Rattus norvegicus

109 known processes

Grn

granulin

Grn biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of protein metabolic process GO:0051246 289 0.181
cell motility GO:0048870 202 0.166
regeneration GO:0031099 163 0.158
collagen catabolic process GO:0030574 2 0.155
cellular response to endogenous stimulus GO:0071495 377 0.145
response to peptide GO:1901652 292 0.134
locomotion GO:0040011 237 0.127
monovalent inorganic cation transport GO:0015672 172 0.119
oxoacid metabolic process GO:0043436 290 0.115
response to peptide hormone GO:0043434 278 0.115
positive regulation of cell migration GO:0030335 96 0.112
cellular component movement GO:0006928 248 0.104
response to growth factor GO:0070848 189 0.104
cellular catabolic process GO:0044248 295 0.102
positive regulation of cell motility GO:2000147 97 0.099
cellular response to hormone stimulus GO:0032870 247 0.097
regulation of signal transduction GO:0009966 318 0.095
tissue development GO:0009888 252 0.094
positive regulation of phosphorus metabolic process GO:0010562 262 0.093
cellular response to organonitrogen compound GO:0071417 197 0.092
female pregnancy GO:0007565 122 0.089
regulation of programmed cell death GO:0043067 341 0.087
protein phosphorylation GO:0006468 345 0.087
regulation of cellular protein metabolic process GO:0032268 267 0.081
negative regulation of response to stimulus GO:0048585 155 0.075
glutamate receptor signaling pathway GO:0007215 43 0.074
regulation of cellular component movement GO:0051270 150 0.073
amine metabolic process GO:0009308 38 0.071
peptidyl amino acid modification GO:0018193 126 0.070
negative regulation of transport GO:0051051 136 0.070
regulation of apoptotic process GO:0042981 335 0.068
phototransduction visible light GO:0007603 2 0.065
regulation of phosphorylation GO:0042325 248 0.064
t cell proliferation GO:0042098 19 0.063
negative regulation of cell death GO:0060548 229 0.063
carbohydrate derivative metabolic process GO:1901135 346 0.062
response to extracellular stimulus GO:0009991 380 0.059
multicellular organism reproduction GO:0032504 233 0.059
programmed cell death GO:0012501 392 0.058
negative regulation of programmed cell death GO:0043069 183 0.057
response to carbohydrate GO:0009743 183 0.057
reproductive process GO:0022414 372 0.057
epithelium development GO:0060429 96 0.056
negative regulation of cell communication GO:0010648 158 0.056
ion homeostasis GO:0050801 212 0.055
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.055
regulation of sperm motility GO:1901317 2 0.055
regulation of tolerance induction to nonself antigen GO:0002655 1 0.055
cellular response to external stimulus GO:0071496 118 0.051
cellular amine metabolic process GO:0044106 38 0.051
response to other organism GO:0051707 220 0.050
positive regulation of gene expression GO:0010628 244 0.049
cell migration GO:0016477 197 0.048
regulation of locomotion GO:0040012 148 0.047
response to nutrient GO:0007584 248 0.045
carboxylic acid metabolic process GO:0019752 289 0.045
regulation of cell proliferation GO:0042127 359 0.044
response to nutrient levels GO:0031667 370 0.044
chemical homeostasis GO:0048878 292 0.042
metal ion homeostasis GO:0055065 186 0.041
cellular ketone metabolic process GO:0042180 51 0.041
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.040
signal transduction by phosphorylation GO:0023014 144 0.040
regulation of cellular amine metabolic process GO:0033238 8 0.040
regulation of phosphorus metabolic process GO:0051174 349 0.039
axonogenesis GO:0007409 71 0.039
lymphocyte activation GO:0046649 43 0.039
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.039
proteolysis GO:0006508 175 0.038
negative regulation of signaling GO:0023057 157 0.038
regulation of protein modification process GO:0031399 194 0.038
regulation of cell motility GO:2000145 131 0.038
positive regulation of cellular amine metabolic process GO:0033240 3 0.038
head development GO:0060322 247 0.037
enzyme linked receptor protein signaling pathway GO:0007167 116 0.037
response to mechanical stimulus GO:0009612 134 0.036
lens fiber cell differentiation GO:0070306 3 0.036
localization of cell GO:0051674 202 0.036
gland development GO:0048732 155 0.035
single organism catabolic process GO:0044712 283 0.035
response to hexose GO:0009746 144 0.033
response to purine containing compound GO:0014074 126 0.033
regulation of catalytic activity GO:0050790 304 0.033
morphogenesis of an epithelium GO:0002009 20 0.032
response to decreased oxygen levels GO:0036293 237 0.032
catabolic process GO:0009056 351 0.032
regulation of cellular ketone metabolic process GO:0010565 27 0.032
regulation of cellular amino acid metabolic process GO:0006521 2 0.032
epithelial cell migration GO:0010631 19 0.031
organic substance catabolic process GO:1901575 316 0.031
ribose phosphate metabolic process GO:0019693 235 0.031
multi multicellular organism process GO:0044706 138 0.030
detection of visible light GO:0009584 3 0.030
growth GO:0040007 165 0.029
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.029
regulation of cell migration GO:0030334 128 0.028
cellular response to growth factor stimulus GO:0071363 162 0.027
response to monosaccharide GO:0034284 159 0.027
g protein coupled receptor signaling pathway GO:0007186 242 0.027
carbohydrate derivative catabolic process GO:1901136 147 0.026
nucleotide metabolic process GO:0009117 279 0.026
regulation of mononuclear cell proliferation GO:0032944 26 0.026
cell morphogenesis involved in differentiation GO:0000904 119 0.025
response to corticosteroid GO:0031960 235 0.025
regulation of cellular localization GO:0060341 263 0.025
organic acid metabolic process GO:0006082 292 0.025
response to estrogen GO:0043627 232 0.025
regulation of immune system process GO:0002682 123 0.025
epithelial cell differentiation GO:0030855 71 0.024
negative regulation of apoptotic process GO:0043066 181 0.024
cell activation GO:0001775 97 0.024
positive regulation of cellular component movement GO:0051272 102 0.024
regulation of phosphate metabolic process GO:0019220 349 0.023
response to acid chemical GO:0001101 222 0.023
cation homeostasis GO:0055080 195 0.023
peptidyl tyrosine phosphorylation GO:0018108 72 0.023
homeostatic process GO:0042592 331 0.022
positive regulation of cell projection organization GO:0031346 111 0.022
positive regulation of locomotion GO:0040017 102 0.022
positive regulation of cellular protein metabolic process GO:0032270 167 0.022
monocarboxylic acid metabolic process GO:0032787 152 0.022
vesicle mediated transport GO:0016192 181 0.022
response to reactive oxygen species GO:0000302 120 0.022
positive regulation of multicellular organismal process GO:0051240 387 0.021
positive regulation of protein metabolic process GO:0051247 178 0.021
response to interleukin 1 GO:0070555 55 0.021
negative regulation of cell proliferation GO:0008285 119 0.020
nucleoside phosphate metabolic process GO:0006753 283 0.020
organophosphate metabolic process GO:0019637 370 0.020
response to amine GO:0014075 46 0.020
regulation of molecular function GO:0065009 398 0.020
tetrapyrrole metabolic process GO:0033013 11 0.020
regulation of anatomical structure size GO:0090066 135 0.019
epithelium migration GO:0090132 19 0.019
negative regulation of cellular component organization GO:0051129 83 0.019
secretion GO:0046903 307 0.019
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
response to biotic stimulus GO:0009607 226 0.019
embryo development GO:0009790 49 0.019
negative regulation of calcium ion transport into cytosol GO:0010523 4 0.019
positive regulation of nervous system development GO:0051962 178 0.019
thyroid gland development GO:0030878 1 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.019
positive regulation of protein phosphorylation GO:0001934 135 0.018
apoptotic process GO:0006915 381 0.018
single organism reproductive process GO:0044702 297 0.018
positive regulation of cell development GO:0010720 176 0.018
regulation of protein phosphorylation GO:0001932 183 0.018
response to cytokine GO:0034097 215 0.018
response to glucose GO:0009749 136 0.018
response to metal ion GO:0010038 253 0.018
cellular amino acid metabolic process GO:0006520 107 0.017
positive regulation of phosphorylation GO:0042327 177 0.017
reproductive structure development GO:0048608 128 0.017
positive regulation of camp metabolic process GO:0030816 31 0.017
response to radiation GO:0009314 137 0.017
positive regulation of protein modification process GO:0031401 142 0.017
negative regulation of phosphate metabolic process GO:0045936 80 0.017
protein maturation GO:0051604 68 0.017
leukocyte proliferation GO:0070661 29 0.017
organonitrogen compound catabolic process GO:1901565 179 0.017
nucleotide biosynthetic process GO:0009165 98 0.017
hormone transport GO:0009914 121 0.017
keratan sulfate metabolic process GO:0042339 1 0.017
regulation of multicellular organismal development GO:2000026 376 0.016
membrane organization GO:0061024 94 0.016
regulation of body fluid levels GO:0050878 90 0.016
regulation of nucleic acid templated transcription GO:1903506 380 0.016
developmental process involved in reproduction GO:0003006 159 0.016
positive regulation of camp biosynthetic process GO:0030819 28 0.016
lymphocyte mediated immunity GO:0002449 14 0.016
taxis GO:0042330 67 0.016
regulation of smooth muscle cell proliferation GO:0048660 75 0.016
receptor mediated endocytosis GO:0006898 42 0.016
negative regulation of protein metabolic process GO:0051248 114 0.016
cellular homeostasis GO:0019725 252 0.016
regulation of angiotensin levels in blood GO:0002002 2 0.016
protein localization GO:0008104 191 0.016
mapk cascade GO:0000165 140 0.016
reproductive system development GO:0061458 128 0.015
regulation of cellular component organization GO:0051128 368 0.015
response to camp GO:0051591 91 0.015
reproduction GO:0000003 245 0.015
defense response GO:0006952 194 0.015
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.015
response to glucocorticoid GO:0051384 223 0.015
cation transmembrane transport GO:0098655 263 0.015
cell adhesion GO:0007155 110 0.015
mitochondrial fusion GO:0008053 2 0.015
purine ribonucleotide metabolic process GO:0009150 227 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
regulation of hydrolase activity GO:0051336 143 0.014
lymphocyte proliferation GO:0046651 29 0.014
aging GO:0007568 241 0.014
cellular protein localization GO:0034613 122 0.014
response to hypoxia GO:0001666 231 0.014
regulation of secretion by cell GO:1903530 208 0.014
response to starvation GO:0042594 59 0.014
cellular chemical homeostasis GO:0055082 247 0.014
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 1 0.014
regulation of mapk cascade GO:0043408 116 0.014
multi organism reproductive process GO:0044703 262 0.013
positive regulation of phosphate metabolic process GO:0045937 262 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
cellular response to insulin stimulus GO:0032869 81 0.013
response to external biotic stimulus GO:0043207 221 0.013
negative regulation of phosphorylation GO:0042326 57 0.013
ion transmembrane transport GO:0034220 365 0.013
positive regulation of cell death GO:0010942 184 0.013
cyclic nucleotide metabolic process GO:0009187 80 0.013
negative regulation of secretion GO:0051048 82 0.013
dna metabolic process GO:0006259 96 0.013
regulation of nucleocytoplasmic transport GO:0046822 28 0.013
cellular macromolecule localization GO:0070727 122 0.013
response to folic acid GO:0051593 14 0.013
multicellular organismal catabolic process GO:0044243 2 0.013
tissue morphogenesis GO:0048729 22 0.012
cell cell signaling GO:0007267 335 0.012
ribonucleotide metabolic process GO:0009259 231 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
tissue remodeling GO:0048771 40 0.012
regulation of heart morphogenesis GO:2000826 2 0.012
regulation of blood coagulation GO:0030193 9 0.012
positive regulation of cellular biosynthetic process GO:0031328 295 0.012
aromatic compound catabolic process GO:0019439 168 0.012
triglyceride homeostasis GO:0070328 2 0.012
developmental growth GO:0048589 100 0.012
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.012
smooth muscle cell proliferation GO:0048659 77 0.012
response to oxygen levels GO:0070482 265 0.012
cellular response to corticosteroid stimulus GO:0071384 69 0.012
negative regulation of release of sequestered calcium ion into cytosol GO:0051280 4 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
intracellular signal transduction GO:0035556 314 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.012
synaptic transmission GO:0007268 235 0.012
regulation of stress activated protein kinase signaling cascade GO:0070302 23 0.012
cation transport GO:0006812 382 0.012
ribonucleotide biosynthetic process GO:0009260 85 0.012
cell part morphogenesis GO:0032990 123 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
cellular response to starvation GO:0009267 27 0.011
muscle structure development GO:0061061 87 0.011
negative regulation of lipase activity GO:0060192 3 0.011
regulation of t cell proliferation GO:0042129 17 0.011
branched chain amino acid transport GO:0015803 2 0.011
purine nucleotide biosynthetic process GO:0006164 83 0.011
respiratory system development GO:0060541 45 0.011
regulation of cell differentiation GO:0045595 320 0.011
sensory perception of bitter taste GO:0050913 4 0.011
multicellular organismal reproductive process GO:0048609 233 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
cellular response to oxygen containing compound GO:1901701 386 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.011
regulation of jnk cascade GO:0046328 19 0.011
behavior GO:0007610 205 0.010
wound healing GO:0042060 122 0.010
purine containing compound biosynthetic process GO:0072522 85 0.010
purine ribonucleotide biosynthetic process GO:0009152 81 0.010
negative regulation of immune system process GO:0002683 39 0.010
negative regulation of calcium ion import GO:0090281 2 0.010
transmembrane transport GO:0055085 412 0.010
response to ketone GO:1901654 182 0.010
regulation of ion transport GO:0043269 245 0.010
innate immune response GO:0045087 35 0.010

Grn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.437
inherited metabolic disorder DOID:655 0 0.437
disease of anatomical entity DOID:7 0 0.133
nervous system disease DOID:863 0 0.133
lipid storage disease DOID:9455 0 0.065
lysosomal storage disease DOID:3211 0 0.065
central nervous system disease DOID:331 0 0.026