Rattus norvegicus

11 known processes

P4hb

prolyl 4-hydroxylase, beta polypeptide

(Aliases: PDIR,PDI)

P4hb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of behavior GO:0050795 61 0.388
regulation of translation GO:0006417 27 0.287
startle response GO:0001964 2 0.230
multicellular organism reproduction GO:0032504 233 0.229
neuromuscular process GO:0050905 2 0.229
organelle organization GO:0006996 266 0.221
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 1 0.194
regulation of cellular protein metabolic process GO:0032268 267 0.181
vesicle mediated transport GO:0016192 181 0.168
tissue development GO:0009888 252 0.153
macromolecular complex assembly GO:0065003 273 0.148
negative regulation of cell death GO:0060548 229 0.144
positive regulation of cellular component organization GO:0051130 200 0.140
behavior GO:0007610 205 0.136
regulation of apoptotic process GO:0042981 335 0.122
Human
multicellular organismal reproductive process GO:0048609 233 0.116
cellular component assembly GO:0022607 360 0.105
regulation of protein metabolic process GO:0051246 289 0.104
aging GO:0007568 241 0.102
positive regulation of developmental process GO:0051094 283 0.100
negative regulation of cell communication GO:0010648 158 0.091
central nervous system development GO:0007417 311 0.091
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.090
establishment of protein localization GO:0045184 141 0.088
carbohydrate metabolic process GO:0005975 130 0.086
secretion GO:0046903 307 0.085
cellular component biogenesis GO:0044085 368 0.084
posttranscriptional regulation of gene expression GO:0010608 37 0.083
positive regulation of endocytosis GO:0045807 28 0.082
cellular catabolic process GO:0044248 295 0.079
positive regulation of biosynthetic process GO:0009891 319 0.077
protein complex assembly GO:0006461 263 0.076
cardiocyte differentiation GO:0035051 22 0.076
regulation of neurogenesis GO:0050767 247 0.076
reproductive process GO:0022414 372 0.074
positive regulation of protein metabolic process GO:0051247 178 0.073
regulation of cell development GO:0060284 263 0.070
regulation of cell migration GO:0030334 128 0.070
positive regulation of cell proliferation GO:0008284 249 0.068
positive regulation of cell differentiation GO:0045597 217 0.068
positive regulation of cellular biosynthetic process GO:0031328 295 0.067
circulatory system development GO:0072359 134 0.065
neuron differentiation GO:0030182 368 0.063
positive regulation of neuron projection development GO:0010976 99 0.062
regulation of endocytosis GO:0030100 42 0.061
positive regulation of cell motility GO:2000147 97 0.061
secretion by cell GO:0032940 248 0.061
positive regulation of gene expression GO:0010628 244 0.060
protein complex subunit organization GO:0071822 302 0.060
cardiovascular system development GO:0072358 134 0.059
regulation of cellular localization GO:0060341 263 0.059
response to metal ion GO:0010038 253 0.059
embryonic cranial skeleton morphogenesis GO:0048701 2 0.058
skeletal system development GO:0001501 41 0.058
cytoskeleton organization GO:0007010 111 0.057
regulation of neuron differentiation GO:0045664 208 0.057
regulation of programmed cell death GO:0043067 341 0.056
Human
sexual reproduction GO:0019953 148 0.055
tube development GO:0035295 89 0.055
neuron projection morphogenesis GO:0048812 122 0.054
regulation of nervous system development GO:0051960 264 0.052
catabolic process GO:0009056 351 0.052
reproductive structure development GO:0048608 128 0.051
regulation of anatomical structure size GO:0090066 135 0.051
muscle tissue development GO:0060537 58 0.050
reproduction GO:0000003 245 0.050
response to ketone GO:1901654 182 0.048
response to cytokine GO:0034097 215 0.047
cell motility GO:0048870 202 0.047
taxis GO:0042330 67 0.047
gamete generation GO:0007276 124 0.046
response to other organism GO:0051707 220 0.045
hepatocyte proliferation GO:0072574 3 0.045
positive regulation of signal transduction GO:0009967 175 0.044
regulation of transcription dna templated GO:0006355 374 0.044
negative regulation of signaling GO:0023057 157 0.044
cellular response to endogenous stimulus GO:0071495 377 0.043
response to wounding GO:0009611 254 0.043
regulation of phagocytosis GO:0050764 13 0.043
organ morphogenesis GO:0009887 75 0.043
macromolecular complex subunit organization GO:0043933 339 0.043
brain development GO:0007420 247 0.042
dna metabolic process GO:0006259 96 0.042
wound healing GO:0042060 122 0.042
motor neuron axon guidance GO:0008045 1 0.042
macromolecule glycosylation GO:0043413 14 0.041
establishment of vesicle localization GO:0051650 31 0.041
cell projection organization GO:0030030 302 0.040
endocytosis GO:0006897 84 0.040
regulation of cell differentiation GO:0045595 320 0.039
antigen processing and presentation GO:0019882 2 0.039
cell migration GO:0016477 197 0.038
positive regulation of cellular protein metabolic process GO:0032270 167 0.038
regulation of signal transduction GO:0009966 318 0.038
Human
regulation of molecular function GO:0065009 398 0.038
response to estradiol GO:0032355 164 0.037
vesicle localization GO:0051648 33 0.036
positive regulation of response to stimulus GO:0048584 285 0.036
positive regulation of dna metabolic process GO:0051054 39 0.036
regulation of chemotaxis GO:0050920 29 0.036
chemosensory behavior GO:0007635 2 0.035
cell adhesion GO:0007155 110 0.035
cellular homeostasis GO:0019725 252 0.035
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.035
regulation of cellular component movement GO:0051270 150 0.034
positive regulation of cell development GO:0010720 176 0.034
neuron projection development GO:0031175 273 0.034
purine ribonucleoside catabolic process GO:0046130 124 0.033
reproductive system development GO:0061458 128 0.033
positive regulation of neurogenesis GO:0050769 165 0.033
cellular response to oxygen containing compound GO:1901701 386 0.033
head development GO:0060322 247 0.033
urogenital system development GO:0001655 78 0.032
regulation of organelle organization GO:0033043 80 0.032
homeostatic process GO:0042592 331 0.031
defense response GO:0006952 194 0.030
transcription dna templated GO:0006351 377 0.030
response to inorganic substance GO:0010035 377 0.030
antigen processing and presentation of peptide antigen GO:0048002 2 0.030
peptidyl lysine hydroxylation GO:0017185 1 0.030
multi organism reproductive process GO:0044703 262 0.029
single organism catabolic process GO:0044712 283 0.029
camera type eye development GO:0043010 48 0.029
regulation of nucleic acid templated transcription GO:1903506 380 0.029
chemical homeostasis GO:0048878 292 0.029
cellular response to vascular endothelial growth factor stimulus GO:0035924 6 0.029
regulation of cell motility GO:2000145 131 0.028
nucleic acid templated transcription GO:0097659 379 0.028
response to growth factor GO:0070848 189 0.027
exocytosis GO:0006887 60 0.027
regulation of anatomical structure morphogenesis GO:0022603 141 0.027
regulation of coagulation GO:0050818 11 0.027
negative regulation of multicellular organismal process GO:0051241 203 0.027
heart development GO:0007507 72 0.027
embryonic skeletal system morphogenesis GO:0048704 3 0.027
cellular chemical homeostasis GO:0055082 247 0.026
response to nutrient levels GO:0031667 370 0.026
positive regulation of apoptotic process GO:0043065 154 0.026
positive regulation of cell communication GO:0010647 271 0.026
translation GO:0006412 35 0.026
regulation of protein localization GO:0032880 81 0.026
epithelium development GO:0060429 96 0.026
protein complex biogenesis GO:0070271 263 0.026
cellular response to external stimulus GO:0071496 118 0.026
developmental process involved in reproduction GO:0003006 159 0.025
positive regulation of cell projection organization GO:0031346 111 0.025
response to hexose GO:0009746 144 0.025
programmed cell death GO:0012501 392 0.025
Human
cellular response to stress GO:0033554 269 0.025
Human
regulation of secretion GO:0051046 224 0.025
biological adhesion GO:0022610 110 0.025
negative regulation of metabolic process GO:0009892 331 0.024
cellular response to growth factor stimulus GO:0071363 162 0.024
blood circulation GO:0008015 183 0.024
negative regulation of cellular amide metabolic process GO:0034249 1 0.024
regulation of locomotion GO:0040012 148 0.024
cellular response to unfolded protein GO:0034620 2 0.023
epithelial cell proliferation GO:0050673 54 0.022
regulation of cell adhesion GO:0030155 52 0.022
positive regulation of phagocytosis GO:0050766 9 0.022
cellular protein complex assembly GO:0043623 44 0.022
negative regulation of catalytic activity GO:0043086 103 0.022
regulation of cell substrate adhesion GO:0010810 18 0.022
axon extension GO:0048675 26 0.021
regulation of multicellular organismal development GO:2000026 376 0.021
protein oligomerization GO:0051259 191 0.021
proteolysis GO:0006508 175 0.021
cellular response to metal ion GO:0071248 55 0.021
anatomical structure morphogenesis GO:0009653 298 0.021
regulation of tube size GO:0035150 89 0.021
rna biosynthetic process GO:0032774 380 0.021
regulation of rna metabolic process GO:0051252 391 0.021
formation of primary germ layer GO:0001704 1 0.020
regulation of cellular component biogenesis GO:0044087 86 0.020
eye development GO:0001654 50 0.020
glucose homeostasis GO:0042593 75 0.020
regulation of hydrolase activity GO:0051336 143 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.020
spermatogenesis GO:0007283 99 0.020
positive regulation of signaling GO:0023056 270 0.019
regulation of cell proliferation GO:0042127 359 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
male gamete generation GO:0048232 99 0.019
olfactory behavior GO:0042048 2 0.019
regulation of actin nucleation GO:0051125 2 0.019
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.019
carbohydrate derivative metabolic process GO:1901135 346 0.019
organic cyclic compound catabolic process GO:1901361 175 0.019
cell substrate adhesion GO:0031589 29 0.019
regulation of protein transport GO:0051223 68 0.018
cellular response to cytokine stimulus GO:0071345 127 0.018
localization of cell GO:0051674 202 0.018
organic substance catabolic process GO:1901575 316 0.018
single organism organelle organization GO:1902589 180 0.018
positive regulation of phosphate metabolic process GO:0045937 262 0.018
multicellular organism growth GO:0035264 1 0.018
establishment of organelle localization GO:0051656 37 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
cellular ketone metabolic process GO:0042180 51 0.017
regulation of catalytic activity GO:0050790 304 0.017
purine ribonucleoside metabolic process GO:0046128 168 0.017
lipid storage GO:0019915 1 0.017
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.017
response to glucose GO:0009749 136 0.017
epithelial cell differentiation GO:0030855 71 0.017
growth GO:0040007 165 0.016
single organism carbohydrate metabolic process GO:0044723 118 0.016
single organism intracellular transport GO:1902582 166 0.016
negative regulation of cellular protein metabolic process GO:0032269 106 0.016
positive regulation of molecular function GO:0044093 230 0.016
cellular component morphogenesis GO:0032989 155 0.016
response to reactive oxygen species GO:0000302 120 0.016
multicellular organismal catabolic process GO:0044243 2 0.016
eye morphogenesis GO:0048592 4 0.016
positive regulation of nervous system development GO:0051962 178 0.016
locomotion GO:0040011 237 0.016
circulatory system process GO:0003013 183 0.016
axon development GO:0061564 96 0.016
cellular amine metabolic process GO:0044106 38 0.016
regulation of proteolysis GO:0030162 66 0.016
response to peptide GO:1901652 292 0.015
cellular response to hormone stimulus GO:0032870 247 0.015
cell part morphogenesis GO:0032990 123 0.015
regeneration GO:0031099 163 0.015
reactive nitrogen species metabolic process GO:2001057 1 0.015
positive regulation of chemotaxis GO:0050921 23 0.015
neuron development GO:0048666 286 0.015
triglyceride homeostasis GO:0070328 2 0.015
multicellular organismal macromolecule metabolic process GO:0044259 21 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
regulation of phosphorylation GO:0042325 248 0.015
response to acid chemical GO:0001101 222 0.014
cellular calcium ion homeostasis GO:0006874 160 0.014
macromolecule localization GO:0033036 252 0.014
protein localization GO:0008104 191 0.014
regulation of cell size GO:0008361 37 0.014
negative regulation of gene expression GO:0010629 199 0.014
regulation of cellular component organization GO:0051128 368 0.014
carbohydrate homeostasis GO:0033500 75 0.014
cellular response to topologically incorrect protein GO:0035967 3 0.014
regulation of rna biosynthetic process GO:2001141 381 0.014
cellular response to organonitrogen compound GO:0071417 197 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
negative regulation of macromolecule metabolic process GO:0010605 260 0.014
positive regulation of catalytic activity GO:0043085 184 0.014
gastrulation GO:0007369 2 0.014
acylglycerol homeostasis GO:0055090 2 0.014
cellular response to inorganic substance GO:0071241 65 0.014
neurological system process GO:0050877 219 0.014
intracellular transport GO:0046907 185 0.014
cytoplasmic transport GO:0016482 115 0.014
negative regulation of response to stimulus GO:0048585 155 0.013
apoptotic process GO:0006915 381 0.013
Human
regulation of cell projection organization GO:0031344 175 0.013
positive regulation of multicellular organismal process GO:0051240 387 0.013
amine metabolic process GO:0009308 38 0.013
actin cytoskeleton organization GO:0030036 73 0.013
cellular component movement GO:0006928 248 0.013
autophagy GO:0006914 19 0.013
ion homeostasis GO:0050801 212 0.013
regulation of secretion by cell GO:1903530 208 0.013
salivary gland development GO:0007431 3 0.013
positive regulation of transport GO:0051050 245 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
camera type eye morphogenesis GO:0048593 2 0.013
regulation of establishment of protein localization GO:0070201 69 0.012
chromosome segregation GO:0007059 2 0.012
negative regulation of protein modification by small protein conjugation or removal GO:1903321 4 0.012
regulation of hormone levels GO:0010817 187 0.012
collagen catabolic process GO:0030574 2 0.012
collagen metabolic process GO:0032963 21 0.012
liver morphogenesis GO:0072576 3 0.012
negative regulation of synaptic transmission GO:0050805 29 0.012
single organism behavior GO:0044708 130 0.012
neural crest cell differentiation GO:0014033 2 0.012
protein secretion GO:0009306 34 0.012
dendrite development GO:0016358 72 0.012
carbohydrate derivative catabolic process GO:1901136 147 0.012
regulation of kinase activity GO:0043549 117 0.012
synaptic vesicle endocytosis GO:0048488 4 0.012
regulation of angiotensin levels in blood GO:0002002 2 0.012
ribonucleotide metabolic process GO:0009259 231 0.012
mapk cascade GO:0000165 140 0.012
glycoprotein biosynthetic process GO:0009101 19 0.012
regulation of immune system process GO:0002682 123 0.012
response to lead ion GO:0010288 33 0.011
protein transport GO:0015031 132 0.011
response to nutrient GO:0007584 248 0.011
endoplasmic reticulum unfolded protein response GO:0030968 2 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
cell morphogenesis GO:0000902 142 0.011
nucleobase containing small molecule metabolic process GO:0055086 316 0.011
regulation of proteasomal protein catabolic process GO:0061136 4 0.011
regulation of cellular amine metabolic process GO:0033238 8 0.011
intracellular signal transduction GO:0035556 314 0.011
Human
macromolecule catabolic process GO:0009057 58 0.011
oxidation reduction process GO:0055114 304 0.011
Human Yeast
reactive oxygen species biosynthetic process GO:1903409 8 0.011
regulation of neuron projection development GO:0010975 161 0.011
enzyme linked receptor protein signaling pathway GO:0007167 116 0.011
macroautophagy GO:0016236 4 0.011
cell cell signaling GO:0007267 335 0.011
regulation of cellular component size GO:0032535 51 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
positive regulation of cell death GO:0010942 184 0.011
regulation of cellular amino acid metabolic process GO:0006521 2 0.011
positive regulation of cell growth GO:0030307 44 0.011
developmental growth GO:0048589 100 0.011
liver development GO:0001889 90 0.011
regulation of developmental growth GO:0048638 45 0.011
protein phosphorylation GO:0006468 345 0.010
regulation of transferase activity GO:0051338 123 0.010
negative regulation of developmental process GO:0051093 125 0.010
cellular metal ion homeostasis GO:0006875 172 0.010
positive regulation of neuron differentiation GO:0045666 126 0.010
respiratory system development GO:0060541 45 0.010
positive regulation of cellular component biogenesis GO:0044089 55 0.010
response to monosaccharide GO:0034284 159 0.010
positive regulation of kinase activity GO:0033674 77 0.010
negative regulation of cell development GO:0010721 82 0.010
positive regulation of transcription dna templated GO:0045893 197 0.010
cell matrix adhesion GO:0007160 19 0.010

P4hb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.291
musculoskeletal system disease DOID:17 0 0.291
connective tissue disease DOID:65 0 0.291
bone development disease DOID:0080006 0 0.058
bone disease DOID:0080001 0 0.058
osteochondrodysplasia DOID:2256 0 0.048
osteogenesis imperfecta DOID:12347 0 0.048
nervous system disease DOID:863 0 0.029
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.014