat
positive regulation of response to stimulus GO:0048584 285 0.020
rhythmic process GO:0048511 156 0.020
dephosphorylation GO:0016311 98 0.020
regulation of purine nucleotide metabolic process GO:1900542 115 0.020
ribonucleoside metabolic process GO:0009119 174 0.020
regulation of peptide transport GO:0090087 87 0.020
cellular cation homeostasis GO:0030003 180 0.020
negative regulation of cell communication GO:0010648 158 0.020
calcium ion homeostasis GO:0055074 162 0.020
response to biotic stimulus GO:0009607 226 0.019
macromolecular complex assembly GO:0065003 273 0.019
Rat
divalent inorganic cation homeostasis GO:0072507 165 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.019
Mouse Rat
cofactor metabolic process GO:0051186 95 0.019
negative regulation of signal transduction GO:0009968 83 0.019
regulation of hydrolase activity GO:0051336 143 0.019
positive regulation of secretion GO:0051047 140 0.019
regulation of multicellular organismal development GO:2000026 376 0.019
Rat
response to purine containing compound GO:0014074 126 0.019
Mouse
cell projection organization GO:0030030 302 0.019
Rat
regulation of cell development GO:0060284 263 0.019
Rat
cellular response to nitrogen compound GO:1901699 210 0.019
carbohydrate derivative biosynthetic process GO:1901137 124 0.019
membrane organization GO:0061024 94 0.019
response to external biotic stimulus GO:0043207 221 0.019
regulation of neuron projection development GO:0010975 161 0.018
Rat
regulation of cellular localization GO:0060341 263 0.018
vesicle mediated transport GO:0016192 181 0.018
protein phosphorylation GO:0006468 345 0.018
cellular calcium ion homeostasis GO:0006874 160 0.018
response to gamma radiation GO:0010332 24 0.018
response to monosaccharide GO:0034284 159 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.018
Mouse
positive regulation of cell differentiation GO:0045597 217 0.018
Rat
regulation of neurogenesis GO:0050767 247 0.018
Rat
multicellular organismal reproductive process GO:0048609 233 0.018
Mouse
immune system process GO:0002376 204 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.018
lipid storage GO:0019915 1 0.018
regulation of neuron death GO:1901214 115 0.018
positive regulation of phosphate metabolic process GO:0045937 262 0.018
ion homeostasis GO:0050801 212 0.018
positive regulation of nervous system development GO:0051962 178 0.018
Rat
cellular response to peptide GO:1901653 133 0.018
positive regulation of biosynthetic process GO:0009891 319 0.018
Mouse Rat
regulation of tube size GO:0035150 89 0.017
glucose metabolic process GO:0006006 52 0.017
jak stat cascade GO:0007259 26 0.017
positive regulation of neurogenesis GO:0050769 165 0.017
Rat
regulation of hormone levels GO:0010817 187 0.017
positive regulation of nucleotide metabolic process GO:0045981 91 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
insulin secretion GO:0030073 69 0.017
organic cyclic compound catabolic process GO:1901361 175 0.017
regulation of cell projection organization GO:0031344 175 0.017
Rat
locomotion GO:0040011 237 0.017
response to calcium ion GO:0051592 59 0.017
macromolecular complex subunit organization GO:0043933 339 0.017
Rat
positive regulation of neuron projection development GO:0010976 99 0.017
Rat
response to bacterium GO:0009617 200 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
neuron projection development GO:0031175 273 0.017
Rat
metal ion homeostasis GO:0055065 186 0.016
response to other organism GO:0051707 220 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
localization of cell GO:0051674 202 0.016
central nervous system development GO:0007417 311 0.016
pyruvate metabolic process GO:0006090 27 0.016
response to carbohydrate GO:0009743 183 0.016
regulation of mapk cascade GO:0043408 116 0.016
aromatic compound catabolic process GO:0019439 168 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
reproduction GO:0000003 245 0.016
Mouse
response to food GO:0032094 27 0.016
positive regulation of molecular function GO:0044093 230 0.016
tissue development GO:0009888 252 0.016
enzyme linked receptor protein signaling pathway GO:0007167 116 0.016
Rat
cellular response to insulin stimulus GO:0032869 81 0.016
regulation of homeostatic process GO:0032844 101 0.016
cellular divalent inorganic cation homeostasis GO:0072503 162 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
positive regulation of phosphorylation GO:0042327 177 0.015
t cell receptor signaling pathway GO:0050852 1 0.015
gtp metabolic process GO:0046039 72 0.015
response to hypoxia GO:0001666 231 0.015
cellular amino acid biosynthetic process GO:0008652 32 0.015
circadian rhythm GO:0007623 88 0.015
growth GO:0040007 165 0.015
protein complex subunit organization GO:0071822 302 0.015
Rat
circulatory system development GO:0072359 134 0.015
regulation of cellular protein metabolic process GO:0032268 267 0.015
response to hexose GO:0009746 144 0.015
sexual reproduction GO:0019953 148 0.015
Mouse
brain development GO:0007420 247 0.015
regulation of transferase activity GO:0051338 123 0.015
response to glucose GO:0009749 136 0.015
regulation of neuron differentiation GO:0045664 208 0.015
Rat
negative regulation of molecular function GO:0044092 133 0.015
neuron differentiation GO:0030182 368 0.015
Rat
gland development GO:0048732 155 0.015
vascular process in circulatory system GO:0003018 96 0.015
response to decreased oxygen levels GO:0036293 237 0.014
cellular component movement GO:0006928 248 0.014
camp metabolic process GO:0046058 63 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
oxidation reduction process GO:0055114 304 0.014
reactive oxygen species biosynthetic process GO:1903409 8 0.014
protein complex assembly GO:0006461 263 0.014
Rat
purine nucleoside triphosphate catabolic process GO:0009146 122 0.014
regulation of protein modification process GO:0031399 194 0.014
cardiovascular system development GO:0072358 134 0.014
cytokine mediated signaling pathway GO:0019221 43 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
Mouse Rat
cellular response to hormone stimulus GO:0032870 247 0.014
amide transport GO:0042886 105 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
Rat
carbohydrate homeostasis GO:0033500 75 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.014
metal ion transport GO:0030001 289 0.014
positive regulation of cell proliferation GO:0008284 249 0.014
hexose metabolic process GO:0019318 58 0.013
vasculature development GO:0001944 70 0.013
muscle structure development GO:0061061 87 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
camera type eye morphogenesis GO:0048593 2 0.013
transcription dna templated GO:0006351 377 0.013
Human Mouse Rat
cell part morphogenesis GO:0032990 123 0.013
regulation of protein kinase activity GO:0045859 105 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
Rat
cellular response to cytokine stimulus GO:0071345 127 0.013
positive regulation of cell communication GO:0010647 271 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.013
ribonucleotide catabolic process GO:0009261 136 0.013
inflammatory response GO:0006954 150 0.013
regulation of neuron apoptotic process GO:0043523 83 0.012
regulation of lipid metabolic process GO:0019216 68 0.012
positive regulation of locomotion GO:0040017 102 0.012
positive regulation of cellular biosynthetic process GO:0031328 295 0.012
Mouse Rat
positive regulation of catabolic process GO:0009896 78 0.012
macromolecule localization GO:0033036 252 0.012
response to acid chemical GO:0001101 222 0.012
regulation of fat cell differentiation GO:0045598 3 0.012
antigen receptor mediated signaling pathway GO:0050851 1 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
purine containing compound catabolic process GO:0072523 138 0.012
cellular response to alcohol GO:0097306 87 0.012
positive regulation of cell development GO:0010720 176 0.012
Rat
single organism carbohydrate metabolic process GO:0044723 118 0.012
regulation of lipid biosynthetic process GO:0046890 38 0.012
carbohydrate catabolic process GO:0016052 40 0.012
regulation of nucleotide catabolic process GO:0030811 65 0.012
negative regulation of neuron death GO:1901215 69 0.012
negative regulation of developmental process GO:0051093 125 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
cyclic nucleotide metabolic process GO:0009187 80 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
positive regulation of cell death GO:0010942 184 0.012
organelle organization GO:0006996 266 0.012
positive regulation of immune system process GO:0002684 90 0.012
phospholipid metabolic process GO:0006644 61 0.012
regulation of cell motility GO:2000145 131 0.012
response to starvation GO:0042594 59 0.012
cell motility GO:0048870 202 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
response to growth factor GO:0070848 189 0.012
Rat
sulfur compound biosynthetic process GO:0044272 19 0.012
glucose homeostasis GO:0042593 75 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
guanosine containing compound catabolic process GO:1901069 71 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
Rat
regulation of blood vessel size GO:0050880 89 0.011
spermatogenesis GO:0007283 99 0.011
Mouse
transmembrane transport GO:0055085 412 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
multi multicellular organism process GO:0044706 138 0.011
negative regulation of neuron apoptotic process GO:0043524 45 0.011
gtp catabolic process GO:0006184 71 0.011
positive regulation of transcription dna templated GO:0045893 197 0.011
Mouse Rat
gamete generation GO:0007276 124 0.011
Mouse
nucleoside triphosphate catabolic process GO:0009143 123 0.011
response to ionizing radiation GO:0010212 59 0.011
sensory organ development GO:0007423 74 0.011
cellular amide metabolic process GO:0043603 44 0.011
sensory perception GO:0007600 101 0.011
head development GO:0060322 247 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
positive regulation of secretion by cell GO:1903532 128 0.011
response to camp GO:0051591 91 0.011
Mouse
positive regulation of nucleoside metabolic process GO:0045979 55 0.011
synaptic transmission GO:0007268 235 0.011
response to amino acid GO:0043200 75 0.011
cellular carbohydrate metabolic process GO:0044262 72 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
Mouse
positive regulation of rna metabolic process GO:0051254 203 0.010
Mouse Rat
cellular response to external stimulus GO:0071496 118 0.010
photoperiodism GO:0009648 4 0.010
reactive oxygen species metabolic process GO:0072593 37 0.010
dna metabolic process GO:0006259 96 0.010
Rat
rna biosynthetic process GO:0032774 380 0.010
Human Mouse Rat
single organism organelle organization GO:1902589 180 0.010
glycerophospholipid metabolic process GO:0006650 47 0.010
ribonucleoside triphosphate catabolic process GO:0009203 122 0.010
protein oligomerization GO:0051259 191 0.010
defense response GO:0006952 194 0.010
cellular component morphogenesis GO:0032989 155 0.010
cellular response to lipid GO:0071396 201 0.010
regulation of cell proliferation GO:0042127 359 0.010
sleep GO:0030431 30 0.010
purine nucleoside catabolic process GO:0006152 124 0.010

Crem disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.043
inherited metabolic disorder DOID:655 0 0.043
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013