Rattus norvegicus

228 known processes

Sphk1

sphingosine kinase 1

Sphk1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
apoptotic process GO:0006915 381 0.105
response to extracellular stimulus GO:0009991 380 0.098
response to cytokine GO:0034097 215 0.093
response to peptide GO:1901652 292 0.090
positive regulation of biosynthetic process GO:0009891 319 0.084
cellular response to nitrogen compound GO:1901699 210 0.077
reproductive process GO:0022414 372 0.073
positive regulation of response to stimulus GO:0048584 285 0.067
Human
regulation of cell differentiation GO:0045595 320 0.067
regulation of immunoglobulin production GO:0002637 4 0.065
multicellular organismal reproductive process GO:0048609 233 0.063
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.062
cellular response to endogenous stimulus GO:0071495 377 0.060
tissue development GO:0009888 252 0.057
regulation of cell motility GO:2000145 131 0.057
regulation of cellular localization GO:0060341 263 0.056
positive regulation of cellular biosynthetic process GO:0031328 295 0.054
organic acid metabolic process GO:0006082 292 0.052
regulation of rna biosynthetic process GO:2001141 381 0.051
Human
cell projection organization GO:0030030 302 0.050
regulation of cell proliferation GO:0042127 359 0.050
Human Mouse
regulation of cellular component organization GO:0051128 368 0.048
programmed cell death GO:0012501 392 0.047
cellular response to external stimulus GO:0071496 118 0.046
response to lipopolysaccharide GO:0032496 191 0.046
response to interleukin 1 GO:0070555 55 0.045
negative regulation of cellular metabolic process GO:0031324 281 0.045
response to purine containing compound GO:0014074 126 0.044
anion transport GO:0006820 178 0.044
response to nutrient GO:0007584 248 0.043
behavior GO:0007610 205 0.042
regulation of molecular function GO:0065009 398 0.041
Human
inflammatory response GO:0006954 150 0.041
Mouse
cellular response to cytokine stimulus GO:0071345 127 0.040
Human
transmembrane transport GO:0055085 412 0.040
response to peptide hormone GO:0043434 278 0.040
rhythmic process GO:0048511 156 0.040
regulation of apoptotic process GO:0042981 335 0.039
anatomical structure formation involved in morphogenesis GO:0048646 83 0.039
Human
reproductive structure development GO:0048608 128 0.039
response to metal ion GO:0010038 253 0.038
carboxylic acid metabolic process GO:0019752 289 0.038
neuron development GO:0048666 286 0.037
reproduction GO:0000003 245 0.037
vesicle mediated transport GO:0016192 181 0.036
regulation of phosphorus metabolic process GO:0051174 349 0.036
cellular component assembly GO:0022607 360 0.035
secretion GO:0046903 307 0.035
response to ketone GO:1901654 182 0.035
regulation of immune system process GO:0002682 123 0.035
locomotion GO:0040011 237 0.034
cell motility GO:0048870 202 0.034
secretion by cell GO:0032940 248 0.033
response to molecule of bacterial origin GO:0002237 194 0.033
negative regulation of metabolic process GO:0009892 331 0.033
transcription dna templated GO:0006351 377 0.033
Human
intracellular signal transduction GO:0035556 314 0.033
Human Yeast
reproductive system development GO:0061458 128 0.033
cellular response to oxygen containing compound GO:1901701 386 0.032
brain development GO:0007420 247 0.032
Mouse
positive regulation of apoptotic process GO:0043065 154 0.032
cellular homeostasis GO:0019725 252 0.032
cellular response to interleukin 1 GO:0071347 37 0.032
regulation of cell development GO:0060284 263 0.032
defense response GO:0006952 194 0.031
Mouse
response to organophosphorus GO:0046683 102 0.031
positive regulation of immune system process GO:0002684 90 0.031
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
regulation of cellular component movement GO:0051270 150 0.030
intracellular transport GO:0046907 185 0.030
Human
ovulation cycle process GO:0022602 50 0.030
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.029
response to camp GO:0051591 91 0.028
response to insulin GO:0032868 133 0.028
immune response GO:0006955 104 0.028
regulation of response to stress GO:0080134 126 0.028
angiogenesis GO:0001525 53 0.028
Human
negative regulation of gene expression GO:0010629 199 0.028
response to corticosteroid GO:0031960 235 0.028
response to acid chemical GO:0001101 222 0.028
positive regulation of multicellular organismal process GO:0051240 387 0.027
negative regulation of protein metabolic process GO:0051248 114 0.027
regulation of immunoglobulin secretion GO:0051023 1 0.027
regulation of locomotion GO:0040012 148 0.027
regulation of cellular amino acid metabolic process GO:0006521 2 0.027
response to external biotic stimulus GO:0043207 221 0.027
nucleic acid templated transcription GO:0097659 379 0.026
Human
single organism reproductive process GO:0044702 297 0.026
regulation of response to wounding GO:1903034 69 0.026
ras protein signal transduction GO:0007265 29 0.026
cellular amino acid metabolic process GO:0006520 107 0.026
regulation of g0 to g1 transition GO:0070316 3 0.026
positive regulation of immunoglobulin production GO:0002639 4 0.026
regulation of cell projection organization GO:0031344 175 0.026
response to carbohydrate GO:0009743 183 0.026
lipid biosynthetic process GO:0008610 128 0.026
positive regulation of programmed cell death GO:0043068 157 0.025
regulation of catalytic activity GO:0050790 304 0.025
regulation of protein metabolic process GO:0051246 289 0.025
regulation of transcription dna templated GO:0006355 374 0.025
Human
regulation of neuron differentiation GO:0045664 208 0.025
response to radiation GO:0009314 137 0.025
organelle organization GO:0006996 266 0.025
regulation of response to external stimulus GO:0032101 106 0.025
aging GO:0007568 241 0.025
protein complex biogenesis GO:0070271 263 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.024
single organism behavior GO:0044708 130 0.024
response to monosaccharide GO:0034284 159 0.024
response to transition metal nanoparticle GO:1990267 122 0.024
cellular ketone metabolic process GO:0042180 51 0.024
protein complex subunit organization GO:0071822 302 0.024
protein transport GO:0015031 132 0.024
Human
neuron differentiation GO:0030182 368 0.024
cellular amine metabolic process GO:0044106 38 0.023
female gonad development GO:0008585 53 0.023
regulation of programmed cell death GO:0043067 341 0.023
regulation of signal transduction GO:0009966 318 0.023
Human
metal ion transport GO:0030001 289 0.023
cellular component biogenesis GO:0044085 368 0.023
cellular chemical homeostasis GO:0055082 247 0.023
positive regulation of cell migration GO:0030335 96 0.023
immune system process GO:0002376 204 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
macromolecule localization GO:0033036 252 0.023
Human
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.023
cell cell signaling GO:0007267 335 0.022
positive regulation of phosphate metabolic process GO:0045937 262 0.022
cellular response to organonitrogen compound GO:0071417 197 0.022
regulation of cellular protein metabolic process GO:0032268 267 0.022
protein homooligomerization GO:0051260 91 0.022
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.022
positive regulation of cell differentiation GO:0045597 217 0.022
macromolecular complex subunit organization GO:0043933 339 0.022
proteolysis GO:0006508 175 0.021
rna metabolic process GO:0016070 406 0.021
Human
protein complex assembly GO:0006461 263 0.021
response to transforming growth factor beta GO:0071559 46 0.021
regulation of multicellular organismal development GO:2000026 376 0.021
anatomical structure morphogenesis GO:0009653 298 0.021
Human
positive regulation of gene expression GO:0010628 244 0.021
positive regulation of cell proliferation GO:0008284 249 0.021
Human Mouse
biological adhesion GO:0022610 110 0.021
nitrogen compound transport GO:0071705 229 0.021
Human
regulation of protein maturation GO:1903317 50 0.020
gonad development GO:0008406 104 0.020
ion homeostasis GO:0050801 212 0.020
cellular response to tumor necrosis factor GO:0071356 46 0.020
Human
regulation of leukocyte migration GO:0002685 24 0.020
response to tumor necrosis factor GO:0034612 56 0.020
Human
cellular response to hormone stimulus GO:0032870 247 0.020
ion transmembrane transport GO:0034220 365 0.020
single organism intracellular transport GO:1902582 166 0.020
Human
macromolecular complex assembly GO:0065003 273 0.019
cation homeostasis GO:0055080 195 0.019
response to hexose GO:0009746 144 0.019
protein oligomerization GO:0051259 191 0.019
regulation of immunoglobulin mediated immune response GO:0002889 2 0.019
small gtpase mediated signal transduction GO:0007264 36 0.019
chemical homeostasis GO:0048878 292 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
organic substance catabolic process GO:1901575 316 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
positive regulation of catalytic activity GO:0043085 184 0.019
response to ammonium ion GO:0060359 71 0.019
anterior posterior pattern specification GO:0009952 1 0.019
cellular response to stress GO:0033554 269 0.019
reactive oxygen species metabolic process GO:0072593 37 0.019
unsaturated fatty acid metabolic process GO:0033559 39 0.019
multicellular organism reproduction GO:0032504 233 0.018
regulation of intracellular signal transduction GO:1902531 218 0.018
Human
positive regulation of defense response GO:0031349 37 0.018
response to oxygen levels GO:0070482 265 0.018
regulation of anatomical structure size GO:0090066 135 0.018
muscle contraction GO:0006936 88 0.018
Human
positive regulation of cell motility GO:2000147 97 0.017
circulatory system development GO:0072359 134 0.017
Human Mouse
anion transmembrane transport GO:0098656 77 0.017
development of primary sexual characteristics GO:0045137 107 0.017
endocytosis GO:0006897 84 0.017
protein localization GO:0008104 191 0.017
Human
regulation of system process GO:0044057 208 0.017
Human
response to inorganic substance GO:0010035 377 0.017
positive regulation of signal transduction GO:0009967 175 0.017
Human
cellular response to organic cyclic compound GO:0071407 202 0.017
cellular component movement GO:0006928 248 0.016
cellular response to lipid GO:0071396 201 0.016
positive regulation of cellular component movement GO:0051272 102 0.016
response to estrogen GO:0043627 232 0.016
regulation of cellular amine metabolic process GO:0033238 8 0.016
neuron projection development GO:0031175 273 0.016
regulation of nervous system development GO:0051960 264 0.016
protein phosphorylation GO:0006468 345 0.016
negative regulation of protein maturation GO:1903318 47 0.016
vitamin transport GO:0051180 14 0.016
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.016
negative regulation of cell proliferation GO:0008285 119 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.016
regulation of peptidase activity GO:0052547 55 0.016
regulation of canonical wnt signaling pathway GO:0060828 4 0.016
divalent inorganic cation transport GO:0072511 134 0.016
negative regulation of programmed cell death GO:0043069 183 0.016
response to decreased oxygen levels GO:0036293 237 0.015
regulation of hydrolase activity GO:0051336 143 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
cation transport GO:0006812 382 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
negative regulation of multicellular organismal process GO:0051241 203 0.015
sex differentiation GO:0007548 113 0.015
positive regulation of secretion by cell GO:1903532 128 0.015
metal ion homeostasis GO:0055065 186 0.015
transcription from rna polymerase ii promoter GO:0006366 252 0.015
negative regulation of molecular function GO:0044092 133 0.015
negative regulation of protein processing GO:0010955 47 0.015
amine metabolic process GO:0009308 38 0.015
development of primary female sexual characteristics GO:0046545 56 0.015
immunoglobulin secretion GO:0048305 1 0.015
positive regulation of transcription dna templated GO:0045893 197 0.014
regulation of secretion by cell GO:1903530 208 0.014
developmental process involved in reproduction GO:0003006 159 0.014
negative regulation of endopeptidase activity GO:0010951 36 0.014
response to nutrient levels GO:0031667 370 0.014
negative regulation of peptidase activity GO:0010466 38 0.014
regulation of blood circulation GO:1903522 110 0.014
response to vitamin GO:0033273 131 0.014
regulation of proteolysis GO:0030162 66 0.014
organic acid transport GO:0015849 116 0.014
catabolic process GO:0009056 351 0.014
multi multicellular organism process GO:0044706 138 0.014
growth GO:0040007 165 0.014
Human
positive regulation of cell death GO:0010942 184 0.014
positive regulation of cell communication GO:0010647 271 0.014
central nervous system development GO:0007417 311 0.014
Mouse
regulation of anatomical structure morphogenesis GO:0022603 141 0.014
Human
axis specification GO:0009798 4 0.014
response to wounding GO:0009611 254 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
cellular response to peptide GO:1901653 133 0.014
regulation of secretion GO:0051046 224 0.014
response to hypoxia GO:0001666 231 0.014
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 2 0.013
male gonad development GO:0008584 59 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
female pregnancy GO:0007565 122 0.013
cellular calcium ion homeostasis GO:0006874 160 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
response to other organism GO:0051707 220 0.013
nucleobase containing small molecule metabolic process GO:0055086 316 0.013
male sex differentiation GO:0046661 64 0.013
cellular response to peptide hormone stimulus GO:0071375 120 0.013
response to growth factor GO:0070848 189 0.013
salivary gland development GO:0007431 3 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
negative regulation of catalytic activity GO:0043086 103 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.013
response to ethanol GO:0045471 162 0.013
positive regulation of rna biosynthetic process GO:1902680 197 0.013
positive regulation of developmental process GO:0051094 283 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
carbohydrate derivative metabolic process GO:1901135 346 0.013
muscle structure development GO:0061061 87 0.013
regulation of defense response GO:0031347 68 0.013
positive regulation of g0 to g1 transition GO:0070318 2 0.013
negative regulation of neuron differentiation GO:0045665 62 0.013
rna biosynthetic process GO:0032774 380 0.013
Human
negative regulation of proteolysis GO:0045861 41 0.013
regulation of endocytosis GO:0030100 42 0.013
response to hydrogen peroxide GO:0042542 89 0.013
regulation of protein processing GO:0070613 50 0.013
nucleoside metabolic process GO:0009116 179 0.013
circulatory system process GO:0003013 183 0.012
cardiac chamber development GO:0003205 1 0.012
negative regulation of cell death GO:0060548 229 0.012
response to glucose GO:0009749 136 0.012
protein maturation GO:0051604 68 0.012
extracellular matrix constituent secretion GO:0070278 4 0.012
positive regulation of molecular function GO:0044093 230 0.012
Human
regulation of hormone levels GO:0010817 187 0.012
muscle system process GO:0003012 115 0.012
Human
tissue remodeling GO:0048771 40 0.012
transmission of nerve impulse GO:0019226 42 0.012
cytoplasmic transport GO:0016482 115 0.012
Human
regulation of ion transport GO:0043269 245 0.012
cell adhesion GO:0007155 110 0.012
synaptic transmission GO:0007268 235 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
intracellular protein transport GO:0006886 79 0.012
Human
regulation of rna metabolic process GO:0051252 391 0.012
Human
negative regulation of phosphate metabolic process GO:0045936 80 0.012
oxoacid metabolic process GO:0043436 290 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.011
pseudopodium organization GO:0031268 3 0.011
gland development GO:0048732 155 0.011
positive regulation of phosphorylation GO:0042327 177 0.011
response to mechanical stimulus GO:0009612 134 0.011
head development GO:0060322 247 0.011
Mouse
lipid metabolic process GO:0006629 283 0.011
leukocyte migration GO:0050900 38 0.011
cellular response to mechanical stimulus GO:0071260 48 0.011
regulation of neurogenesis GO:0050767 247 0.011
neuronal action potential GO:0019228 35 0.011
regulation of cell migration GO:0030334 128 0.011
cytokine mediated signaling pathway GO:0019221 43 0.011
Human
response to nicotine GO:0035094 51 0.011
molting cycle process GO:0022404 2 0.011
heart morphogenesis GO:0003007 3 0.011
response to ionizing radiation GO:0010212 59 0.011
activation of cysteine type endopeptidase activity GO:0097202 4 0.011
amino acid transmembrane transport GO:0003333 33 0.011
vitamin d metabolic process GO:0042359 4 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
response to bacterium GO:0009617 200 0.011
neuron death GO:0070997 127 0.011
divalent metal ion transport GO:0070838 132 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
regulation of angiogenesis GO:0045765 39 0.011
Human
mesoderm development GO:0007498 2 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
blood circulation GO:0008015 183 0.011
regulation of endopeptidase activity GO:0052548 51 0.011
cellular lipid metabolic process GO:0044255 208 0.010
positive regulation of neuron differentiation GO:0045666 126 0.010
calcium ion transport GO:0006816 131 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
blood vessel development GO:0001568 69 0.010
Human Mouse
positive regulation of intracellular signal transduction GO:1902533 138 0.010
Human
action potential GO:0001508 54 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
protein heterooligomerization GO:0051291 89 0.010
response to oxidative stress GO:0006979 186 0.010
negative regulation of cellular biosynthetic process GO:0031327 161 0.010
development of primary male sexual characteristics GO:0046546 59 0.010
positive regulation of transport GO:0051050 245 0.010
regulation of protein modification process GO:0031399 194 0.010
reactive nitrogen species metabolic process GO:2001057 1 0.010
positive regulation of cardiac muscle contraction GO:0060452 4 0.010
nucleotide metabolic process GO:0009117 279 0.010
neuron neuron synaptic transmission GO:0007270 60 0.010
regulation of phosphorylation GO:0042325 248 0.010
positive regulation of behavior GO:0048520 38 0.010
cellular response to alcohol GO:0097306 87 0.010
positive regulation of ion transport GO:0043270 94 0.010

Sphk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027
nervous system disease DOID:863 0 0.027
central nervous system disease DOID:331 0 0.016