Rattus norvegicus

192 known processes

Hap1

huntingtin-associated protein 1

(Aliases: HAP1-A,HAP1-B)

Hap1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organophosphate metabolic process GO:0019637 370 0.373
regulation of phosphorus metabolic process GO:0051174 349 0.190
regulation of cellular component organization GO:0051128 368 0.185
regulation of nucleic acid templated transcription GO:1903506 380 0.162
organelle organization GO:0006996 266 0.142
regulation of system process GO:0044057 208 0.136
organic acid metabolic process GO:0006082 292 0.131
regulation of rna metabolic process GO:0051252 391 0.128
nucleic acid templated transcription GO:0097659 379 0.122
regulation of molecular function GO:0065009 398 0.105
nucleobase containing small molecule metabolic process GO:0055086 316 0.102
cell projection organization GO:0030030 302 0.090
transcription dna templated GO:0006351 377 0.089
nucleotide metabolic process GO:0009117 279 0.085
cation transport GO:0006812 382 0.085
neuron projection morphogenesis GO:0048812 122 0.081
cellular response to endogenous stimulus GO:0071495 377 0.081
response to nicotine GO:0035094 51 0.079
response to inorganic substance GO:0010035 377 0.078
anatomical structure morphogenesis GO:0009653 298 0.078
rna metabolic process GO:0016070 406 0.075
response to camp GO:0051591 91 0.071
multi organism reproductive process GO:0044703 262 0.071
defense response GO:0006952 194 0.070
carboxylic acid metabolic process GO:0019752 289 0.068
regulation of hormone levels GO:0010817 187 0.067
response to insulin GO:0032868 133 0.067
regulation of transcription dna templated GO:0006355 374 0.065
cell projection morphogenesis GO:0048858 123 0.064
inorganic cation transmembrane transport GO:0098662 202 0.064
regulation of phosphate metabolic process GO:0019220 349 0.064
rna biosynthetic process GO:0032774 380 0.064
axon development GO:0061564 96 0.063
enzyme linked receptor protein signaling pathway GO:0007167 116 0.063
purine nucleotide metabolic process GO:0006163 229 0.061
response to metal ion GO:0010038 253 0.061
purine containing compound metabolic process GO:0072521 253 0.059
nucleoside phosphate metabolic process GO:0006753 283 0.059
peptide secretion GO:0002790 86 0.056
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.056
brain development GO:0007420 247 0.056
cellular catabolic process GO:0044248 295 0.055
positive regulation of phosphorus metabolic process GO:0010562 262 0.054
organonitrogen compound biosynthetic process GO:1901566 167 0.054
oxoacid metabolic process GO:0043436 290 0.054
cellular component biogenesis GO:0044085 368 0.054
positive regulation of rna metabolic process GO:0051254 203 0.053
secretion GO:0046903 307 0.053
vesicle mediated transport GO:0016192 181 0.051
neuron projection development GO:0031175 273 0.051
ribonucleotide metabolic process GO:0009259 231 0.051
ribose phosphate metabolic process GO:0019693 235 0.050
reproductive process GO:0022414 372 0.049
anterior posterior pattern specification GO:0009952 1 0.048
single organism biosynthetic process GO:0044711 342 0.047
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.047
nucleoside phosphate biosynthetic process GO:1901293 102 0.047
regulation of rna biosynthetic process GO:2001141 381 0.047
single organism catabolic process GO:0044712 283 0.046
rhythmic synaptic transmission GO:0060024 1 0.046
purine containing compound biosynthetic process GO:0072522 85 0.045
organic substance catabolic process GO:1901575 316 0.045
response to decreased oxygen levels GO:0036293 237 0.044
single organism reproductive process GO:0044702 297 0.044
cation transmembrane transport GO:0098655 263 0.043
reproduction GO:0000003 245 0.043
transcription from rna polymerase ii promoter GO:0006366 252 0.042
monocarboxylic acid metabolic process GO:0032787 152 0.042
response to hypoxia GO:0001666 231 0.042
negative regulation of cellular biosynthetic process GO:0031327 161 0.042
negative regulation of biosynthetic process GO:0009890 168 0.042
central nervous system development GO:0007417 311 0.042
response to peptide GO:1901652 292 0.041
cellular component assembly GO:0022607 360 0.041
positive regulation of cellular biosynthetic process GO:0031328 295 0.040
chemical homeostasis GO:0048878 292 0.040
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.040
response to monosaccharide GO:0034284 159 0.040
protein complex biogenesis GO:0070271 263 0.040
carbohydrate derivative metabolic process GO:1901135 346 0.039
single organism intracellular transport GO:1902582 166 0.039
positive regulation of rna biosynthetic process GO:1902680 197 0.039
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.038
organonitrogen compound catabolic process GO:1901565 179 0.038
amide transport GO:0042886 105 0.038
response to estrogen GO:0043627 232 0.038
purine nucleotide biosynthetic process GO:0006164 83 0.037
immune system process GO:0002376 204 0.037
developmental growth GO:0048589 100 0.037
negative regulation of signaling GO:0023057 157 0.036
positive regulation of ion transport GO:0043270 94 0.036
negative regulation of multicellular organismal process GO:0051241 203 0.036
catabolic process GO:0009056 351 0.036
sexual reproduction GO:0019953 148 0.036
cyclic nucleotide metabolic process GO:0009187 80 0.036
multicellular organismal reproductive process GO:0048609 233 0.036
response to acid chemical GO:0001101 222 0.035
organophosphate biosynthetic process GO:0090407 143 0.035
macromolecular complex assembly GO:0065003 273 0.035
positive regulation of nucleic acid templated transcription GO:1903508 197 0.035
response to oxygen levels GO:0070482 265 0.035
regulation of signal transduction GO:0009966 318 0.035
negative regulation of macromolecule metabolic process GO:0010605 260 0.034
regulation of membrane potential GO:0042391 110 0.034
regulation of programmed cell death GO:0043067 341 0.033
embryonic pattern specification GO:0009880 1 0.033
nitrogen compound transport GO:0071705 229 0.033
response to alkaloid GO:0043279 132 0.033
positive regulation of gene expression GO:0010628 244 0.033
purine ribonucleotide metabolic process GO:0009150 227 0.033
peptide transport GO:0015833 97 0.032
axis specification GO:0009798 4 0.032
regulation of organelle organization GO:0033043 80 0.032
organelle localization GO:0051640 55 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.032
cell part morphogenesis GO:0032990 123 0.032
axonogenesis GO:0007409 71 0.032
cellular amine metabolic process GO:0044106 38 0.032
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.031
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.031
regulation of neuron differentiation GO:0045664 208 0.031
cellular homeostasis GO:0019725 252 0.031
protein complex assembly GO:0006461 263 0.030
regulation of nucleotide metabolic process GO:0006140 117 0.030
cellular component movement GO:0006928 248 0.030
establishment of protein localization GO:0045184 141 0.030
dephosphorylation GO:0016311 98 0.030
negative regulation of metabolic process GO:0009892 331 0.030
cell morphogenesis involved in differentiation GO:0000904 119 0.030
regulation of peptide transport GO:0090087 87 0.030
regulation of hormone secretion GO:0046883 106 0.030
amine metabolic process GO:0009308 38 0.029
metal ion transport GO:0030001 289 0.029
protein transport GO:0015031 132 0.029
single organism organelle organization GO:1902589 180 0.029
response to ethanol GO:0045471 162 0.029
nucleotide biosynthetic process GO:0009165 98 0.029
regulation of secretion GO:0051046 224 0.029
signal release GO:0023061 145 0.028
negative regulation of cellular component organization GO:0051129 83 0.028
regulation of cell projection organization GO:0031344 175 0.027
response to peptide hormone GO:0043434 278 0.027
transmembrane transport GO:0055085 412 0.027
cellular response to oxygen containing compound GO:1901701 386 0.027
behavior GO:0007610 205 0.027
secretion by cell GO:0032940 248 0.027
negative regulation of cellular metabolic process GO:0031324 281 0.027
negative regulation of response to stimulus GO:0048585 155 0.026
purine ribonucleotide biosynthetic process GO:0009152 81 0.026
multicellular organism reproduction GO:0032504 233 0.026
macromolecular complex subunit organization GO:0043933 339 0.026
cellular amino acid metabolic process GO:0006520 107 0.026
regulation of respiratory gaseous exchange by neurological system process GO:0002087 1 0.026
programmed cell death GO:0012501 392 0.025
homeostatic process GO:0042592 331 0.025
taxis GO:0042330 67 0.025
negative regulation of phosphate metabolic process GO:0045936 80 0.025
neuron development GO:0048666 286 0.024
head development GO:0060322 247 0.024
cellular ion homeostasis GO:0006873 184 0.024
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.024
locomotion GO:0040011 237 0.024
regulation of cell differentiation GO:0045595 320 0.024
response to organophosphorus GO:0046683 102 0.024
ribose phosphate biosynthetic process GO:0046390 87 0.024
cellular response to organonitrogen compound GO:0071417 197 0.024
cellular chemical homeostasis GO:0055082 247 0.024
negative regulation of cell death GO:0060548 229 0.023
cyclic nucleotide biosynthetic process GO:0009190 63 0.023
regulation of peptide hormone secretion GO:0090276 80 0.023
negative regulation of defecation GO:2000293 1 0.023
regulation of heart contraction GO:0008016 48 0.023
developmental process involved in reproduction GO:0003006 159 0.022
response to glucose GO:0009749 136 0.022
eye morphogenesis GO:0048592 4 0.022
regulation of purine nucleotide metabolic process GO:1900542 115 0.022
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.022
regulation of feeding behavior GO:0060259 14 0.022
centrosome organization GO:0051297 1 0.022
protein localization GO:0008104 191 0.022
cellular ketone metabolic process GO:0042180 51 0.022
response to nutrient levels GO:0031667 370 0.021
blood circulation GO:0008015 183 0.021
cellular response to peptide hormone stimulus GO:0071375 120 0.021
embryonic axis specification GO:0000578 1 0.021
intracellular signal transduction GO:0035556 314 0.021
negative regulation of cell communication GO:0010648 158 0.021
response to vitamin GO:0033273 131 0.020
cell cycle GO:0007049 101 0.020
negative regulation of catalytic activity GO:0043086 103 0.020
male sex differentiation GO:0046661 64 0.020
establishment of organelle localization GO:0051656 37 0.020
macromolecule localization GO:0033036 252 0.020
protein complex subunit organization GO:0071822 302 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.020
response to purine containing compound GO:0014074 126 0.020
metal ion homeostasis GO:0055065 186 0.020
positive regulation of multicellular organismal process GO:0051240 387 0.019
negative regulation of phosphorus metabolic process GO:0010563 80 0.019
negative regulation of nucleic acid templated transcription GO:1903507 117 0.019
regulation of apoptotic process GO:0042981 335 0.019
regulation of blood pressure GO:0008217 83 0.019
cellular metal ion homeostasis GO:0006875 172 0.019
cell cell signaling GO:0007267 335 0.019
negative regulation of gene expression GO:0010629 199 0.019
regulation of cellular localization GO:0060341 263 0.019
regulation of cell development GO:0060284 263 0.019
cellular macromolecular complex assembly GO:0034622 58 0.019
gamete generation GO:0007276 124 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
regulation of phosphorylation GO:0042325 248 0.019
negative regulation of cell proliferation GO:0008285 119 0.019
cell morphogenesis GO:0000902 142 0.019
negative regulation of signal transduction GO:0009968 83 0.018
regulation of developmental growth GO:0048638 45 0.018
response to carbohydrate GO:0009743 183 0.018
negative regulation of secretion GO:0051048 82 0.018
response to oxidative stress GO:0006979 186 0.018
protein oligomerization GO:0051259 191 0.018
positive regulation of developmental process GO:0051094 283 0.018
positive regulation of nucleotide metabolic process GO:0045981 91 0.018
cation homeostasis GO:0055080 195 0.017
circulatory system development GO:0072359 134 0.017
second messenger mediated signaling GO:0019932 51 0.017
cellular response to hormone stimulus GO:0032870 247 0.017
regulation of defecation GO:2000292 1 0.017
regulation of blood circulation GO:1903522 110 0.017
carbohydrate derivative catabolic process GO:1901136 147 0.017
defecation GO:0030421 1 0.017
cytoskeleton organization GO:0007010 111 0.017
cyclic purine nucleotide metabolic process GO:0052652 62 0.017
camp metabolic process GO:0046058 63 0.017
cytoplasmic transport GO:0016482 115 0.017
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.017
cellular divalent inorganic cation homeostasis GO:0072503 162 0.016
response to growth factor GO:0070848 189 0.016
hormone transport GO:0009914 121 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
regulation of cellular amino acid metabolic process GO:0006521 2 0.016
calcium ion homeostasis GO:0055074 162 0.016
negative regulation of amine transport GO:0051953 24 0.016
positive regulation of cell communication GO:0010647 271 0.016
cellular calcium ion homeostasis GO:0006874 160 0.015
regulation of multicellular organismal development GO:2000026 376 0.015
positive regulation of molecular function GO:0044093 230 0.015
female pregnancy GO:0007565 122 0.015
cellular potassium ion transport GO:0071804 72 0.015
cellular lipid metabolic process GO:0044255 208 0.015
heart process GO:0003015 57 0.015
aging GO:0007568 241 0.015
negative regulation of neuron differentiation GO:0045665 62 0.015
cell cycle process GO:0022402 57 0.014
cardiovascular system development GO:0072358 134 0.014
dna metabolic process GO:0006259 96 0.014
reproductive system development GO:0061458 128 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
lipid metabolic process GO:0006629 283 0.014
protein phosphorylation GO:0006468 345 0.014
regulation of peptide secretion GO:0002791 82 0.014
positive regulation of transport GO:0051050 245 0.014
cellular response to nitrogen compound GO:1901699 210 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
cellular response to peptide GO:1901653 133 0.014
regulation of neurotransmitter uptake GO:0051580 1 0.014
circulatory system process GO:0003013 183 0.014
regulation of respiratory system process GO:0044065 1 0.014
regulation of muscle contraction GO:0006937 53 0.014
purine ribonucleoside metabolic process GO:0046128 168 0.014
camera type eye development GO:0043010 48 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
ion homeostasis GO:0050801 212 0.014
negative regulation of molecular function GO:0044092 133 0.014
heterocycle catabolic process GO:0046700 167 0.013
g protein coupled receptor signaling pathway GO:0007186 242 0.013
positive regulation of biosynthetic process GO:0009891 319 0.013
regulation of protein metabolic process GO:0051246 289 0.013
response to cytokine GO:0034097 215 0.013
negative regulation of programmed cell death GO:0043069 183 0.013
purine nucleoside catabolic process GO:0006152 124 0.013
regulation of renal sodium excretion GO:0035813 20 0.013
cellular response to stress GO:0033554 269 0.013
regulation of metal ion transport GO:0010959 118 0.013
regulation of insulin secretion GO:0050796 65 0.013
palate development GO:0060021 2 0.013
regulation of cellular protein metabolic process GO:0032268 267 0.013
response to transition metal nanoparticle GO:1990267 122 0.013
response to hexose GO:0009746 144 0.013
centrosome cycle GO:0007098 1 0.013
regulation of hydrolase activity GO:0051336 143 0.013
negative regulation of rna biosynthetic process GO:1902679 118 0.013
divalent metal ion transport GO:0070838 132 0.013
cell cycle checkpoint GO:0000075 2 0.013
cell activation GO:0001775 97 0.013
membrane repolarization GO:0086009 1 0.013
cardiac conduction GO:0061337 2 0.013
regulation of cellular ketone metabolic process GO:0010565 27 0.013
response to bacterium GO:0009617 200 0.012
cell growth GO:0016049 104 0.012
potassium ion transmembrane transport GO:0071805 71 0.012
rna localization GO:0006403 4 0.012
heart contraction GO:0060047 57 0.012
exocytosis GO:0006887 60 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
tissue development GO:0009888 252 0.012
cellular response to metal ion GO:0071248 55 0.012
proteolysis GO:0006508 175 0.012
male gamete generation GO:0048232 99 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
neurotransmitter uptake GO:0001504 3 0.012
regulation of secretion by cell GO:1903530 208 0.012
negative regulation of secretion by cell GO:1903531 72 0.012
multicellular organismal signaling GO:0035637 44 0.012
positive regulation of transcription dna templated GO:0045893 197 0.012
synaptic vesicle transport GO:0048489 23 0.012
regulation of establishment of planar polarity GO:0090175 2 0.012
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.012
organ morphogenesis GO:0009887 75 0.012
sensory organ development GO:0007423 74 0.012
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.011
negative regulation of transcription dna templated GO:0045892 116 0.011
sequestering of metal ion GO:0051238 9 0.011
negative regulation of purine nucleotide metabolic process GO:1900543 23 0.011
negative regulation of transport GO:0051051 136 0.011
regulation of ion transmembrane transport GO:0034765 121 0.011
regulation of catalytic activity GO:0050790 304 0.011
regulation of body fluid levels GO:0050878 90 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
camp biosynthetic process GO:0006171 47 0.011
regulation of growth GO:0040008 105 0.011
cellular response to oxidative stress GO:0034599 76 0.011
neurological system process GO:0050877 219 0.011
muscle system process GO:0003012 115 0.011
cellular protein complex assembly GO:0043623 44 0.011
regulation of cellular component biogenesis GO:0044087 86 0.011
positive regulation of secretion GO:0051047 140 0.011
purine containing compound catabolic process GO:0072523 138 0.011
positive regulation of protein modification process GO:0031401 142 0.011
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
positive regulation of organelle organization GO:0010638 48 0.011
regulation of cell growth GO:0001558 85 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
organic hydroxy compound metabolic process GO:1901615 115 0.011
feeding behavior GO:0007631 53 0.011
positive regulation of cellular component biogenesis GO:0044089 55 0.011
regulation of nervous system development GO:0051960 264 0.011
neuron neuron synaptic transmission GO:0007270 60 0.010
negative regulation of rna metabolic process GO:0051253 123 0.010
regulation of transferase activity GO:0051338 123 0.010
microtubule organizing center organization GO:0031023 1 0.010
neuromuscular synaptic transmission GO:0007274 2 0.010
cellular cation homeostasis GO:0030003 180 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.010
positive regulation of protein metabolic process GO:0051247 178 0.010
glycosyl compound metabolic process GO:1901657 182 0.010
monovalent inorganic cation transport GO:0015672 172 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.010
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.010
prepulse inhibition GO:0060134 1 0.010
synaptic growth at neuromuscular junction GO:0051124 1 0.010
nucleoside metabolic process GO:0009116 179 0.010
positive regulation of cell proliferation GO:0008284 249 0.010
negative regulation of nucleotide metabolic process GO:0045980 23 0.010
regulation of nucleotide biosynthetic process GO:0030808 47 0.010
regulation of ion transport GO:0043269 245 0.010
intracellular protein transport GO:0006886 79 0.010

Hap1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.025
renal tubular transport disease DOID:447 0 0.016
kidney disease DOID:557 0 0.016
urinary system disease DOID:18 0 0.016
disease of metabolism DOID:0014667 0 0.012
long qt syndrome DOID:2843 0 0.011