Rattus norvegicus

45 known processes

Mknk1

MAP kinase-interacting serine/threonine kinase 1

(Aliases: MGC112775)

Mknk1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to endogenous stimulus GO:0071495 377 0.120
positive regulation of biosynthetic process GO:0009891 319 0.086
organophosphate metabolic process GO:0019637 370 0.069
cellular response to hormone stimulus GO:0032870 247 0.068
macromolecule localization GO:0033036 252 0.068
regulation of cell proliferation GO:0042127 359 0.066
positive regulation of multicellular organismal process GO:0051240 387 0.065
negative regulation of metabolic process GO:0009892 331 0.052
cell projection organization GO:0030030 302 0.050
cellular response to oxygen containing compound GO:1901701 386 0.049
neuron development GO:0048666 286 0.049
regulation of cellular localization GO:0060341 263 0.049
secretion GO:0046903 307 0.048
regulation of signal transduction GO:0009966 318 0.043
Fly
organic acid metabolic process GO:0006082 292 0.042
oxoacid metabolic process GO:0043436 290 0.042
regulation of phosphorus metabolic process GO:0051174 349 0.041
carbohydrate derivative metabolic process GO:1901135 346 0.039
nucleobase containing small molecule metabolic process GO:0055086 316 0.039
response to camp GO:0051591 91 0.039
response to organophosphorus GO:0046683 102 0.038
carboxylic acid metabolic process GO:0019752 289 0.037
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.037
macromolecular complex subunit organization GO:0043933 339 0.036
regulation of phosphorylation GO:0042325 248 0.035
single organism catabolic process GO:0044712 283 0.035
amine metabolic process GO:0009308 38 0.034
positive regulation of catalytic activity GO:0043085 184 0.034
neuron apoptotic process GO:0051402 88 0.034
response to peptide GO:1901652 292 0.034
cellular response to organic cyclic compound GO:0071407 202 0.034
regulation of nucleic acid templated transcription GO:1903506 380 0.034
single organism biosynthetic process GO:0044711 342 0.034
regulation of cellular protein metabolic process GO:0032268 267 0.034
protein complex subunit organization GO:0071822 302 0.033
multi organism reproductive process GO:0044703 262 0.033
regulation of cellular component organization GO:0051128 368 0.033
cellular component assembly GO:0022607 360 0.033
cellular component biogenesis GO:0044085 368 0.033
neurological system process GO:0050877 219 0.032
positive regulation of transport GO:0051050 245 0.032
positive regulation of cell death GO:0010942 184 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.032
response to oxygen levels GO:0070482 265 0.031
nucleotide metabolic process GO:0009117 279 0.031
negative regulation of cellular biosynthetic process GO:0031327 161 0.031
regulation of phosphate metabolic process GO:0019220 349 0.031
positive regulation of cellular biosynthetic process GO:0031328 295 0.031
response to estrogen GO:0043627 232 0.031
cellular response to lipid GO:0071396 201 0.031
single organism intracellular transport GO:1902582 166 0.030
circulatory system development GO:0072359 134 0.030
single organism reproductive process GO:0044702 297 0.030
regulation of molecular function GO:0065009 398 0.030
cardiovascular system development GO:0072358 134 0.029
cellular homeostasis GO:0019725 252 0.029
cellular component movement GO:0006928 248 0.029
cellular amine metabolic process GO:0044106 38 0.029
negative regulation of cellular metabolic process GO:0031324 281 0.029
positive regulation of phosphate metabolic process GO:0045937 262 0.029
regulation of neuron death GO:1901214 115 0.028
neuron projection development GO:0031175 273 0.028
nucleic acid templated transcription GO:0097659 379 0.028
positive regulation of programmed cell death GO:0043068 157 0.028
positive regulation of rna metabolic process GO:0051254 203 0.028
intracellular transport GO:0046907 185 0.028
cellular catabolic process GO:0044248 295 0.028
nucleoside phosphate metabolic process GO:0006753 283 0.028
cellular macromolecule localization GO:0070727 122 0.027
organelle organization GO:0006996 266 0.027
cellular ketone metabolic process GO:0042180 51 0.027
cellular protein localization GO:0034613 122 0.027
reproductive process GO:0022414 372 0.027
organic substance catabolic process GO:1901575 316 0.027
negative regulation of transport GO:0051051 136 0.026
cellular chemical homeostasis GO:0055082 247 0.026
response to acid chemical GO:0001101 222 0.026
regulation of system process GO:0044057 208 0.026
positive regulation of phosphorylation GO:0042327 177 0.026
neuron differentiation GO:0030182 368 0.026
response to nutrient levels GO:0031667 370 0.026
catabolic process GO:0009056 351 0.025
regulation of catalytic activity GO:0050790 304 0.025
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.025
response to peptide hormone GO:0043434 278 0.025
regulation of ion transport GO:0043269 245 0.025
mapk cascade GO:0000165 140 0.025
regulation of nervous system development GO:0051960 264 0.025
behavior GO:0007610 205 0.024
response to extracellular stimulus GO:0009991 380 0.024
metal ion homeostasis GO:0055065 186 0.024
regulation of transcription dna templated GO:0006355 374 0.024
protein transport GO:0015031 132 0.024
positive regulation of protein metabolic process GO:0051247 178 0.024
regulation of protein metabolic process GO:0051246 289 0.024
homeostatic process GO:0042592 331 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.023
reproduction GO:0000003 245 0.023
neuron death GO:0070997 127 0.023
response to purine containing compound GO:0014074 126 0.023
intracellular signal transduction GO:0035556 314 0.023
Human Mouse Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.023
cell type specific apoptotic process GO:0097285 134 0.023
regulation of cellular amino acid metabolic process GO:0006521 2 0.023
positive regulation of apoptotic process GO:0043065 154 0.023
organonitrogen compound biosynthetic process GO:1901566 167 0.023
regulation of rna metabolic process GO:0051252 391 0.022
response to decreased oxygen levels GO:0036293 237 0.022
locomotion GO:0040011 237 0.022
cellular cation homeostasis GO:0030003 180 0.022
regulation of neuron apoptotic process GO:0043523 83 0.022
rna biosynthetic process GO:0032774 380 0.022
positive regulation of developmental process GO:0051094 283 0.021
g protein coupled receptor signaling pathway GO:0007186 242 0.021
establishment of protein localization GO:0045184 141 0.021
protein oligomerization GO:0051259 191 0.021
positive regulation of cell proliferation GO:0008284 249 0.021
cellular amino acid metabolic process GO:0006520 107 0.021
protein complex biogenesis GO:0070271 263 0.021
regulation of secretion GO:0051046 224 0.021
reactive oxygen species biosynthetic process GO:1903409 8 0.021
rna metabolic process GO:0016070 406 0.021
protein localization GO:0008104 191 0.021
regulation of homeostatic process GO:0032844 101 0.021
regulation of kinase activity GO:0043549 117 0.021
cation homeostasis GO:0055080 195 0.021
ribose phosphate metabolic process GO:0019693 235 0.021
regulation of transferase activity GO:0051338 123 0.021
regulation of rna biosynthetic process GO:2001141 381 0.021
response to hypoxia GO:0001666 231 0.021
central nervous system development GO:0007417 311 0.021
multicellular organism reproduction GO:0032504 233 0.021
negative regulation of rna metabolic process GO:0051253 123 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
regulation of cell differentiation GO:0045595 320 0.020
positive regulation of molecular function GO:0044093 230 0.020
regulation of programmed cell death GO:0043067 341 0.020
ribonucleoside metabolic process GO:0009119 174 0.020
ribonucleotide metabolic process GO:0009259 231 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
organic acid transport GO:0015849 116 0.020
vesicle mediated transport GO:0016192 181 0.020
response to estradiol GO:0032355 164 0.020
organic anion transport GO:0015711 132 0.019
response to metal ion GO:0010038 253 0.019
cellular response to nitrogen compound GO:1901699 210 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
chemical homeostasis GO:0048878 292 0.019
tissue development GO:0009888 252 0.019
protein phosphorylation GO:0006468 345 0.019
fatty acid metabolic process GO:0006631 99 0.019
ion homeostasis GO:0050801 212 0.019
positive regulation of transcription dna templated GO:0045893 197 0.018
response to mechanical stimulus GO:0009612 134 0.018
purine containing compound metabolic process GO:0072521 253 0.018
response to nutrient GO:0007584 248 0.018
anatomical structure morphogenesis GO:0009653 298 0.018
carbohydrate metabolic process GO:0005975 130 0.018
positive regulation of protein modification process GO:0031401 142 0.018
regulation of mapk cascade GO:0043408 116 0.018
cell cell signaling GO:0007267 335 0.018
negative regulation of biosynthetic process GO:0009890 168 0.018
cellular metal ion homeostasis GO:0006875 172 0.018
regulation of protein kinase activity GO:0045859 105 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
heterocycle catabolic process GO:0046700 167 0.017
glycosyl compound metabolic process GO:1901657 182 0.017
carboxylic acid transport GO:0046942 115 0.017
divalent inorganic cation homeostasis GO:0072507 165 0.017
protein complex assembly GO:0006461 263 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
negative regulation of gene expression GO:0010629 199 0.017
regulation of neurogenesis GO:0050767 247 0.017
positive regulation of phosphorus metabolic process GO:0010562 262 0.017
cellular divalent inorganic cation homeostasis GO:0072503 162 0.017
axis specification GO:0009798 4 0.017
response to inorganic substance GO:0010035 377 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
aromatic compound catabolic process GO:0019439 168 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.017
response to monosaccharide GO:0034284 159 0.016
metal ion transport GO:0030001 289 0.016
cellular response to stress GO:0033554 269 0.016
regulation of protein modification process GO:0031399 194 0.016
regulation of cell development GO:0060284 263 0.016
regulation of cell motility GO:2000145 131 0.016
anion transport GO:0006820 178 0.016
response to temperature stimulus GO:0009266 94 0.016
regulation of reactive oxygen species metabolic process GO:2000377 26 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.016
cation transport GO:0006812 382 0.016
cellular lipid metabolic process GO:0044255 208 0.016
regulation of membrane potential GO:0042391 110 0.016
brain development GO:0007420 247 0.016
angiogenesis GO:0001525 53 0.016
negative regulation of macromolecule metabolic process GO:0010605 260 0.016
positive regulation of gene expression GO:0010628 244 0.016
purine ribonucleoside metabolic process GO:0046128 168 0.016
oxidation reduction process GO:0055114 304 0.016
regulation of anatomical structure morphogenesis GO:0022603 141 0.016
nucleotide catabolic process GO:0009166 139 0.016
transcription from rna polymerase ii promoter GO:0006366 252 0.016
reactive oxygen species metabolic process GO:0072593 37 0.016
response to carbohydrate GO:0009743 183 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
regulation of hormone levels GO:0010817 187 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
nitrogen compound transport GO:0071705 229 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
anatomical structure formation involved in morphogenesis GO:0048646 83 0.015
positive regulation of cell motility GO:2000147 97 0.015
negative regulation of cell communication GO:0010648 158 0.015
Fly
positive regulation of cellular component organization GO:0051130 200 0.015
positive regulation of endothelial cell migration GO:0010595 4 0.015
organic acid biosynthetic process GO:0016053 83 0.015
multicellular organism growth GO:0035264 1 0.015
regulation of intracellular signal transduction GO:1902531 218 0.015
Fly
synaptic transmission GO:0007268 235 0.015
response to ethanol GO:0045471 162 0.015
transmembrane transport GO:0055085 412 0.015
cellular response to organonitrogen compound GO:0071417 197 0.015
positive regulation of neuron death GO:1901216 43 0.015
response to hexose GO:0009746 144 0.015
proteolysis GO:0006508 175 0.015
blood vessel development GO:0001568 69 0.014
response to oxidative stress GO:0006979 186 0.014
calcium ion homeostasis GO:0055074 162 0.014
transcription dna templated GO:0006351 377 0.014
negative regulation of phosphate metabolic process GO:0045936 80 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
nucleoside metabolic process GO:0009116 179 0.014
cellular ion homeostasis GO:0006873 184 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
protein heterooligomerization GO:0051291 89 0.014
lipid metabolic process GO:0006629 283 0.014
cellular response to peptide GO:1901653 133 0.014
response to growth factor GO:0070848 189 0.014
carboxylic acid biosynthetic process GO:0046394 83 0.014
positive regulation of mapk cascade GO:0043410 92 0.014
localization of cell GO:0051674 202 0.014
female pregnancy GO:0007565 122 0.014
taxis GO:0042330 67 0.013
muscle system process GO:0003012 115 0.013
cellular response to cytokine stimulus GO:0071345 127 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.013
multi multicellular organism process GO:0044706 138 0.013
regulation of apoptotic process GO:0042981 335 0.013
secretion by cell GO:0032940 248 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
signal release GO:0023061 145 0.013
negative regulation of phosphorus metabolic process GO:0010563 80 0.013
negative regulation of signaling GO:0023057 157 0.013
Fly
neuron projection morphogenesis GO:0048812 122 0.013
organophosphate catabolic process GO:0046434 148 0.013
positive regulation of cell projection organization GO:0031346 111 0.013
cellular response to peptide hormone stimulus GO:0071375 120 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
regulation of protein localization GO:0032880 81 0.013
regulation of protein phosphorylation GO:0001932 183 0.013
macromolecular complex assembly GO:0065003 273 0.013
positive regulation of locomotion GO:0040017 102 0.013
activation of protein kinase activity GO:0032147 47 0.013
response to transition metal nanoparticle GO:1990267 122 0.013
response to glucose GO:0009749 136 0.013
actin filament based process GO:0030029 86 0.013
positive regulation of kinase activity GO:0033674 77 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.013
membrane tubulation GO:0097320 2 0.013
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.013
multicellular organismal signaling GO:0035637 44 0.012
positive regulation of nucleic acid templated transcription GO:1903508 197 0.012
cellular response to alcohol GO:0097306 87 0.012
vasculature development GO:0001944 70 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
response to cytokine GO:0034097 215 0.012
cytoplasmic transport GO:0016482 115 0.012
apoptotic process GO:0006915 381 0.012
Mouse
cytokinetic process GO:0032506 1 0.012
vascular process in circulatory system GO:0003018 96 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
insulin like growth factor receptor signaling pathway GO:0048009 3 0.012
positive regulation of cell development GO:0010720 176 0.012
regulation of vesicle mediated transport GO:0060627 81 0.012
ion transmembrane transport GO:0034220 365 0.012
endocytosis GO:0006897 84 0.012
smooth muscle cell migration GO:0014909 36 0.012
positive regulation of nervous system development GO:0051962 178 0.012
membrane organization GO:0061024 94 0.012
reproductive structure development GO:0048608 128 0.012
regulation of establishment of protein localization GO:0070201 69 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
Fly
blood circulation GO:0008015 183 0.012
response to vitamin GO:0033273 131 0.012
negative regulation of cell death GO:0060548 229 0.011
cell migration GO:0016477 197 0.011
positive regulation of signaling GO:0023056 270 0.011
antigen receptor mediated signaling pathway GO:0050851 1 0.011
cellular response to lipopolysaccharide GO:0071222 55 0.011
cellular component morphogenesis GO:0032989 155 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.011
cytoskeleton dependent cytokinesis GO:0061640 2 0.011
regulation of tube size GO:0035150 89 0.011
head development GO:0060322 247 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
positive regulation of protein kinase activity GO:0045860 73 0.011
cellular response to external stimulus GO:0071496 118 0.011
growth GO:0040007 165 0.011
Fly
organic cyclic compound catabolic process GO:1901361 175 0.011
positive regulation of cell migration GO:0030335 96 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
jnk cascade GO:0007254 28 0.011
response to retinoic acid GO:0032526 63 0.011
response to external biotic stimulus GO:0043207 221 0.011
positive regulation of secretion GO:0051047 140 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
neuronal action potential GO:0019228 35 0.011
monocarboxylic acid metabolic process GO:0032787 152 0.011
regulation of neuron differentiation GO:0045664 208 0.011
regulation of cell migration GO:0030334 128 0.011
response to radiation GO:0009314 137 0.011
regulation of fat cell differentiation GO:0045598 3 0.011
regulation of blood vessel size GO:0050880 89 0.011
regulation of lipid metabolic process GO:0019216 68 0.011
negative regulation of developmental process GO:0051093 125 0.011
single organism organelle organization GO:1902589 180 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
action potential GO:0001508 54 0.011
ribonucleoside triphosphate metabolic process GO:0009199 141 0.011
defense response GO:0006952 194 0.011
cell projection morphogenesis GO:0048858 123 0.011
signal transduction by phosphorylation GO:0023014 144 0.010
sexual reproduction GO:0019953 148 0.010
regulation of cellular component movement GO:0051270 150 0.010
cell cycle GO:0007049 101 0.010
response to wounding GO:0009611 254 0.010
cellular carbohydrate metabolic process GO:0044262 72 0.010
positive regulation of neurogenesis GO:0050769 165 0.010
negative regulation of cell proliferation GO:0008285 119 0.010
blood vessel morphogenesis GO:0048514 58 0.010
negative regulation of nucleic acid templated transcription GO:1903507 117 0.010
lipid storage GO:0019915 1 0.010
appendage morphogenesis GO:0035107 4 0.010
cytosolic calcium ion homeostasis GO:0051480 140 0.010
positive regulation of cellular component movement GO:0051272 102 0.010
programmed cell death GO:0012501 392 0.010
Mouse
nucleoside phosphate catabolic process GO:1901292 140 0.010
positive regulation of neuron apoptotic process GO:0043525 33 0.010
nucleoside phosphate biosynthetic process GO:1901293 102 0.010
lipid biosynthetic process GO:0008610 128 0.010

Mknk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.017
musculoskeletal system disease DOID:17 0 0.015
disease of cellular proliferation DOID:14566 0 0.012
sensory system disease DOID:0050155 0 0.012
central nervous system disease DOID:331 0 0.011