Rattus norvegicus

123 known processes

Apln

apelin

(Aliases: Apel)

Apln biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell proliferation GO:0042127 359 0.120
apoptotic process GO:0006915 381 0.114
positive regulation of cell death GO:0010942 184 0.113
positive regulation of programmed cell death GO:0043068 157 0.095
regulation of molecular function GO:0065009 398 0.090
programmed cell death GO:0012501 392 0.089
macromolecular complex subunit organization GO:0043933 339 0.086
cellular component assembly GO:0022607 360 0.081
protein complex assembly GO:0006461 263 0.081
organic substance catabolic process GO:1901575 316 0.079
cellular component biogenesis GO:0044085 368 0.079
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.076
cellular calcium ion homeostasis GO:0006874 160 0.073
regulation of programmed cell death GO:0043067 341 0.073
regulation of apoptotic process GO:0042981 335 0.068
response to hypoxia GO:0001666 231 0.065
regulation of transcription dna templated GO:0006355 374 0.064
homeostatic process GO:0042592 331 0.064
positive regulation of apoptotic process GO:0043065 154 0.064
purine nucleoside triphosphate metabolic process GO:0009144 141 0.058
catabolic process GO:0009056 351 0.056
cell cell signaling GO:0007267 335 0.056
response to wounding GO:0009611 254 0.056
organelle organization GO:0006996 266 0.055
cellular ion homeostasis GO:0006873 184 0.054
metal ion homeostasis GO:0055065 186 0.054
protein complex biogenesis GO:0070271 263 0.053
response to inorganic substance GO:0010035 377 0.053
protein complex subunit organization GO:0071822 302 0.052
regulation of catalytic activity GO:0050790 304 0.052
nucleobase containing small molecule metabolic process GO:0055086 316 0.052
cellular response to oxygen containing compound GO:1901701 386 0.052
macromolecular complex assembly GO:0065003 273 0.051
ribose phosphate metabolic process GO:0019693 235 0.051
protein localization GO:0008104 191 0.050
response to glucocorticoid GO:0051384 223 0.050
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.049
secretion GO:0046903 307 0.049
negative regulation of response to stimulus GO:0048585 155 0.047
rna metabolic process GO:0016070 406 0.047
nucleoside metabolic process GO:0009116 179 0.047
response to decreased oxygen levels GO:0036293 237 0.046
regulation of phosphorus metabolic process GO:0051174 349 0.046
cellular catabolic process GO:0044248 295 0.046
regulation of cellular localization GO:0060341 263 0.046
central nervous system development GO:0007417 311 0.045
brain development GO:0007420 247 0.045
carbohydrate derivative catabolic process GO:1901136 147 0.045
anatomical structure morphogenesis GO:0009653 298 0.045
g protein coupled receptor signaling pathway GO:0007186 242 0.045
positive regulation of phosphate metabolic process GO:0045937 262 0.044
neuron projection development GO:0031175 273 0.044
response to oxygen levels GO:0070482 265 0.044
regulation of multicellular organismal development GO:2000026 376 0.043
establishment of protein localization GO:0045184 141 0.043
organophosphate metabolic process GO:0019637 370 0.042
positive regulation of transcription dna templated GO:0045893 197 0.042
anion transport GO:0006820 178 0.041
purine ribonucleotide catabolic process GO:0009154 136 0.041
positive regulation of biosynthetic process GO:0009891 319 0.040
carbohydrate derivative metabolic process GO:1901135 346 0.040
response to estradiol GO:0032355 164 0.040
cellular metal ion homeostasis GO:0006875 172 0.040
chemical homeostasis GO:0048878 292 0.039
oxoacid metabolic process GO:0043436 290 0.039
regulation of phosphate metabolic process GO:0019220 349 0.039
ribonucleotide metabolic process GO:0009259 231 0.039
response to corticosteroid GO:0031960 235 0.038
neuron development GO:0048666 286 0.038
wound healing GO:0042060 122 0.038
nucleic acid templated transcription GO:0097659 379 0.038
nucleotide catabolic process GO:0009166 139 0.038
organophosphate catabolic process GO:0046434 148 0.037
transcription dna templated GO:0006351 377 0.037
protein phosphorylation GO:0006468 345 0.037
protein oligomerization GO:0051259 191 0.037
reproductive process GO:0022414 372 0.037
multi organism reproductive process GO:0044703 262 0.037
cellular chemical homeostasis GO:0055082 247 0.037
nucleoside catabolic process GO:0009164 126 0.037
negative regulation of metabolic process GO:0009892 331 0.036
intracellular signal transduction GO:0035556 314 0.036
negative regulation of cell communication GO:0010648 158 0.035
purine nucleoside triphosphate catabolic process GO:0009146 122 0.035
single organism catabolic process GO:0044712 283 0.035
multi multicellular organism process GO:0044706 138 0.035
rna biosynthetic process GO:0032774 380 0.035
organonitrogen compound catabolic process GO:1901565 179 0.034
cation transport GO:0006812 382 0.034
response to nutrient levels GO:0031667 370 0.034
response to peptide hormone GO:0043434 278 0.034
regulation of cell differentiation GO:0045595 320 0.034
purine ribonucleotide metabolic process GO:0009150 227 0.034
ribonucleoside metabolic process GO:0009119 174 0.033
negative regulation of signaling GO:0023057 157 0.033
nucleoside triphosphate metabolic process GO:0009141 144 0.033
heterocycle catabolic process GO:0046700 167 0.033
regulation of system process GO:0044057 208 0.033
regulation of response to stress GO:0080134 126 0.033
head development GO:0060322 247 0.033
monovalent inorganic cation transport GO:0015672 172 0.033
nucleobase containing compound catabolic process GO:0034655 152 0.032
nucleotide metabolic process GO:0009117 279 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.032
potassium ion transport GO:0006813 97 0.032
calcium ion homeostasis GO:0055074 162 0.032
nitrogen compound transport GO:0071705 229 0.032
protein transport GO:0015031 132 0.031
cellular nitrogen compound catabolic process GO:0044270 163 0.031
response to metal ion GO:0010038 253 0.031
regulation of anatomical structure size GO:0090066 135 0.031
cell projection organization GO:0030030 302 0.031
positive regulation of phosphorus metabolic process GO:0010562 262 0.031
cytoskeleton organization GO:0007010 111 0.031
glycosyl compound metabolic process GO:1901657 182 0.031
positive regulation of cell proliferation GO:0008284 249 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.030
ribonucleotide catabolic process GO:0009261 136 0.030
ribonucleoside triphosphate catabolic process GO:0009203 122 0.030
cellular amine metabolic process GO:0044106 38 0.029
ribonucleoside catabolic process GO:0042454 126 0.029
single organism organelle organization GO:1902589 180 0.029
cation homeostasis GO:0055080 195 0.029
positive regulation of nucleic acid templated transcription GO:1903508 197 0.028
purine nucleotide catabolic process GO:0006195 136 0.028
purine ribonucleoside metabolic process GO:0046128 168 0.028
neurological system process GO:0050877 219 0.028
regulation of cellular component organization GO:0051128 368 0.028
ion homeostasis GO:0050801 212 0.028
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.028
purine nucleoside metabolic process GO:0042278 169 0.027
organic acid metabolic process GO:0006082 292 0.027
purine containing compound metabolic process GO:0072521 253 0.027
cellular homeostasis GO:0019725 252 0.027
positive regulation of gene expression GO:0010628 244 0.027
positive regulation of rna metabolic process GO:0051254 203 0.027
positive regulation of catalytic activity GO:0043085 184 0.026
response to extracellular stimulus GO:0009991 380 0.026
amine metabolic process GO:0009308 38 0.026
positive regulation of multicellular organismal process GO:0051240 387 0.026
cellular response to endogenous stimulus GO:0071495 377 0.026
positive regulation of cellular component organization GO:0051130 200 0.026
regulation of tube size GO:0035150 89 0.026
female pregnancy GO:0007565 122 0.026
positive regulation of hydrolase activity GO:0051345 86 0.026
regulation of phosphorylation GO:0042325 248 0.026
response to oxidative stress GO:0006979 186 0.025
regulation of defense response GO:0031347 68 0.025
transmembrane transport GO:0055085 412 0.025
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
regulation of potassium ion transport GO:0043266 29 0.025
actin filament based process GO:0030029 86 0.025
regulation of secretion by cell GO:1903530 208 0.025
regulation of membrane potential GO:0042391 110 0.025
circulatory system process GO:0003013 183 0.024
cytosolic calcium ion homeostasis GO:0051480 140 0.024
regulation of nucleic acid templated transcription GO:1903506 380 0.024
purine nucleotide metabolic process GO:0006163 229 0.024
neuron differentiation GO:0030182 368 0.024
positive regulation of molecular function GO:0044093 230 0.024
purine containing compound catabolic process GO:0072523 138 0.024
regulation of blood vessel size GO:0050880 89 0.023
cellular ketone metabolic process GO:0042180 51 0.023
nucleoside phosphate metabolic process GO:0006753 283 0.023
positive regulation of rna biosynthetic process GO:1902680 197 0.023
inflammatory response GO:0006954 150 0.023
divalent inorganic cation homeostasis GO:0072507 165 0.023
divalent metal ion transport GO:0070838 132 0.023
negative regulation of phosphorus metabolic process GO:0010563 80 0.023
negative regulation of molecular function GO:0044092 133 0.023
action potential GO:0001508 54 0.023
purine ribonucleoside catabolic process GO:0046130 124 0.023
response to peptide GO:1901652 292 0.023
guanosine containing compound catabolic process GO:1901069 71 0.023
organic cyclic compound catabolic process GO:1901361 175 0.023
lipid metabolic process GO:0006629 283 0.023
response to nicotine GO:0035094 51 0.023
negative regulation of macromolecule metabolic process GO:0010605 260 0.023
regulation of nervous system development GO:0051960 264 0.022
regulation of ion transport GO:0043269 245 0.022
aromatic compound catabolic process GO:0019439 168 0.022
oxidation reduction process GO:0055114 304 0.022
carboxylic acid metabolic process GO:0019752 289 0.022
regulation of cellular protein metabolic process GO:0032268 267 0.022
ion transmembrane transport GO:0034220 365 0.022
circulatory system development GO:0072359 134 0.022
positive regulation of phosphorylation GO:0042327 177 0.022
negative regulation of cellular metabolic process GO:0031324 281 0.022
regulation of cellular component biogenesis GO:0044087 86 0.021
cardiovascular system development GO:0072358 134 0.021
nucleoside phosphate catabolic process GO:1901292 140 0.021
synaptic transmission GO:0007268 235 0.021
cellular divalent inorganic cation homeostasis GO:0072503 162 0.021
response to mechanical stimulus GO:0009612 134 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.021
positive regulation of transport GO:0051050 245 0.021
response to nutrient GO:0007584 248 0.021
purine nucleoside catabolic process GO:0006152 124 0.021
regulation of locomotion GO:0040012 148 0.021
positive regulation of signaling GO:0023056 270 0.021
regulation of hydrolase activity GO:0051336 143 0.021
regulation of nucleoside metabolic process GO:0009118 66 0.021
regeneration GO:0031099 163 0.021
regulation of cellular amine metabolic process GO:0033238 8 0.020
cellular cation homeostasis GO:0030003 180 0.020
nucleoside triphosphate catabolic process GO:0009143 123 0.020
muscle system process GO:0003012 115 0.020
response to alkaloid GO:0043279 132 0.020
immune system process GO:0002376 204 0.020
glycosyl compound catabolic process GO:1901658 126 0.020
positive regulation of response to stimulus GO:0048584 285 0.020
cellular lipid metabolic process GO:0044255 208 0.020
regulation of secretion GO:0051046 224 0.019
regulation of nucleotide catabolic process GO:0030811 65 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
regulation of protein metabolic process GO:0051246 289 0.019
metal ion transport GO:0030001 289 0.019
regulation of rna biosynthetic process GO:2001141 381 0.019
defense response GO:0006952 194 0.019
cellular macromolecule localization GO:0070727 122 0.019
organic anion transport GO:0015711 132 0.019
cell adhesion GO:0007155 110 0.019
cellular component movement GO:0006928 248 0.019
regulation of immune system process GO:0002682 123 0.019
sensory perception of pain GO:0019233 73 0.019
locomotion GO:0040011 237 0.018
transcription from rna polymerase ii promoter GO:0006366 252 0.018
regulation of purine nucleotide metabolic process GO:1900542 115 0.018
cellular amino acid metabolic process GO:0006520 107 0.018
negative regulation of nucleic acid templated transcription GO:1903507 117 0.018
single organism intracellular transport GO:1902582 166 0.018
regulation of intracellular signal transduction GO:1902531 218 0.018
regulation of response to external stimulus GO:0032101 106 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.018
negative regulation of signal transduction GO:0009968 83 0.018
reproduction GO:0000003 245 0.017
positive regulation of developmental process GO:0051094 283 0.017
regulation of catabolic process GO:0009894 113 0.017
regulation of blood circulation GO:1903522 110 0.017
carboxylic acid transport GO:0046942 115 0.017
regulation of organelle organization GO:0033043 80 0.017
cellular protein localization GO:0034613 122 0.017
regulation of neuron projection development GO:0010975 161 0.017
intracellular protein transport GO:0006886 79 0.017
monocarboxylic acid metabolic process GO:0032787 152 0.017
cellular response to stress GO:0033554 269 0.017
peptide secretion GO:0002790 86 0.017
regulation of signal transduction GO:0009966 318 0.017
cellular response to organic cyclic compound GO:0071407 202 0.017
regulation of anatomical structure morphogenesis GO:0022603 141 0.017
macromolecule localization GO:0033036 252 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.017
cellular response to lipid GO:0071396 201 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.017
vascular process in circulatory system GO:0003018 96 0.017
response to temperature stimulus GO:0009266 94 0.016
regulation of rna metabolic process GO:0051252 391 0.016
regulation of cellular catabolic process GO:0031329 101 0.016
neuronal action potential GO:0019228 35 0.016
biological adhesion GO:0022610 110 0.016
proteolysis GO:0006508 175 0.016
heart contraction GO:0060047 57 0.016
response to carbohydrate GO:0009743 183 0.016
cation transmembrane transport GO:0098655 263 0.016
response to radiation GO:0009314 137 0.016
blood vessel morphogenesis GO:0048514 58 0.016
ribonucleoside triphosphate metabolic process GO:0009199 141 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
positive regulation of cellular protein metabolic process GO:0032270 167 0.016
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.016
regulation of protein transport GO:0051223 68 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
single organism biosynthetic process GO:0044711 342 0.016
peptidyl amino acid modification GO:0018193 126 0.016
ras protein signal transduction GO:0007265 29 0.016
anterior posterior pattern specification GO:0009952 1 0.016
positive regulation of cell communication GO:0010647 271 0.016
response to growth factor GO:0070848 189 0.016
hormone secretion GO:0046879 115 0.016
intracellular transport GO:0046907 185 0.016
regulation of neuron differentiation GO:0045664 208 0.015
eye morphogenesis GO:0048592 4 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 53 0.015
signal release GO:0023061 145 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
organ morphogenesis GO:0009887 75 0.015
regulation of neurogenesis GO:0050767 247 0.015
regulation of peptide hormone secretion GO:0090276 80 0.015
cell type specific apoptotic process GO:0097285 134 0.015
heart morphogenesis GO:0003007 3 0.015
small gtpase mediated signal transduction GO:0007264 36 0.015
gtp catabolic process GO:0006184 71 0.015
organic acid transport GO:0015849 116 0.015
protein heterooligomerization GO:0051291 89 0.015
regulation of synaptic transmission GO:0050804 141 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.015
anatomical structure formation involved in morphogenesis GO:0048646 83 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.015
positive regulation of nervous system development GO:0051962 178 0.015
regulation of nucleotide metabolic process GO:0006140 117 0.015
cellular response to growth factor stimulus GO:0071363 162 0.014
regulation of protein modification process GO:0031399 194 0.014
cell morphogenesis GO:0000902 142 0.014
regulation of protein localization GO:0032880 81 0.014
carbohydrate metabolic process GO:0005975 130 0.014
amide transport GO:0042886 105 0.014
negative regulation of biosynthetic process GO:0009890 168 0.014
positive regulation of cellular catabolic process GO:0031331 71 0.014
secretion by cell GO:0032940 248 0.014
regulation of mapk cascade GO:0043408 116 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
response to hexose GO:0009746 144 0.014
regulation of cytoskeleton organization GO:0051493 49 0.014
fatty acid metabolic process GO:0006631 99 0.014
positive regulation of mapk cascade GO:0043410 92 0.014
positive regulation of ion transport GO:0043270 94 0.014
axis specification GO:0009798 4 0.014
negative regulation of cell death GO:0060548 229 0.014
negative regulation of gene expression GO:0010629 199 0.014
positive regulation of cellular component biogenesis GO:0044089 55 0.014
regulation of cell development GO:0060284 263 0.014
muscle cell proliferation GO:0033002 84 0.013
regulation of establishment of protein localization GO:0070201 69 0.013
aging GO:0007568 241 0.013
positive regulation of secretion GO:0051047 140 0.013
cellular response to external stimulus GO:0071496 118 0.013
positive regulation of gtpase activity GO:0043547 47 0.013
negative regulation of phosphorylation GO:0042326 57 0.013
response to monosaccharide GO:0034284 159 0.013
regulation of peptide transport GO:0090087 87 0.013
transmission of nerve impulse GO:0019226 42 0.013
positive regulation of protein modification process GO:0031401 142 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
guanosine containing compound metabolic process GO:1901068 74 0.013
motor neuron axon guidance GO:0008045 1 0.013
non canonical wnt signaling pathway GO:0035567 3 0.013
cellular protein complex assembly GO:0043623 44 0.013
positive regulation of nucleotide metabolic process GO:0045981 91 0.013
regulation of inflammatory response GO:0050727 48 0.013
regulation of neurological system process GO:0031644 43 0.013
cellular response to hormone stimulus GO:0032870 247 0.013
actin cytoskeleton organization GO:0030036 73 0.013
renal system development GO:0072001 67 0.013
rho protein signal transduction GO:0007266 11 0.013
cellular response to organonitrogen compound GO:0071417 197 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
sensory perception GO:0007600 101 0.013
cellular response to mechanical stimulus GO:0071260 48 0.013
unsaturated fatty acid metabolic process GO:0033559 39 0.013
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
behavior GO:0007610 205 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
cellular component morphogenesis GO:0032989 155 0.012
cell cycle checkpoint GO:0000075 2 0.012
l glutamate import GO:0051938 2 0.012
negative regulation of phosphate metabolic process GO:0045936 80 0.012
neuromuscular process GO:0050905 2 0.012
positive regulation of cellular biosynthetic process GO:0031328 295 0.012
response to ethanol GO:0045471 162 0.012
regulation of hormone levels GO:0010817 187 0.012
positive regulation of cell development GO:0010720 176 0.012
regulation of kinase activity GO:0043549 117 0.012
positive regulation of blood circulation GO:1903524 65 0.012
response to bacterium GO:0009617 200 0.012
regulation of response to wounding GO:1903034 69 0.012
regulation of synaptic plasticity GO:0048167 70 0.012
regulation of metal ion transport GO:0010959 118 0.012
regulation of muscle system process GO:0090257 79 0.012
gtp metabolic process GO:0046039 72 0.012
cellular response to nitrogen compound GO:1901699 210 0.012
response to acid chemical GO:0001101 222 0.012
tissue remodeling GO:0048771 40 0.012
positive regulation of gtp catabolic process GO:0033126 48 0.012
negative regulation of cellular biosynthetic process GO:0031327 161 0.012
cellular response to steroid hormone stimulus GO:0071383 93 0.012
negative regulation of vascular permeability GO:0043116 3 0.012
peptide transport GO:0015833 97 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
response to reactive oxygen species GO:0000302 120 0.011
positive regulation of nucleotide catabolic process GO:0030813 53 0.011
localization of cell GO:0051674 202 0.011
positive regulation of protein phosphorylation GO:0001934 135 0.011
regulation of hormone secretion GO:0046883 106 0.011
growth GO:0040007 165 0.011
regulation of sensory perception of pain GO:0051930 29 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.011
single organismal cell cell adhesion GO:0016337 42 0.011
regulation of cell migration GO:0030334 128 0.011
response to ketone GO:1901654 182 0.011
negative regulation of innate immune response GO:0045824 4 0.011
calcium ion transport GO:0006816 131 0.011
gamete generation GO:0007276 124 0.011
single organism reproductive process GO:0044702 297 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
negative regulation of transport GO:0051051 136 0.011
muscle structure development GO:0061061 87 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
negative regulation of protein phosphorylation GO:0001933 44 0.011
cytoplasmic transport GO:0016482 115 0.011
negative regulation of programmed cell death GO:0043069 183 0.011
generation of precursor metabolites and energy GO:0006091 62 0.011
response to insulin GO:0032868 133 0.011
peptide hormone secretion GO:0030072 84 0.011
respiratory gaseous exchange GO:0007585 4 0.011
membrane hyperpolarization GO:0060081 11 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
tissue development GO:0009888 252 0.010
cellular response to oxygen levels GO:0071453 60 0.010
organic hydroxy compound metabolic process GO:1901615 115 0.010
insulin secretion GO:0030073 69 0.010
organic hydroxy compound transport GO:0015850 77 0.010
response to glucose GO:0009749 136 0.010
ribonucleoside monophosphate metabolic process GO:0009161 88 0.010
response to vitamin GO:0033273 131 0.010
positive regulation of catabolic process GO:0009896 78 0.010
amino acid transport GO:0006865 70 0.010
cellular response to peptide GO:1901653 133 0.010
angiogenesis GO:0001525 53 0.010
regulation of calcium ion transport GO:0051924 77 0.010
vesicle mediated transport GO:0016192 181 0.010
positive regulation of secretion by cell GO:1903532 128 0.010

Apln disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 0 0.047
sensory system disease DOID:0050155 0 0.047
disease of anatomical entity DOID:7 0 0.047
eye and adnexa disease DOID:1492 0 0.047
nervous system disease DOID:863 0 0.047
eye disease DOID:5614 0 0.047
disease of metabolism DOID:0014667 0 0.020
inherited metabolic disorder DOID:655 0 0.011