Rattus norvegicus

0 known processes

Mknk2

MAP kinase-interacting serine/threonine kinase 2

Mknk2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of molecular function GO:0065009 398 0.159
rna metabolic process GO:0016070 406 0.122
regulation of cellular protein metabolic process GO:0032268 267 0.095
Rat
rna biosynthetic process GO:0032774 380 0.091
response to peptide GO:1901652 292 0.088
cellular amino acid metabolic process GO:0006520 107 0.083
lipid metabolic process GO:0006629 283 0.076
regulation of nucleic acid templated transcription GO:1903506 380 0.075
intracellular signal transduction GO:0035556 314 0.075
Human Mouse Fly
immune system process GO:0002376 204 0.075
Human
regulation of cellular catabolic process GO:0031329 101 0.075
regulation of catalytic activity GO:0050790 304 0.071
aging GO:0007568 241 0.070
negative regulation of cellular metabolic process GO:0031324 281 0.068
transcription dna templated GO:0006351 377 0.066
catabolic process GO:0009056 351 0.066
regulation of protein metabolic process GO:0051246 289 0.063
Rat
negative regulation of macromolecule metabolic process GO:0010605 260 0.062
single organism catabolic process GO:0044712 283 0.061
nucleic acid templated transcription GO:0097659 379 0.061
protein phosphorylation GO:0006468 345 0.059
Human Mouse Rat Fly
regulation of protein phosphorylation GO:0001932 183 0.058
macromolecule localization GO:0033036 252 0.056
regulation of cell development GO:0060284 263 0.054
regulation of phosphorylation GO:0042325 248 0.053
regulation of anatomical structure morphogenesis GO:0022603 141 0.053
regulation of protein modification process GO:0031399 194 0.053
positive regulation of protein modification process GO:0031401 142 0.052
oxoacid metabolic process GO:0043436 290 0.052
carboxylic acid metabolic process GO:0019752 289 0.052
nucleoside metabolic process GO:0009116 179 0.050
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.049
ribonucleotide metabolic process GO:0009259 231 0.048
store operated calcium entry GO:0002115 2 0.048
small molecule biosynthetic process GO:0044283 124 0.046
regulation of phosphorus metabolic process GO:0051174 349 0.046
regulation of cell differentiation GO:0045595 320 0.046
negative regulation of metabolic process GO:0009892 331 0.045
organophosphate metabolic process GO:0019637 370 0.045
neuron differentiation GO:0030182 368 0.045
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.045
regulation of multicellular organismal development GO:2000026 376 0.045
nucleotide catabolic process GO:0009166 139 0.043
purine nucleoside triphosphate metabolic process GO:0009144 141 0.043
response to peptide hormone GO:0043434 278 0.042
nucleobase containing small molecule metabolic process GO:0055086 316 0.041
positive regulation of phosphate metabolic process GO:0045937 262 0.041
organic acid metabolic process GO:0006082 292 0.041
negative regulation of phosphorus metabolic process GO:0010563 80 0.041
neurological system process GO:0050877 219 0.040
positive regulation of gene expression GO:0010628 244 0.039
establishment of protein localization GO:0045184 141 0.039
ribonucleoside metabolic process GO:0009119 174 0.039
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.038
organic acid biosynthetic process GO:0016053 83 0.038
regulation of catabolic process GO:0009894 113 0.038
response to ketone GO:1901654 182 0.037
nucleotide metabolic process GO:0009117 279 0.037
regulation of cellular ketone metabolic process GO:0010565 27 0.037
regulation of neurogenesis GO:0050767 247 0.037
organonitrogen compound catabolic process GO:1901565 179 0.037
regulation of rna biosynthetic process GO:2001141 381 0.036
ribose phosphate metabolic process GO:0019693 235 0.036
cellular component assembly GO:0022607 360 0.035
nucleoside phosphate metabolic process GO:0006753 283 0.035
cellular ketone metabolic process GO:0042180 51 0.035
regulation of phosphate metabolic process GO:0019220 349 0.035
cellular response to organonitrogen compound GO:0071417 197 0.035
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.035
cellular response to peptide GO:1901653 133 0.035
negative regulation of cellular protein metabolic process GO:0032269 106 0.035
positive regulation of molecular function GO:0044093 230 0.035
protein localization GO:0008104 191 0.035
apoptotic process GO:0006915 381 0.034
Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.034
tissue development GO:0009888 252 0.034
regulation of rna metabolic process GO:0051252 391 0.034
regulation of intracellular signal transduction GO:1902531 218 0.034
Fly
cellular component movement GO:0006928 248 0.034
programmed cell death GO:0012501 392 0.034
Mouse
circulatory system development GO:0072359 134 0.033
cellular macromolecule localization GO:0070727 122 0.033
single organism biosynthetic process GO:0044711 342 0.033
cellular response to stress GO:0033554 269 0.033
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.033
cellular response to endogenous stimulus GO:0071495 377 0.032
purine containing compound metabolic process GO:0072521 253 0.032
positive regulation of biosynthetic process GO:0009891 319 0.032
regulation of lipid metabolic process GO:0019216 68 0.032
regulation of cell proliferation GO:0042127 359 0.032
regulation of signal transduction GO:0009966 318 0.032
Fly
small gtpase mediated signal transduction GO:0007264 36 0.032
Fly
carbohydrate derivative metabolic process GO:1901135 346 0.032
coenzyme metabolic process GO:0006732 86 0.031
multi organism reproductive process GO:0044703 262 0.031
purine ribonucleotide metabolic process GO:0009150 227 0.031
regulation of cellular component organization GO:0051128 368 0.031
response to wounding GO:0009611 254 0.031
response to reactive oxygen species GO:0000302 120 0.031
organic substance catabolic process GO:1901575 316 0.031
carbohydrate derivative catabolic process GO:1901136 147 0.031
negative regulation of cellular biosynthetic process GO:0031327 161 0.031
ras protein signal transduction GO:0007265 29 0.030
Fly
regulation of protein transport GO:0051223 68 0.030
regulation of cellular amino acid metabolic process GO:0006521 2 0.030
glycosyl compound metabolic process GO:1901657 182 0.030
nucleoside phosphate catabolic process GO:1901292 140 0.029
anatomical structure morphogenesis GO:0009653 298 0.029
regulation of transcription dna templated GO:0006355 374 0.029
cellular lipid metabolic process GO:0044255 208 0.029
positive regulation of cell communication GO:0010647 271 0.029
cellular response to oxygen containing compound GO:1901701 386 0.029
metal ion transport GO:0030001 289 0.029
purine nucleotide metabolic process GO:0006163 229 0.029
nucleoside catabolic process GO:0009164 126 0.028
negative regulation of protein metabolic process GO:0051248 114 0.028
cofactor metabolic process GO:0051186 95 0.028
negative regulation of molecular function GO:0044092 133 0.028
cellular response to nitrogen compound GO:1901699 210 0.028
cellular amine metabolic process GO:0044106 38 0.028
response to nutrient levels GO:0031667 370 0.028
regulation of membrane potential GO:0042391 110 0.027
positive regulation of cellular protein metabolic process GO:0032270 167 0.027
response to extracellular stimulus GO:0009991 380 0.027
response to metal ion GO:0010038 253 0.027
intracellular protein transport GO:0006886 79 0.027
regulation of cellular localization GO:0060341 263 0.027
negative regulation of rna metabolic process GO:0051253 123 0.027
aromatic compound catabolic process GO:0019439 168 0.027
cellular response to hormone stimulus GO:0032870 247 0.027
positive regulation of rna metabolic process GO:0051254 203 0.027
regulation of kinase activity GO:0043549 117 0.026
heterocycle catabolic process GO:0046700 167 0.026
amine metabolic process GO:0009308 38 0.026
response to lipopolysaccharide GO:0032496 191 0.026
positive regulation of signaling GO:0023056 270 0.026
response to growth factor GO:0070848 189 0.026
multi multicellular organism process GO:0044706 138 0.026
macromolecular complex subunit organization GO:0043933 339 0.026
reproductive process GO:0022414 372 0.026
regulation of neuron differentiation GO:0045664 208 0.025
regulation of nucleoside metabolic process GO:0009118 66 0.025
response to estrogen GO:0043627 232 0.025
positive regulation of protein phosphorylation GO:0001934 135 0.024
ribonucleoside catabolic process GO:0042454 126 0.024
negative regulation of nervous system development GO:0051961 79 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.024
establishment of tissue polarity GO:0007164 2 0.024
organelle organization GO:0006996 266 0.024
behavior GO:0007610 205 0.024
protein complex subunit organization GO:0071822 302 0.024
ribonucleoside triphosphate catabolic process GO:0009203 122 0.023
cellular nitrogen compound catabolic process GO:0044270 163 0.023
muscle structure development GO:0061061 87 0.023
response to acid chemical GO:0001101 222 0.023
positive regulation of catalytic activity GO:0043085 184 0.023
defense response GO:0006952 194 0.023
regulation of small gtpase mediated signal transduction GO:0051056 48 0.022
Fly
cell migration GO:0016477 197 0.022
lipid biosynthetic process GO:0008610 128 0.022
signal transduction by phosphorylation GO:0023014 144 0.022
negative regulation of gene expression GO:0010629 199 0.022
response to oxidative stress GO:0006979 186 0.022
cellular response to peptide hormone stimulus GO:0071375 120 0.022
protein complex assembly GO:0006461 263 0.022
negative regulation of cell differentiation GO:0045596 99 0.022
peptide biosynthetic process GO:0043043 3 0.022
positive regulation of transcription dna templated GO:0045893 197 0.022
nucleoside triphosphate metabolic process GO:0009141 144 0.022
regulation of protein kinase activity GO:0045859 105 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.021
regulation of cell projection organization GO:0031344 175 0.021
negative regulation of transcription dna templated GO:0045892 116 0.021
negative regulation of phosphate metabolic process GO:0045936 80 0.021
regulation of cellular amine metabolic process GO:0033238 8 0.021
positive regulation of phosphorylation GO:0042327 177 0.021
organic cyclic compound catabolic process GO:1901361 175 0.021
negative regulation of developmental process GO:0051093 125 0.021
gtp catabolic process GO:0006184 71 0.021
negative regulation of cell death GO:0060548 229 0.020
positive regulation of response to stimulus GO:0048584 285 0.020
ribonucleoside triphosphate metabolic process GO:0009199 141 0.020
response to insulin GO:0032868 133 0.020
regulation of transferase activity GO:0051338 123 0.020
response to inorganic substance GO:0010035 377 0.020
cellular response to reactive oxygen species GO:0034614 55 0.019
locomotion GO:0040011 237 0.019
response to nutrient GO:0007584 248 0.019
cellular catabolic process GO:0044248 295 0.019
peptidyl amino acid modification GO:0018193 126 0.019
Rat
nucleobase containing compound catabolic process GO:0034655 152 0.019
organophosphate catabolic process GO:0046434 148 0.019
reproduction GO:0000003 245 0.019
ribonucleotide catabolic process GO:0009261 136 0.019
negative regulation of nucleic acid templated transcription GO:1903507 117 0.019
response to cadmium ion GO:0046686 35 0.019
positive regulation of cellular biosynthetic process GO:0031328 295 0.019
lipid localization GO:0010876 62 0.019
positive regulation of programmed cell death GO:0043068 157 0.019
proteolysis GO:0006508 175 0.019
tube development GO:0035295 89 0.019
purine ribonucleoside catabolic process GO:0046130 124 0.018
macromolecular complex assembly GO:0065003 273 0.018
wound healing GO:0042060 122 0.018
regulation of cellular component movement GO:0051270 150 0.018
negative regulation of biosynthetic process GO:0009890 168 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
brain development GO:0007420 247 0.018
homeostatic process GO:0042592 331 0.018
localization of cell GO:0051674 202 0.018
multicellular organismal signaling GO:0035637 44 0.018
positive regulation of multicellular organismal process GO:0051240 387 0.018
protein localization to organelle GO:0033365 57 0.018
cellular protein localization GO:0034613 122 0.018
regulation of gtpase activity GO:0043087 57 0.018
regulation of nervous system development GO:0051960 264 0.018
cell projection organization GO:0030030 302 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.018
ion transmembrane transport GO:0034220 365 0.018
neuron projection development GO:0031175 273 0.018
multicellular organism reproduction GO:0032504 233 0.018
positive regulation of catabolic process GO:0009896 78 0.017
cell motility GO:0048870 202 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.017
response to ethanol GO:0045471 162 0.017
positive regulation of transport GO:0051050 245 0.017
purine nucleoside metabolic process GO:0042278 169 0.017
positive regulation of cellular component organization GO:0051130 200 0.017
cellular chemical homeostasis GO:0055082 247 0.017
purine containing compound catabolic process GO:0072523 138 0.017
single organism carbohydrate metabolic process GO:0044723 118 0.017
regulation of protein localization GO:0032880 81 0.017
sensory perception GO:0007600 101 0.017
negative regulation of protein phosphorylation GO:0001933 44 0.017
negative regulation of catalytic activity GO:0043086 103 0.017
central nervous system development GO:0007417 311 0.017
negative regulation of neurogenesis GO:0050768 78 0.017
guanosine containing compound catabolic process GO:1901069 71 0.017
response to carbohydrate GO:0009743 183 0.016
purine ribonucleoside metabolic process GO:0046128 168 0.016
regulation of locomotion GO:0040012 148 0.016
carbohydrate derivative biosynthetic process GO:1901137 124 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.016
gtp metabolic process GO:0046039 72 0.016
positive regulation of rna biosynthetic process GO:1902680 197 0.016
multicellular organismal reproductive process GO:0048609 233 0.016
negative regulation of cellular component organization GO:0051129 83 0.016
regulation of nucleotide metabolic process GO:0006140 117 0.016
neuron development GO:0048666 286 0.016
chemical homeostasis GO:0048878 292 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
positive regulation of nucleic acid templated transcription GO:1903508 197 0.015
positive regulation of cell proliferation GO:0008284 249 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
head development GO:0060322 247 0.015
regeneration GO:0031099 163 0.015
asymmetric protein localization GO:0008105 2 0.015
response to hexose GO:0009746 144 0.015
nucleoside triphosphate catabolic process GO:0009143 123 0.015
response to mechanical stimulus GO:0009612 134 0.015
immune response GO:0006955 104 0.015
organic hydroxy compound metabolic process GO:1901615 115 0.015
enzyme linked receptor protein signaling pathway GO:0007167 116 0.015
positive regulation of signal transduction GO:0009967 175 0.015
single organism intracellular transport GO:1902582 166 0.015
cation transport GO:0006812 382 0.015
positive regulation of ion transport GO:0043270 94 0.015
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.015
female pregnancy GO:0007565 122 0.015
anterior posterior pattern specification GO:0009952 1 0.015
negative regulation of cell development GO:0010721 82 0.015
muscle system process GO:0003012 115 0.015
monovalent inorganic cation transport GO:0015672 172 0.015
regulation of immune system process GO:0002682 123 0.015
regulation of cell migration GO:0030334 128 0.015
cellular component biogenesis GO:0044085 368 0.014
cytoskeleton organization GO:0007010 111 0.014
cation homeostasis GO:0055080 195 0.014
regulation of hormone levels GO:0010817 187 0.014
response to bacterium GO:0009617 200 0.014
cellular response to oxidative stress GO:0034599 76 0.014
purine ribonucleotide catabolic process GO:0009154 136 0.014
response to radiation GO:0009314 137 0.014
response to monosaccharide GO:0034284 159 0.014
positive regulation of developmental process GO:0051094 283 0.014
circulatory system process GO:0003013 183 0.014
negative regulation of cell communication GO:0010648 158 0.014
Fly
negative regulation of rna biosynthetic process GO:1902679 118 0.014
cellular component morphogenesis GO:0032989 155 0.014
cell morphogenesis involved in differentiation GO:0000904 119 0.014
inorganic ion transmembrane transport GO:0098660 229 0.014
single organism behavior GO:0044708 130 0.014
muscle cell proliferation GO:0033002 84 0.014
transmembrane transport GO:0055085 412 0.014
cell cell signaling GO:0007267 335 0.014
chromatin organization GO:0006325 34 0.014
protein oligomerization GO:0051259 191 0.014
striated muscle tissue development GO:0014706 58 0.014
negative regulation of cell proliferation GO:0008285 119 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.013
regulation of proteasomal protein catabolic process GO:0061136 4 0.013
blood circulation GO:0008015 183 0.013
cell adhesion GO:0007155 110 0.013
nucleoside phosphate biosynthetic process GO:1901293 102 0.013
monosaccharide metabolic process GO:0005996 61 0.013
glycosyl compound catabolic process GO:1901658 126 0.013
negative regulation of neuron differentiation GO:0045665 62 0.013
regulation of cell morphogenesis GO:0022604 77 0.013
protein complex biogenesis GO:0070271 263 0.013
single organism cellular localization GO:1902580 102 0.013
negative regulation of apoptotic process GO:0043066 181 0.013
glycerolipid metabolic process GO:0046486 67 0.013
negative regulation of protein modification process GO:0031400 52 0.013
lipid storage GO:0019915 1 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
cell cycle checkpoint GO:0000075 2 0.013
regulation of fat cell differentiation GO:0045598 3 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.013
cellular response to acid chemical GO:0071229 75 0.013
chromosome segregation GO:0007059 2 0.013
ion homeostasis GO:0050801 212 0.013
cell growth GO:0016049 104 0.013
cardiovascular system development GO:0072358 134 0.013
single organism reproductive process GO:0044702 297 0.013
regulation of ras protein signal transduction GO:0046578 45 0.013
Fly
response to cytokine GO:0034097 215 0.013
carboxylic acid biosynthetic process GO:0046394 83 0.013
regulation of nucleocytoplasmic transport GO:0046822 28 0.012
positive regulation of cell development GO:0010720 176 0.012
single organism organelle organization GO:1902589 180 0.012
protein heterooligomerization GO:0051291 89 0.012
negative regulation of cell projection organization GO:0031345 50 0.012
cellular homeostasis GO:0019725 252 0.012
response to glucose GO:0009749 136 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
mapk cascade GO:0000165 140 0.012
sequestering of triglyceride GO:0030730 1 0.012
cell morphogenesis GO:0000902 142 0.012
response to estradiol GO:0032355 164 0.012
response to glucocorticoid GO:0051384 223 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
protein transport GO:0015031 132 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.012
regulation of ion transport GO:0043269 245 0.012
regulation of response to wounding GO:1903034 69 0.012
rho protein signal transduction GO:0007266 11 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
alcohol metabolic process GO:0006066 77 0.012
secretion by cell GO:0032940 248 0.012
protein localization to nucleus GO:0034504 39 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
response to interleukin 1 GO:0070555 55 0.011
neurotrophin production GO:0032898 2 0.011
cellular response to lipid GO:0071396 201 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.011
purine nucleoside catabolic process GO:0006152 124 0.011
regulation of smooth muscle cell proliferation GO:0048660 75 0.011
response to retinoic acid GO:0032526 63 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
regulation of secretion GO:0051046 224 0.011
muscle tissue development GO:0060537 58 0.011
syncytium formation GO:0006949 4 0.011
transmission of nerve impulse GO:0019226 42 0.011
purine ribonucleotide biosynthetic process GO:0009152 81 0.011
negative regulation of signaling GO:0023057 157 0.011
Fly
regulation of cell motility GO:2000145 131 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
regulation of mapk cascade GO:0043408 116 0.011
protein maturation GO:0051604 68 0.011
regulation of response to external stimulus GO:0032101 106 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
Fly
myoblast fusion GO:0007520 2 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
jak stat cascade GO:0007259 26 0.011
response to other organism GO:0051707 220 0.011
response to decreased oxygen levels GO:0036293 237 0.011
vesicle mediated transport GO:0016192 181 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.010
morphogenesis of an epithelium GO:0002009 20 0.010
organic acid transport GO:0015849 116 0.010
regulation of purine nucleotide catabolic process GO:0033121 65 0.010
response to transforming growth factor beta GO:0071559 46 0.010
positive regulation of cell death GO:0010942 184 0.010
multicellular organism growth GO:0035264 1 0.010
reactive nitrogen species metabolic process GO:2001057 1 0.010
nucleotide biosynthetic process GO:0009165 98 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
liver development GO:0001889 90 0.010
dephosphorylation GO:0016311 98 0.010

Mknk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.016
myopathy DOID:423 0 0.013
muscular disease DOID:0080000 0 0.013
musculoskeletal system disease DOID:17 0 0.013
muscle tissue disease DOID:66 0 0.013