Rattus norvegicus

0 known processes

Tnks2

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

Tnks2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of transcription factor import into nucleus GO:0042993 4 0.175
protein targeting GO:0006605 61 0.159
vesicle mediated transport GO:0016192 181 0.159
intracellular transport GO:0046907 185 0.155
positive regulation of cell communication GO:0010647 271 0.148
Human
protein phosphorylation GO:0006468 345 0.134
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.133
cellular response to stress GO:0033554 269 0.126
protein import GO:0017038 37 0.126
regulation of rna biosynthetic process GO:2001141 381 0.124
regulation of programmed cell death GO:0043067 341 0.114
single organism cellular localization GO:1902580 102 0.109
apoptotic process GO:0006915 381 0.109
regulation of transcription dna templated GO:0006355 374 0.102
programmed cell death GO:0012501 392 0.101
regulation of intracellular signal transduction GO:1902531 218 0.098
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.097
intracellular signal transduction GO:0035556 314 0.081
regulation of protein metabolic process GO:0051246 289 0.081
positive regulation of rna biosynthetic process GO:1902680 197 0.081
regulation of protein import into nucleus GO:0042306 24 0.080
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.074
positive regulation of secretion GO:0051047 140 0.071
nucleic acid templated transcription GO:0097659 379 0.068
positive regulation of signaling GO:0023056 270 0.068
Human
cell projection organization GO:0030030 302 0.066
transcription from rna polymerase ii promoter GO:0006366 252 0.066
negative regulation of cell cycle phase transition GO:1901988 4 0.064
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.063
cellular macromolecule localization GO:0070727 122 0.060
Human
single organism intracellular transport GO:1902582 166 0.060
establishment of protein localization to organelle GO:0072594 44 0.059
rna biosynthetic process GO:0032774 380 0.058
protein targeting to nucleus GO:0044744 35 0.057
protein localization GO:0008104 191 0.057
Human
positive regulation of cell differentiation GO:0045597 217 0.057
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.056
positive regulation of cell development GO:0010720 176 0.056
protein localization to organelle GO:0033365 57 0.056
Human
neuron projection development GO:0031175 273 0.055
positive regulation of response to stimulus GO:0048584 285 0.055
Human
regulation of protein targeting GO:1903533 28 0.055
purine ribonucleotide metabolic process GO:0009150 227 0.055
cell cycle g1 s phase transition GO:0044843 13 0.054
single organism organelle organization GO:1902589 180 0.052
positive regulation of developmental process GO:0051094 283 0.052
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.052
positive regulation of nervous system development GO:0051962 178 0.051
cellular response to oxidative stress GO:0034599 76 0.050
rna metabolic process GO:0016070 406 0.049
response to tumor necrosis factor GO:0034612 56 0.049
intracellular protein transport GO:0006886 79 0.049
protein autophosphorylation GO:0046777 66 0.048
cellular protein localization GO:0034613 122 0.048
Human
regulation of apoptotic process GO:0042981 335 0.048
anterior posterior pattern specification GO:0009952 1 0.047
organophosphate catabolic process GO:0046434 148 0.047
response to peptide GO:1901652 292 0.046
response to growth factor GO:0070848 189 0.045
cellular response to growth factor stimulus GO:0071363 162 0.045
behavior GO:0007610 205 0.044
negative regulation of cellular biosynthetic process GO:0031327 161 0.044
regulation of cellular component organization GO:0051128 368 0.044
Fly
positive regulation of protein localization to nucleus GO:1900182 15 0.043
regulation of cellular amino acid metabolic process GO:0006521 2 0.043
establishment of protein localization GO:0045184 141 0.043
regulation of postsynaptic membrane potential GO:0060078 25 0.042
response to amine GO:0014075 46 0.042
negative regulation of cellular metabolic process GO:0031324 281 0.042
negative regulation of cell communication GO:0010648 158 0.042
negative regulation of transcription dna templated GO:0045892 116 0.042
positive regulation of cellular biosynthetic process GO:0031328 295 0.041
neurological system process GO:0050877 219 0.041
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.041
positive regulation of multicellular organismal process GO:0051240 387 0.040
catabolic process GO:0009056 351 0.039
negative regulation of metabolic process GO:0009892 331 0.038
carbohydrate derivative metabolic process GO:1901135 346 0.038
Human Fly
response to lipopolysaccharide GO:0032496 191 0.038
positive regulation of cellular component organization GO:0051130 200 0.038
negative regulation of protein metabolic process GO:0051248 114 0.037
positive regulation of phosphate metabolic process GO:0045937 262 0.036
dephosphorylation GO:0016311 98 0.036
response to oxidative stress GO:0006979 186 0.036
regulation of nucleic acid templated transcription GO:1903506 380 0.035
chromosome segregation GO:0007059 2 0.035
negative regulation of macromolecule metabolic process GO:0010605 260 0.035
memory GO:0007613 54 0.035
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.035
amine metabolic process GO:0009308 38 0.035
purine nucleotide metabolic process GO:0006163 229 0.034
positive regulation of intracellular signal transduction GO:1902533 138 0.034
mitotic cell cycle checkpoint GO:0007093 1 0.034
response to molecule of bacterial origin GO:0002237 194 0.034
protein localization to nucleus GO:0034504 39 0.034
negative regulation of signaling GO:0023057 157 0.034
regulation of cellular localization GO:0060341 263 0.034
multicellular organism growth GO:0035264 1 0.034
exocytosis GO:0006887 60 0.034
regulation of cell differentiation GO:0045595 320 0.033
positive regulation of neurogenesis GO:0050769 165 0.033
single organism behavior GO:0044708 130 0.033
anatomical structure morphogenesis GO:0009653 298 0.032
positive regulation of biosynthetic process GO:0009891 319 0.032
cellular amine metabolic process GO:0044106 38 0.032
response to cytokine GO:0034097 215 0.032
response to external biotic stimulus GO:0043207 221 0.032
cellular catabolic process GO:0044248 295 0.031
negative regulation of gene expression GO:0010629 199 0.031
cellular ketone metabolic process GO:0042180 51 0.031
transcription dna templated GO:0006351 377 0.031
dna integrity checkpoint GO:0031570 2 0.031
negative regulation of rna biosynthetic process GO:1902679 118 0.030
regulation of peptide transport GO:0090087 87 0.030
response to ammonium ion GO:0060359 71 0.030
nuclear import GO:0051170 35 0.030
carbohydrate derivative catabolic process GO:1901136 147 0.029
protein dephosphorylation GO:0006470 38 0.029
response to alkaloid GO:0043279 132 0.029
positive regulation of nucleic acid templated transcription GO:1903508 197 0.029
cellular component biogenesis GO:0044085 368 0.029
Fly
positive regulation of transport GO:0051050 245 0.028
regeneration GO:0031099 163 0.028
regulation of cellular ketone metabolic process GO:0010565 27 0.028
jak stat cascade GO:0007259 26 0.028
regulation of purine nucleotide metabolic process GO:1900542 115 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.027
macromolecular complex assembly GO:0065003 273 0.027
Fly
response to amphetamine GO:0001975 25 0.027
peptidyl tyrosine modification GO:0018212 72 0.027
cytoplasmic transport GO:0016482 115 0.027
negative regulation of nucleic acid templated transcription GO:1903507 117 0.027
positive regulation of transcription dna templated GO:0045893 197 0.027
single organism nuclear import GO:1902593 35 0.027
regulation of cell development GO:0060284 263 0.026
negative regulation of programmed cell death GO:0043069 183 0.026
regulation of nucleocytoplasmic transport GO:0046822 28 0.026
regulation of rna metabolic process GO:0051252 391 0.025
neuron development GO:0048666 286 0.025
immune system process GO:0002376 204 0.025
regulation of protein phosphorylation GO:0001932 183 0.025
cell cycle phase transition GO:0044770 21 0.025
mitotic dna damage checkpoint GO:0044773 1 0.025
cell cycle checkpoint GO:0000075 2 0.025
response to inorganic substance GO:0010035 377 0.025
negative regulation of apoptotic process GO:0043066 181 0.025
negative regulation of multicellular organismal process GO:0051241 203 0.025
multicellular organismal reproductive process GO:0048609 233 0.025
behavioral response to ethanol GO:0048149 1 0.024
positive regulation of rna metabolic process GO:0051254 203 0.024
peptidyl tyrosine phosphorylation GO:0018108 72 0.024
negative regulation of rna metabolic process GO:0051253 123 0.024
macromolecular complex subunit organization GO:0043933 339 0.024
Fly
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.024
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
ras protein signal transduction GO:0007265 29 0.024
regulation of membrane potential GO:0042391 110 0.023
calcium ion dependent exocytosis GO:0017156 16 0.023
positive regulation of cytoplasmic transport GO:1903651 32 0.023
regulation of neurogenesis GO:0050767 247 0.023
organic acid metabolic process GO:0006082 292 0.023
regulation of signal transduction GO:0009966 318 0.022
Human
regulation of catalytic activity GO:0050790 304 0.022
response to other organism GO:0051707 220 0.022
negative regulation of cell death GO:0060548 229 0.022
glycosyl compound catabolic process GO:1901658 126 0.022
negative regulation of nervous system development GO:0051961 79 0.022
reproduction GO:0000003 245 0.022
muscle system process GO:0003012 115 0.022
nucleoside catabolic process GO:0009164 126 0.022
regulation of phosphorus metabolic process GO:0051174 349 0.021
single organism biosynthetic process GO:0044711 342 0.021
central nervous system development GO:0007417 311 0.021
regulation of nervous system development GO:0051960 264 0.021
small gtpase mediated signal transduction GO:0007264 36 0.021
nucleoside triphosphate catabolic process GO:0009143 123 0.021
regulation of cellular amine metabolic process GO:0033238 8 0.021
mitotic cell cycle phase transition GO:0044772 20 0.021
regulation of nucleotide metabolic process GO:0006140 117 0.021
protein import into nucleus GO:0006606 35 0.021
response to increased oxygen levels GO:0036296 45 0.020
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.020
regulation of neuron differentiation GO:0045664 208 0.020
response to oxygen levels GO:0070482 265 0.020
response to cocaine GO:0042220 39 0.020
regulation of cytokine production GO:0001817 56 0.020
negative regulation of secretion GO:0051048 82 0.020
secretion GO:0046903 307 0.020
nucleotide metabolic process GO:0009117 279 0.019
organelle organization GO:0006996 266 0.019
protein transport GO:0015031 132 0.019
positive regulation of phosphorylation GO:0042327 177 0.019
cell cell signaling GO:0007267 335 0.019
developmental growth GO:0048589 100 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.019
single organism catabolic process GO:0044712 283 0.019
cognition GO:0050890 92 0.018
g protein coupled receptor signaling pathway GO:0007186 242 0.018
metal ion transport GO:0030001 289 0.018
organic substance catabolic process GO:1901575 316 0.018
cellular response to oxygen containing compound GO:1901701 386 0.018
positive regulation of protein transport GO:0051222 41 0.018
aromatic compound catabolic process GO:0019439 168 0.017
regulation of cell projection organization GO:0031344 175 0.017
cellular response to endogenous stimulus GO:0071495 377 0.017
cation transport GO:0006812 382 0.017
sister chromatid segregation GO:0000819 1 0.017
secretion by cell GO:0032940 248 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
regulation of nucleoside metabolic process GO:0009118 66 0.017
positive regulation of secretion by cell GO:1903532 128 0.017
positive regulation of protein metabolic process GO:0051247 178 0.017
learning or memory GO:0007611 90 0.017
nucleotide catabolic process GO:0009166 139 0.017
regulation of growth GO:0040008 105 0.016
regulation of canonical wnt signaling pathway GO:0060828 4 0.016
Human
purine containing compound catabolic process GO:0072523 138 0.016
negative regulation of cellular protein metabolic process GO:0032269 106 0.016
peptidyl amino acid modification GO:0018193 126 0.016
multi organism reproductive process GO:0044703 262 0.016
regulation of catabolic process GO:0009894 113 0.016
positive regulation of neuron projection development GO:0010976 99 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
axis specification GO:0009798 4 0.016
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
response to bacterium GO:0009617 200 0.015
response to acid chemical GO:0001101 222 0.015
organophosphate metabolic process GO:0019637 370 0.015
purine ribonucleotide catabolic process GO:0009154 136 0.015
regulation of protein modification process GO:0031399 194 0.015
positive regulation of gene expression GO:0010628 244 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
reproductive structure development GO:0048608 128 0.015
regulation of cellular component movement GO:0051270 150 0.015
growth GO:0040007 165 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.015
homeostatic process GO:0042592 331 0.015
second messenger mediated signaling GO:0019932 51 0.014
muscle organ development GO:0007517 50 0.014
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.014
neuron differentiation GO:0030182 368 0.014
peptide transport GO:0015833 97 0.014
positive regulation of catalytic activity GO:0043085 184 0.014
response to hydrogen peroxide GO:0042542 89 0.014
regulation of molecular function GO:0065009 398 0.014
positive regulation of peptide hormone secretion GO:0090277 50 0.014
g1 s transition of mitotic cell cycle GO:0000082 12 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
response to interleukin 15 GO:0070672 4 0.014
nucleoside phosphate catabolic process GO:1901292 140 0.014
ion homeostasis GO:0050801 212 0.014
regulation of neuron projection development GO:0010975 161 0.014
regulation of cell growth GO:0001558 85 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.014
response to reactive oxygen species GO:0000302 120 0.013
response to ethanol GO:0045471 162 0.013
response to toxic substance GO:0009636 133 0.013
divalent metal ion transport GO:0070838 132 0.013
defense response GO:0006952 194 0.013
reproductive process GO:0022414 372 0.013
gliogenesis GO:0042063 93 0.013
embryonic pattern specification GO:0009880 1 0.013
regulation of anatomical structure morphogenesis GO:0022603 141 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
regulation of multicellular organismal development GO:2000026 376 0.013
heterocycle catabolic process GO:0046700 167 0.013
response to glucose GO:0009749 136 0.013
dendrite development GO:0016358 72 0.013
i kappab kinase nf kappab signaling GO:0007249 19 0.013
purine containing compound metabolic process GO:0072521 253 0.013
nucleoside monophosphate metabolic process GO:0009123 93 0.013
positive regulation of peptide secretion GO:0002793 52 0.013
cell cycle process GO:0022402 57 0.013
ribonucleoside triphosphate catabolic process GO:0009203 122 0.012
cellular amino acid metabolic process GO:0006520 107 0.012
regulation of protein localization to nucleus GO:1900180 25 0.012
regulation of transcription factor import into nucleus GO:0042990 11 0.012
regulation of phosphorylation GO:0042325 248 0.012
carboxylic acid metabolic process GO:0019752 289 0.012
positive regulation of signal transduction GO:0009967 175 0.012
Human
proteolysis GO:0006508 175 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.012
response to peptide hormone GO:0043434 278 0.012
cellular ion homeostasis GO:0006873 184 0.012
vascular process in circulatory system GO:0003018 96 0.012
regulation of intracellular transport GO:0032386 65 0.012
positive regulation of intracellular transport GO:0032388 39 0.012
cellular response to nitrogen compound GO:1901699 210 0.012
positive regulation of protein import into nucleus GO:0042307 14 0.012
negative regulation of transport GO:0051051 136 0.012
single organism carbohydrate metabolic process GO:0044723 118 0.012
Human Fly
cellular response to hexose stimulus GO:0071331 65 0.012
nitrogen compound transport GO:0071705 229 0.012
negative regulation of cellular component organization GO:0051129 83 0.011
response to biotic stimulus GO:0009607 226 0.011
positive regulation of locomotion GO:0040017 102 0.011
regulation of cell cycle g1 s phase transition GO:1902806 7 0.011
peptide secretion GO:0002790 86 0.011
tissue development GO:0009888 252 0.011
response to radiation GO:0009314 137 0.011
response to cgmp GO:0070305 3 0.011
regulation of locomotion GO:0040012 148 0.011
positive regulation of molecular function GO:0044093 230 0.011
negative regulation of dendrite development GO:2000171 9 0.011
mitotic spindle organization GO:0007052 2 0.011
regulation of phosphate metabolic process GO:0019220 349 0.011
response to uv GO:0009411 8 0.011
muscle structure development GO:0061061 87 0.011
regulation of cell proliferation GO:0042127 359 0.011
macromolecule localization GO:0033036 252 0.011
Human
ribonucleoside metabolic process GO:0009119 174 0.011
golgi vesicle transport GO:0048193 22 0.011
antigen processing and presentation GO:0019882 2 0.011
amide transport GO:0042886 105 0.011
purine nucleoside triphosphate catabolic process GO:0009146 122 0.011
positive regulation of rap gtpase activity GO:0032854 4 0.011
response to extracellular stimulus GO:0009991 380 0.011
response to carbohydrate GO:0009743 183 0.011
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 1 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
ribonucleoside triphosphate metabolic process GO:0009199 141 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.011
negative regulation of cell proliferation GO:0008285 119 0.011
regulation of cellular component biogenesis GO:0044087 86 0.011
Fly
cellular divalent inorganic cation homeostasis GO:0072503 162 0.010
organic cyclic compound catabolic process GO:1901361 175 0.010
dna metabolic process GO:0006259 96 0.010
positive regulation of catabolic process GO:0009896 78 0.010
positive regulation of nucleocytoplasmic transport GO:0046824 17 0.010
rho protein signal transduction GO:0007266 11 0.010
positive regulation of cell migration GO:0030335 96 0.010
oxoacid metabolic process GO:0043436 290 0.010
embryonic axis specification GO:0000578 1 0.010
regulation of secretion by cell GO:1903530 208 0.010

Tnks2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.068
brain disease DOID:936 0 0.068
disease of anatomical entity DOID:7 0 0.068
nervous system disease DOID:863 0 0.068
cerebral degeneration DOID:1443 0 0.020
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.015
eye disease DOID:5614 0 0.015
musculoskeletal system disease DOID:17 0 0.011