Rattus norvegicus

52 known processes

Als2

amyotrophic lateral sclerosis 2 (juvenile) homolog (human)

Als2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxoacid metabolic process GO:0043436 290 0.092
lipid metabolic process GO:0006629 283 0.079
organic acid metabolic process GO:0006082 292 0.066
carboxylic acid metabolic process GO:0019752 289 0.050
regulation of programmed cell death GO:0043067 341 0.049
single organism biosynthetic process GO:0044711 342 0.040
neuron differentiation GO:0030182 368 0.039
central nervous system development GO:0007417 311 0.038
intracellular signal transduction GO:0035556 314 0.038
catabolic process GO:0009056 351 0.033
Human Mouse
brain development GO:0007420 247 0.032
programmed cell death GO:0012501 392 0.031
positive regulation of multicellular organismal process GO:0051240 387 0.031
cellular lipid metabolic process GO:0044255 208 0.030
regulation of apoptotic process GO:0042981 335 0.029
neuron projection development GO:0031175 273 0.029
regulation of cellular component organization GO:0051128 368 0.028
response to glucocorticoid GO:0051384 223 0.028
head development GO:0060322 247 0.028
response to metal ion GO:0010038 253 0.028
response to inorganic substance GO:0010035 377 0.028
organic substance catabolic process GO:1901575 316 0.027
Human Mouse
cellular amine metabolic process GO:0044106 38 0.027
regulation of multicellular organismal development GO:2000026 376 0.027
organelle organization GO:0006996 266 0.027
Human Mouse
oxidation reduction process GO:0055114 304 0.027
cellular response to endogenous stimulus GO:0071495 377 0.027
nucleic acid templated transcription GO:0097659 379 0.026
single organism catabolic process GO:0044712 283 0.026
Human Mouse
multicellular organism growth GO:0035264 1 0.026
positive regulation of biosynthetic process GO:0009891 319 0.026
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.026
Human
macromolecule localization GO:0033036 252 0.025
Mouse
response to growth factor GO:0070848 189 0.025
apoptotic process GO:0006915 381 0.025
response to nutrient levels GO:0031667 370 0.025
cellular amino acid metabolic process GO:0006520 107 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
regulation of signal transduction GO:0009966 318 0.024
Human Mouse
rna metabolic process GO:0016070 406 0.024
cell cell signaling GO:0007267 335 0.024
Mouse
cellular response to oxygen containing compound GO:1901701 386 0.024
nucleobase containing small molecule metabolic process GO:0055086 316 0.024
Human Mouse
amine metabolic process GO:0009308 38 0.023
reproductive process GO:0022414 372 0.023
cellular component assembly GO:0022607 360 0.023
regulation of cell projection organization GO:0031344 175 0.023
regulation of neuron projection development GO:0010975 161 0.023
regulation of neurogenesis GO:0050767 247 0.023
ion transmembrane transport GO:0034220 365 0.023
regulation of cell differentiation GO:0045595 320 0.023
regulation of neuron differentiation GO:0045664 208 0.023
carbohydrate derivative metabolic process GO:1901135 346 0.023
Human Mouse
g protein coupled receptor signaling pathway GO:0007186 242 0.023
cell projection organization GO:0030030 302 0.022
cellular response to growth factor stimulus GO:0071363 162 0.022
positive regulation of cellular component organization GO:0051130 200 0.022
negative regulation of cell death GO:0060548 229 0.021
positive regulation of molecular function GO:0044093 230 0.021
Human
cation transport GO:0006812 382 0.021
cellular response to stress GO:0033554 269 0.021
blood circulation GO:0008015 183 0.021
transmembrane transport GO:0055085 412 0.021
response to purine containing compound GO:0014074 126 0.021
cellular component biogenesis GO:0044085 368 0.021
organophosphate metabolic process GO:0019637 370 0.021
Human Mouse
positive regulation of phosphate metabolic process GO:0045937 262 0.020
Human
response to corticosteroid GO:0031960 235 0.020
positive regulation of developmental process GO:0051094 283 0.020
regulation of rna metabolic process GO:0051252 391 0.020
cellular catabolic process GO:0044248 295 0.020
Human Mouse
positive regulation of signaling GO:0023056 270 0.020
homeostatic process GO:0042592 331 0.020
response to ketone GO:1901654 182 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
response to acid chemical GO:0001101 222 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
regulation of cell development GO:0060284 263 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.020
Human
regulation of cellular amine metabolic process GO:0033238 8 0.020
positive regulation of phosphorus metabolic process GO:0010562 262 0.020
Human
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.019
cellular chemical homeostasis GO:0055082 247 0.019
regulation of transcription dna templated GO:0006355 374 0.019
chemical homeostasis GO:0048878 292 0.019
single organism organelle organization GO:1902589 180 0.019
secretion GO:0046903 307 0.019
secretion by cell GO:0032940 248 0.019
regulation of nervous system development GO:0051960 264 0.019
organonitrogen compound biosynthetic process GO:1901566 167 0.019
cellular ketone metabolic process GO:0042180 51 0.019
small molecule biosynthetic process GO:0044283 124 0.019
single organism reproductive process GO:0044702 297 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.018
neurological system process GO:0050877 219 0.018
reproduction GO:0000003 245 0.018
carboxylic acid biosynthetic process GO:0046394 83 0.018
response to peptide GO:1901652 292 0.018
regulation of system process GO:0044057 208 0.018
regulation of phosphorus metabolic process GO:0051174 349 0.018
Human Mouse
nitrogen compound transport GO:0071705 229 0.018
response to peptide hormone GO:0043434 278 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
Human Mouse
regulation of rna biosynthetic process GO:2001141 381 0.018
response to ethanol GO:0045471 162 0.018
positive regulation of transport GO:0051050 245 0.017
circulatory system process GO:0003013 183 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
positive regulation of cell death GO:0010942 184 0.017
response to extracellular stimulus GO:0009991 380 0.017
negative regulation of cell communication GO:0010648 158 0.017
protein phosphorylation GO:0006468 345 0.017
Human
regulation of nucleic acid templated transcription GO:1903506 380 0.017
nucleotide metabolic process GO:0009117 279 0.017
Human Mouse
rna biosynthetic process GO:0032774 380 0.017
multi organism reproductive process GO:0044703 262 0.017
regulation of secretion GO:0051046 224 0.017
regulation of intracellular signal transduction GO:1902531 218 0.017
Human Mouse
positive regulation of cell proliferation GO:0008284 249 0.017
negative regulation of metabolic process GO:0009892 331 0.017
lipid biosynthetic process GO:0008610 128 0.017
positive regulation of transcription dna templated GO:0045893 197 0.016
regulation of phosphate metabolic process GO:0019220 349 0.016
Human Mouse
organic acid biosynthetic process GO:0016053 83 0.016
ion homeostasis GO:0050801 212 0.016
locomotion GO:0040011 237 0.016
regulation of hormone levels GO:0010817 187 0.016
purine containing compound metabolic process GO:0072521 253 0.016
Human Mouse
cellular homeostasis GO:0019725 252 0.016
negative regulation of programmed cell death GO:0043069 183 0.016
growth GO:0040007 165 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
metal ion transport GO:0030001 289 0.016
positive regulation of catalytic activity GO:0043085 184 0.016
Human
response to oxidative stress GO:0006979 186 0.016
Mouse
positive regulation of gene expression GO:0010628 244 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
Human
inorganic cation transmembrane transport GO:0098662 202 0.016
regulation of molecular function GO:0065009 398 0.015
Human Mouse
positive regulation of cell communication GO:0010647 271 0.015
developmental process involved in reproduction GO:0003006 159 0.015
cellular component movement GO:0006928 248 0.015
anion transport GO:0006820 178 0.015
multicellular organism reproduction GO:0032504 233 0.015
proteolysis GO:0006508 175 0.015
localization of cell GO:0051674 202 0.015
transcription dna templated GO:0006351 377 0.015
negative regulation of signaling GO:0023057 157 0.015
signal release GO:0023061 145 0.015
response to nutrient GO:0007584 248 0.015
regulation of membrane potential GO:0042391 110 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
cell morphogenesis GO:0000902 142 0.015
macromolecular complex subunit organization GO:0043933 339 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
Human Mouse
cell morphogenesis involved in differentiation GO:0000904 119 0.015
regulation of cellular localization GO:0060341 263 0.015
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
Human
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
Human Mouse
fatty acid metabolic process GO:0006631 99 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
regulation of cell proliferation GO:0042127 359 0.014
cellular response to hormone stimulus GO:0032870 247 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.014
Human Mouse
ras protein signal transduction GO:0007265 29 0.014
cation transmembrane transport GO:0098655 263 0.014
positive regulation of neurogenesis GO:0050769 165 0.014
positive regulation of cell development GO:0010720 176 0.014
positive regulation of protein modification process GO:0031401 142 0.014
Human
intracellular transport GO:0046907 185 0.014
Mouse
regulation of cellular ketone metabolic process GO:0010565 27 0.014
monocarboxylic acid biosynthetic process GO:0072330 48 0.014
response to carbohydrate GO:0009743 183 0.014
anterior posterior pattern specification GO:0009952 1 0.014
organic acid transport GO:0015849 116 0.014
regulation of secretion by cell GO:1903530 208 0.014
inorganic ion transmembrane transport GO:0098660 229 0.014
cell part morphogenesis GO:0032990 123 0.014
regulation of protein metabolic process GO:0051246 289 0.014
Human
aging GO:0007568 241 0.014
positive regulation of response to stimulus GO:0048584 285 0.013
regulation of protein modification process GO:0031399 194 0.013
Human
organic hydroxy compound metabolic process GO:1901615 115 0.013
response to hexose GO:0009746 144 0.013
salivary gland development GO:0007431 3 0.013
response to monosaccharide GO:0034284 159 0.013
regulation of anatomical structure size GO:0090066 135 0.013
Human
regulation of catalytic activity GO:0050790 304 0.013
Human Mouse
regulation of proteasomal protein catabolic process GO:0061136 4 0.013
sex differentiation GO:0007548 113 0.013
metal ion homeostasis GO:0055065 186 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
alpha amino acid metabolic process GO:1901605 71 0.013
protein complex subunit organization GO:0071822 302 0.013
monocarboxylic acid metabolic process GO:0032787 152 0.013
cellular response to lipid GO:0071396 201 0.013
response to estrogen GO:0043627 232 0.013
cellular ion homeostasis GO:0006873 184 0.013
response to decreased oxygen levels GO:0036293 237 0.013
circulatory system development GO:0072359 134 0.013
gastrulation GO:0007369 2 0.013
cell projection morphogenesis GO:0048858 123 0.013
ribonucleoside catabolic process GO:0042454 126 0.013
Human Mouse
negative regulation of cellular metabolic process GO:0031324 281 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
Human Mouse
divalent inorganic cation homeostasis GO:0072507 165 0.012
anatomical structure formation involved in morphogenesis GO:0048646 83 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
positive regulation of neuron projection development GO:0010976 99 0.012
purine containing compound catabolic process GO:0072523 138 0.012
Human Mouse
cellular response to organonitrogen compound GO:0071417 197 0.012
eye morphogenesis GO:0048592 4 0.012
axis specification GO:0009798 4 0.012
regulation of synaptic transmission GO:0050804 141 0.012
reproductive structure development GO:0048608 128 0.012
heart morphogenesis GO:0003007 3 0.012
regulation of cellular catabolic process GO:0031329 101 0.012
Human Mouse
organophosphate biosynthetic process GO:0090407 143 0.012
chromosome segregation GO:0007059 2 0.012
response to wounding GO:0009611 254 0.012
peptide transport GO:0015833 97 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
response to transition metal nanoparticle GO:1990267 122 0.012
positive regulation of nervous system development GO:0051962 178 0.012
tissue development GO:0009888 252 0.012
sensory perception GO:0007600 101 0.012
regulation of homeostatic process GO:0032844 101 0.012
morphogenesis of embryonic epithelium GO:0016331 3 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
Human Mouse
protein complex assembly GO:0006461 263 0.012
developmental growth GO:0048589 100 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
regulation of catabolic process GO:0009894 113 0.012
Human Mouse
gland development GO:0048732 155 0.012
cellular cation homeostasis GO:0030003 180 0.011
neuron projection morphogenesis GO:0048812 122 0.011
regulation of anatomical structure morphogenesis GO:0022603 141 0.011
cation homeostasis GO:0055080 195 0.011
hormone secretion GO:0046879 115 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
Human Mouse
positive regulation of secretion by cell GO:1903532 128 0.011
gamete generation GO:0007276 124 0.011
dephosphorylation GO:0016311 98 0.011
macromolecular complex assembly GO:0065003 273 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
cell motility GO:0048870 202 0.011
protein oligomerization GO:0051259 191 0.011
response to alkaloid GO:0043279 132 0.011
response to insulin GO:0032868 133 0.011
salivary gland morphogenesis GO:0007435 1 0.011
positive regulation of phosphorylation GO:0042327 177 0.011
Human
cellular metal ion homeostasis GO:0006875 172 0.011
protein complex biogenesis GO:0070271 263 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
Human Mouse
purine nucleotide metabolic process GO:0006163 229 0.011
Human Mouse
response to radiation GO:0009314 137 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
regulation of ion transport GO:0043269 245 0.011
synaptic growth at neuromuscular junction GO:0051124 1 0.011
single organism intracellular transport GO:1902582 166 0.011
Mouse
gonad development GO:0008406 104 0.011
forebrain development GO:0030900 98 0.011
axonogenesis GO:0007409 71 0.011
synaptic transmission GO:0007268 235 0.011
Mouse
cell migration GO:0016477 197 0.011
protein localization GO:0008104 191 0.011
Mouse
axon development GO:0061564 96 0.011
regulation of cellular protein metabolic process GO:0032268 267 0.011
Human
negative regulation of developmental process GO:0051093 125 0.010
cellular component morphogenesis GO:0032989 155 0.010
cellular calcium ion homeostasis GO:0006874 160 0.010
sexual reproduction GO:0019953 148 0.010
adult locomotory behavior GO:0008344 4 0.010
positive regulation of rna biosynthetic process GO:1902680 197 0.010
response to vitamin GO:0033273 131 0.010
phosphatidylinositol dephosphorylation GO:0046856 4 0.010
regulation of organelle organization GO:0033043 80 0.010
regulation of blood circulation GO:1903522 110 0.010
purine nucleotide catabolic process GO:0006195 136 0.010
Human Mouse
cytoskeleton organization GO:0007010 111 0.010
organic acid catabolic process GO:0016054 49 0.010
cellular protein localization GO:0034613 122 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
positive regulation of protein phosphorylation GO:0001934 135 0.010
Human
positive regulation of apoptotic process GO:0043065 154 0.010

Als2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
Human
nervous system disease DOID:863 0 0.024
Human
disease of cellular proliferation DOID:14566 0 0.018
sensory system disease DOID:0050155 0 0.014
cancer DOID:162 0 0.013
disease of metabolism DOID:0014667 0 0.010
central nervous system disease DOID:331 0 0.010
Human