Rattus norvegicus

187 known processes

Kdm1

lysine (K)-specific demethylase 1

(Aliases: Aof2,RGD1562975)

Kdm1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleic acid templated transcription GO:0097659 379 0.071
transcription dna templated GO:0006351 377 0.069
macromolecular complex subunit organization GO:0043933 339 0.050
regulation of nucleic acid templated transcription GO:1903506 380 0.050
regulation of cellular component organization GO:0051128 368 0.050
regulation of protein metabolic process GO:0051246 289 0.047
organic substance catabolic process GO:1901575 316 0.047
regulation of rna biosynthetic process GO:2001141 381 0.046
negative regulation of gene expression GO:0010629 199 0.045
Human
cellular catabolic process GO:0044248 295 0.045
macromolecule localization GO:0033036 252 0.044
regulation of multicellular organismal development GO:2000026 376 0.044
carboxylic acid metabolic process GO:0019752 289 0.044
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.042
Human
regulation of rna metabolic process GO:0051252 391 0.041
rna biosynthetic process GO:0032774 380 0.040
transcription from rna polymerase ii promoter GO:0006366 252 0.039
cellular response to stress GO:0033554 269 0.039
Human
organic acid metabolic process GO:0006082 292 0.039
rna metabolic process GO:0016070 406 0.038
organelle organization GO:0006996 266 0.038
oxoacid metabolic process GO:0043436 290 0.037
negative regulation of rna metabolic process GO:0051253 123 0.037
Human
catabolic process GO:0009056 351 0.036
chromosome segregation GO:0007059 2 0.035
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.034
ribonucleotide metabolic process GO:0009259 231 0.034
negative regulation of macromolecule metabolic process GO:0010605 260 0.034
Human
positive regulation of multicellular organismal process GO:0051240 387 0.033
regulation of catalytic activity GO:0050790 304 0.032
dna integrity checkpoint GO:0031570 2 0.031
positive regulation of rna metabolic process GO:0051254 203 0.031
organophosphate metabolic process GO:0019637 370 0.031
central nervous system development GO:0007417 311 0.030
negative regulation of metabolic process GO:0009892 331 0.030
Human
regulation of transcription dna templated GO:0006355 374 0.030
negative regulation of cellular biosynthetic process GO:0031327 161 0.029
Human
cellular ketone metabolic process GO:0042180 51 0.028
positive regulation of biosynthetic process GO:0009891 319 0.027
positive regulation of gene expression GO:0010628 244 0.027
positive regulation of cell differentiation GO:0045597 217 0.027
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.026
cellular amine metabolic process GO:0044106 38 0.026
homeostatic process GO:0042592 331 0.026
regulation of apoptotic process GO:0042981 335 0.026
Human
positive regulation of developmental process GO:0051094 283 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
ion transmembrane transport GO:0034220 365 0.025
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.024
Human
regulation of cellular protein metabolic process GO:0032268 267 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.024
protein complex subunit organization GO:0071822 302 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
transmembrane transport GO:0055085 412 0.023
positive regulation of neurogenesis GO:0050769 165 0.022
neuron projection development GO:0031175 273 0.022
positive regulation of cellular protein metabolic process GO:0032270 167 0.022
proteolysis GO:0006508 175 0.022
amine metabolic process GO:0009308 38 0.022
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.022
Human
nucleobase containing small molecule metabolic process GO:0055086 316 0.022
regulation of response to stress GO:0080134 126 0.021
Human
regulation of cellular localization GO:0060341 263 0.021
regulation of programmed cell death GO:0043067 341 0.021
Human
cellular chemical homeostasis GO:0055082 247 0.021
negative regulation of cellular metabolic process GO:0031324 281 0.020
Human
negative regulation of apoptotic process GO:0043066 181 0.020
Human
regulation of molecular function GO:0065009 398 0.020
nucleotide metabolic process GO:0009117 279 0.019
single organism organelle organization GO:1902589 180 0.019
nucleoside phosphate metabolic process GO:0006753 283 0.019
negative regulation of biosynthetic process GO:0009890 168 0.019
Human
negative regulation of rna biosynthetic process GO:1902679 118 0.019
Human
single organism reproductive process GO:0044702 297 0.019
spindle organization GO:0007051 2 0.019
apoptotic process GO:0006915 381 0.019
Human
reproductive process GO:0022414 372 0.019
response to growth factor GO:0070848 189 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
neuron development GO:0048666 286 0.018
nitrogen compound transport GO:0071705 229 0.018
response to decreased oxygen levels GO:0036293 237 0.018
cellular amino acid metabolic process GO:0006520 107 0.018
carbohydrate derivative metabolic process GO:1901135 346 0.018
intracellular transport GO:0046907 185 0.018
positive regulation of signaling GO:0023056 270 0.018
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
protein modification by small protein conjugation or removal GO:0070647 35 0.018
regulation of neurogenesis GO:0050767 247 0.018
positive regulation of molecular function GO:0044093 230 0.018
positive regulation of response to stimulus GO:0048584 285 0.018
reproduction GO:0000003 245 0.018
cellular response to endogenous stimulus GO:0071495 377 0.018
positive regulation of transcription dna templated GO:0045893 197 0.017
response to oxygen levels GO:0070482 265 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
regulation of cellular catabolic process GO:0031329 101 0.017
cation homeostasis GO:0055080 195 0.017
negative regulation of cell communication GO:0010648 158 0.017
Human
glycosyl compound metabolic process GO:1901657 182 0.017
ribonucleoside metabolic process GO:0009119 174 0.017
chemical homeostasis GO:0048878 292 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
Human
oxidation reduction process GO:0055114 304 0.017
Human
positive regulation of nervous system development GO:0051962 178 0.017
cell projection organization GO:0030030 302 0.017
multicellular organism growth GO:0035264 1 0.017
single organism catabolic process GO:0044712 283 0.017
cation transport GO:0006812 382 0.016
embryonic pattern specification GO:0009880 1 0.016
intracellular signal transduction GO:0035556 314 0.016
Human
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.016
Human
nucleoside metabolic process GO:0009116 179 0.016
cell cycle GO:0007049 101 0.016
regulation of cell differentiation GO:0045595 320 0.016
purine ribonucleotide metabolic process GO:0009150 227 0.016
nuclear transport GO:0051169 49 0.016
anatomical structure morphogenesis GO:0009653 298 0.016
ion homeostasis GO:0050801 212 0.016
positive regulation of transport GO:0051050 245 0.015
protein phosphorylation GO:0006468 345 0.015
mitotic spindle organization GO:0007052 2 0.015
regulation of phosphorus metabolic process GO:0051174 349 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
Human
neurological system process GO:0050877 219 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.015
cellular response to oxygen containing compound GO:1901701 386 0.015
negative regulation of nucleic acid templated transcription GO:1903507 117 0.015
Human
single organism intracellular transport GO:1902582 166 0.015
single organism cellular localization GO:1902580 102 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
multi organism reproductive process GO:0044703 262 0.015
regulation of catabolic process GO:0009894 113 0.015
cell motility GO:0048870 202 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
regulation of nervous system development GO:0051960 264 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
metal ion transport GO:0030001 289 0.014
response to acid chemical GO:0001101 222 0.014
regulation of cell cycle GO:0051726 73 0.014
reproductive structure development GO:0048608 128 0.014
regulation of organelle organization GO:0033043 80 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
Human
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.014
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.014
head development GO:0060322 247 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
neuron differentiation GO:0030182 368 0.014
response to estrogen GO:0043627 232 0.014
negative regulation of cell death GO:0060548 229 0.014
Human
cellular cation homeostasis GO:0030003 180 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
regulation of mrna splicing via spliceosome GO:0048024 3 0.014
gamete generation GO:0007276 124 0.014
development of primary sexual characteristics GO:0045137 107 0.014
metal ion homeostasis GO:0055065 186 0.014
nucleocytoplasmic transport GO:0006913 48 0.014
regulation of neuron differentiation GO:0045664 208 0.013
carbohydrate metabolic process GO:0005975 130 0.013
lipid metabolic process GO:0006629 283 0.013
nucleoside triphosphate metabolic process GO:0009141 144 0.013
gastrulation GO:0007369 2 0.013
purine nucleoside metabolic process GO:0042278 169 0.013
ribonucleotide biosynthetic process GO:0009260 85 0.013
purine nucleoside triphosphate metabolic process GO:0009144 141 0.013
response to nutrient levels GO:0031667 370 0.013
response to wounding GO:0009611 254 0.013
negative regulation of developmental process GO:0051093 125 0.013
axis specification GO:0009798 4 0.013
programmed cell death GO:0012501 392 0.013
Human
cell cycle checkpoint GO:0000075 2 0.013
negative regulation of transcription dna templated GO:0045892 116 0.013
Human
anion transport GO:0006820 178 0.013
organic acid transport GO:0015849 116 0.013
ribose phosphate biosynthetic process GO:0046390 87 0.013
gonad development GO:0008406 104 0.013
response to extracellular stimulus GO:0009991 380 0.013
protein complex assembly GO:0006461 263 0.012
regulation of hydrolase activity GO:0051336 143 0.012
protein localization GO:0008104 191 0.012
protein targeting to nucleus GO:0044744 35 0.012
tissue development GO:0009888 252 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
cellular component assembly GO:0022607 360 0.012
positive regulation of cell development GO:0010720 176 0.012
organic anion transport GO:0015711 132 0.012
adult locomotory behavior GO:0008344 4 0.012
cellular component movement GO:0006928 248 0.012
cell cycle process GO:0022402 57 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
reproductive system development GO:0061458 128 0.012
sex differentiation GO:0007548 113 0.012
dna metabolic process GO:0006259 96 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
purine containing compound metabolic process GO:0072521 253 0.012
locomotion GO:0040011 237 0.012
negative regulation of cell cycle phase transition GO:1901988 4 0.011
regulation of protein modification process GO:0031399 194 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
macromolecular complex assembly GO:0065003 273 0.011
cellular macromolecule localization GO:0070727 122 0.011
response to inorganic substance GO:0010035 377 0.011
regulation of cell proliferation GO:0042127 359 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
response to hypoxia GO:0001666 231 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
cellular ion homeostasis GO:0006873 184 0.011
regulation of proteolysis GO:0030162 66 0.011
protein transport GO:0015031 132 0.011
regulation of cell development GO:0060284 263 0.011
cellular homeostasis GO:0019725 252 0.011
cation transmembrane transport GO:0098655 263 0.011
regulation of cellular response to stress GO:0080135 49 0.011
Human
purine ribonucleoside metabolic process GO:0046128 168 0.011
positive regulation of signal transduction GO:0009967 175 0.011
embryo development GO:0009790 49 0.011
bmp signaling pathway GO:0030509 4 0.011
nucleotide biosynthetic process GO:0009165 98 0.011
protein localization to nucleus GO:0034504 39 0.011
acid secretion GO:0046717 48 0.011
negative regulation of cell proliferation GO:0008285 119 0.011
mitotic sister chromatid segregation GO:0000070 1 0.011
regulation of intracellular signal transduction GO:1902531 218 0.010
Human
macromolecule catabolic process GO:0009057 58 0.010
protein oligomerization GO:0051259 191 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
regulation of anatomical structure morphogenesis GO:0022603 141 0.010
regulation of phosphorylation GO:0042325 248 0.010
organophosphate biosynthetic process GO:0090407 143 0.010
multicellular organism reproduction GO:0032504 233 0.010
response to estradiol GO:0032355 164 0.010
protein maturation GO:0051604 68 0.010
protein processing GO:0016485 68 0.010
immune system process GO:0002376 204 0.010
regulation of neuron projection development GO:0010975 161 0.010
positive regulation of cell communication GO:0010647 271 0.010
protein complex biogenesis GO:0070271 263 0.010
sensory organ development GO:0007423 74 0.010
cytoskeleton organization GO:0007010 111 0.010
regulation of cell projection organization GO:0031344 175 0.010
inorganic cation transmembrane transport GO:0098662 202 0.010

Kdm1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.023
cancer DOID:162 0 0.020
disease of cellular proliferation DOID:14566 0 0.020
organ system cancer DOID:0050686 0 0.013
central nervous system disease DOID:331 0 0.011