Rattus norvegicus

95 known processes

Sema4f

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F

Sema4f biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of nucleotide biosynthetic process GO:0030808 47 0.141
regulation of multicellular organismal development GO:2000026 376 0.128
positive regulation of phosphorus metabolic process GO:0010562 262 0.108
cyclic nucleotide biosynthetic process GO:0009190 63 0.102
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.099
cyclic purine nucleotide metabolic process GO:0052652 62 0.097
positive regulation of cellular biosynthetic process GO:0031328 295 0.079
ion transmembrane transport GO:0034220 365 0.074
cyclic nucleotide metabolic process GO:0009187 80 0.071
organonitrogen compound biosynthetic process GO:1901566 167 0.070
protein localization GO:0008104 191 0.069
response to extracellular stimulus GO:0009991 380 0.068
regulation of phosphorus metabolic process GO:0051174 349 0.067
nucleotide metabolic process GO:0009117 279 0.067
intracellular signal transduction GO:0035556 314 0.065
cation transport GO:0006812 382 0.063
regulation of nucleotide metabolic process GO:0006140 117 0.063
nucleobase containing small molecule metabolic process GO:0055086 316 0.060
positive regulation of response to stimulus GO:0048584 285 0.057
positive regulation of biosynthetic process GO:0009891 319 0.057
purine containing compound biosynthetic process GO:0072522 85 0.055
nucleoside phosphate biosynthetic process GO:1901293 102 0.054
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.053
regulation of phosphate metabolic process GO:0019220 349 0.051
nucleoside phosphate metabolic process GO:0006753 283 0.050
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.048
secretion GO:0046903 307 0.047
positive regulation of phosphate metabolic process GO:0045937 262 0.047
ribose phosphate biosynthetic process GO:0046390 87 0.046
cellular ketone metabolic process GO:0042180 51 0.043
camp metabolic process GO:0046058 63 0.043
purine containing compound metabolic process GO:0072521 253 0.043
reproduction GO:0000003 245 0.043
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.041
purine ribonucleotide metabolic process GO:0009150 227 0.041
purine nucleotide biosynthetic process GO:0006164 83 0.040
negative regulation of multicellular organismal process GO:0051241 203 0.040
synaptic transmission GO:0007268 235 0.040
ribonucleotide biosynthetic process GO:0009260 85 0.039
regulation of cellular amine metabolic process GO:0033238 8 0.038
ion homeostasis GO:0050801 212 0.038
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.038
organic acid metabolic process GO:0006082 292 0.038
regulation of cellular amino acid metabolic process GO:0006521 2 0.037
response to nutrient levels GO:0031667 370 0.037
nitrogen compound transport GO:0071705 229 0.037
protein phosphorylation GO:0006468 345 0.037
carbohydrate derivative biosynthetic process GO:1901137 124 0.037
single organism behavior GO:0044708 130 0.036
positive regulation of cell differentiation GO:0045597 217 0.036
brain development GO:0007420 247 0.036
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.036
positive regulation of nucleotide metabolic process GO:0045981 91 0.036
amine metabolic process GO:0009308 38 0.035
positive regulation of nucleic acid templated transcription GO:1903508 197 0.034
regulation of cell differentiation GO:0045595 320 0.034
positive regulation of neurogenesis GO:0050769 165 0.033
regulation of membrane potential GO:0042391 110 0.033
ribose phosphate metabolic process GO:0019693 235 0.032
negative regulation of response to stimulus GO:0048585 155 0.032
nucleotide biosynthetic process GO:0009165 98 0.032
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.031
purine nucleotide metabolic process GO:0006163 229 0.031
multicellular organismal signaling GO:0035637 44 0.031
positive regulation of developmental process GO:0051094 283 0.031
response to peptide GO:1901652 292 0.030
positive regulation of phosphorylation GO:0042327 177 0.030
purine ribonucleotide biosynthetic process GO:0009152 81 0.030
regulation of transcription dna templated GO:0006355 374 0.030
multicellular organismal reproductive process GO:0048609 233 0.030
regulation of secretion by cell GO:1903530 208 0.029
camp biosynthetic process GO:0006171 47 0.029
transmission of nerve impulse GO:0019226 42 0.028
behavior GO:0007610 205 0.028
response to growth factor GO:0070848 189 0.027
regulation of cellular ketone metabolic process GO:0010565 27 0.027
nucleic acid templated transcription GO:0097659 379 0.027
sodium ion transport GO:0006814 82 0.027
cellular amine metabolic process GO:0044106 38 0.027
sodium ion transmembrane transport GO:0035725 67 0.027
cellular response to stress GO:0033554 269 0.027
single organism reproductive process GO:0044702 297 0.027
positive regulation of gene expression GO:0010628 244 0.026
metal ion homeostasis GO:0055065 186 0.026
response to radiation GO:0009314 137 0.026
multi organism reproductive process GO:0044703 262 0.026
adult locomotory behavior GO:0008344 4 0.026
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.026
cellular response to hormone stimulus GO:0032870 247 0.026
transmembrane transport GO:0055085 412 0.026
action potential GO:0001508 54 0.025
homeostatic process GO:0042592 331 0.025
negative regulation of biosynthetic process GO:0009890 168 0.025
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.025
transcription dna templated GO:0006351 377 0.025
regulation of catalytic activity GO:0050790 304 0.025
circadian rhythm GO:0007623 88 0.025
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
regulation of cell development GO:0060284 263 0.024
positive regulation of multicellular organismal process GO:0051240 387 0.024
positive regulation of cell proliferation GO:0008284 249 0.024
cellular ion homeostasis GO:0006873 184 0.024
organophosphate metabolic process GO:0019637 370 0.024
multicellular organism reproduction GO:0032504 233 0.024
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.024
gliogenesis GO:0042063 93 0.023
regulation of nervous system development GO:0051960 264 0.023
negative regulation of transport GO:0051051 136 0.023
cellular response to cytokine stimulus GO:0071345 127 0.023
response to ethanol GO:0045471 162 0.023
positive regulation of transcription dna templated GO:0045893 197 0.023
regulation of synaptic transmission GO:0050804 141 0.022
cation transmembrane transport GO:0098655 263 0.022
cellular amino acid metabolic process GO:0006520 107 0.022
positive regulation of molecular function GO:0044093 230 0.022
single organism biosynthetic process GO:0044711 342 0.022
neurological system process GO:0050877 219 0.022
cellular response to endogenous stimulus GO:0071495 377 0.022
rhythmic process GO:0048511 156 0.022
organelle organization GO:0006996 266 0.022
ribonucleotide metabolic process GO:0009259 231 0.022
regulation of molecular function GO:0065009 398 0.022
cellular response to peptide GO:1901653 133 0.022
response to lipopolysaccharide GO:0032496 191 0.022
positive regulation of nervous system development GO:0051962 178 0.022
g protein coupled receptor signaling pathway GO:0007186 242 0.022
carbohydrate derivative metabolic process GO:1901135 346 0.021
regulation of neurogenesis GO:0050767 247 0.021
regulation of nucleic acid templated transcription GO:1903506 380 0.021
inorganic ion transmembrane transport GO:0098660 229 0.021
cellular response to oxygen containing compound GO:1901701 386 0.021
regulation of phosphorylation GO:0042325 248 0.021
macromolecule localization GO:0033036 252 0.021
response to cytokine GO:0034097 215 0.020
negative regulation of cell communication GO:0010648 158 0.020
enzyme linked receptor protein signaling pathway GO:0007167 116 0.020
circulatory system process GO:0003013 183 0.020
positive regulation of intracellular signal transduction GO:1902533 138 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
rna biosynthetic process GO:0032774 380 0.020
cellular catabolic process GO:0044248 295 0.020
epithelium development GO:0060429 96 0.020
membrane organization GO:0061024 94 0.020
regulation of cell proliferation GO:0042127 359 0.019
single organism organelle organization GO:1902589 180 0.019
response to peptide hormone GO:0043434 278 0.019
cellular response to external stimulus GO:0071496 118 0.019
oxoacid metabolic process GO:0043436 290 0.019
second messenger mediated signaling GO:0019932 51 0.019
regulation of rna metabolic process GO:0051252 391 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
locomotion GO:0040011 237 0.019
response to oxidative stress GO:0006979 186 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
regulation of protein modification process GO:0031399 194 0.018
glycosyl compound metabolic process GO:1901657 182 0.018
regulation of signal transduction GO:0009966 318 0.018
head development GO:0060322 247 0.018
aging GO:0007568 241 0.018
regulation of camp biosynthetic process GO:0030817 38 0.018
positive regulation of neuron differentiation GO:0045666 126 0.018
secretion by cell GO:0032940 248 0.018
cellular divalent inorganic cation homeostasis GO:0072503 162 0.018
metal ion transport GO:0030001 289 0.018
single organism membrane organization GO:0044802 74 0.018
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.017
cellular lipid metabolic process GO:0044255 208 0.017
regulation of cellular localization GO:0060341 263 0.017
rna metabolic process GO:0016070 406 0.017
response to decreased oxygen levels GO:0036293 237 0.017
regulation of camp metabolic process GO:0030814 43 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
response to inorganic substance GO:0010035 377 0.017
reproductive process GO:0022414 372 0.017
response to acid chemical GO:0001101 222 0.017
spindle organization GO:0007051 2 0.016
regulation of apoptotic process GO:0042981 335 0.016
regulation of cell projection organization GO:0031344 175 0.016
positive regulation of camp biosynthetic process GO:0030819 28 0.016
response to other organism GO:0051707 220 0.016
developmental process involved in reproduction GO:0003006 159 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
behavioral response to cocaine GO:0048148 6 0.015
inorganic cation transmembrane transport GO:0098662 202 0.015
carboxylic acid metabolic process GO:0019752 289 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.015
embryonic pattern specification GO:0009880 1 0.015
gamete generation GO:0007276 124 0.015
single organism cellular localization GO:1902580 102 0.015
organophosphate biosynthetic process GO:0090407 143 0.015
chemical homeostasis GO:0048878 292 0.015
neuron development GO:0048666 286 0.015
response to molecule of bacterial origin GO:0002237 194 0.015
regulation of purine nucleotide metabolic process GO:1900542 115 0.015
cell projection organization GO:0030030 302 0.015
axon development GO:0061564 96 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
regulation of rna biosynthetic process GO:2001141 381 0.014
regulation of ion transport GO:0043269 245 0.014
positive regulation of signaling GO:0023056 270 0.014
negative regulation of cellular biosynthetic process GO:0031327 161 0.014
regulation of peptide transport GO:0090087 87 0.014
ras protein signal transduction GO:0007265 29 0.014
negative regulation of macromolecule metabolic process GO:0010605 260 0.014
sexual reproduction GO:0019953 148 0.014
cell cell signaling GO:0007267 335 0.014
cognition GO:0050890 92 0.014
learning GO:0007612 33 0.014
cellular response to oxygen levels GO:0071453 60 0.014
cellular homeostasis GO:0019725 252 0.014
signal transduction by phosphorylation GO:0023014 144 0.014
regulation of secretion GO:0051046 224 0.013
synaptic vesicle endocytosis GO:0048488 4 0.013
cytoskeleton organization GO:0007010 111 0.013
axis specification GO:0009798 4 0.013
cellular response to steroid hormone stimulus GO:0071383 93 0.013
regulation of blood pressure GO:0008217 83 0.013
response to biotic stimulus GO:0009607 226 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
regulation of cellular component organization GO:0051128 368 0.013
cellular response to peptide hormone stimulus GO:0071375 120 0.013
negative regulation of cellular component organization GO:0051129 83 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
maintenance of location GO:0051235 17 0.013
establishment of protein localization GO:0045184 141 0.013
regulation of body fluid levels GO:0050878 90 0.013
positive regulation of transport GO:0051050 245 0.013
cardiovascular system development GO:0072358 134 0.013
macromolecular complex subunit organization GO:0043933 339 0.013
response to nutrient GO:0007584 248 0.013
learning or memory GO:0007611 90 0.012
programmed cell death GO:0012501 392 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
neuron projection morphogenesis GO:0048812 122 0.012
synaptic growth at neuromuscular junction GO:0051124 1 0.012
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.012
central nervous system development GO:0007417 311 0.012
anterior posterior pattern specification GO:0009952 1 0.012
muscle structure development GO:0061061 87 0.012
forebrain development GO:0030900 98 0.012
negative regulation of cell death GO:0060548 229 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.012
cellular protein localization GO:0034613 122 0.011
positive regulation of synaptic transmission GO:0050806 62 0.011
axon cargo transport GO:0008088 1 0.011
defense response GO:0006952 194 0.011
cell morphogenesis GO:0000902 142 0.011
vesicle mediated transport GO:0016192 181 0.011
ensheathment of neurons GO:0007272 40 0.011
divalent inorganic cation homeostasis GO:0072507 165 0.011
transcription from rna polymerase ii promoter GO:0006366 252 0.011
establishment of vesicle localization GO:0051650 31 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
oxidation reduction process GO:0055114 304 0.011
lipid metabolic process GO:0006629 283 0.011
regulation of protein metabolic process GO:0051246 289 0.011
male gamete generation GO:0048232 99 0.011
regeneration GO:0031099 163 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
response to insulin GO:0032868 133 0.011
calcium mediated signaling GO:0019722 23 0.011
positive regulation of protein modification process GO:0031401 142 0.011
potassium ion homeostasis GO:0055075 2 0.011
neuronal action potential GO:0019228 35 0.011
endoplasmic reticulum organization GO:0007029 1 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
glial cell differentiation GO:0010001 65 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
cellular component assembly GO:0022607 360 0.010
embryonic axis specification GO:0000578 1 0.010
catabolic process GO:0009056 351 0.010
exocytosis GO:0006887 60 0.010
response to transforming growth factor beta GO:0071559 46 0.010
positive regulation of cell death GO:0010942 184 0.010
response to ketone GO:1901654 182 0.010
organic substance catabolic process GO:1901575 316 0.010
response to vitamin GO:0033273 131 0.010
cellular component biogenesis GO:0044085 368 0.010
response to hexose GO:0009746 144 0.010
positive regulation of apoptotic process GO:0043065 154 0.010
cation homeostasis GO:0055080 195 0.010
regulation of response to stress GO:0080134 126 0.010

Sema4f disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.070
urinary system disease DOID:18 0 0.070
kidney disease DOID:557 0 0.025
nervous system disease DOID:863 0 0.015
central nervous system disease DOID:331 0 0.013